| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soraya Mahmoudi, Amir Abbas Farshid, Esmaeal Tamaddonfard, Mehdi Imani, Farahnaz Noroozini. Behavioral, histopathological, and biochemical evaluations on the effects of cinnamaldehyde, naloxone, and their combination in morphine-induced cerebellar toxicity. Drug and chemical toxicology. 2019-10-28. PMID:31656103. |
body and cerebellum weights, stride width, time spent on the rotarod, purkinje cell number, thickness of molecular and granular layers, superoxide dismutase (sod), and total antioxidant capacity (tac) decreased as a result of administrating morphine. |
2019-10-28 |
2023-08-13 |
rat |
| Khushboo Srivastava, Ratnakar Tripathi, Rajnikant Mishr. Age-dependent alterations in expression and co-localization of Pax6 and Ras-GAP in brain of aging mice. Journal of chemical neuroanatomy. vol 92. 2019-10-22. PMID:29787792. |
the co-localization of pax6 and ras-gap were observed in dentate gyrus (dg) and sub-granular zone (sgz) of hippocampus, in glomerular (glla) and mitral cells (mice) of olfactory lobe, granular cells (grce), purkinje cell (puce) and molecular cell layer (mola) of cerebellum, internal plexiform layer (inpl), molecular layer (mola) of cerebral cortex and in intercalated cells of amygdala (itc), caudate nucleus regions in brain of aging mice. |
2019-10-22 |
2023-08-13 |
mouse |
| Yannick Bailly, Sylvia Rabacchi, Rachel M Sherrard, Jean-Luc Rodeau, Valérie Demais, Ann M Lohof, Jean Marian. Elimination of all redundant climbing fiber synapses requires granule cells in the postnatal cerebellum. Scientific reports. vol 8. issue 1. 2019-10-22. PMID:29968809. |
the specific critical period for this effect appears to be directly related to the timing of purkinje cell and granule cell development in different cerebellar lobules, indicating a close, spatiotemporal synchrony between granule-cell development and olivo-cerebellar synaptic maturation. |
2019-10-22 |
2023-08-13 |
Not clear |
| Latika Nagpal, Chenglai Fu, Solomon H Snyde. Inositol Hexakisphosphate Kinase-2 in Cerebellar Granule Cells Regulates Purkinje Cells and Motor Coordination via Protein 4.1N. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 34. 2019-10-22. PMID:30006360. |
both of these proteins are highly expressed in granule cells of the cerebellum where their interaction regulates purkinje cell morphology and cerebellar synapses. |
2019-10-22 |
2023-08-13 |
mouse |
| Saori Kikuchihara, Shouta Sugio, Kenji F Tanaka, Takaki Watanabe, Masanobu Kano, Yoshihiko Yamazaki, Masahiko Watanabe, Kazuhiro Ikenak. Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice. Journal of neurochemistry. vol 147. issue 3. 2019-09-27. PMID:29920672. |
here, we examined the cerebellum of mlc1-over-expressing mouse and found that the distribution of bergmann glia (bg) was normally compacted along the purkinje cell (pc) layer until postnatal day 10 (p10), while most bg were dispersed throughout the molecular layer by p28. |
2019-09-27 |
2023-08-13 |
mouse |
| Michael Rabenstein, Franziska Peter, Arndt Rolfs, Moritz J Frec. Impact of Reduced Cerebellar EAAT Expression on Purkinje Cell Firing Pattern of NPC1-deficient Mice. Scientific reports. vol 8. issue 1. 2019-09-19. PMID:29463856. |
impact of reduced cerebellar eaat expression on purkinje cell firing pattern of npc1-deficient mice. |
2019-09-19 |
2023-08-13 |
mouse |
| Peter M DiGeronimo, Nicholas A Crossland, Angela Jugan, Javier G Nevarez, Thomas N Tully, Dawn E Evan. Diabetes Mellitus With Concurrent Cerebellar Degeneration and Necrosis in a Domestic Goose ( Anser anser domesticus). Journal of avian medicine and surgery. vol 32. issue 2. 2019-09-17. PMID:29905099. |
