| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyo-Soon Yun, Mi-Sook Park, Eun-Sang Ji, Tae-Woon Kim, Il-Gyu Ko, Hyun-Bae Kim, Hong Ki. Treadmill exercise ameliorates symptoms of attention deficit/hyperactivity disorder through reducing Purkinje cell loss and astrocytic reaction in spontaneous hypertensive rats. Journal of exercise rehabilitation. vol 10. issue 1. 2014-03-28. PMID:24678501. |
therefore, the present results suggested that treadmill exercise might exert ameliorating effect on adhd through reduction of purkinje cell loss and astrocytic reaction in the cerebellum. |
2014-03-28 |
2023-08-12 |
rat |
| M Paola Castelli, Alberto Casti, Angelo Casu, Roberto Frau, Marco Bortolato, Saturnino Spiga, Maria Grazia Enna. Regional distribution of 5α-reductase type 2 in the adult rat brain: an immunohistochemical analysis. Psychoneuroendocrinology. vol 38. issue 2. 2014-03-24. PMID:22776423. |
parasagittal and coronal sections revealed 5αr2 immunoreactivity throughout most brain regions, with strong immunolabeling in the layers iii and vi of the prefrontal and somatosensory cortex, olfactory bulb, thalamic nuclei, ca3 field of hippocampus, basolateral amygdala and purkinje cell layer of cerebellum. |
2014-03-24 |
2023-08-12 |
rat |
| Zhibao Guo, Xijuan Wang, Jun Xiao, Yihui Wang, Hong Lu, Junfang Teng, Wei Wan. Early postnatal GFAP-expressing cells produce multilineage progeny in cerebrum and astrocytes in cerebellum of adult mice. Brain research. vol 1532. 2014-03-21. PMID:23939222. |
x-gal-positive cells in the cerebellum coexpressed the astroglial marker blbp, but not the granule cell marker neun, purkinje cell marker calbindin or oligodendrocyte precursor cell marker ng2. |
2014-03-21 |
2023-08-12 |
mouse |
| Kairong Li, Alan W Leung, Qiuxia Guo, Wentian Yang, James Y H L. Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 3. 2014-03-13. PMID:24431450. |
in the absence of bg, inward invagination of gcp persists but is uncoupled from the folding of the purkinje cell layer and the basement membrane, leading to disorganized lamination and an absence of cerebellar folia. |
2014-03-13 |
2023-08-12 |
mouse |
| Ibhazeheibo Kingsley, Koibuchi Noriyuk. DE71 suppresses thyroid hormone-mediated dendritogenesis and neuritogenesis in the developing cerebellum. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 27. issue 2. 2014-03-06. PMID:23652225. |
employing primary cerebellar culture from new born rats, our study revealed that low dose de71 significantly suppressed th-mediated purkinje cell dendrite arborization. |
2014-03-06 |
2023-08-12 |
rat |
| Jeong-Won Jeong, Vijay N Tiwari, Michael E Behen, Harry T Chugani, Diane C Chugan. In vivo detection of reduced Purkinje cell fibers with diffusion MRI tractography in children with autistic spectrum disorders. Frontiers in human neuroscience. vol 8. 2014-03-04. PMID:24592234. |
the detection of diffusion changes in cerebellum may provide an in vivo biomarker of purkinje cell pathology in children with asd. |
2014-03-04 |
2023-08-12 |
human |
| Xiaowei Wang, Benjamin J Whalley, Gary J Stephen. The du(2J) mouse model of ataxia and absence epilepsy has deficient cannabinoid CB₁ receptor-mediated signalling. The Journal of physiology. vol 591. issue 16. 2014-03-03. PMID:23732642. |
cerebellar ataxias are a group of progressive, debilitating diseases often associated with abnormal purkinje cell (pc) firing and/or degeneration. |
2014-03-03 |
2023-08-12 |
mouse |
| Bethany K Wilson, Ellen J Hes. Animal models for dystonia. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 7. 2014-02-26. PMID:23893454. |
symptomatic animal models have also established the critical role of the cerebellum in dystonia, particularly abnormal glutamate signaling and aberrant purkinje cell activity. |
2014-02-26 |
2023-08-12 |
human |
| G Urkasemsin, K E Linder, J S Bell, A de Lahunta, N J Olb. Mapping of Purkinje neuron loss and polyglucosan body accumulation in hereditary cerebellar degeneration in Scottish terriers. Veterinary pathology. vol 49. issue 5. 2014-02-19. PMID:21753036. |
mapping of purkinje neuron loss and polyglucosan body accumulation in hereditary cerebellar degeneration in scottish terriers. |
2014-02-19 |
2023-08-12 |
dog |
| G Urkasemsin, K E Linder, J S Bell, A de Lahunta, N J Olb. Mapping of Purkinje neuron loss and polyglucosan body accumulation in hereditary cerebellar degeneration in Scottish terriers. Veterinary pathology. vol 49. issue 5. 2014-02-19. PMID:21753036. |
this study demonstrates significant purkinje cell loss and increased polyglucosan bodies in the cerebellum of affected scottish terriers. |
2014-02-19 |
2023-08-12 |
dog |
| Ji-Eun Kim, Mal-Soon Shin, Tae-Beom Seo, Eun-Sang Ji, Seong-Soo Baek, Sam-Jun Lee, Joon-Ki Park, Chang-Ju Ki. Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups. Molecular medicine reports. vol 8. issue 2. 2014-02-13. PMID:23760019. |
abnormalities of the cerebellum in autism include purkinje cell loss and motor disturbance. |
2014-02-13 |
2023-08-12 |
rat |
