| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Vashchinkina, Anne Panhelainen, Olga Yu Vekovischeva, Teemu Aitta-aho, Bjarke Ebert, Nancy A Ator, Esa R Korp. GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 15. 2012-06-15. PMID:22496576. |
increased ampa/nmda receptor current ratio and increased frequency, amplitude, and rectification of ampa receptor responses suggested persistent targeting of glua2-lacking ampa receptors in excitatory synapses of vta dopamine neurons ex vivo after thip administration. |
2012-06-15 |
2023-08-12 |
mouse |
| Matthew T C Brown, Clio Korn, Christian Lüsche. Mimicking synaptic effects of addictive drugs with selective dopamine neuron stimulation. Channels (Austin, Tex.). vol 5. issue 6. 2012-06-08. PMID:21785269. |
a single injection of cocaine has been shown to induce a change in the ampa receptor (ampar) subunit composition at glutamatergic synapses onto ventral tegmental area (vta) dopamine (da) neurons. |
2012-06-08 |
2023-08-12 |
Not clear |
| D A Lane, B Reed, M J Kreek, V M Picke. Differential glutamate AMPA-receptor plasticity in subpopulations of VTA neurons in the presence or absence of residual cocaine: implications for the development of addiction. Neuropharmacology. vol 61. issue 7. 2012-01-27. PMID:21215761. |
our results demonstrate that systemic cocaine produces glur1 trafficking specifically in non-da neurons of the vta, which may subsequently contribute to the abstinent-induced enhancement of ampa receptor synaptic transmission in mesocorticolimbic da neurons leading to heightened drug seeking behavior. |
2012-01-27 |
2023-08-12 |
mouse |
| A E Panhelainen, O Y Vekovischeva, T Aitta-Aho, I Rasanen, I Ojanperä, E R Korp. Diazepam-induced neuronal plasticity attenuates locomotor responses to morphine and amphetamine challenges in mice. Neuroscience. vol 192. 2012-01-18. PMID:21782898. |
a single administration of benzodiazepine-site ligands of the inhibitory gaba(a) receptors has been shown to lead to persistently potentiated ampa receptor-mediated responses in dopaminergic neurons of the ventral tegmental area (vta). |
2012-01-18 |
2023-08-12 |
mouse |
| Danyan Mao, Keith Gallagher, Daniel S McGehe. Nicotine potentiation of excitatory inputs to ventral tegmental area dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543600. |
brief exposure of nicotine to brain slices from drug-naive adult rats followed by a period of recovery resulted in an nmda receptor (nmdar)-dependent increase of ampa receptor/nmdar ratio in vta da neurons, which is consistent with the induction of ltp. |
2011-08-05 |
2023-08-12 |
rat |
| Kwang Ho Choi, Scott Edwards, Danielle L Graham, Erin B Larson, Kimberly N Whisler, Diana Simmons, Allyson K Friedman, Jessica J Walsh, Zia Rahman, Lisa M Monteggia, Amelia J Eisch, Rachael L Neve, Eric J Nestler, Ming-Hu Han, David W Sel. Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613507. |
reinforcement-related regulation of ampa glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. |
2011-08-04 |
2023-08-12 |
rat |
| Kwang Ho Choi, Scott Edwards, Danielle L Graham, Erin B Larson, Kimberly N Whisler, Diana Simmons, Allyson K Friedman, Jessica J Walsh, Zia Rahman, Lisa M Monteggia, Amelia J Eisch, Rachael L Neve, Eric J Nestler, Ming-Hu Han, David W Sel. Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613507. |
here we show that daily intravenous cocaine self-administration, but not passive cocaine administration, induces dynamic upregulation of the ampa glutamate receptor subunits glur1 and glur2 in the ventral tegmental area (vta) of rats. |
2011-08-04 |
2023-08-12 |
rat |
| Kwang Ho Choi, Scott Edwards, Danielle L Graham, Erin B Larson, Kimberly N Whisler, Diana Simmons, Allyson K Friedman, Jessica J Walsh, Zia Rahman, Lisa M Monteggia, Amelia J Eisch, Rachael L Neve, Eric J Nestler, Ming-Hu Han, David W Sel. Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613507. |
overexpression of glur1(wt) in rat vta primarily infected dopamine neurons (75%) and increased ampa receptor-mediated membrane rectification in these neurons with ampa application. |
2011-08-04 |
2023-08-12 |
rat |
| Kwang Ho Choi, Scott Edwards, Danielle L Graham, Erin B Larson, Kimberly N Whisler, Diana Simmons, Allyson K Friedman, Jessica J Walsh, Zia Rahman, Lisa M Monteggia, Amelia J Eisch, Rachael L Neve, Eric J Nestler, Ming-Hu Han, David W Sel. Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613507. |
together, these results suggest that dynamic regulation of ampa receptors in the vta during cocaine self-administration contributes to cocaine addiction by acting to facilitate subsequent cocaine use. |
2011-08-04 |
2023-08-12 |
rat |