necropsy revealed severe pancreatic atrophy and fibrosis with regionally extensive cerebellar encephalomalacia and generalized purkinje cell degeneration and necrosis. |
2019-09-17 |
2023-08-13 |
rat |
| Guo-He Tan, Yuan-Yuan Liu, Lu Wang, Kui Li, Ze-Qiang Zhang, Hong-Fu Li, Zhong-Fei Yang, Yang Li, Dan Li, Ming-Yue Wu, Chun-Lei Yu, Juan-Juan Long, Ren-Chao Chen, Li-Xi Li, Lu-Ping Yin, Ji-Wei Liu, Xue-Wen Cheng, Qi Shen, You-Sheng Shu, Kenji Sakimura, Lu-Jian Liao, Zhi-Ying Wu, Zhi-Qi Xion. PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Cell research. vol 28. issue 1. 2019-09-12. PMID:29056747. |
furthermore, recording made in cerebellar slices showed that optogenetic stimulation of gcs results in transient elevation followed by suppression of purkinje cell firing. |
2019-09-12 |
2023-08-13 |
mouse |
| Paula A Zamudio-Bulcock, Gregg E Homanics, John J Woodwar. Loss of Ethanol Inhibition of N-Methyl-D-Aspartate Receptor-Mediated Currents and Plasticity of Cerebellar Synapses in Mice Expressing the GluN1(F639A) Subunit. Alcoholism, clinical and experimental research. vol 42. issue 4. 2019-08-12. PMID:29323417. |
in the mature mouse cerebellum, nmdars at the cerebellar climbing fiber (cf) to purkinje cell (pc) synapse are inhibited by low concentrations of etoh and the long-term depression (ltd) of parallel fiber (pf)-mediated currents induced by concurrent activation of pfs and cfs (pf-ltd) requires activation of etoh-sensitive nmdars. |
2019-08-12 |
2023-08-13 |
mouse |
| Rodrigo Muñoz-Castañeda, David Díaz, Leticia Peris, Annie Andrieux, Christophe Bosc, José M Muñoz-Castañeda, Carsten Janke, José R Alonso, Marie-Jo Moutin, Eduardo Weruag. Cytoskeleton stability is essential for the integrity of the cerebellum and its motor- and affective-related behaviors. Scientific reports. vol 8. issue 1. 2019-08-12. PMID:29449678. |
such association was here studied using the purkinje cell degeneration mutant mouse, a model of selective and progressive cerebellar degeneration that lacks the cytosolic carboxypeptidase 1 (ccp1). |
2019-08-12 |
2023-08-13 |
mouse |
| Soichi Nagao, Takeru Hond. [Artificial Intelligence and Cerebellar Motor Learning]. Brain and nerve = Shinkei kenkyu no shinpo. vol 71. issue 7. 2019-08-07. PMID:31289241. |
ten years later, ito found the synaptic plasticity of long-term depression at cerebellar purkinje cell synapses, which underlies cerebellar learning. |
2019-08-07 |
2023-08-13 |
Not clear |
| Maria Sundberg, Ivan Tochitsky, David E Buchholz, Kellen Winden, Ville Kujala, Kush Kapur, Deniz Cataltepe, Daria Turner, Min-Joon Han, Clifford J Woolf, Mary E Hatten, Mustafa Sahi. Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin. Molecular psychiatry. vol 23. issue 11. 2019-07-31. PMID:29449635. |
here, we developed a cerebellar purkinje cell (pc) model of tsc with patient-derived human induced pluripotent stem cells (hipscs) to characterize the molecular mechanisms underlying cerebellar abnormalities in asd and tsc. |
2019-07-31 |
2023-08-13 |
human |
| Sung Min Nam, Jin Seok Seo, Sang-Soep Nahm, Byung-Joon Chan. Effects of Ascorbic Acid on Osteopontin Expression and Axonal Myelination in the Developing Cerebellum of Lead-Exposed Rat Pups. International journal of environmental research and public health. vol 16. issue 6. 2019-07-24. PMID:30893812. |
at postnatal day (pnd) 21, results from nissl staining and opn immunohistochemistry demonstrated that opn was detected in the purkinje cell layer in the cerebellum. |
2019-07-24 |
2023-08-13 |
rat |
| Lauren M Watson, Maggie M K Wong, Jane Vowles, Sally A Cowley, Esther B E Becke. A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells. Cerebellum (London, England). vol 17. issue 4. 2019-07-23. PMID:29397531. |
