| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Owen Y Chao, Salil Saurav Pathak, Hao Zhang, George J Augustine, Jason M Christie, Chikako Kikuchi, Hiroki Taniguchi, Yi-Mei Yan. Social memory deficit caused by dysregulation of the cerebellar vermis. Nature communications. vol 14. issue 1. 2023-09-26. PMID:37752149. |
we selectively increased the excitability of molecular layer interneurons (mlis) to suppress purkinje cell firing in the mouse cerebellar vermis. |
2023-09-26 |
2023-10-07 |
mouse |
| Franziska Auer, Katherine Nardone, Koji Matsuda, Masahiko Hibi, David Schoppi. Purkinje Cells Control Posture in Larval Zebrafish ( bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745506. |
moreover, by comparing the contributions of purkinje cell ablations to posture in time, we uncover signatures of emerging cerebellar control of posture across early development. |
2023-09-25 |
2023-10-07 |
zebrafish |
| Youngyun Jin, Taewan Kim, Taewoon Ki. Effect of Physical Exercise on Mitochondrial Dysfunction and Purkinje Cell Survival in the Cerebellum of 3xTg-AD Mice. Journal of integrative neuroscience. vol 22. issue 5. 2023-09-21. PMID:37735133. |
effect of physical exercise on mitochondrial dysfunction and purkinje cell survival in the cerebellum of 3xtg-ad mice. |
2023-09-21 |
2023-10-07 |
mouse |
| Soyoung Jun, Muwoong Kim, Heeyoun Park, Eunmi Hwang, Yukio Yamamoto, Keiko Tanaka-Yamamot. Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells. Cell reports. vol 42. issue 9. 2023-09-14. PMID:37708022. |
megf11-kd in gcs of developing mice results in abnormal cerebellar structures, including extensively ectopic purkinje cell (pc) somas, and in impaired motor functions. |
2023-09-14 |
2023-10-07 |
mouse |
| Yu-Young Tsai, Chiu-Lun Shen, Dhananjaya D, Ching-Yen Tsai, Woan-Yuh Tar. Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency. Communications biology. vol 6. issue 1. 2023-09-05. PMID:37670183. |
finally, prenatal supplementation with 7,8-dihydroxyflavone, a trkb agonist, restored granule cell differentiation, purkinje cell dendritic complexity and foliation-the intercrural fissure in particular-in the neonatal cerebellum of rbm4dko mice, which also showed improved motor learning in adulthood. |
2023-09-05 |
2023-10-07 |
mouse |
| Chao Li, Han Zhang, Kexin Tong, Menghua Cai, Fei Gao, Jia Yang, Yi Xu, Huaishan Wang, Hui Chen, Yu Hu, Wei He, Jianmin Zhan. Genetic Deletion of Thorase Causes Purkinje Cell Loss and Impaired Motor Coordination Behavior. Cells. vol 12. issue 16. 2023-08-26. PMID:37626842. |
thorase deletion resulted in more purkinje neuron apoptosis, leading to purkinje cell loss in the cerebellum of thorase cko mice. |
2023-08-26 |
2023-09-07 |
mouse |
| David J Herzfeld, Mati Joshua, Stephen G Lisberge. Rate versus synchrony codes for cerebellar control of motor behavior. Neuron. vol 111. issue 15. 2023-08-03. PMID:37536289. |
simultaneous recordings from purkinje cell pairs in the cerebellum of rhesus macaques reveal how these cells coordinate their activity to drive smooth pursuit eye movements. |
2023-08-03 |
2023-08-14 |
Not clear |
| Silas E Busch, Christian Hanse. Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human. Science (New York, N.Y.). vol 381. issue 6656. 2023-07-27. PMID:37499000. |
canonically, each purkinje cell (pc) in the adult cerebellum receives only one climbing fiber (cf) from the inferior olive. |
2023-07-27 |
2023-08-14 |
mouse |
| Mizuki Kato, Erik De Schutte. Models of Purkinje cell dendritic tree selection during early cerebellar development. PLoS computational biology. vol 19. issue 7. 2023-07-24. PMID:37486917. |
models of purkinje cell dendritic tree selection during early cerebellar development. |
2023-07-24 |
2023-08-14 |
Not clear |
| Yuto Okuno, Kazuto Sakoori, Kyoko Matsuyama, Miwako Yamasaki, Masahiko Watanabe, Kouichi Hashimoto, Takaki Watanabe, Masanobu Kan. PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum. Frontiers in molecular neuroscience. vol 16. 2023-07-10. PMID:37426069. |
ptpδ is a presynaptic organizer for the formation and maintenance of climbing fiber to purkinje cell synapses in the developing cerebellum. |
2023-07-10 |
2023-08-14 |
mouse |
| Yuto Okuno, Kazuto Sakoori, Kyoko Matsuyama, Miwako Yamasaki, Masahiko Watanabe, Kouichi Hashimoto, Takaki Watanabe, Masanobu Kan. PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum. Frontiers in molecular neuroscience. vol 16. 2023-07-10. PMID:37426069. |
in the cerebellum of neonatal rodents, each purkinje cell (pc) receives synaptic inputs from multiple (more than 4) climbing fibers (cfs). |
2023-07-10 |
2023-08-14 |
mouse |
