| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eisuke Koy. Microglia: The new player orchestrating cocaine-induced expression of calcium-permeable AMPA receptors. Brain, behavior, and immunity. 2023-11-26. PMID:38008387. |
microglia: the new player orchestrating cocaine-induced expression of calcium-permeable ampa receptors. |
2023-11-26 |
2023-11-28 |
Not clear |
| Paula Izquierdo-Altarejos, Andrea Cabrera-Pastor, Mar Martínez-García, Carlos Sánchez-Huertas, Alberto Hernández, Victoria Moreno-Manzano, Vicente Felip. Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats. Journal of neuroinflammation. vol 20. issue 1. 2023-01-02. PMID:36593485. |
this leads to microglia activation and reduced smad7-ikb pathway, which induces nf-κb nuclear translocation in neurons, increasing il-1β which alters ampa and nmda receptors membrane expression, leading to cognitive impairment. |
2023-01-02 |
2023-08-14 |
rat |
| Xu Ding, Fei-Fei Liao, Li Su, Xi Yang, Wei Yang, Qing-Hua Ren, Jin-Zhe Zhang, Huan-Min Wan. Sciatic nerve block downregulates the BDNF pathway to alleviate the neonatal incision-induced exaggeration of incisional pain via decreasing microglial activation. Brain, behavior, and immunity. 2022-07-19. PMID:35853558. |
these results suggest that decreased activation of spinal microglia contributes to beneficial effects of sciatic nerve block on the neonatal incision-induced exaggeration of incisional pain via downregulating bdnf/shp2/glua1-containing ampa receptor signaling. |
2022-07-19 |
2023-08-14 |
rat |
| Michele Malaguarnera, Marta Llansola, Tiziano Balzano, Belén Gómez-Giménez, Carles Antúnez-Muñoz, Núria Martínez-Alarcón, Rahebeh Mahdinia, Vicente Felip. Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30858801. |
the effects of bicuculline on microglia and astrocyte activation, il-1β content, on membrane expression of ampa and nmda glutamate receptors subunits in the hippocampus and on spatial learning and memory as well as anxiety were assessed. |
2020-10-01 |
2023-08-13 |
rat |
| Virginia Correani, Sara Martire, Giuseppina Mignogna, Lisa Beatrice Caruso, Italo Tempera, Alessandra Giorgi, Maddalena Grieco, Luciana Mosca, M Eugenia Schininà, Bruno Maras, Maria d'Erm. Poly(ADP-ribosylated) proteins in β-amyloid peptide-stimulated microglial cells. Biochemical pharmacology. vol 167. 2020-03-30. PMID:30414941. |
parylation of nedd4 may be involved in the recruiting of this protein to the plasma membrane where it regulates the endocytosis of ampa receptors, whereas usp10 may be responsible for the increase of p53 levels in amyloid stimulated microglia. |
2020-03-30 |
2023-08-13 |
Not clear |
| Yan-Hua Li, Jing-Wen Yu, Jian-Yin Xi, Wen-Bo Yu, Jian-Chun Liu, Qing Wang, Li-Juan Song, Ling Feng, Ya-Ping Yan, Guang-Xian Zhang, Bao-Guo Xiao, Cun-Gen M. Fasudil Enhances Therapeutic Efficacy of Neural Stem Cells in the Mouse Model of MPTP-Induced Parkinson's Disease. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27590141. |
compared with the treatment of fasudil or nscs alone, the combined intervention more effectively inhibited the activation and aggregation of microglia and astrocytes, displayed stronger anti-inflammatory and antioxidant effects, induced more neurotrophic factor nt-3, and affected the dynamic homeostasis of nmda and ampa receptors in mptp-pd mice. |
2018-05-18 |
2023-08-13 |
mouse |
| Andrea Cabrera-Pastor, Vicente Hernandez-Rabaza, Lucas Taoro-Gonzalez, Tiziano Balzano, Marta Llansola, Vicente Felip. In vivo administration of extracellular cGMP normalizes TNF-α and membrane expression of AMPA receptors in hippocampus and spatial reference memory but not IL-1β, NMDA receptors in membrane and working memory in hyperammonemic rats. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189036. |
hyperammonemia also activates microglia and increases tnf-α, alters membrane expression of ampa receptor subunits (increased glua1 and reduced glua2) and impairs reference memory. |
2018-01-11 |
