| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jose Gazulla, Carlota Ruiz-Gazulla, Maria Tintor. GABAergic Pharmacotherapy in the Treatment of Motor Disorders of the Central Nervous System. Current pharmaceutical design. vol 21. issue 34. 2016-08-15. PMID:26365142. |
cortical cerebellar atrophy (cca) shows purkinje cell loss, and ataxia caused by it was alleviated by gabapentin and pregabalin. |
2016-08-15 |
2023-08-13 |
Not clear |
| Juliana Redondo, Kevin Kemp, Kelly Hares, Claire Rice, Neil Scolding, Alastair Wilkin. Purkinje Cell Pathology and Loss in Multiple Sclerosis Cerebellum. Brain pathology (Zurich, Switzerland). vol 25. issue 6. 2016-08-10. PMID:25411024. |
purkinje cell pathology and loss in multiple sclerosis cerebellum. |
2016-08-10 |
2023-08-13 |
Not clear |
| Melissa Ingram, Emily A L Wozniak, Lisa Duvick, Rendong Yang, Paul Bergmann, Robert Carson, Brennon O'Callaghan, Huda Y Zoghbi, Christine Henzler, Harry T Or. Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways. Neuron. vol 89. issue 6. 2016-08-02. PMID:26948890. |
we used rna sequencing to profile cerebellar gene expression in pcp2-atxn1[82q] mice with ataxia and progressive pathology and pcp2-atxn1[30q]d776 animals having ataxia in absence of purkinje cell progressive pathology. |
2016-08-02 |
2023-08-13 |
mouse |
| Tooka Aavani, Shadna A Rana, Richard Hawkes, Quentin J Pittma. Maternal immune activation produces cerebellar hyperplasia and alterations in motor and social behaviors in male and female mice. Cerebellum (London, England). vol 14. issue 5. 2016-07-22. PMID:25863812. |
when sagittal sections of the cerebellum were immunostained for calbindin and purkinje cell numbers were counted, we observed greater numbers of purkinje cells in poly(i:c) offspring at both p18 and ~ p120. |
2016-07-22 |
2023-08-13 |
mouse |
| Kyla R Hamling, Zachary J C Tobias, Tamily A Weissma. Mapping the development of cerebellar Purkinje cells in zebrafish. Developmental neurobiology. vol 75. issue 11. 2016-07-12. PMID:25655100. |
this study establishes a quantitative spatiotemporal map of purkinje cell development in zebrafish that provides an important metric for studies of cerebellar development and disease. |
2016-07-12 |
2023-08-13 |
zebrafish |
| Greta Sokoloff, Alan M Plumeau, Didhiti Mukherjee, Mark S Blumber. Twitch-related and rhythmic activation of the developing cerebellar cortex. Journal of neurophysiology. vol 114. issue 3. 2016-06-17. PMID:26156383. |
taking advantage of known stages of cerebellar cortical development, we examined the relationship between purkinje cell activity (including complex and simple spikes), nuchal and hindlimb emg activity, and behavioral state in unanesthetized 4-, 8-, and 12-day-old rats. |
2016-06-17 |
2023-08-13 |
rat |
| Zhenfei Ning, Andrew S McLellan, Melanie Ball, Freda Wynne, Cora O'Neill, Walter Mills, John P Quinn, Dirk A Kleinjan, Richard J Anney, Ruaidhre J Carmody, Gerard O'Keeffe, Tom Moor. Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region. Human molecular genetics. vol 24. issue 18. 2016-05-31. PMID:26089202. |
in addition, the presence of a spry3 transcript exon in a previously described x chromosome deletion associated with autism, and the cerebellar interlobular variation in spry3 expression coincident with the reported pattern of purkinje cell loss in autism, suggest spry3 as a candidate susceptibility locus for autism. |
2016-05-31 |
2023-08-13 |
mouse |
| Michele A Calton, Jeremy R Howard, Ronald M Harper, Dan Goldowitz, Guy Mittlema. The Cerebellum and SIDS: Disordered Breathing in a Mouse Model of Developmental Cerebellar Purkinje Cell Loss during Recovery from Hypercarbia. Frontiers in neurology. vol 7. 2016-05-31. PMID:27242661. |
the cerebellum and sids: disordered breathing in a mouse model of developmental cerebellar purkinje cell loss during recovery from hypercarbia. |
2016-05-31 |
2023-08-13 |
mouse |
| Abdur Rahman Ansari, Le Wen, Hai-Bo Huang, Ji-Xiang Wang, Xi-Yao Huang, Ke-Mei Peng, Hua-Zhen Li. Lipopolysaccharide stimulation upregulated Toll-like receptor 4 expression in chicken cerebellum. Veterinary immunology and immunopathology. vol 166. issue 3-4. 2016-05-20. PMID:26049167. |
tlr4 was constitutively expressed in the purkinje cell layer, pia mater, neurons in medulla and blood vessels in the cerebellum and lps stimulation significantly up-regulated tlr4 expression on day 14 in the chicken cerebellum. |
2016-05-20 |
2023-08-13 |
chicken |
| Takashi Matsuwaki, Akira Kobayashi, Kanade Mase, Katsuyuki Nakamura, Shin-Ichi Nakano, Takahiro Miyoshi, Keitaro Yamanouchi, Masugi Nishihar. Possible involvement of the cerebellum in motor-function impairment in progranulin-deficient mice. Neuroreport. vol 26. issue 14. 2016-05-16. PMID:26302163. |
the results showed that the density of purkinje cell dendrites in the molecular layer of the cerebellum was significantly higher in ko mice than in wt mice, although the number of cell bodies was comparable between the genotypes. |
2016-05-16 |
2023-08-13 |
mouse |
| Evelyn K Shih, Gabriella Sekerková, Gen Ohtsuki, Kimberly A Aldinger, Victor V Chizhikov, Christian Hansel, Enrico Mugnaini, Kathleen J Mille. The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration Phenotype. Cerebellum (London, England). vol 14. issue 3. 2016-05-02. PMID:25626522. |
