| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Caitlin V Cosme, Andrea L Gutman, Ryan T LaLumier. The Dorsal Agranular Insular Cortex Regulates the Cued Reinstatement of Cocaine-Seeking, but not Food-Seeking, Behavior in Rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 10. 2016-05-09. PMID:25837282. |
prior studies suggest that the insular cortex (ic), and particularly its posterior region (the pic), is involved in nicotine craving and relapse in humans and rodents. |
2016-05-09 |
2023-08-13 |
rat |
| Abhiram Pushparaj, Aaron S Kim, Martin Musiol, Jose M Trigo, Bernard Le Fol. Involvement of the rostral agranular insular cortex in nicotine self-administration in rats. Behavioural brain research. vol 290. 2016-04-04. PMID:25934486. |
involvement of the rostral agranular insular cortex in nicotine self-administration in rats. |
2016-04-04 |
2023-08-13 |
rat |
| Abhiram Pushparaj, Aaron S Kim, Martin Musiol, Jose M Trigo, Bernard Le Fol. Involvement of the rostral agranular insular cortex in nicotine self-administration in rats. Behavioural brain research. vol 290. 2016-04-04. PMID:25934486. |
our prior work demonstrated the involvement of the caudal granular subregion of the insular cortex in a rat model of nicotine self-administration. |
2016-04-04 |
2023-08-13 |
rat |
| Abhiram Pushparaj, Aaron S Kim, Martin Musiol, Jose M Trigo, Bernard Le Fol. Involvement of the rostral agranular insular cortex in nicotine self-administration in rats. Behavioural brain research. vol 290. 2016-04-04. PMID:25934486. |
modulating insular cortex function appears to be a promising approach for nicotine dependence treatment. |
2016-04-04 |
2023-08-13 |
rat |
| Amy C Janes, Stacey Farmer, Alyssa L Peechatka, Blaise de B Frederick, Scott E Luka. Insula-Dorsal Anterior Cingulate Cortex Coupling is Associated with Enhanced Brain Reactivity to Smoking Cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 7. 2016-01-25. PMID:25567427. |
the insula plays a critical role in maintaining nicotine dependence and reactivity to smoking cues. |
2016-01-25 |
2023-08-13 |
human |
| Amy C Janes, Stacey Farmer, Alyssa L Peechatka, Blaise de B Frederick, Scott E Luka. Insula-Dorsal Anterior Cingulate Cortex Coupling is Associated with Enhanced Brain Reactivity to Smoking Cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 7. 2016-01-25. PMID:25567427. |
collectively, these data provide a more network-level understanding of the insula's role in nicotine dependence and shows a relationship between inherent brain organization and smoking cue-reactivity. |
2016-01-25 |
2023-08-13 |
human |
| Amy C Janes, Robert S Ross, Stacey Farmer, Blaise B Frederick, Lisa D Nickerson, Scott E Lukas, Chantal E Ster. Memory retrieval of smoking-related images induce greater insula activation as revealed by an fMRI-based delayed matching to sample task. Addiction biology. vol 20. issue 2. 2015-10-21. PMID:24261848. |
the insula, which is involved in maintaining nicotine dependence, was active during the successful retrieval of previously viewed smoking versus neutral images. |
2015-10-21 |
2023-08-12 |
human |
| Ozra Dehkordi, Jed E Rose, Sadegh Asadi, Kebreten F Manaye, Richard M Millis, Annapurni Jayam-Trout. Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system. Journal of neuroscience research. vol 93. issue 2. 2015-08-19. PMID:25223294. |
other structures of the nicotine brain-reward circuitry activated by nic-pm included the hypothalamus, paraventricular thalamic nucleus, lateral habenular nucleus, hippocampus, amygdala, accumbens nucleus, piriform cortex, angular insular cortex, anterior olfactory nucleus, lateral septal nucleus, bed nucleus of stria terminalis, cingulate and medial prefrontal cortex, olfactory tubercle, and medial and lateral orbital cortex. |
2015-08-19 |
2023-08-13 |
mouse |
| Wu Yang, Feng Wang, Zhen Zhang, Xiang Ren, Zhiyuan Zhang, Yang Li, Tao Su. [Altered effective connectivity of insula in nicotine addiction]. Zhonghua yi xue za zhi. vol 94. issue 21. 2015-05-16. PMID:25152295. |
[altered effective connectivity of insula in nicotine addiction]. |
2015-05-16 |
2023-08-13 |
Not clear |
| Wu Yang, Feng Wang, Zhen Zhang, Xiang Ren, Zhiyuan Zhang, Yang Li, Tao Su. [Altered effective connectivity of insula in nicotine addiction]. Zhonghua yi xue za zhi. vol 94. issue 21. 2015-05-16. PMID:25152295. |
to explore the changes of effective connectivity associated with insula in different nicotine addiction sessions so as to understand its role and function. |
2015-05-16 |
2023-08-13 |
Not clear |