2023-08-13 |
rat |
| Chiara Cervetto, Daniela Frattaroli, Arianna Venturini, Mario Passalacqua, Mario Nobile, Susanna Alloisio, Carlo Tacchetti, Guido Maura, Luigi Francesco Agnati, Manuela Marcol. Calcium-permeable AMPA receptors trigger vesicular glutamate release from Bergmann gliosomes. Neuropharmacology. vol 99. 2016-08-30. PMID:26260232. |
we found that: 1) the rat cerebellar purified astrocyte processes (gliosomes) expressed astrocytic and bergmann markers and exhibited negligible contamination by nerve terminals, microglia, or oligodendrocytes; 2) activation of ca2+-permeable ampa receptors caused ca2+ signals in the processes, and the release of glutamate from the processes; 3) effectiveness of rose bengal, trypan blue or bafilomycin a1, indicated that activation of the ampa receptors evoked vesicular glutamate release. |
2016-08-30 |
2023-08-13 |
rat |
| Judy Choi, Beate Stradmann-Bellinghausen, Eduard Yakubov, Nicolai E Savaskan, Anne Régnier-Vigourou. Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages. Cancer biology & therapy. vol 16. issue 8. 2016-05-12. PMID:26047211. |
quantitative real-time pcr analysis showed (i) significant increases in the expressions of gria2 (glua2 or ampa receptor 2), slc1a2 (eaat2), slc1a3 (eaat1), (ii) a near-significant decrease in the expression of slc7a11 (cystine-glutamate antiporter xct) and (iii) a remarkable increase in glul expression (glutamine synthetase) in these cells compared to adult primary human microglia. |
2016-05-12 |
2023-08-13 |
human |
| Graham L Collingridge, Stephane Peinea. Strippers reveal their depressing secrets: removing AMPA receptors. Neuron. vol 82. issue 1. 2014-06-02. PMID:24698263. |
(2014) describe a novel form of long-term depression of ampa receptor-mediated synaptic transmission in the hippocampus involving the activation of microglia. |
2014-06-02 |
2023-08-13 |
Not clear |
| Kaoru Beppu, Yuki Kosai, Mizuho A Kido, Nozomi Akimoto, Yuki Mori, Yuichiro Kojima, Kyota Fujita, Yuko Okuno, Yukiko Yamakawa, Masataka Ifuku, Rika Shinagawa, Junichi Nabekura, Rolf Sprengel, Mami Nod. Expression, subunit composition, and function of AMPA-type glutamate receptors are changed in activated microglia; possible contribution of GluA2 (GluR-B)-deficiency under pathological conditions. Glia. vol 61. issue 6. 2013-10-29. PMID:23468421. |
microglia express ampa (α-amino-hydroxy-5-methyl-isoxazole-4-propionate)-type of glutamate (glu) receptors (ampar), which are highly ca(2+) impermeable due to the expression of glua2. |
2013-10-29 |
2023-08-12 |
mouse |
| Kyungmin Ji, Gulcan Akgul, Lonnie P Wollmuth, Stella E Tsirk. Microglia actively regulate the number of functional synapses. PloS one. vol 8. issue 2. 2013-08-26. PMID:23393609. |
conversely, the addition of microglia to neuronal cultures decreases synaptic activity and reduces the density of synapses, spine numbers, surface expression of ampa receptor (glua1), and levels of synaptic adhesion molecules. |
2013-08-26 |
2023-08-12 |
Not clear |
| Catia Giordano, Luigia Cristino, Livio Luongo, Dario Siniscalco, Stefania Petrosino, Fabiana Piscitelli, Ida Marabese, Luisa Gatta, Francesca Rossi, Roberta Imperatore, Enza Palazzo, Vito de Novellis, Vincenzo Di Marzo, Sabatino Maion. TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception. Cerebral cortex (New York, N.Y. : 1991). vol 22. issue 11. 2013-03-14. PMID:22139792. |
caspase-3 release and upregulation of ampa receptors in microglia, caspase-1 and il-1β release in astrocytes, and upregulation of il-1 receptor-1, trpv1, and vglut1 in glutamatergic neurons, were also observed. |
2013-03-14 |
2023-08-12 |
mouse |
| Andrzej Zylu. [Pain mechanisms in Complex Regional Pain Syndrome Type 1--a review]. Chirurgia narzadow ruchu i ortopedia polska. vol 74. issue 4. 2010-01-13. PMID:19999621. |
