| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hoda Ranjbar, Monavareh Soti, Kristi A Kohlmeier, Mahyar Janahmadi, Mohammad Shaban. Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP. BMC neuroscience vol 24 issue 1 2023 36869289 |
although ataxia is associated with cerebellar dysfunction, little is known about the effects of 3-ap exposure on purkinje cell electrophysiological properties. |
2023-03-03 |
2023-03-06 |
Not clear |
| Fabrice Faure, Lidia Yshii, Toufic Renno, Isabelle Coste, Bastien Joubert, Virginie Desestret, Roland Liblau, J\\xc3\\xa9r\\xc3\\xb4me Honnora. A Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model. Cerebellum (London, England) vol issue 2023 36729270 |
ataxia and gait instability were assessed in treated mice as well as autoantibody levels, purkinje cell density, and immune infiltration in the cerebellum. |
2023-02-02 |
2023-03-06 |
mouse |
| Karla P Figueroa, Collin J Anderson, Sharan Paul, Warunee Dansithong, Mandi Gandelman, Daniel R Scoles, Stefan M Puls. Slc9a6 mutation causes Purkinje cell loss and ataxia in the shaker rat. Human molecular genetics vol issue 2023 36621975 |
slc9a6 mutation causes purkinje cell loss and ataxia in the shaker rat. |
2023-01-09 |
2023-01-30 |
rat |
| Karla P Figueroa, Collin J Anderson, Sharan Paul, Warunee Dansithong, Mandi Gandelman, Daniel R Scoles, Stefan M Puls. Slc9a6 mutation causes Purkinje cell loss and ataxia in the shaker rat. Human molecular genetics vol issue 2023 36621975 |
the shaker rat carries a naturally occurring mutation leading to progressive ataxia characterized by purkinje cell (pc) loss. |
2023-01-09 |
2023-01-30 |
rat |
| Sylvie Picker-Minh, Ilaria Luperi, Ethiraj Ravindran, Nadine Kraemer, Sami Zaqout, Gisela Stoltenburg-Didinger, Olaf Ninnemann, Luis R Hernandez-Miranda, Shyamala Mani, Angela M Kaind. PTRH2 is Necessary for Purkinje Cell Differentiation and Survival and its Loss Recapitulates Progressive Cerebellar Atrophy and Ataxia Seen in IMNEPD Patients. Cerebellum (London, England) vol issue 2022 36219306 |
ptrh2 is necessary for purkinje cell differentiation and survival and its loss recapitulates progressive cerebellar atrophy and ataxia seen in imnepd patients. |
2022-10-11 |
2023-01-30 |
Not clear |
| Takehiro Takahashi, Milan Stoiljkovic, Eric Song, Xiao-Bing Gao, Yuki Yasumoto, Eriko Kudo, Fernando Carvalho, Yong Kong, Annsea Park, Marya Shanabrough, Klara Szigeti-Buck, Zhong-Wu Liu, Ashley Kristant, Yalan Zhang, Parker Sulkowski, Peter M Glazer, Leonard K Kaczmarek, Tamas L Horvath, Akiko Iwasak. LINE-1 activation in the cerebellum drives ataxia. Neuron vol issue 2022 36070749 |
we demonstrated that l1 activation in the cerebellum led to purkinje cell dysfunctions and degeneration and was sufficient to cause ataxia. |
2022-09-07 |
2023-01-30 |
mouse |
| Brenda Toscano M\\xc3\\xa1rquez, Anna A Cook, Max Rice, Alexia Smileski, Kristen Vieira-Lomasney, Fran\\xc3\\xa7ois Charron, R Anne McKinney, Alanna J Wat. Molecular Identity and Location Influence Purkinje Cell Vulnerability in Autosomal-Recessive Spastic Ataxia of Charlevoix-Saguenay Mice. Frontiers in cellular neuroscience vol 15 issue 2021 34970120 |
molecular identity and location influence purkinje cell vulnerability in autosomal-recessive spastic ataxia of charlevoix-saguenay mice. |
2021-12-31 |
2023-01-26 |
mouse |
| Carlos Del Pilar, Rafael Lebr\\xc3\\xb3n-Gal\\xc3\\xa1n, Ester P\\xc3\\xa9rez-Mart\\xc3\\xadn, Laura P\\xc3\\xa9rez-Revuelta, Carmelo Antonio \\xc3\\x81vila-Zarza, Jos\\xc3\\xa9 Ram\\xc3\\xb3n Alonso, Diego Clemente, Eduardo Weruaga, David D\\xc3\\xada. The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations. Frontiers in cellular neuroscience vol 15 issue 2021 34916910 |
consequently, a model of human cerebellar degeneration and ataxia -the purkinje cell degeneration (pcd) mouse- has been employed, as it allows the study of different processes of selective neuronal death in the same animal, i.e., purkinje cells in the cerebellum and mitral cells in the olfactory bulb. |
2021-12-17 |
2023-01-26 |
mouse |
| Ravi Chopra, Vikram G Shakkotta. Translating cerebellar Purkinje neuron physiology to progress in dominantly inherited ataxia. Future neurology vol 9 issue 2 2021 25221437 |
translating cerebellar purkinje neuron physiology to progress in dominantly inherited ataxia. |
2021-10-21 |
2023-01-25 |
Not clear |
| Ravi Chopra, Vikram G Shakkotta. Translating cerebellar Purkinje neuron physiology to progress in dominantly inherited ataxia. Future neurology vol 9 issue 2 2021 25221437 |
cerebellar ataxia is a symptom of a number of conditions, and the emerging evidence that purkinje neuron dysfunction, in particular, abnormal purkinje neuron repetitive firing, is a major driver of motor dysfunction in a subset of dominantly inherited ataxias is dicussed. |
