| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qionger He, Heather Titley, Giorgio Grasselli, Claire Piochon, Christian Hanse. Ethanol affects NMDA receptor signaling at climbing fiber-Purkinje cell synapses in mice and impairs cerebellar LTD. Journal of neurophysiology. vol 109. issue 5. 2013-08-15. PMID:23221414. |
it has recently been demonstrated that functional n-methyl-(d)-aspartate (nmda) receptors are postsynaptically expressed at climbing fiber (cf) to purkinje cell synapses in the adult cerebellum. |
2013-08-15 |
2023-08-12 |
mouse |
| S J James, Svitlana Shpyleva, Stepan Melnyk, Oleksandra Pavliv, I P Pogribn. Complex epigenetic regulation of engrailed-2 (EN-2) homeobox gene in the autism cerebellum. Translational psychiatry. vol 3. 2013-08-15. PMID:23423141. |
together, these results suggest that the normal en-2 downregulation that signals purkinje cell maturation during late prenatal and early-postnatal development may not have occurred in some individuals with autism and that the postnatal persistence of en-2 overexpression may contribute to autism cerebellar abnormalities. |
2013-08-15 |
2023-08-12 |
Not clear |
| Alice Chort, Sandro Alves, Martina Marinello, Béatrice Dufresnois, Jean-Gabriel Dornbierer, Christelle Tesson, Morwena Latouche, Darren P Baker, Martine Barkats, Khalid H El Hachimi, Merle Ruberg, Alexandre Janer, Giovanni Stevanin, Alexis Brice, Annie Sittle. Interferon β induces clearance of mutant ataxin 7 and improves locomotion in SCA7 knock-in mice. Brain : a journal of neurology. vol 136. issue Pt 6. 2013-08-07. PMID:23518714. |
finally, since neuronal death does not occur in the cerebellum of sca7(266q/5q) mice, we showed in primary cell cultures expressing mutant ataxin 7 that interferon beta treatment improves purkinje cell survival. |
2013-08-07 |
2023-08-12 |
mouse |
| Aleksandra Badura, Martijn Schonewille, Kai Voges, Elisa Galliano, Nicolas Renier, Zhenyu Gao, Laurens Witter, Freek E Hoebeek, Alain Chédotal, Chris I De Zeeu. Climbing fiber input shapes reciprocity of Purkinje cell firing. Neuron. vol 78. issue 4. 2013-08-05. PMID:23643935. |
the cerebellum fine-tunes motor activity via its purkinje cell output. |
2013-08-05 |
2023-08-12 |
mouse |
| Christina Gavino, Stéphane Richar. Loss of p53 in quaking viable mice leads to Purkinje cell defects and reduced survival. Scientific reports. vol 1. 2013-08-01. PMID:22355603. |
in addition, immunohistochemistry revealed purkinje cell degeneration in the cerebellum. |
2013-08-01 |
2023-08-12 |
mouse |
| Azad Kumar, J Raphael Gibbs, Alexandra Beilina, Allissa Dillman, Ravindran Kumaran, Daniah Trabzuni, Mina Ryten, Robert Walker, