| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Konstantinos Sarantis, Katerina Antoniou, Nikolaos Matsokis, Fevronia Angelato. Exposure to novel environment is characterized by an interaction of D1/NMDA receptors underlined by phosphorylation of the NMDA and AMPA receptor subunits and activation of ERK1/2 signaling, leading to epigenetic changes and gene expression in rat hippocampus. Neurochemistry international. vol 60. issue 1. 2012-06-20. PMID:22080157. |
our results showed that the "spatial" novelty induced in rat hippocampus and pfc (a) a significant increase in phosphorylation of nmda and ampa receptor subunits, as well as a robust phosphorylation/activation of erk1/2 signaling, which are both dependent on the concomitant stimulation of d1/nmda receptors and are both abolished by habituation procedure, (b) chromatin remodeling events (phosphorylation-acetylation of histone h3) and (c) an increase in the immediate early genes (iegs) c-fos and zif-268 expression in the ca1 region of hippocampus, which is dependent on the co-activation of d1/nmda and acetylcholine muscarinic receptors. |
2012-06-20 |
2023-08-12 |
rat |
| Patrick M Kanju, Kodeeswaran Parameshwaran, Catrina Sims-Robinson, Subramaniam Uthayathas, Eleanor M Josephson, Nagalingam Rajakumar, Muralikrishnan Dhanasekaran, Vishnu Suppiramania. Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus. PloS one. vol 7. issue 2. 2012-06-18. PMID:22355337. |
here we investigated whether long term potentiation (ltp) and synaptic currents, mediated by alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (ampa) and n-methyl-d-aspartate (nmda) receptors in the ca1 hippocampal region, are affected following cholinergic lesions of the ms. stereotaxic intra-medioseptal infusions of a selective immunotoxin, 192-saporin, against cholinergic neurons or sterile saline were made in adult rats. |
2012-06-18 |
2023-08-12 |
rat |
| Patrick M Kanju, Kodeeswaran Parameshwaran, Catrina Sims-Robinson, Subramaniam Uthayathas, Eleanor M Josephson, Nagalingam Rajakumar, Muralikrishnan Dhanasekaran, Vishnu Suppiramania. Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus. PloS one. vol 7. issue 2. 2012-06-18. PMID:22355337. |
four days after infusions, hippocampal slices were made and ltp, whole cell, and single channel (ampa or nmda receptor) currents were recorded. |
2012-06-18 |
2023-08-12 |
rat |
| Enikö A Kramár, Lulu Y Chen, Julie C Lauterborn, Danielle A Simmons, Christine M Gall, Gary Lync. BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:20674095. |
comparable rescue results were obtained after elevating endogenous bdnf protein levels in hippocampus with 4 daily injections of a short half-life ampakine (positive modulator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate [ampa]-type glutamate receptors). |
2012-06-15 |
2023-08-12 |
human |
| Rodrigo F Oliveira, Myungsook Kim, Kim T Blackwel. Subcellular location of PKA controls striatal plasticity: stochastic simulations in spiny dendrites. PLoS computational biology. vol 8. issue 2. 2012-06-04. PMID:22346744. |
experiments have shown that blocking the interaction of pka with akaps disrupts its subcellular location and prevents ltp in the hippocampus and striatum; however, these experiments have not revealed whether the critical function of anchoring is to locate pka near the camp that activates it or near its targets, such as ampa receptors located in the post-synaptic density. |
2012-06-04 |
2023-08-12 |
Not clear |
| Toshihiro Nomura, Wataru Kakegawa, Shinji Matsuda, Kazuhisa Kohda, Jun Nishiyama, Takao Takahashi, Michisuke Yuzak. Cerebellar long-term depression requires dephosphorylation of TARP in Purkinje cells. The European journal of neuroscience. vol 35. issue 3. 2012-05-29. PMID:22239345. |
like hippocampal ltd, cerebellar ltd is mediated by the endocytosis of ampa (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate) receptors at postsynaptic sites. |
