| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takemitsu Hayashi, Tomoya Onozato, Isao Wanajo, Morimichi Hayashi, Hiroo Takeda, Yoshikazu Fujimor. Longitudinal analysis of motor symptoms and histopathology in woozy mice, a model of cerebellar ataxia. Neuroreport. vol 28. issue 13. 2018-04-23. PMID:28723727. |
in addition to the observation of ubiquitin-positive aggregates at 6 weeks of age, purkinje cell loss at 9 weeks of age and cerebellar atrophy were confirmed by histopathology. |
2018-04-23 |
2023-08-13 |
mouse |
| Géraldine Sicot, Laurent Servais, Diana M Dinca, Axelle Leroy, Cynthia Prigogine, Fadia Medja, Sandra O Braz, Aline Huguet-Lachon, Cerina Chhuon, Annie Nicole, Noëmy Gueriba, Ruan Oliveira, Bernard Dan, Denis Furling, Maurice S Swanson, Ida Chiara Guerrera, Guy Cheron, Geneviève Gourdon, Mário Gomes-Pereir. Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy. Cell reports. vol 19. issue 13. 2018-04-20. PMID:28658620. |
we found pronounced rna toxicity in the bergmann glia of the cerebellum, in association with abnormal purkinje cell firing and fine motor incoordination in dm1 mice. |
2018-04-20 |
2023-08-13 |
mouse |
| Suteera Vibulyaseck, Hirofumi Fujita, Yuanjun Luo, Anh Khoa Tran, Arata Oh-Nishi, Yuichi Ono, Shinji Hirano, Izumi Sugihar. Spatial rearrangement of Purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum. The Journal of comparative neurology. vol 525. issue 14. 2018-04-19. PMID:28542916. |
spatial rearrangement of purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum. |
2018-04-19 |
2023-08-13 |
mouse |
| Suteera Vibulyaseck, Hirofumi Fujita, Yuanjun Luo, Anh Khoa Tran, Arata Oh-Nishi, Yuichi Ono, Shinji Hirano, Izumi Sugihar. Spatial rearrangement of Purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum. The Journal of comparative neurology. vol 525. issue 14. 2018-04-19. PMID:28542916. |
to understand the developmental process of this compartmental pattern, we identified groups of purkinje cell subsets in the entire mouse cerebellum at embryonic day (e) 14.5 by staining purkinje cell subset markers. |
2018-04-19 |
2023-08-13 |
mouse |
| Suteera Vibulyaseck, Hirofumi Fujita, Yuanjun Luo, Anh Khoa Tran, Arata Oh-Nishi, Yuichi Ono, Shinji Hirano, Izumi Sugihar. Spatial rearrangement of Purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum. The Journal of comparative neurology. vol 525. issue 14. 2018-04-19. PMID:28542916. |
the results indicate that while the longitudinal shift of domains of purkinje cell subsets forms the longitudinally striped compartments in the anterior and posterior cerebellum, the lateral shift of particular domains of purkinje cell subsets underlies the laterally expanded arrangement of stripes in central lobules. |
2018-04-19 |
2023-08-13 |
mouse |
| Suteera Vibulyaseck, Hirofumi Fujita, Yuanjun Luo, Anh Khoa Tran, Arata Oh-Nishi, Yuichi Ono, Shinji Hirano, Izumi Sugihar. Spatial rearrangement of Purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum. The Journal of comparative neurology. vol 525. issue 14. 2018-04-19. PMID:28542916. |
thus, the rearrangement of purkinje cell subsets in the embryonic cerebellum is critically related to the compartmental organization in the mammalian cerebellum. |
2018-04-19 |
2023-08-13 |
mouse |
| Lauren C Boudewyn, Jakub Sikora, Ladislav Kuchar, Jana Ledvinova, Yulia Grishchuk, Shirley L Wang, Kostantin Dobrenis, Steven U Walkle. N-butyldeoxynojirimycin delays motor deficits, cerebellar microgliosis, and Purkinje cell loss in a mouse model of mucolipidosis type IV. Neurobiology of disease. vol 105. 2018-04-18. PMID:28610891. |
n-butyldeoxynojirimycin delays motor deficits, cerebellar microgliosis, and purkinje cell loss in a mouse model of mucolipidosis type iv. |
2018-04-18 |
2023-08-13 |
mouse |
| Lauren C Boudewyn, Jakub Sikora, Ladislav Kuchar, Jana Ledvinova, Yulia Grishchuk, Shirley L Wang, Kostantin Dobrenis, Steven U Walkle. N-butyldeoxynojirimycin delays motor deficits, cerebellar microgliosis, and Purkinje cell loss in a mouse model of mucolipidosis type IV. Neurobiology of disease. vol 105. 2018-04-18. PMID:28610891. |
several studies have demonstrated that n-butyldeoxynojirimycin (nb-dnj, also known as miglustat), an inhibitor of the enzyme glucosylceramide synthase (gcs), successfully delays the onset of motor deficits, improves longevity, and rescues some of the cerebellar abnormalities (e.g., purkinje cell death) seen in another lysosomal disease known as niemann-pick type c (npc). |
2018-04-18 |
2023-08-13 |
mouse |
| Chunyi Liu, Mei Mei, Qiuling Li, Peristera Roboti, Qianqian Pang, Zhengzhou Ying, Fei Gao, Martin Lowe, Shilai Ba. Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 2. 2018-04-09. PMID:28028212. |
these cellular defects manifest as reduced cerebellar size and purkinje cell number, leading to ataxia. |
2018-04-09 |
2023-08-13 |
mouse |