| Kamendra Kumar, Nisha Patro, Ishan Patr. Impaired structural and functional development of cerebellum following gestational exposure of deltamethrin in rats: role of reelin. Cellular and molecular neurobiology. vol 33. issue 5. 2014-01-29. PMID:23681596. |
reelin is an extracellular matrix molecule that is involved in the normal development of the cerebellar lamination, bergmann glial fibres alignment, purkinje cell monolayer arrangement and granule cell migration. |
2014-01-29 |
2023-08-12 |
rat |
| Masanobu Kano, Hisako Nakayama, Kouichi Hashimoto, Kazuo Kitamura, Kenji Sakimura, Masahiko Watanab. Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development. The Journal of physiology. vol 591. issue 13. 2014-01-28. PMID:23359672. |
in the cerebellum, one-to-one connection from a climbing fibre (cf) to a purkinje cell (pc) is established through four distinct phases: (1) strengthening of a single cf among multiple cfs in each pc at postnatal age p3-p7 days, (2) translocation of a single strengthened cf to pc dendrites from around p9, (3) early-phase (p7 to around p11) and (4) late-phase (around p12-p17) elimination of weak cf synapses from pc somata. |
2014-01-28 |
2023-08-12 |
mouse |
| Jonathan T Fleming, Wenjuan He, Chuanming Hao, Tatiana Ketova, Fong C Pan, Christopher C V Wright, Ying Litingtung, Chin Chian. The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors. Developmental cell. vol 27. issue 3. 2014-01-09. PMID:24229643. |
the purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors. |
2014-01-09 |
2023-08-12 |
Not clear |
| Luc Poncelet, Céline Héraud, Marie Springinsfeld, Kunie Ando, Anna Kabova, Andreas Beineke, Dominique Peeters, Anne Op De Beeck, Jean-Pierre Brio. Identification of feline panleukopenia virus proteins expressed in Purkinje cell nuclei of cats with cerebellar hypoplasia. Veterinary journal (London, England : 1997). vol 196. issue 3. 2013-12-23. PMID:23159676. |
identification of feline panleukopenia virus proteins expressed in purkinje cell nuclei of cats with cerebellar hypoplasia. |
2013-12-23 |
2023-08-12 |
Not clear |
| Luc Poncelet, Céline Héraud, Marie Springinsfeld, Kunie Ando, Anna Kabova, Andreas Beineke, Dominique Peeters, Anne Op De Beeck, Jean-Pierre Brio. Identification of feline panleukopenia virus proteins expressed in Purkinje cell nuclei of cats with cerebellar hypoplasia. Veterinary journal (London, England : 1997). vol 196. issue 3. 2013-12-23. PMID:23159676. |
in pcr-confirmed, fpv-associated feline cerebellar hypoplasia, expression of the fpv vp2 protein was demonstrated by immunohistochemistry in purkinje cell nuclei in 4/10 cases and expression of the fpv non-structural protein ns1 was demonstrated in purkinje cell nuclei in 5/10 cases. |
2013-12-23 |
2023-08-12 |
Not clear |
| Erik L de Graaf, Wilbert P Vermeij, Monique C de Waard, Yvonne Rijksen, Ingrid van der Pluijm, Casper C Hoogenraad, Jan H J Hoeijmakers, A F Maarten Altelaar, Albert J R Hec. Spatio-temporal analysis of molecular determinants of neuronal degeneration in the aging mouse cerebellum. Molecular & cellular proteomics : MCP. vol 12. issue 5. 2013-12-09. PMID:23399551. |
in summary, this study provides a highly comprehensive spatial and temporal view of the dynamic changes in the cerebellum and purkinje cell signaling in particular, indicating that synapse signaling is one of the first processes to be affected in this premature aging model, leading to neuron morphological changes, neuron degeneration, inflammation, and ultimately behavior disorders. |
2013-12-09 |
2023-08-12 |
mouse |
| Elisa J Cops, Maithili Sashindranath, Maria Daglas, Kieran M Short, Candida da Fonseca Pereira, Terence Y Pang, Roger H Lijnen, Ian M Smyth, Anthony J Hannan, Andre L Samson, Robert L Medcal. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental neurology. vol 249. 2013-12-09. PMID:23939410. |
here we show that t4 mice develop signs of cerebellar damage within 10 weeks of birth including atrophy of purkinje cell soma and dendrites, astrogliosis, reduced molecular layer volume and altered gait. |
2013-12-09 |
2023-08-12 |
mouse |
| Elisa J Cops, Maithili Sashindranath, Maria Daglas, Kieran M Short, Candida da Fonseca Pereira, Terence Y Pang, Roger H Lijnen, Ian M Smyth, Anthony J Hannan, Andre L Samson, Robert L Medcal. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental neurology. vol 249. 2013-12-09. PMID:23939410. |
we propose that elevated cerebellar tpa levels exert a common pathway of purkinje cell damage. |
2013-12-09 |
2023-08-12 |
mouse |
| Elisa J Cops, Maithili Sashindranath, Maria Daglas, Kieran M Short, Candida da Fonseca Pereira, Terence Y Pang, Roger H Lijnen, Ian M Smyth, Anthony J Hannan, Andre L Samson, Robert L Medcal. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental neurology. vol 249. 2013-12-09. PMID:23939410. |
therapeutically lowering cerebellar tpa levels may represent a novel means of preserving purkinje cell integrity and motor coordination across a wide range of neurodegenerative diseases. |
2013-12-09 |
2023-08-12 |
mouse |