| Haoran Huang, Vikram G Shakkotta. Targeting Ion Channels and Purkinje Neuron Intrinsic Membrane Excitability as a Therapeutic Strategy for Cerebellar Ataxia. Life (Basel, Switzerland). vol 13. issue 6. 2023-06-28. PMID:37374132. |
in this review, we propose that perturbations in cerebellar purkinje neuron intrinsic membrane excitability, a result of ion channel dysregulation, is a common pathophysiologic mechanism that drives motor impairment and vulnerability to degeneration in cerebellar ataxias of widely differing genetic etiologies. |
2023-06-28 |
2023-08-14 |
Not clear |
| Micaela Lucarelli, Serena Camuso, Chiara Di Pietro, Francesco Bruno, Piergiorgio La Rosa, Daniela Marazziti, Maria Teresa Fiorenza, Sonia Canterin. Reduced Cerebellar BDNF Availability Affects Postnatal Differentiation and Maturation of Granule Cells in a Mouse Model of Cholesterol Dyshomeostasis. Molecular neurobiology. 2023-06-14. PMID:37314654. |
the prominent feature of the disorder is the progressive purkinje cell degeneration leading to ataxia.in a mouse model of npc1 disease, we have previously demonstrated that impaired sonic hedgehog signaling causes defective proliferation of granule cells (gcs) and abnormal cerebellar morphogenesis. |
2023-06-14 |
2023-08-14 |
mouse |
| Xin-Tai Wang, Lin Zhou, Bin-Bin Dong, Fang-Xiao Xu, De-Juan Wang, En-Wei Shen, Xin-Yu Cai, Yin Wang, Na Wang, Sheng-Jian Ji, Wei Chen, Martijn Schonewille, J Julius Zhu, Chris I De Zeeuw, Ying She. cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning. eLife. vol 12. 2023-05-10. PMID:37159499. |
granule cell-specific blocking of epac-pkcε signaling abolishes presynaptic long-term potentiation at the parallel fiber to purkinje cell synapses and impairs basic performance and learning of cerebellar motor behavior. |
2023-05-10 |
2023-08-14 |
mouse |
| Yang Liu, Li-Xin Cao, Wei-Yao Wang, Yong-Rui Piao, Jun-Ya Wang, Chun-Ping Chu, Yan-Hua Bing, De-Lai Qi. GLP-1 enhances hyperpolarization-activated currents of mouse cerebellar Purkinje cell Frontiers in molecular neuroscience. vol 16. 2023-04-24. PMID:37089690. |
in the cerebellar cortex, glp-1 receptor is abundantly expressed in the molecular layer, purkinje cell (pc) layer and granular layer, indicating that glp-1 may modulate the cerebellar neuronal activity. |
2023-04-24 |
2023-08-14 |
mouse |
| An Cheng, Ichiro Kawahata, Yifei Wang, Wenbin Jia, Wang Haoyang, Tomoki Sekimori, Yi Chen, Hiroyoshi Suzuki, Atsushi Takeda, Nadia Stefanova, David I Finkelstein, Wenbo Ma, Min Chen, Takuya Sasaki, Kohji Fukunag. Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation. Brain : a journal of neurology. 2023-04-21. PMID:37082980. |
lastly, aav5-dependent epsin-2 knock-down mice exhibited decreased levels of αsyn aggregate accumulation in purkinje neurons and oligodendrocytes, as well as improved myelin levels and purkinje neuron function in the cerebellum and motor performance. |
2023-04-21 |
2023-08-14 |
mouse |
| Yaroslav Kolinko, Milena Kralickova, Jan Cendeli. Reduction of Microvessel Number and Length in the Cerebellum of Purkinje Cell Degeneration Mice. Cerebellum (London, England). 2023-04-18. PMID:37071329. |
reduction of microvessel number and length in the cerebellum of purkinje cell degeneration mice. |
2023-04-18 |
2023-08-14 |
mouse |
| Yaroslav Kolinko, Milena Kralickova, Jan Cendeli. Reduction of Microvessel Number and Length in the Cerebellum of Purkinje Cell Degeneration Mice. Cerebellum (London, England). 2023-04-18. PMID:37071329. |
in this study, we compared the vascularity of the individual cerebellar components of 3-month-old wild-type mice (n = 8) and purkinje cell degeneration (pcd) mutant mice, which represent a model of hereditary cerebellar degeneration (n = 8). |
2023-04-18 |
2023-08-14 |
mouse |
| Sol Pose-Méndez, Paul Schramm, Barbara Winter, Jochen C Meier, Konstantinos Ampatzis, Reinhard W Köste. Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish. eLife. vol 12. 2023-04-12. PMID:37042514. |
however, regeneration of the principal neuron of the evolutionary conserved cerebellum, the purkinje cell (pc), is believed to be limited to developmental stages based on invasive lesions. |
2023-04-12 |
2023-08-14 |
zebrafish |
| Sarmad Hayder Weli Weli, Ahmad Yahyazade. Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide. Journal of chemical neuroanatomy. vol 130. 2023-03-29. PMID:36989922. |
in the sk + gb group, the total number purkinje cell, and granular cells, as well as the mean volumes of molecular layer, granular layer, white matter, and cerebellum were significantly increased than the sk group (p < 0.05). |
2023-03-29 |
2023-08-14 |
rat |