| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stacey L Reeber, Tom S Otis, Roy V Sillito. New roles for the cerebellum in health and disease. Frontiers in systems neuroscience. vol 7. 2013-12-02. PMID:24294192. |
we discuss genetic, electrophysiological, and behavioral evidence that implicates purkinje cell dysfunction as a major culprit in several diseases and offer a hypothesis as to how canonical cerebellar functions might be at fault in non-motor as well as motor diseases. |
2013-12-02 |
2023-08-12 |
human |
| Philipp Ebel, Katharina Vom Dorp, Elisabeth Petrasch-Parwez, Armin Zlomuzica, Kiyoka Kinugawa, Jean Mariani, David Minich, Christina Ginkel, Jochen Welcker, Joachim Degen, Matthias Eckhardt, Ekrem Dere, Peter Dörmann, Klaus Willeck. Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities. The Journal of biological chemistry. vol 288. issue 29. 2013-11-29. PMID:23760501. |
lacz reporter expression in the brain reveals cers6 expression in hippocampus, cortex, and the purkinje cell layer of the cerebellum. |
2013-11-29 |
2023-08-12 |
mouse |
| Magali Basille-Dugay, Magda M Hamza, Céline Tassery, Bénédicte Parent, Emilie Raoult, Magalie Bénard, Rita Raisman-Vozari, David Vaudry, Delphine C Bure. Spatio-temporal characterization of the pleiotrophinergic system in mouse cerebellum: evidence for its key role during ontogenesis. Experimental neurology. vol 247. 2013-11-26. PMID:23454176. |
in contrast, subarachnoidal injection of ptn in the cerebellum significantly reduced the rate of migration of granule cells, exacerbated their apoptosis and induced an atrophy of the purkinje cell dendritic tree. |
2013-11-26 |
2023-08-12 |
mouse |
| Mark D Benton, Amanda H Lewis, Jason S Bant, Indira M Rama. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. Journal of neurophysiology. vol 109. issue 10. 2013-11-25. PMID:23446695. |
to examine the properties of somatic kca currents, we recorded voltage-clamped kca currents in purkinje cell bodies isolated from postnatal day 17-21 mouse cerebellum. |
2013-11-25 |
2023-08-12 |
mouse |
| Rachel Babij, Michelle Lee, Etty Cortés, Jean-Paul G Vonsattel, Phyllis L Faust, Elan D Loui. Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains. Brain : a journal of neurology. vol 136. issue Pt 10. 2013-11-25. PMID:24030953. |
we performed a detailed morphological analysis of the purkinje cell axonal compartment in 49 essential tremor and 39 control brains, using calbindin d28k immunohistochemistry on 100-µm cerebellar cortical vibratome tissue sections. |
2013-11-25 |
2023-08-12 |
Not clear |
| Mahnaz Taherianfard, Maryam Sharifi, Mina Tadjali, Mahboubeh Kohkiloezade. Modulation of NR1 subunit of N-methyl-D-aspartate receptor by ovariectomy and passive avoidance learning. Iranian journal of neurology. vol 11. issue 4. 2013-11-19. PMID:24250883. |
two sites of mammalian brain which are important in learning and memory are ca1 region of hippocampus and purkinje cell layer of cerebellum. |
2013-11-19 |
2023-08-12 |
human |
| Mahnaz Taherianfard, Maryam Sharifi, Mina Tadjali, Mahboubeh Kohkiloezade. Modulation of NR1 subunit of N-methyl-D-aspartate receptor by ovariectomy and passive avoidance learning. Iranian journal of neurology. vol 11. issue 4. 2013-11-19. PMID:24250883. |
so, the aim of present investigation was to study of the effect of ovariectomy and passive avoidance learning on nr1 subunit of n-methyl-d-aspartate (nmda) receptor distribution in ca1 region of hippocampus and purkinje cell layer of cerebellum. |
2013-11-19 |
2023-08-12 |
human |
