| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Priscila Hachimine, Neal Seepersad, Sandra Babic, Robert Ranald. Concurrent antagonism of NMDA and AMPA receptors in the ventral tegmental area reduces the expression of conditioned approach learning in rats. Behavioural brain research. vol 298. issue Pt B. 2016-09-20. PMID:26542814. |
these findings indicate that expression of conditioned approach learning requires nmda or ampa receptor stimulation in the vta. |
2016-09-20 |
2023-08-13 |
rat |
| Hui-Ling Wang, Jia Qi, Shiliang Zhang, Huikun Wang, Marisela Morale. Rewarding Effects of Optical Stimulation of Ventral Tegmental Area Glutamatergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 48. 2016-03-28. PMID:26631475. |
vta injections of ampa or nmda receptor antagonists blocked optical self-stimulation and place preference. |
2016-03-28 |
2023-08-13 |
mouse |
| Kathryn Hausknecht, Samir Haj-Dahmane, Ying-Ling Shen, Paul Vezina, Cynthia Dlugos, Roh-Yu She. Excitatory synaptic function and plasticity is persistently altered in ventral tegmental area dopamine neurons after prenatal ethanol exposure. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 4. 2016-01-05. PMID:25284318. |
in pe animals, we observed a persistent augmentation in calcium-permeable ampa receptor (cp-ampar) expression, indicated by increased rectification and reduced decay time of ampar-mediated excitatory postsynaptic currents (ampar-epscs), enhanced depression of ampar-epscs by naspm (a selective cp-ampar antagonist), and increased glua3 subunits in vta da neuron dendrites. |
2016-01-05 |
2023-08-13 |
rat |
| Han-Ting Chen, Jin-Chung Che. Role of the ventral tegmental area in methamphetamine extinction: AMPA receptor-mediated neuroplasticity. Learning & memory (Cold Spring Harbor, N.Y.). vol 22. issue 3. 2015-10-27. PMID:25691515. |
role of the ventral tegmental area in methamphetamine extinction: ampa receptor-mediated neuroplasticity. |
2015-10-27 |
2023-08-13 |
Not clear |
| Staci E Engle, J Michael McIntosh, Ryan M Drena. Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via α6-containing nicotinic receptors. Neuropharmacology. vol 91. 2015-09-28. PMID:25484253. |
nicotine and ethanol cooperate to enhance ventral tegmental area ampa receptor function via α6-containing nicotinic receptors. |
2015-09-28 |
2023-08-13 |
mouse |
| Staci E Engle, J Michael McIntosh, Ryan M Drena. Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via α6-containing nicotinic receptors. Neuropharmacology. vol 91. 2015-09-28. PMID:25484253. |
exposing vta slices from c57bl/6 wt animals to drinking-relevant concentrations of ethanol causes a marked enhancement of α-amino-3-hydroxy-5-methyl-isoxazolepropionic acid (ampa) receptor (ampar) function in vta neurons. |
2015-09-28 |
2023-08-13 |
mouse |
| Zhenyu Sheng, Ammy M Santiago, Mark P Thomas, Vanessa H Rout. Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry. Molecular and cellular neurosciences. vol 62. 2015-06-12. PMID:25107627. |
sepscs were completely blocked by ampa and nmda glutamate receptor antagonists (cnqx 20 μm, n=4; apv 20μm, n=4; respectively), demonstrating that these sepscs were mediated by glutamatergic transmission onto vta da neurons. |
2015-06-12 |
2023-08-13 |
mouse |
| Junshi Wang, Robert W Bina, Jeffrey C Wingard, Ernest F Terwilliger, Ronald P Hammer, Ella M Nikulin. Knockdown of tropomyosin-related kinase B receptor expression in the nucleus accumbens shell prevents intermittent social defeat stress-induced cross-sensitization to amphetamine in rats. The European journal of neuroscience. vol 39. issue 6. 2014-11-07. PMID:24354924. |
nac trkb knockdown also prevented stress-induced elevation of bdnf and the glutamate receptor type 1 (glua1) subunit of ampa receptor in the vta, as well as Δfosb expression in the nac. |
2014-11-07 |
2023-08-12 |
rat |
| Jessica A Loweth, Kuei Y Tseng, Marina E Wol. Using metabotropic glutamate receptors to modulate cocaine's synaptic and behavioral effects: mGluR1 finds a niche. Current opinion in neurobiology. vol 23. issue 4. 2014-02-27. PMID:23385114. |
in several brain regions (ventral tegmental area (vta), cerebellum, and amygdala), stimulation of mglur1 selectively inhibits synaptic transmission mediated by calcium-permeable ampa receptors (cp-ampars) and thus produces synaptic depression. |
2014-02-27 |
2023-08-12 |
Not clear |
| Staci E Engle, Pei-Yu Shih, J Michael McIntosh, Ryan M Drena. α4α6β2* nicotinic acetylcholine receptor activation on ventral tegmental area dopamine neurons is sufficient to stimulate a depolarizing conductance and enhance surface AMPA receptor function. Molecular pharmacology. vol 84. issue 3. 2013-11-26. PMID:23788655. |
finally, ampa receptor (ampar) function was not similarly enhanced in brain slices from α6l9's mice lacking α4 nachr subunits, suggesting that α4α6β2* nachrs are important for enhancing ampar function in vta da neurons. |