| Andrea Kobiella, Stephan Ripke, Nils B Kroemer, Christian Vollmert, Sabine Vollstädt-Klein, Dorothea E Ulshöfer, Michael N Smolk. Acute and chronic nicotine effects on behaviour and brain activation during intertemporal decision making. Addiction biology. vol 19. issue 5. 2015-05-11. PMID:23679679. |
moreover, there was an acute nicotine effect in non-smokers on processing of the reward magnitude: nicotine increased the correlation of blood oxygen level-dependent response and mean amount in the left hippocampus, amygdala and anterior insula. |
2015-05-11 |
2023-08-12 |
Not clear |
| Elise M Weerts, Gary S Wand, Hiroto Kuwabara, Xiaoqiang Xu, J James Frost, Dean F Wong, Mary E McCau. Association of smoking with μ-opioid receptor availability before and during naltrexone blockade in alcohol-dependent subjects. Addiction biology. vol 19. issue 4. 2015-04-20. PMID:23252742. |
subjects who had higher scores on the fagerström nicotine dependence test had significantly lower basal scan binding potential (bpnd ) across mesolimbic regions, including the amygdala, cingulate, globus pallidus, thalamus and insula. |
2015-04-20 |
2023-08-12 |
human |
| Natassia Gaznick, Daniel Tranel, Ashton McNutt, Antoine Bechar. Basal ganglia plus insula damage yields stronger disruption of smoking addiction than basal ganglia damage alone. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 16. issue 4. 2015-03-26. PMID:24169814. |
the main objective of this study was to elucidate the importance of the basal ganglia (bg) and insula (ins) for nicotine addiction and smoking behavior. |
2015-03-26 |
2023-08-12 |
Not clear |
| Munir G Kutlu, Dennis Burke, Susan Slade, Brandon J Hall, Jed E Rose, Edward D Levi. Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. Behavioural brain research. vol 256. 2014-12-18. PMID:23948214. |
role of insular cortex d₁ and d₂ dopamine receptors in nicotine self-administration in rats. |
2014-12-18 |
2023-08-12 |
rat |
| Munir G Kutlu, Dennis Burke, Susan Slade, Brandon J Hall, Jed E Rose, Edward D Levi. Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. Behavioural brain research. vol 256. 2014-12-18. PMID:23948214. |
in the current set of studies, the roles of d₁ and d₂ receptors in the insular cortex in the self-administration of nicotine by rats were assessed. |
2014-12-18 |
2023-08-12 |
rat |
| Munir G Kutlu, Dennis Burke, Susan Slade, Brandon J Hall, Jed E Rose, Edward D Levi. Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. Behavioural brain research. vol 256. 2014-12-18. PMID:23948214. |
acute local infusions of the d₁ antagonist sch-23390 into the insula (1-2 μg/side) significantly decreased nicotine self-administration by more than 50%. |
2014-12-18 |
2023-08-12 |
rat |
| Munir G Kutlu, Dennis Burke, Susan Slade, Brandon J Hall, Jed E Rose, Edward D Levi. Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. Behavioural brain research. vol 256. 2014-12-18. PMID:23948214. |
repeated infusions of sch-23390 into the agranular insula caused continuing decreases in nicotine self-administration without signs of tolerance. |
2014-12-18 |
2023-08-12 |
rat |
| Munir G Kutlu, Dennis Burke, Susan Slade, Brandon J Hall, Jed E Rose, Edward D Levi. Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. Behavioural brain research. vol 256. 2014-12-18. PMID:23948214. |
these studies show the importance of da d₁ systems in the insula for nicotine reward. |
2014-12-18 |
2023-08-12 |
rat |
| Bernard Le Foll, Abhiram Pushparaj, Yaroslaw Pryslawsky, Benoit Forget, Kiran Vemuri, Alexandros Makriyannis, Jose M Trig. Translational strategies for therapeutic development in nicotine addiction: rethinking the conventional bench to bedside approach. Progress in neuro-psychopharmacology & biological psychiatry. vol 52. 2014-12-12. PMID:24140878. |
a 'bed side to bench strategy' was used to study the role of the insula (part of the frontal cortex) in nicotine addiction. |
2014-12-12 |
2023-08-12 |
Not clear |
| Andreas Gutzeit, Johannes M Froehlich, Klaus Hergan, Nicole Graf, Christoph A Binkert, Dieter Meier, Mike Brügger, Carolin Reischauer, Reto Sutter, Marcus Herdener, Tillmann Schubert, Sebastian Kos, Martin Grosshans, Matus Straka, Jochen Mutschle. Insula-specific H magnetic resonance spectroscopy reactions in heavy smokers under acute nicotine withdrawal and after oral nicotine substitution. European addiction research. vol 19. issue 4. 2014-11-06. PMID:23257512. |
the aim of this study was to clarify whether addiction-specific neurometabolic reaction patterns occur in the insular cortex during acute nicotine withdrawal in tobacco smokers in comparison to nonsmokers. |
2014-11-06 |
2023-08-12 |
human |