2012-05-29 |
2023-08-12 |
Not clear |
| Toshihiro Nomura, Wataru Kakegawa, Shinji Matsuda, Kazuhisa Kohda, Jun Nishiyama, Takao Takahashi, Michisuke Yuzak. Cerebellar long-term depression requires dephosphorylation of TARP in Purkinje cells. The European journal of neuroscience. vol 35. issue 3. 2012-05-29. PMID:22239345. |
activity-dependent dephosphorylation of stargazin (an ampa receptor auxiliary protein) by calcineurin regulates hippocampal ltd, but whether and how stargazin is involved in cerebellar ltd is unknown. |
2012-05-29 |
2023-08-12 |
Not clear |
| Dong Li, Christian G Specht, Clarissa L Waites, Charlotte Butler-Munro, Sergio Leal-Ortiz, Janie W Foote, David Genoux, Craig C Garner, Johanna M Montgomer. SAP97 directs NMDA receptor spine targeting and synaptic plasticity. The Journal of physiology. vol 589. issue Pt 18. 2012-05-25. PMID:21768261. |
however, by recording from pairs of synaptically coupled hippocampal neurons, we show that αsap97 occludes ltp by enhancing the levels of postsynaptic ampa receptors, while βsap97 blocks ltp by reducing the synaptic localization of nmda receptors. |
2012-05-25 |
2023-08-12 |
Not clear |
| Stefania Risso Bradley, Jason M Uslaner, Rose B Flick, Ariel Lee, Kristina M Groover, Peter H Hutso. The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling. Pharmacology, biochemistry, and behavior. vol 101. issue 1. 2012-05-25. PMID:22138407. |
finally, we report that behaviorally efficacious doses of amn082 modulate phosphorylation of ampa and nmda receptor subunits in the hippocampus. |
2012-05-25 |
2023-08-12 |
Not clear |
| Silvia Bassani, Lorenzo A Cingolani, Pamela Valnegri, Alessandra Folci, Jonathan Zapata, Antonella Gianfelice, Carlo Sala, Yukiko Goda, Maria Passafar. The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking. Neuron. vol 73. issue 6. 2012-05-15. PMID:22445342. |
here we show that tspan7 overexpression promotes the formation of filopodia and dendritic spines in cultured hippocampal neurons from embryonic rats, whereas tspan7 silencing reduces head size and stability of spines and ampa receptor currents. |
2012-05-15 |
2023-08-12 |
rat |
| Silvia Bassani, Lorenzo A Cingolani, Pamela Valnegri, Alessandra Folci, Jonathan Zapata, Antonella Gianfelice, Carlo Sala, Yukiko Goda, Maria Passafar. The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking. Neuron. vol 73. issue 6. 2012-05-15. PMID:22445342. |
these findings indicate that, in hippocampal neurons, tspan7 regulates ampa receptor trafficking by limiting pick1 accessibility to ampa receptors and suggest an additional mechanism for the functional maturation of glutamatergic synapses, whose impairment is implicated in intellectual disability. |
2012-05-15 |
2023-08-12 |
rat |
| Martin B Gill, Akihiko S Kato, He Wang, David S Bred. AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform. The European journal of neuroscience. vol 35. issue 2. 2012-05-08. PMID:22211840. |
why cornichon-2 (cnih-2), another ampa receptor-associated protein, modulates ampa receptor gating and pharmacology in hippocampal neurons but not cerebellar granule neurons remains unresolved. |
2012-05-08 |
2023-08-12 |
Not clear |
| Rodrigo S Sestito, Lucas B Trindade, Rodrigo G de Souza, Lucila N Kerbauy, Melina M Iyomasa, Maria L N M Ros. Effect of isolation rearing on the expression of AMPA glutamate receptors in the hippocampal formation. Journal of psychopharmacology (Oxford, England). vol 25. issue 12. 2012-04-26. PMID:20952455. |
in this immunohistochemistry study we evaluate the changes in the expression of glur1 and glur2 ampa receptors in the hippocampus, amygdala and entorhinal cortex induced by isolation rearing. |
2012-04-26 |
2023-08-12 |
human |
| Rodrigo S Sestito, Lucas B Trindade, Rodrigo G de Souza, Lucila N Kerbauy, Melina M Iyomasa, Maria L N M Ros. Effect of isolation rearing on the expression of AMPA glutamate receptors in the hippocampal formation. Journal of psychopharmacology (Oxford, England). vol 25. issue 12. 2012-04-26. PMID:20952455. |
