| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Duarri, Meng-Chin A Lin, Michiel R Fokkens, Michel Meijer, Cleo J L M Smeets, Esther A R Nibbeling, Erik Boddeke, Richard J Sinke, Harm H Kampinga, Diane M Papazian, Dineke S Verbee. Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner. Cellular and molecular life sciences : CMLS. vol 72. issue 17. 2015-10-29. PMID:25854634. |
the dominantly inherited cerebellar ataxias are a heterogeneous group of neurodegenerative disorders caused by purkinje cell loss in the cerebellum. |
2015-10-29 |
2023-08-13 |
Not clear |
| Anna Duarri, Meng-Chin A Lin, Michiel R Fokkens, Michel Meijer, Cleo J L M Smeets, Esther A R Nibbeling, Erik Boddeke, Richard J Sinke, Harm H Kampinga, Diane M Papazian, Dineke S Verbee. Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner. Cellular and molecular life sciences : CMLS. vol 72. issue 17. 2015-10-29. PMID:25854634. |
our findings suggest that altered kv4.3 channel localization and/or functioning resulting from sca19/22 mutations may lead to purkinje cell loss, neurodegeneration and ataxia. |
2015-10-29 |
2023-08-13 |
Not clear |
| John S Stahl, Zachary C Thumse. Flocculus Purkinje cell signals in mouse Cacna1a calcium channel mutants of escalating severity: an investigation of the role of firing irregularity in ataxia. Journal of neurophysiology. vol 112. issue 10. 2015-10-19. PMID:25143538. |
flocculus purkinje cell signals in mouse cacna1a calcium channel mutants of escalating severity: an investigation of the role of firing irregularity in ataxia. |
2015-10-19 |
2023-08-13 |
mouse |
| Volga Tarlac, Louise Kelly, Robert P Anderson, Nicole Bye, Elsdon Store. Coeliac disease patients do not produce antibodies to a common cerebellar epitope. Cerebellum & ataxias. vol 1. 2015-09-02. PMID:26331042. |
our aim was to determine whether there is molecular mimicry between cerebellar purkinje cell antigens and gluten in subjects selected for recent diagnosis of cd rather than for ataxia. |
2015-09-02 |
2023-08-13 |
human |
| Francesca Maltecca, Elisa Baseggio, Francesco Consolato, Davide Mazza, Paola Podini, Samuel M Young, Ilaria Drago, Ben A Bahr, Aldamaria Puliti, Franca Codazzi, Angelo Quattrini, Giorgio Casar. Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model. The Journal of clinical investigation. vol 125. issue 1. 2015-04-21. PMID:25485680. |
purkinje neuron ca2+ influx reduction rescues ataxia in sca28 model. |
2015-04-21 |
2023-08-13 |
mouse |
| Katiuska Luna-Cancalon, Kristine M Sikora, Samuel S Pappas, Vikrant Singh, Heike Wulff, Henry L Paulson, Margit Burmeister, Vikram G Shakkotta. Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcay(ji-hes) mice. Neurobiology of disease. vol 67. 2015-01-06. PMID:24727095. |
these results suggest that a combination of reduced purkinje neuron activity and increased dcn intrinsic excitability can result in a combination of ataxia and a dystonia-like gait in mice. |
2015-01-06 |
2023-08-13 |
mouse |
| Caryline Agler, Dahlia M Nielsen, Ganokon Urkasemsin, Andrew Singleton, Noriko Tonomura, Snaevar Sigurdsson, Ruqi Tang, Keith Linder, Sampath Arepalli, Dena Hernandez, Kerstin Lindblad-Toh, Joyce van de Leemput, Alison Motsinger-Reif, Dennis P O'Brien, Jerold Bell, Tonya Harris, Steven Steinberg, Natasha J Olb. Canine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24. PLoS genetics. vol 10. issue 2. 2014-12-15. PMID:24516392. |
old english sheepdogs and gordon setters suffer from a juvenile onset, autosomal recessive form of canine hereditary ataxia primarily affecting the purkinje neuron of the cerebellar cortex. |
2014-12-15 |
2023-08-12 |
mouse |
| Chengzu Long, Chad E Grueter, Kunhua Song, Song Qin, Xiaoxia Qi, Y Megan Kong, John M Shelton, James A Richardson, Chun-Li Zhang, Rhonda Bassel-Duby, Eric N Olso. Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 31. 2014-10-03. PMID:25049392. |
ataxia and purkinje cell degeneration in mice lacking the camta1 transcription factor. |
2014-10-03 |
2023-08-13 |
mouse |
| Chengzu Long, Chad E Grueter, Kunhua Song, Song Qin, Xiaoxia Qi, Y Megan Kong, John M Shelton, James A Richardson, Chun-Li Zhang, Rhonda Bassel-Duby, Eric N Olso. Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 31. 2014-10-03. PMID:25049392. |
here, we show that global or nervous system deletion of camta1 in mice causes severe ataxia with purkinje cell degeneration and cerebellar atrophy, partially resembling the consequences of haploinsufficiency of the human camta1 locus. |
2014-10-03 |
2023-08-13 |
mouse |
| Kefeng Qin, Tianbing Ding, Yi Xiao, Wenyu Ma, Zhen Wang, Jimin Gao, Lili Zha. Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity. PloS one. vol 8. issue 12. 2014-09-19. PMID:24339999. |
however the artificial expression of dpl in the prp-deficient mouse brain causes ataxia with purkinje cell death. |
