All Relations between cerebellum purkinje cell and Ataxia

Publication Sentence Publish Date Extraction Date Species
Chunyi Liu, Mei Mei, Qiuling Li, Peristera Roboti, Qianqian Pang, Zhengzhou Ying, Fei Gao, Martin Lowe, Shilai Ba. Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 2. 2018-04-09. PMID:28028212. purkinje cell loss and ataxia first appear during postnatal development but progressively worsen with age. 2018-04-09 2023-08-13 mouse
G Urkasemsin, D M Nielsen, A Singleton, S Arepalli, D Hernandez, C Agler, N J Olb. Genetics of Hereditary Ataxia in Scottish Terriers. Journal of veterinary internal medicine. vol 31. issue 4. 2018-01-03. PMID:28556454. scottish terriers have a high incidence of juvenile onset hereditary ataxia primarily affecting the purkinje neuron of the cerebellar cortex and causing slowly progressive cerebellar dysfunction. 2018-01-03 2023-08-13 Not clear
Karla P Figueroa, Sharan Paul, Tito Calì, Raffaele Lopreiato, Sukanya Karan, Martina Frizzarin, Darren Ames, Ginevra Zanni, Marisa Brini, Warunee Dansithong, Brett Milash, Daniel R Scoles, Ernesto Carafoli, Stefan M Puls. Spontaneous shaker rat mutant - a new model for X-linked tremor/ataxia. Disease models & mechanisms. vol 9. issue 5. 2017-12-12. PMID:27013529. the shaker rat is an x-linked recessive spontaneous model of progressive purkinje cell (pc) degeneration exhibiting a shaking ataxia and wide stance. 2017-12-12 2023-08-13 rat
Yu Miyazaki, Xiaofei Du, Shin-Ichi Muramatsu, Christopher M Gome. An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron. Science translational medicine. vol 8. issue 347. 2017-12-07. PMID:27412786. spinocerebellar ataxia type 6 (sca6) is a dominantly inherited neurodegenerative disease characterized by slowly progressive ataxia and purkinje cell degeneration. 2017-12-07 2023-08-13 mouse
G J Stephen. Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia? The Journal of physiology. vol 594. issue 16. 2017-08-29. PMID:26970080. cerebellar ataxias represent a spectrum of disorders which are, however, linked by common symptoms of motor incoordination and typically associated with deficiency in purkinje cell firing activity and, often, degeneration. 2017-08-29 2023-08-13 mouse
Kevin C Kemp, Amelia J Cook, Juliana Redondo, Kathreena M Kurian, Neil J Scolding, Alastair Wilkin. Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia. Acta neuropathologica communications. vol 4. issue 1. 2017-06-21. PMID:27215193. purkinje cell injury, structural plasticity and fusion in patients with friedreich's ataxia. 2017-06-21 2023-08-13 Not clear
Kevin C Kemp, Amelia J Cook, Juliana Redondo, Kathreena M Kurian, Neil J Scolding, Alastair Wilkin. Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia. Acta neuropathologica communications. vol 4. issue 1. 2017-06-21. PMID:27215193. here we present a pathological study showing novel and fundamental insights into purkinje cell injury, remodelling and repair in friedreich's ataxia; the most common inherited ataxia. 2017-06-21 2023-08-13 Not clear
Kevin C Kemp, Amelia J Cook, Juliana Redondo, Kathreena M Kurian, Neil J Scolding, Alastair Wilkin. Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia. Acta neuropathologica communications. vol 4. issue 1. 2017-06-21. PMID:27215193. for the first time in a genetic condition, we have also shown a disease-related increase in the frequency of purkinje cell fusion and heterokaryon formation in friedreich's ataxia cases; with evidence that underlying levels of cerebellar inflammation influence heterokaryon formation. 2017-06-21 2023-08-13 Not clear
Melanie D Mark, Jan Claudius Schwitalla, Michelle Groemmke, Stefan Herlitz. Keeping Our Calcium in Balance to Maintain Our Balance. Biochemical and biophysical research communications. vol 483. issue 4. 2017-06-06. PMID:27392710. the gene mutations responsible for half of the ea members and over 35 of the sca subtypes have been identified, and several have been found to be responsible for cerebellar atrophy, abnormal intracellular calcium levels, dysregulation of purkinje cell pacemaking, altered cerebellar synaptic transmission and/or ataxia in mouse models. 2017-06-06 2023-08-13 mouse
Jose Gazulla, Carlota Ruiz-Gazulla, Maria Tintor. GABAergic Pharmacotherapy in the Treatment of Motor Disorders of the Central Nervous System. Current pharmaceutical design. vol 21. issue 34. 2016-08-15. PMID:26365142. cortical cerebellar atrophy (cca) shows purkinje cell loss, and ataxia caused by it was alleviated by gabapentin and pregabalin. 2016-08-15 2023-08-13 Not clear
