Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Paul J Kenn. Tobacco dependence, the insular cortex and the hypocretin connection. Pharmacology, biochemistry, and behavior. vol 97. issue 4. 2011-04-25. PMID:20816891. |
finally, the data suggesting that hypocretin transmission in the insular cortex may play an important role in regulating nicotine self-administration behavior in rats will be reviewed. |
2011-04-25 |
2023-08-12 |
human |
Anna E Goudriaan, Michiel B de Ruiter, Wim van den Brink, Jaap Oosterlaan, Dick J Veltma. Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study. Addiction biology. vol 15. issue 4. 2011-02-28. PMID:20840335. |
in a stratified analysis, the hsm subgroup with higher fagerström test for nicotine dependence scores (ftnd m = 5.4) showed higher brain activation in ventromedial prefrontal cortex, rostral anterior cingulate cortex, insula and middle/superior temporal gyrus while watching smoking-related pictures (relative to neutral pictures) than the hsm subgroup with lower ftnd scores (ftnd m = 2.9) and than non-smoking hc. |
2011-02-28 |
2023-08-12 |
Not clear |
Benoit Forget, Abhiram Pushparaj, Bernard Le Fol. Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction. Biological psychiatry. vol 68. issue 3. 2010-11-22. PMID:20299008. |
granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction. |
2010-11-22 |
2023-08-12 |
human |
Benoit Forget, Abhiram Pushparaj, Bernard Le Fol. Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction. Biological psychiatry. vol 68. issue 3. 2010-11-22. PMID:20299008. |
nicotine is the principal component of tobacco smoke, resulting in addiction, and recent evidence suggests that damage to the insular cortex (insula) disrupts tobacco addiction in human smokers. |
2010-11-22 |
2023-08-12 |
human |
Amir Abdolahi, Glen Acosta, Florence J Breslin, Scott E Hemby, Wendy J Lync. Incubation of nicotine seeking is associated with enhanced protein kinase A-regulated signaling of dopamine- and cAMP-regulated phosphoprotein of 32 kDa in the insular cortex. The European journal of neuroscience. vol 31. issue 4. 2010-07-08. PMID:20384816. |
incubation of nicotine seeking is associated with enhanced protein kinase a-regulated signaling of dopamine- and camp-regulated phosphoprotein of 32 kda in the insular cortex. |
2010-07-08 |
2023-08-12 |
rat |
Amir Abdolahi, Glen Acosta, Florence J Breslin, Scott E Hemby, Wendy J Lync. Incubation of nicotine seeking is associated with enhanced protein kinase A-regulated signaling of dopamine- and cAMP-regulated phosphoprotein of 32 kDa in the insular cortex. The European journal of neuroscience. vol 31. issue 4. 2010-07-08. PMID:20384816. |
in this study we used an animal model of nicotine addiction to examine the possibility that changes in insular cortex levels of dopamine (da)- and camp-regulated phosphoprotein of 32 kda (darpp-32), a phosphoprotein enriched in da neurons containing da d1 receptors, may be associated with changes in vulnerability to nicotine addiction. |
2010-07-08 |
2023-08-12 |
rat |
Amir Abdolahi, Glen Acosta, Florence J Breslin, Scott E Hemby, Wendy J Lync. Incubation of nicotine seeking is associated with enhanced protein kinase A-regulated signaling of dopamine- and cAMP-regulated phosphoprotein of 32 kDa in the insular cortex. The European journal of neuroscience. vol 31. issue 4. 2010-07-08. PMID:20384816. |
these results demonstrate incubation of drug seeking following extended access to nicotine self-administration and suggest that enhanced protein kinase a signaling in the insular cortex via phosphorylation of darpp-32 at thr34 is associated with this effect. |
2010-07-08 |
2023-08-12 |
rat |
Jonathan A Hollander, Qun Lu, Michael D Cameron, Theodore M Kamenecka, Paul J Kenn. Insular hypocretin transmission regulates nicotine reward. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 49. 2009-01-30. PMID:19033203. |
in addition, we show that hypocretin-containing fibers innervate the insula, hcrt-1 receptors are located on insular cells, and blockade of hcrt-1 receptors in the insula but not in the adjacent somatosensory cortex decreases nicotine self-administration. |
2009-01-30 |
2023-08-12 |
human |
E F Domino, S Minoshima, S K Guthrie, L Ohl, L Ni, R A Koeppe, D J Cross, J Zubiet. Effects of nicotine on regional cerebral glucose metabolism in awake resting tobacco smokers. Neuroscience. vol 101. issue 2. 2001-02-01. PMID:11074150. |
structures with a decrease in regional cerebral metabolism of glucose (pepper minus nicotine) were the left insula and right inferior occipital gyrus, with z scores >3.5. |
2001-02-01 |
2023-08-12 |
human |