2013-11-26 |
2023-08-12 |
mouse |
| b' Charles Ducrot, Emmanuel Fortier, Claude Bouchard, Pierre-Paul Rompr\\xc3\\xa. Opposite modulation of brain stimulation reward by NMDA and AMPA receptors in the ventral tegmental area. Frontiers in systems neuroscience. vol 7. 2013-10-09. PMID:24106463.' |
opposite modulation of brain stimulation reward by nmda and ampa receptors in the ventral tegmental area. |
2013-10-09 |
2023-08-12 |
rat |
| b' Charles Ducrot, Emmanuel Fortier, Claude Bouchard, Pierre-Paul Rompr\\xc3\\xa. Opposite modulation of brain stimulation reward by NMDA and AMPA receptors in the ventral tegmental area. Frontiers in systems neuroscience. vol 7. 2013-10-09. PMID:24106463.' |
glutamate induces two types of excitatory response on vta neurons, a fast and short lasting depolarization mediated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (ampa) receptors and a longer lasting depolarization mediated by nmda receptors. |
2013-10-09 |
2023-08-12 |
rat |
| b' Charles Ducrot, Emmanuel Fortier, Claude Bouchard, Pierre-Paul Rompr\\xc3\\xa. Opposite modulation of brain stimulation reward by NMDA and AMPA receptors in the ventral tegmental area. Frontiers in systems neuroscience. vol 7. 2013-10-09. PMID:24106463.' |
a role for the two glutamate receptors in modulation of vta neuronal activity is evidenced by the functional change in ampa and nmda synaptic responses that result from repeated exposure to reward. |
2013-10-09 |
2023-08-12 |
rat |
| b' Charles Ducrot, Emmanuel Fortier, Claude Bouchard, Pierre-Paul Rompr\\xc3\\xa. Opposite modulation of brain stimulation reward by NMDA and AMPA receptors in the ventral tegmental area. Frontiers in systems neuroscience. vol 7. 2013-10-09. PMID:24106463.' |
since both receptors contribute to the action of glutamate on vta neuronal activity, we studied the effects of vta ampa and nmda receptor blockade on reward induced by electrical brain stimulation. |
2013-10-09 |
2023-08-12 |
rat |
| b' Charles Ducrot, Emmanuel Fortier, Claude Bouchard, Pierre-Paul Rompr\\xc3\\xa. Opposite modulation of brain stimulation reward by NMDA and AMPA receptors in the ventral tegmental area. Frontiers in systems neuroscience. vol 7. 2013-10-09. PMID:24106463.' |
reward thresholds were measured with the curve-shift paradigm before and for 2 h after bilateral vta microinjections of the ampa antagonist, nbqx (2,3,-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo(f)quinoxaline-7-sulfonamide, 0, 80, and 800 pmol/0.5 μl/side) and of a single dose (0.825 nmol/0.5 μl/side) of the nmda antagonist, pppa (2r,4s)-4-(3-phosphonopropyl)-2-piperidinecarboxylic acid). |
2013-10-09 |
2023-08-12 |
rat |
| Xavier De Jaeger, Stephanie F Bishop, Tasha Ahmad, Danika Lyons, Garye Ami Ng, Steven R Laviolett. The effects of AMPA receptor blockade in the prelimbic cortex on systemic and ventral tegmental area opiate reward sensitivity. Psychopharmacology. vol 225. issue 3. 2013-06-21. PMID:22972411. |
the effects of ampa receptor blockade in the prelimbic cortex on systemic and ventral tegmental area opiate reward sensitivity. |
2013-06-21 |
2023-08-12 |
Not clear |
| Takehiro Kudo, Motokazu Uchigashima, Taisuke Miyazaki, Kohtarou Konno, Miwako Yamasaki, Yuchio Yanagawa, Masabumi Minami, Masahiko Watanab. Three types of neurochemical projection from the bed nucleus of the stria terminalis to the ventral tegmental area in adult mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 50. 2013-02-27. PMID:23238719. |
vglut2(+) terminals in the vta exclusively formed asymmetrical synapses, which expressed ampa receptors on postsynaptic membrane. |
2013-02-27 |
2023-08-12 |
mouse |
| Marina E Wolf, Kuei Y Tsen. Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why? Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22754497. |
calcium-permeable ampa receptors in the vta and nucleus accumbens after cocaine exposure: when, how, and why? |
2012-10-02 |
2023-08-12 |
Not clear |
| Marina E Wolf, Kuei Y Tsen. Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why? Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22754497. |
in animal models of drug addiction, cocaine exposure has been shown to increase levels of calcium-permeable ampa receptors (cp-ampars) in two brain regions that are critical for motivation and reward-the ventral tegmental area (vta) and the nucleus accumbens (nac). |
2012-10-02 |
2023-08-12 |
Not clear |
| Thorfinn T Riday, Barry E Kosofsky, C J Malang. The rewarding and locomotor-sensitizing effects of repeated cocaine administration are distinct and separable in mice. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22197517. |
expression of ampa receptor subunits (glur1 and glur2) and cre binding protein (creb) was measured in the ventral tegmental area (vta), dorsolateral striatum (str) and nucleus accumbens (nac) before and after a sensitizing regimen of cocaine, with and without icss. |
2012-07-27 |
2023-08-12 |
mouse |