| Linda Hasadsri, James Lee, Bonnie H Wang, Lalitha Yekkirala, Mingtao Wan. Anti-yo associated paraneoplastic cerebellar degeneration in a man with large cell cancer of the lung. Case reports in neurological medicine. vol 2013. 2013-10-29. PMID:24167748. |
purkinje cell cytoplasmic antibody type 1 (pca-1), or anti-yo, is the most frequently detected autoantibody in paraneoplastic cerebellar degeneration (pcd). |
2013-10-29 |
2023-08-12 |
Not clear |
| Maren C Kiessling, Andreas Büttner, Camilla Butti, Jens Müller-Starck, Stefan Milz, Patrick R Hof, Hans-Georg Frank, Christoph Schmit. Intact numbers of cerebellar purkinje and granule cells in sudden infant death syndrome: a stereologic analysis and critical review of neuropathologic evidence. Journal of neuropathology and experimental neurology. vol 72. issue 9. 2013-10-21. PMID:23965745. |
neither the volumes of the cerebellar external granule cell layer, molecular layer, internal granule cell layer (including the purkinje cell layer), and white matter nor the total numbers of purkinje cells, granule cells in the internal granule cell layer, and the number of granule cells per purkinje cell showed statistically significant differences between the sids cases and the controls. |
2013-10-21 |
2023-08-12 |
Not clear |
| Takeyuki Sugawara, Chihiro Hisatsune, Tung Dinh Le, Tsutomu Hashikawa, Moritoshi Hirono, Mitsuharu Hattori, Soichi Nagao, Katsuhiko Mikoshib. Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 30. 2013-10-17. PMID:23884927. |
although several molecules have been identified as regulators for spine maintenance in hippocampal and cortical neurons, it is poorly understood how purkinje cell (pc) spines are maintained in the mature cerebellum. |
2013-10-17 |
2023-08-12 |
mouse |
| Marlies Oostland, M Renate Buijink, Johannes A van Hoof. Serotonergic control of Purkinje cell maturation and climbing fibre elimination by 5-HT3 receptors in the juvenile mouse cerebellum. The Journal of physiology. vol 591. issue 7. 2013-09-23. PMID:23318873. |
serotonergic control of purkinje cell maturation and climbing fibre elimination by 5-ht3 receptors in the juvenile mouse cerebellum. |
2013-09-23 |
2023-08-12 |
mouse |
| Maria Grazia Bottone, Dal Bo Veronica, Valeria Maria Piccolini, Giovanni Bottiroli, Sandra Angelica De Pascali, Francesco Paolo Fanizzi, Graziella Bernocch. Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: effects of platinum compounds. Journal of chemical neuroanatomy. vol 46. issue 1-2. 2013-09-19. PMID:23017299. |
based on the effects of both pt compounds on purkinje cell differentiation, it should be emphasized that prpc, together with the synergistic action of the co-localized anti-apoptotic protein, acts as a neuroprotective protein countering cytotoxicity in the postnatal critical phases of cerebellum development. |
2013-09-19 |
2023-08-12 |
rat |
| Jia-xiang Wang, Peng Li, Yue Zho. Distribution and morphology of ghrelin-immunopositive cells in the cerebellum of the African ostrich. Tissue & cell. vol 44. issue 6. 2013-09-11. PMID:22795873. |
the cerebellar cortex comprises a molecular layer, a purkinje cell layer and a granular layer; ghrelin-immunopositive (ghrelin-ip) cells were localized throughout the entire cerebellum, but sparsely in the medulla. |
2013-09-11 |
2023-08-12 |
Not clear |
| Jocelyn J Lippman Bell, Tamar Lordkipanidze, Natalie Cobb, Anna Dunaevsk. Bergmann glial ensheathment of dendritic spines regulates synapse number without affecting spine motility. Neuron glia biology. vol 6. issue 3. 2013-09-06. PMID:21044397. |