2014-09-19 |
2023-08-12 |
mouse |
| Andrea G Marshall, Jennifer A Watson, Jada J Hallengren, Brandon J Walters, Lynn E Dobrunz, Ludwig Francillon, Julie A Wilson, Scott E Phillips, Scott M Wilso. Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14). PloS one. vol 8. issue 12. 2014-09-16. PMID:24358326. |
we previously showed that loss of usp14 in ataxia (ax (j)) mice results in reduced ubiquitin levels, motor endplate disease, purkinje cell axonal dystrophy and decreased hippocampal paired pulse facilitation (ppf) during the first 4-6 weeks of life, and early postnatal lethality by two months of age. |
2014-09-16 |
2023-08-12 |
mouse |
| Hadi Kazemi, Erwin-Josef Speckmann, Ali Gorj. Familial hemiplegic migraine and spreading depression. Iranian journal of child neurology. vol 8. issue 3. 2014-08-21. PMID:25143767. |
fhm1 with ataxia is attributable to specific mutations that differ from mutations that cause pure fhm1 and have peculiar consequences on cerebellar cav2.1 currents that lead to profound purkinje cell dysfunction and neuronal loss with atrophy. |
2014-08-21 |
2023-08-13 |
mouse |
| Joshua J White, Marife Arancillo, Trace L Stay, Nicholas A George-Jones, Sabrina L Levy, Detlef H Heck, Roy V Sillito. Cerebellar zonal patterning relies on Purkinje cell neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 24. 2014-08-04. PMID:24920627. |
as expected, blocking purkinje cell neurotransmission caused ataxia. |
2014-08-04 |
2023-08-13 |
mouse |
| Rachael Anne Dunlop, Paul Alan Cox, Sandra Anne Banack, Kenneth John Rodger. The non-protein amino acid BMAA is misincorporated into human proteins in place of L-serine causing protein misfolding and aggregation. PloS one. vol 8. issue 9. 2014-07-07. PMID:24086518. |
for example, the mouse sticky mutation sti, which results in undetected mischarging of trna(ala) with serine resulting in the substitution of serine for alanine in proteins causes cerebellar purkinje cell loss and ataxia in laboratory animals. |
2014-07-07 |
2023-08-12 |
mouse |
| Gabriella Sekerková, Jin-Ah Kim, Maximiliano J Nigro, Esther B E Becker, Jana Hartmann, Lutz Birnbaumer, Enrico Mugnaini, Marco Martin. Early onset of ataxia in moonwalker mice is accompanied by complete ablation of type II unipolar brush cells and Purkinje cell dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 50. 2014-03-07. PMID:24336732. |
early onset of ataxia in moonwalker mice is accompanied by complete ablation of type ii unipolar brush cells and purkinje cell dysfunction. |
2014-03-07 |
2023-08-12 |
mouse |
| Xiaowei Wang, Benjamin J Whalley, Gary J Stephen. The du(2J) mouse model of ataxia and absence epilepsy has deficient cannabinoid CB₁ receptor-mediated signalling. The Journal of physiology. vol 591. issue 16. 2014-03-03. PMID:23732642. |
cerebellar ataxias are a group of progressive, debilitating diseases often associated with abnormal purkinje cell (pc) firing and/or degeneration. |
2014-03-03 |
2023-08-12 |
mouse |
| Elisa J Cops, Maithili Sashindranath, Maria Daglas, Kieran M Short, Candida da Fonseca Pereira, Terence Y Pang, Roger H Lijnen, Ian M Smyth, Anthony J Hannan, Andre L Samson, Robert L Medcal. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental neurology. vol 249. 2013-12-09. PMID:23939410. |
purkinje cell damage manifests as motor incoordination and ataxia - a prominent feature of many human disorders including spinocerebellar ataxia and huntington's disease. |
2013-12-09 |
2023-08-12 |
mouse |
| Elisa J Cops, Maithili Sashindranath, Maria Daglas, Kieran M Short, Candida da Fonseca Pereira, Terence Y Pang, Roger H Lijnen, Ian M Smyth, Anthony J Hannan, Andre L Samson, Robert L Medcal. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental neurology. vol 249. 2013-12-09. PMID:23939410. |
thus, excess tpa levels may be sufficient to cause targeted purkinje cell degeneration and ataxia. |
2013-12-09 |
2023-08-12 |
mouse |
| Mark D Benton, Amanda H Lewis, Jason S Bant, Indira M Rama. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. Journal of neurophysiology. vol 109. issue 10. 2013-11-25. PMID:23446695. |
moreover, augmentation of bk current may partially underlie the action of ebio and chlorzoxazone to alleviate disrupted purkinje cell firing associated with genetic ataxias. |
2013-11-25 |
2023-08-12 |
mouse |
| Aleksandra Badura, Martijn Schonewille, Kai Voges, Elisa Galliano, Nicolas Renier, Zhenyu Gao, Laurens Witter, Freek E Hoebeek, Alain Chédotal, Chris I De Zeeu. Climbing fiber input shapes reciprocity of Purkinje cell firing. Neuron. vol 78. issue 4. 2013-08-05. PMID:23643935. |
ptf1a::cre;robo3(lox/lox) mice showed severe ataxia highlighting that climbing fiber input and its impact on reciprocity of purkinje cell firing play an important role in motor coordination. |
2013-08-05 |
2023-08-12 |
mouse |