although the cerebellum shows grossly normal foliation, tippy mutants display a complex cerebellar purkinje cell phenotype consisting of abnormal dendritic branching with immature spine features and patchy, non-apoptotic cell death that is associated with widespread dystrophy and degeneration of the purkinje cell axons throughout the white matter, the cerebellar nuclei, and the vestibular nuclei. |
2016-05-02 |
2023-08-13 |
mouse |
| Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z Gong, Chet Preston, Louis Wang, Jae Kyo Yi, Chih-Li Lin, Wei Sun, Demetri D Spyropoulos, Soyoung Rhee, Mingsong Li, Jie Zhou, Shaoyu Ge, Guofeng Zhang, Ashley J Snider, Yusuf A Hannun, Lina M Obeid, Cungui Ma. Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS genetics. vol 11. issue 10. 2016-04-29. PMID:26474409. |
acer3 knockout causes an age-dependent accumulation of various ceramides and c18:1-monohexosylceramide and abolishes the age-related increase in the levels of sphingosine and s1p in the brain; thereby resulting in purkinje cell degeneration in the cerebellum and deficits in motor coordination and balance. |
2016-04-29 |
2023-08-13 |
mouse |
| Anna Dulneva, Sheena Lee, Peter L Oliver, Katalin Di Gleria, Benedikt M Kessler, Kay E Davies, Esther B E Becke. The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum. Human molecular genetics. vol 24. issue 14. 2016-04-28. PMID:25908616. |
here, we report impairments in dendritic growth and synapse formation early on during purkinje cell development in the mwk cerebellum that are accompanied by alterations in calcium signaling. |
2016-04-28 |
2023-08-13 |
mouse |
| Anna Dulneva, Sheena Lee, Peter L Oliver, Katalin Di Gleria, Benedikt M Kessler, Kay E Davies, Esther B E Becke. The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum. Human molecular genetics. vol 24. issue 14. 2016-04-28. PMID:25908616. |
these findings provide the first mechanistic insights into the trpc3-dependent mechanisms, by which activated calcium signaling is coupled to lipid metabolism and the regulation of purkinje cell development in the mwk cerebellum. |
2016-04-28 |
2023-08-13 |
mouse |
| Kwan Young Lee, Young Im Kim, Se Hoon Kim, Hyung Seo Park, Youn Joon Park, Myung Sook Ha, Yunju Jin, Dong Kwan Ki. Propofol effects on cerebellar long-term depression. Neuroscience letters. vol 609. 2016-04-12. PMID:26455962. |
using the whole-cell patch-clamp technique in wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (pf) to purkinje cell (pc) synapses (pf-ltd). |
2016-04-12 |
2023-08-13 |
rat |
| Xiaoqi Pan, Lanlan Zhu, Huiping Lu, Dun Wang, Qing Lu, Hong Ya. Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo. Oxidative medicine and cellular longevity. vol 2015. 2016-04-08. PMID:26185593. |
in vivo, rats at 40 mg/kg/day acr by gavage for 12 days showed weight loss and gait abnormality, purkinje cell nuclear condensation, and dna damage in rat cerebellum. |
2016-04-08 |
2023-08-13 |
rat |
| N V Samosudova, V P Reuto. [PLASTIC REORGANIZATION OF THE ULTRASTRUCTURE OF SYNAPSES IN THE CEREBELLUM DUE TO TOXIC EFFECTS OF GLUTAMATE AND NO-GENERATING COMPOUND]. Morfologiia (Saint Petersburg, Russia). vol 148. issue 5. 2016-04-08. PMID:26987215. |
ultrastructural changes in synapses between parallel fibers (pf) and the spines of purkinje cell dendrites (pcd) in frog cerebellum were studied after exposure to high concentrations (1 mm) of glutamate (glu) and no-generating compound in experimental model. |
2016-04-08 |
2023-08-13 |
Not clear |
| Shyam Kumar Sudhakar, Benjamin Torben-Nielsen, Erik De Schutte. Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses. PLoS computational biology. vol 11. issue 12. 2016-04-06. PMID:26630202. |
cerebellar nuclear neurons use time and rate coding to transmit purkinje neuron pauses. |
2016-04-06 |
2023-08-13 |
Not clear |
| Rodrigo Pascual, Martina Valencia, Carlos Bustamant. Antenatal betamethasone produces protracted changes in anxiety-like behaviors and in the expression of microtubule-associated protein 2, brain-derived neurotrophic factor and the tyrosine kinase B receptor in the rat cerebellar cortex. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 43. 2016-02-17. PMID:25889225. |
in the present study, we evaluated whether betamethasone alters the immunohistochemical expression of proteins that participate in cerebellar purkinje cell dendritic development and maintenance, including microtubule-associated protein 2 (map2), brain-derived neurotrophic factor (bdnf) and the tyrosine kinase b receptor (trkb), which are located predominantly in the cerebellar molecular layer where purkinje cell dendritogenesis occurs. |
2016-02-17 |
2023-08-13 |
human |
| Mirthe Erkens, Keiko Tanaka-Yamamoto, Guy Cheron, Javier Márquez-Ruiz, Cynthia Prigogine, Jan Tg Schepens, Nael Nadif Kasri, George J Augustine, Wiljan Jaj Hendrik. Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression. Molecular brain. vol 8. 2016-01-19. PMID:25571783. |
protein tyrosine phosphatase receptor type r is required for purkinje cell responsiveness in cerebellar long-term depression. |
2016-01-19 |
2023-08-13 |
Not clear |