| Bert M Verheijen, Romina J G Gentier, Denise J H P Hermes, Fred W van Leeuwen, David A Hopkin. Selective Transgenic Expression of Mutant Ubiquitin in Purkinje Cell Stripes in the Cerebellum. Cerebellum (London, England). vol 16. issue 3. 2018-03-20. PMID:27966098. |
selective transgenic expression of mutant ubiquitin in purkinje cell stripes in the cerebellum. |
2018-03-20 |
2023-08-13 |
Not clear |
| Yuri Kanamaru, Jianxue Li, Natalie Stewart, Richard L Sidman, Emi Takahash. Cerebellar Pathways in Mouse Model of Purkinje Cell Degeneration Detected by High-Angular Resolution Diffusion Imaging Tractography. Cerebellum (London, England). vol 16. issue 3. 2018-03-20. PMID:28102462. |
cerebellar pathways in mouse model of purkinje cell degeneration detected by high-angular resolution diffusion imaging tractography. |
2018-03-20 |
2023-08-13 |
mouse |
| Yuri Kanamaru, Jianxue Li, Natalie Stewart, Richard L Sidman, Emi Takahash. Cerebellar Pathways in Mouse Model of Purkinje Cell Degeneration Detected by High-Angular Resolution Diffusion Imaging Tractography. Cerebellum (London, England). vol 16. issue 3. 2018-03-20. PMID:28102462. |
in this mr study, we imaged with high-angular resolution diffusion imaging (hardi) abnormal cerebellar cortical structure (gray matter) and myelinated axonal pathways (white matter) of a mouse spontaneous mutation, purkinje cell degeneration (pcd), in which almost all purkinje neurons degenerate, mainly between postnatal days 20 and 35. |
2018-03-20 |
2023-08-13 |
mouse |
| Stephanie De Munter, Simon Verheijden, Esther Vanderstuyft, Ana Rita Malheiro, Pedro Brites, David Gall, Serge N Schiffmann, Myriam Bae. Early-onset Purkinje cell dysfunction underlies cerebellar ataxia in peroxisomal multifunctional protein-2 deficiency. Neurobiology of disease. vol 94. 2018-02-27. PMID:27353294. |
the gross morphology of the cerebellum and purkinje cell arborization were normal. |
2018-02-27 |
2023-08-13 |
mouse |
| Samah Kandeel, Naema Mahmoud Elhosary, Mona Mohamed Abo El-Noor, Mohamed Balah. Electric injury-induced Purkinje cell apoptosis in rat cerebellum: Histological and immunohistochemical study. Journal of chemical neuroanatomy. vol 81. 2018-02-06. PMID:28254550. |
electric injury-induced purkinje cell apoptosis in rat cerebellum: histological and immunohistochemical study. |
2018-02-06 |
2023-08-13 |
rat |
| Kazuhiko Yamaguchi, Shigeyoshi Itohara, Masao It. Reassessment of long-term depression in cerebellar Purkinje cells in mice carrying mutated GluA2 C terminus. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 36. 2018-01-29. PMID:27551099. |
long-term depression (ltd) of synaptic transmission from parallel fibers (pfs) to a purkinje cell (pc) in the cerebellum has been considered to be a core mechanism of motor learning. |
2018-01-29 |
2023-08-13 |
mouse |
| Austin Ferro, Emily Carbone, Evan Marzouk, Asher Siegel, Donna Nguyen, Kailen Polley, Jessilyn Hartman, Kimberley Frederick, Stephen Ives, Sarita Lagalwa. Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function. Journal of visualized experiments : JoVE. issue 119. 2018-01-29. PMID:28190022. |
cytoarchitectural integrity of the cerebellum can be assessed using immunofluorescence assays that detect purkinje cell nuclei and purkinje cell dendrites and soma. |
2018-01-29 |
2023-08-13 |
mouse |
| Pablo M Blazquez, GyuTae Kim, Tatyana A Yakushev. Searching for an Internal Representation of Stimulus Kinematics in the Response of Ventral Paraflocculus Purkinje Cells. Cerebellum (London, England). vol 16. issue 4. 2018-01-29. PMID:28439779. |
our data stand in contrast with data obtained from cerebellar crus i, wherein purkinje cell discharge contains information related to moving visual stimuli. |
2018-01-29 |
2023-08-13 |
Not clear |
| Lance T Pflieger, Warunee Dansithong, Sharan Paul, Daniel R Scoles, Karla P Figueroa, Pratap Meera, Thomas S Otis, Julio C Facelli, Stefan M Puls. Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2. Human molecular genetics. vol 26. issue 16. 2018-01-17. PMID:28525545. |
atxn2q127 mice are characterized by a progressive motor phenotype onset, and have progressive cerebellar molecular and neurophysiological (purkinje cell firing frequency) phenotypes. |
2018-01-17 |
2023-08-13 |
mouse |
| G Urkasemsin, D M Nielsen, A Singleton, S Arepalli, D Hernandez, C Agler, N J Olb. Genetics of Hereditary Ataxia in Scottish Terriers. Journal of veterinary internal medicine. vol 31. issue 4. 2018-01-03. PMID:28556454. |
scottish terriers have a high incidence of juvenile onset hereditary ataxia primarily affecting the purkinje neuron of the cerebellar cortex and causing slowly progressive cerebellar dysfunction. |
2018-01-03 |
2023-08-13 |
Not clear |
| Evandro F Fang, Vilhelm A Boh. NAD Autophagy. vol 13. issue 2. 2017-11-28. PMID:27929719. |
mutation in atm causes the disease ataxia telangiectasia (a-t) with clinical features including ataxia, severe cerebellar atrophy and purkinje cell loss. |
2017-11-28 |
2023-08-13 |
mouse |