| Zhiqiang Liu, Jing Han, Lintao Jia, Jean-Christian Maillet, Guang Bai, Lin Xu, Zhengping Jia, Qiaohua Zheng, Wandong Zhang, Robert Monette, Zul Merali, Zhou Zhu, Wei Wang, Wei Ren, Xia Zhan. Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning. PloS one. vol 5. issue 12. 2011-07-05. PMID:21187978. |
here we show in rats that chronic cannabinoid exposure activates vta cannabinoid cb1 receptors to induce transient neurotransmission depression at vta local glu-da synapses through activation of nmda receptors and subsequent endocytosis of ampa receptor glur2 subunits. |
2011-07-05 |
2023-08-12 |
rat |
| Brian C Nolan, Michelle Saliba, Christopher Tanchez, Robert Ranald. Behavioral activating effects of selective AMPA receptor antagonism in the ventral tegmental area. Pharmacology. vol 86. issue 5-6. 2011-04-11. PMID:21135569. |
behavioral activating effects of selective ampa receptor antagonism in the ventral tegmental area. |
2011-04-11 |
2023-08-12 |
rat |
| Brian C Nolan, Michelle Saliba, Christopher Tanchez, Robert Ranald. Behavioral activating effects of selective AMPA receptor antagonism in the ventral tegmental area. Pharmacology. vol 86. issue 5-6. 2011-04-11. PMID:21135569. |
the current study tested the hypothesis that nbqx (a selective ampa receptor antagonist) in the ventral tegmental area (vta) would reduce cocaine seeking. |
2011-04-11 |
2023-08-12 |
rat |
| Brian C Nolan, Michelle Saliba, Christopher Tanchez, Robert Ranald. Behavioral activating effects of selective AMPA receptor antagonism in the ventral tegmental area. Pharmacology. vol 86. issue 5-6. 2011-04-11. PMID:21135569. |
these results failed to support the hypothesis that ampa receptor antagonism in vta would reduce cocaine seeking and suggest that such antagonism causes general activating effects and may enhance the capacity of cocaine-css to function as conditioned reinforcers. |
2011-04-11 |
2023-08-12 |
rat |
| D A Lane, A Jaferi, M J Kreek, V M Picke. Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral tegmental area. Neuroscience. vol 169. issue 2. 2010-11-23. PMID:20553819. |
acute and chronic cocaine differentially alter the subcellular distribution of ampa glur1 subunits in region-specific neurons within the mouse ventral tegmental area. |
2010-11-23 |
2023-08-12 |
mouse |
| D A Lane, A Jaferi, M J Kreek, V M Picke. Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral tegmental area. Neuroscience. vol 169. issue 2. 2010-11-23. PMID:20553819. |
cocaine administration increases ampa glur1 expression and receptor-mediated activation of the ventral tegmental area (vta). |
2010-11-23 |
2023-08-12 |
mouse |
| D A Lane, A Jaferi, M J Kreek, V M Picke. Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral tegmental area. Neuroscience. vol 169. issue 2. 2010-11-23. PMID:20553819. |
to test this hypothesis, we used electron microscopic immunolabeling of ampa glur1 subunits and tyrosine hydroxylase (th), the enzyme needed for dopamine synthesis, in the cortical-associated parabrachial (pb) and in the limbic-associated paranigral (pn) vta of adult male c57bl/6 mice receiving either a single injection (acute) or repeated escalating-doses for 14 days (chronic) of cocaine. |
2010-11-23 |
2023-08-12 |
mouse |
| D A Lane, A Jaferi, M J Kreek, V M Picke. Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral tegmental area. Neuroscience. vol 169. issue 2. 2010-11-23. PMID:20553819. |
th-labeled dendrites within the pb vta showed increased cytoplasmic glur1 immunogold particle density consistent with decreased ampa receptor-mediated glutamatergic transmission. |
2010-11-23 |
2023-08-12 |
mouse |
| Cameron H Good, Carl R Lupic. Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534838. |
using a unique rat brain slice preparation, we found that ppn stimulation activates afferents targeting glur2-containing ampa receptors (ampar) on vta da neurons, and these afferents did not exhibit long-term depression (ltd). |
2010-08-24 |
2023-08-12 |
rat |
| Cameron H Good, Carl R Lupic. Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534838. |
in contrast, activation of glutamate afferents onto the same da neurons via stimulation within the vta evoked epscs mediated by glur2-lacking ampars that demonstrated ltd or epscs mediated by glur2-containing ampa receptors that did not express ltd. twenty-four hours after single cocaine injections to rats, glur2-lacking ampars were increased at both ppn and local vta projections, and this permitted ltd expression in both pathways. |
2010-08-24 |
2023-08-12 |
rat |
| Cameron H Good, Carl R Lupic. Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534838. |
these results demonstrate that cocaine more globally increases glur2-lacking ampa receptors at all glutamate synapses on vta dopamine neurons, whereas delta(9)-thc selectively increased glur2-lacking ampa receptors at subcortical ppn synapses. |
2010-08-24 |
2023-08-12 |
rat |