by day 35 of differentiation, subpopulations of cells representative of the two cerebellar germinal zones, the rhombic lip (atoh1-positive) and ventricular zone (ptf1a-positive), could be identified, with the latter giving rise to cells positive for purkinje cell progenitor-specific markers, including lhx5, kirrel2, olig2 and skor2. |
2019-07-23 |
2023-08-13 |
mouse |
| Lauren M Watson, Maggie M K Wong, Jane Vowles, Sally A Cowley, Esther B E Becke. A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells. Cerebellum (London, England). vol 17. issue 4. 2019-07-23. PMID:29397531. |
further maturation was observed following dissociation and co-culture of these cerebellar progenitors with mouse cerebellar cells, with 10% of human cells staining positive for the purkinje cell marker calbindin by day 70 of differentiation. |
2019-07-23 |
2023-08-13 |
mouse |
| Rebecca M Long, Janelle M P Pakan, David J Graham, Peter L Hurd, Cristian Gutierrez-Ibañez, Douglas R Wyli. Modulation of complex spike activity differs between zebrin-positive and -negative Purkinje cells in the pigeon cerebellum. Journal of neurophysiology. vol 120. issue 1. 2019-07-16. PMID:29589816. |
the cerebellum is organized into parasagittal zones defined by its climbing and mossy fiber inputs, efferent projections, and purkinje cell (pc) response properties. |
2019-07-16 |
2023-08-13 |
pigeon |
| Maxime W C Rousseaux, Tyler Tschumperlin, Hsiang-Chih Lu, Elizabeth P Lackey, Vitaliy V Bondar, Ying-Wooi Wan, Qiumin Tan, Carolyn J Adamski, Jillian Friedrich, Kirk Twaroski, Weili Chen, Jakub Tolar, Christine Henzler, Ajay Sharma, Aleksandar Bajić, Tao Lin, Lisa Duvick, Zhandong Liu, Roy V Sillitoe, Huda Y Zoghbi, Harry T Or. ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism. Neuron. vol 97. issue 6. 2019-07-15. PMID:29526553. |
importantly, loss of cic in the cerebellum does not cause ataxia or purkinje cell degeneration. |
2019-07-15 |
2023-08-13 |
Not clear |
| Ioannis Mavroudi. Cerebellar pathology in Alzheimer's disease. Hellenic journal of nuclear medicine. vol 22 Suppl. 2019-07-12. PMID:30877735. |
although the cerebellum has not been extensively studied in ad, recent studies have revealed evidence of a unique pathological pattern of the cerebellar cortex, including loss of purkinje cells, synaptic alterations in the mossy fibres, granule cell dendrites, parallel fibres and purkinje cell dendrites with substantial loss of dendritic spines, and considerable alterations in ultrathin sections. |
2019-07-12 |
2023-08-13 |
monkey |
| Vincent Picher-Martel, Nicolas Dupr. Current and Promising Therapies in Autosomal Recessive Ataxias. CNS & neurological disorders drug targets. vol 17. issue 3. 2019-07-11. PMID:29676235. |
the genetic mutations mostly result in the accumulation of toxic metabolites which causes purkinje neuron lost and eventual cerebellar dysfunction. |
2019-07-11 |
2023-08-13 |
Not clear |
| Brittney L Gurda, Jessica H Bagel, Samantha J Fisher, Mark L Schultz, Andrew P Lieberman, Peter Hand, Charles H Vite, Gary P Swai. LC3 Immunostaining in the Inferior Olivary Nuclei of Cats With Niemann-Pick Disease Type C1 Is Associated With Patterned Purkinje Cell Loss. Journal of neuropathology and experimental neurology. vol 77. issue 3. 2019-07-01. PMID:29346563. |
high densities of accumulated lc3 were seen in subdivisions of the inferior olive, which project to cerebellar regions that show the most purkinje cell loss, suggesting that autophagic abnormalities in specific climbing fibers may contribute to the spatial pattern of purkinje cell loss seen. |
2019-07-01 |
2023-08-13 |
Not clear |