in the cerebellum, lamellar bergmann glial (bg) appendages wrap tightly around almost every purkinje cell dendritic spine. |
2013-09-06 |
2023-08-12 |
Not clear |
| Onkar B Sawant, Emilie R Lunde, Shannon E Washburn, Wei-Jung A Chen, Charles R Goodlett, Timothy A Cud. Different patterns of regional Purkinje cell loss in the cerebellar vermis as a function of the timing of prenatal ethanol exposure in an ovine model. Neurotoxicology and teratology. vol 35. 2013-09-06. PMID:23195754. |
different patterns of regional purkinje cell loss in the cerebellar vermis as a function of the timing of prenatal ethanol exposure in an ovine model. |
2013-09-06 |
2023-08-12 |
rat |
| Onkar B Sawant, Emilie R Lunde, Shannon E Washburn, Wei-Jung A Chen, Charles R Goodlett, Timothy A Cud. Different patterns of regional Purkinje cell loss in the cerebellar vermis as a function of the timing of prenatal ethanol exposure in an ovine model. Neurotoxicology and teratology. vol 35. 2013-09-06. PMID:23195754. |
studies in rat models of fetal alcohol spectrum disorders have indicated that the cerebellum is particularly vulnerable to ethanol-induced purkinje cell loss during the third trimester-equivalent, with striking regional differences in vulnerability in which early-maturing regions in the vermis show significantly more loss than the late-maturing regions. |
2013-09-06 |
2023-08-12 |
rat |
| Onkar B Sawant, Emilie R Lunde, Shannon E Washburn, Wei-Jung A Chen, Charles R Goodlett, Timothy A Cud. Different patterns of regional Purkinje cell loss in the cerebellar vermis as a function of the timing of prenatal ethanol exposure in an ovine model. Neurotoxicology and teratology. vol 35. 2013-09-06. PMID:23195754. |
fetal cerebellar purkinje cell counts were performed in an early-maturing region (lobules i-x) and a late-maturing region (lobules vic-vii) from mid-sagittal sections of the cerebellar vermis. |
2013-09-06 |
2023-08-12 |
rat |
| Onkar B Sawant, Emilie R Lunde, Shannon E Washburn, Wei-Jung A Chen, Charles R Goodlett, Timothy A Cud. Different patterns of regional Purkinje cell loss in the cerebellar vermis as a function of the timing of prenatal ethanol exposure in an ovine model. Neurotoxicology and teratology. vol 35. 2013-09-06. PMID:23195754. |
these data confirmed that the previous findings in rat models that third trimester-equivalent prenatal ethanol exposure resulted in regionally-specific purkinje cell loss in the early-maturing region of the vermis, and further demonstrated that first trimester ethanol exposure caused more generalized fetal cerebellar purkinje cell loss, independent of the cerebellar vermal region. |
2013-09-06 |
2023-08-12 |
rat |
| Lingwei Kong, Roy C Y Choi, Karl W K Tsim, Naihe Jing, Don K Nakayama, Zhongbiao Wan. Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum. Neuroscience letters. vol 543. 2013-09-06. PMID:23570724. |
rkirre mrna was mainly expressed in the granular layers and purkinje cell layer in the developing cerebellum, revealing a possible involvement of rkirre in granule cell migration and purkinje cell development. |
2013-09-06 |
2023-08-12 |
rat |
| Takayasu Mikuni, Naofumi Uesaka, Hiroyuki Okuno, Hirokazu Hirai, Karl Deisseroth, Haruhiko Bito, Masanobu Kan. Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron. vol 78. issue 6. 2013-08-30. PMID:23791196. |
here, we report that the immediate early gene arc/arg3.1 mediates elimination of surplus climbing fiber (cf) to purkinje cell (pc) synapses in the developing cerebellum. |
2013-08-30 |
2023-08-12 |
Not clear |