the following hypotheses were mentioned: 1) sensitization of dorsal root neurons on afferent barrage form site of injury, of which each, also non-nociceptive, can induce an activation of the nociceptive pathway; 2) interactions between the nervous and immune systems, when pain stimulation as a result of injury or inflammation activate microglia cells in central nerve system, what probably is responsible for development of spontaneous pain; 3) the role of of glutamatergic n-metyl-d-asparagin receptor (nmda), which increased activity reduces pain experience due to changes of conductance and number of ampa receptors, that mediate fast pain transmission; 4) the phenomenon of allodynia, when a touch stimuli, temperature or limb position change is experienced as a pain. |
2010-01-13 |
2023-08-12 |
Not clear |
| Guo Jun Liu, Rajini Nagarajah, Richard B Banati, Max R Bennet. Glutamate induces directed chemotaxis of microglia. The European journal of neuroscience. vol 29. issue 6. 2009-06-09. PMID:19302147. |
this chemotaxis is meditated by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (ampa) and metabotropic glutamate receptors on the microglia. |
2009-06-09 |
2023-08-12 |
Not clear |
| Maxwell R Bennet. Synaptic P2X7 receptor regenerative-loop hypothesis for depression. The Australian and New Zealand journal of psychiatry. vol 41. issue 7. 2007-10-04. PMID:17558618. |
infections can change this state by activating toll-like (tol) receptors on the microglia concomitantly with their p2x7 receptor activation by the regenerative loop, thereby releasing the cytokine interleukin-1beta, which decreases the ampa receptors in the neural membrane, so decreasing synaptic efficacy and changing the functional state of the neural network in which the synapse resides. |
2007-10-04 |
2023-08-12 |
Not clear |
| Maxwell R Bennet. Synaptic P2X7 receptor regenerative-loop hypothesis for depression. The Australian and New Zealand journal of psychiatry. vol 41. issue 7. 2007-10-04. PMID:17558618. |
this synaptic atp can also act on microglia p2x7 receptors to release the cytokine tumour necrosis factor-alpha (tnf-alpha), as can glutamate, with this tnf-alpha acting on the post-synaptic neuronal membrane to increase glutamate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (ampa) receptors there. |
2007-10-04 |
2023-08-12 |
Not clear |
| Guo Jun Liu, Adrianna Kalous, Eryn L Werry, Max R Bennet. Purine release from spinal cord microglia after elevation of calcium by glutamate. Molecular pharmacology. vol 70. issue 3. 2006-09-28. PMID:16760362. |
the 4-fold increase in atp release from microglia in response to glutamate (0.5 mm) was blocked by alpha-aminohydroxy-5-methyl-isoxazole-4-proprionate (ampa)/kainate receptor antagonist 6-cyano-7-nitroguinoxaline-2,3-dione and specific ampa receptor antagonist 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5h-2,3-benzodiazepine hydrochloride (gyki 52466) but not by n-methyl-d-aspartic acid or metabotropic glutamate receptor antagonists. |
2006-09-28 |
2023-08-12 |
mouse |
| Randolph N Christensen, Byeong Keun Ha, Fang Sun, Jacqueline C Bresnahan, Michael S Beatti. Kainate induces rapid redistribution of the actin cytoskeleton in ameboid microglia. Journal of neuroscience research. vol 84. issue 1. 2006-09-08. PMID:16625662. |
this study describes the microglial response to the glutamate receptor agonist kainate (ka) and shows via immunochemistry that the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (ampa)-type glutamate receptor subunit glur1 is present on cultured microglia. |
2006-09-08 |
2023-08-12 |
Not clear |
| Liliana Bernardino, Sara Xapelli, Ana P Silva, Birthe Jakobsen, Frantz R Poulsen, Catarina R Oliveira, Annamaria Vezzani, João O Malva, Jens Zimme. Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 29. 2006-02-15. PMID:16033883. |
ampa exposure was associated with activation and proliferation of microglia as assessed by macrophage antigen-1 and bromodeoxyuridine immunohistochemistry, suggesting a functional recruitment of cytokine-producing cells at sites of neurodegeneration. |
2006-02-15 |
2023-08-12 |
mouse |