2021-10-21 |
2023-01-25 |
Not clear |
| Ravi Chopra, Vikram G Shakkotta. Translating cerebellar Purkinje neuron physiology to progress in dominantly inherited ataxia. Future neurology vol 9 issue 2 2021 25221437 |
common mechanisms of dysfunction and speculate about potential therapeutic targets, suggesting that purkinje neuron firing abnormalities are a novel target for improving motor dysfunction in patients with some forms of dominantly inherited ataxia are proposed. |
2021-10-21 |
2023-01-25 |
Not clear |
| Emily A L Wozniak, Zhao Chen, Sharan Paul, Praseuth Yang, Karla P Figueroa, Jill Friedrich, Tyler Tschumperlin, Michael Berken, Melissa Ingram, Christine Henzler, Stefan M Pulst, Harry T Or. Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice. Cell reports vol 37 issue 2 2021 34644575 |
a sca1 mouse model, pcp2-atxn1[30q]d776, has severe ataxia in absence of progressive purkinje neuron degeneration and death. |
2021-10-13 |
2023-01-26 |
mouse |
| Kamyar Zahedi, Marybeth Brooks, Sharon Barone, Negah Rahmati, Tracy Murray Stewart, Matthew Dunworth, Christina Destefano-Shields, Nupur Dasgupta, Steve Davidson, Diana M Lindquist, Christine E Fuller, Roger D Smith, John L Cleveland, Robert A Casero, Manoocher Soleiman. Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia. Journal of neuroinflammation vol 17 issue 1 2021 33054763 |
ablation of polyamine catabolic enzymes provokes purkinje cell damage, neuroinflammation, and severe ataxia. |
2021-08-19 |
2023-01-26 |
Not clear |
| Lauren N Miterko, Tao Lin, Joy Zhou, Meike E van der Heijden, Jaclyn Beckinghausen, Joshua J White, Roy V Sillito. Neuromodulation of the cerebellum rescues movement in a mouse model of ataxia. Nature communications vol 12 issue 1 2021 33637754 |
indeed, genetically eliminating purkinje cell neurotransmission blocked the ability of dbs to reduce ataxia. |
2021-03-15 |
2023-01-26 |
mouse |
| Eriola Hoxha, Ilaria Balbo, Maria Concetta Miniaci, Filippo Tempi. Purkinje Cell Signaling Deficits in Animal Models of Ataxia. Frontiers in synaptic neuroscience vol 10 issue 2021 29760657 |
purkinje cell signaling deficits in animal models of ataxia. |
2021-02-18 |
2023-01-26 |
Not clear |
| Guillermo Philipps, Elizabeth D Tate, Michael R Pranzatell. Intensive Combination Immunotherapy and Neuroinflammation Resolution in a Child With Anti-PCA-1 (Yo) Paraneoplastic Syndrome and 2 Malignancies. Child neurology open vol 5 issue 2020 30288393 |
when her severe ataxia progressed, neuroinflammation was characterized by high cerebrospinal fluid purkinje cell cytoplasmic antibody type 1 titers, oligoclonal bands, and neurofilament light chain. |
2020-10-01 |
2023-01-26 |
Not clear |
| Samira Abbasi, Ataollah Abbasi, Yashar Sarbaz, Mahyar Janahmad. Power Spectral Density Analysis of Purkinje Cell Tonic and Burst Firing Patterns From a Rat Model of Ataxia and Riluzole Treated. Basic and clinical neuroscience vol 8 issue 1 2020 28446951 |
power spectral density analysis of purkinje cell tonic and burst firing patterns from a rat model of ataxia and riluzole treated. |
2020-10-01 |
2023-01-26 |
Not clear |
| Man Ding, Chao Weng, Shanghua Fan, Qian Cao, Zuneng L. Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay. Frontiers in molecular neuroscience vol 10 issue 2020 28588446 |
purkinje cell degeneration and motor coordination deficits in a new mouse model of autosomal recessive spastic ataxia of charlevoix-saguenay. |
2020-09-29 |
2023-01-26 |
Not clear |
| Vanessa Hull, Yan Wang, Travis Burns, Sheng Zhang, Sarah Sternbach, Jennifer McDonough, Fuzheng Guo, David Pleasur. Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice. Annals of neurology vol 87 issue 3 2020 31925837 |
we now demonstrate that inhibiting naa synthesis by intracisternal administration of a locked nucleic acid antisense oligonucleotide to young-adult aspartoacylase-deficient mice reverses their pre-existing ataxia and diminishes cerebellar and thalamic vacuolation and purkinje cell dendritic atrophy. |
2020-08-03 |
2023-01-26 |
mouse |
| Marliawaty I Gusti Bagus, Clayton Gordy, Rosario Sanchez-Gonzalez, Michael Strupp, Hans Strak. Impact of 4-aminopyridine on vestibulo-ocular reflex performance. Journal of neurology vol 266 issue Suppl 1 2020 31270663 |
clinically and pharmacologically, the observed 4-ap-mediated increase of peripheral vestibular input under resting and dynamic conditions can contribute to the observed therapeutic effects of 4-ap in downbeat and upbeat nystagmus as well as episodic ataxia type 2, by an indirect increase of cerebellar purkinje cell discharge. |
2020-02-10 |
2023-01-26 |
xenopus_laevis |