the results suggest that isolation rearing from weaning induces changes on the expression of ampa glutamate receptors in the hippocampus similar to those reported for postmortem human brains with schizophrenia. |
2012-04-26 |
2023-08-12 |
human |
| Takeshi Kanno, Takahiro Yaguchi, Tetsu Nagata, Tadashi Shimizu, Akito Tanaka, Tomoyuki Nishizak. Indomethacin enhances learning and memory potential by interacting with CaMKII. Journal of cellular physiology. vol 227. issue 3. 2012-04-25. PMID:21503887. |
im (100 µm) significantly increased the rate of spontaneous ampa receptor-mediated miniature excitatory postsynaptic currents elicited from ca1 pyramidal neurons of rat hippocampal slices, without affecting the amplitude, and enhanced extracellular high k(+) (20 mm)-induced glutamate release from rat hippocampal slices, indicating that im stimulates presynaptic glutamate release. |
2012-04-25 |
2023-08-12 |
mouse |
| Giovanna D'Arcangelo, Daniele Grossi, Giovanna De Chiara, Maria Chiara de Stefano, Giancarlo Cortese, Gennaro Citro, Stefano Rufini, Virginia Tancredi, Daniela Merlo, Claudio Fran. Glutamatergic neurotransmission in a mouse model of Niemann-Pick type C disease. Brain research. vol 1396. 2012-04-17. PMID:21575932. |
we found that a prolonged application of ka and ampa in npc1-/- mice do not induce the dramatic decrease of synaptic transmission observed in wt hippocampal slices suggesting a functional impairment of presynaptic ka receptors and an imbalance of ampa receptor exo/endocytosis. |
2012-04-17 |
2023-08-12 |
mouse |
| Giovanna D'Arcangelo, Daniele Grossi, Giovanna De Chiara, Maria Chiara de Stefano, Giancarlo Cortese, Gennaro Citro, Stefano Rufini, Virginia Tancredi, Daniela Merlo, Claudio Fran. Glutamatergic neurotransmission in a mouse model of Niemann-Pick type C disease. Brain research. vol 1396. 2012-04-17. PMID:21575932. |
in line with electrophysiological data, we also found notable differences in calcium influx during ka and ampa bath application in npc1-/- hippocampal culture as compared with wt. |
2012-04-17 |
2023-08-12 |
mouse |
| Mohammed K Hankir, James R Parkinson, Stephen R Bloom, Jimmy D Bel. The effects of glutamate receptor agonists and antagonists on mouse hypothalamic and hippocampal neuronal activity shown through manganese enhanced MRI. NeuroImage. vol 59. issue 2. 2012-04-17. PMID:21925279. |
administration of monosodium glutamate (msg) and the ionotropic glutamate receptor (iglur) agonists nmda and ampa resulted in significantly increased signal intensity (si) in the arcuate nucleus (arc), the suprachiasmatic nucleus (scn) and the ca3 region of the hippocampus of mice consistent with increased neuronal activity. |
2012-04-17 |
2023-08-12 |
mouse |
| Wagner Zago, Manuel Buttini, Thomas A Comery, Christopher Nishioka, Shyra J Gardai, Peter Seubert, Dora Games, Frédérique Bard, Dale Schenk, Gene G Kinne. Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 8. 2012-04-16. PMID:22357853. |
in the current report, we demonstrated that 3d6 binds to soluble, synaptotoxic assemblies of aβ(1-42) and prevents multiple downstream functional consequences in rat hippocampal neurons including changes in glutamate ampa receptor trafficking, ad-type tau phosphorylation, and loss of dendritic spines. |
2012-04-16 |
2023-08-12 |
mouse |
| Karine Pozo, Lorenzo A Cingolani, Silvia Bassani, Fanny Laurent, Maria Passafaro, Yukiko God. β3 integrin interacts directly with GluA2 AMPA receptor subunit and regulates AMPA receptor expression in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 4. 2012-03-28. PMID:22232691. |
β3 integrin interacts directly with glua2 ampa receptor subunit and regulates ampa receptor expression in hippocampal neurons. |
2012-03-28 |
2023-08-12 |
mouse |