Juliana Redondo, Kevin Kemp, Kelly Hares, Claire Rice, Neil Scolding, Alastair Wilkin. Purkinje Cell Pathology and Loss in Multiple Sclerosis Cerebellum. Brain pathology (Zurich, Switzerland). vol 25. issue 6. 2016-08-10. PMID:25411024. as purkinje cell axons are the sole output of the cerebellar cortex, understanding pathologic processes within these cells is crucial to develop strategies to prevent their loss and thus reduce ataxia. 2016-08-10 2023-08-13 Not clear
Melissa Ingram, Emily A L Wozniak, Lisa Duvick, Rendong Yang, Paul Bergmann, Robert Carson, Brennon O'Callaghan, Huda Y Zoghbi, Christine Henzler, Harry T Or. Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways. Neuron. vol 89. issue 6. 2016-08-02. PMID:26948890. we used rna sequencing to profile cerebellar gene expression in pcp2-atxn1[82q] mice with ataxia and progressive pathology and pcp2-atxn1[30q]d776 animals having ataxia in absence of purkinje cell progressive pathology. 2016-08-02 2023-08-13 mouse
S Jarius, B Wildeman. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. Journal of neuroinflammation. vol 12. 2016-06-21. PMID:26377085. 'medusa-head ataxia': the expanding spectrum of purkinje cell antibodies in autoimmune cerebellar ataxia. 2016-06-21 2023-08-13 Not clear
S Jarius, B Wildeman. 'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC. Journal of neuroinflammation. vol 12. 2016-06-21. PMID:26377184. 'medusa head ataxia': the expanding spectrum of purkinje cell antibodies in autoimmune cerebellar ataxia. 2016-06-21 2023-08-13 Not clear
S Jarius, B Wildeman. 'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook. Journal of neuroinflammation. vol 12. 2016-06-21. PMID:26377319. 'medusa head ataxia': the expanding spectrum of purkinje cell antibodies in autoimmune cerebellar ataxia. 2016-06-21 2023-08-13 Not clear
Kinya Ishikawa, Hidehiro Mizusaw. The chromosome 16q-linked autosomal dominant cerebellar ataxia (16q-ADCA): A newly identified degenerative ataxia in Japan showing peculiar morphological changes of the Purkinje cell: The 50th Anniversary of Japanese Society of Neuropathology. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 30. issue 5. 2016-02-17. PMID:20667009. the chromosome 16q-linked autosomal dominant cerebellar ataxia (16q-adca): a newly identified degenerative ataxia in japan showing peculiar morphological changes of the purkinje cell: the 50th anniversary of japanese society of neuropathology. 2016-02-17 2023-08-12 Not clear
Samira Abbasi, Ataollah Abbasi, Yashar Sarbaz, Afshin Ebrahim. Analysis spectrum of normal and ataxia Purkinje cell output and classification using artificial neural network. The Journal of neuropsychiatry and clinical neurosciences. vol 26. issue 4. 2015-12-07. PMID:26037870. analysis spectrum of normal and ataxia purkinje cell output and classification using artificial neural network. 2015-12-07 2023-08-13 Not clear
James M Dell'Orco, Aaron H Wasserman, Ravi Chopra, Melissa A C Ingram, Yuan-Shih Hu, Vikrant Singh, Heike Wulff, Puneet Opal, Harry T Orr, Vikram G Shakkotta. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 32. 2015-11-05. PMID:26269637. these results suggest that purkinje neuron dendritic remodeling in ataxia is an adaptive response to increases in intrinsic membrane excitability. 2015-11-05 2023-08-13 mouse
Anna Duarri, Meng-Chin A Lin, Michiel R Fokkens, Michel Meijer, Cleo J L M Smeets, Esther A R Nibbeling, Erik Boddeke, Richard J Sinke, Harm H Kampinga, Diane M Papazian, Dineke S Verbee. Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner. Cellular and molecular life sciences : CMLS. vol 72. issue 17. 2015-10-29. PMID:25854634. the dominantly inherited cerebellar ataxias are a heterogeneous group of neurodegenerative disorders caused by purkinje cell loss in the cerebellum. 2015-10-29 2023-08-13 Not clear
Anna Duarri, Meng-Chin A Lin, Michiel R Fokkens, Michel Meijer, Cleo J L M Smeets, Esther A R Nibbeling, Erik Boddeke, Richard J Sinke, Harm H Kampinga, Diane M Papazian, Dineke S Verbee. Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner. Cellular and molecular life sciences : CMLS. vol 72. issue 17. 2015-10-29. PMID:25854634. our findings suggest that altered kv4.3 channel localization and/or functioning resulting from sca19/22 mutations may lead to purkinje cell loss, neurodegeneration and ataxia. 2015-10-29 2023-08-13 Not clear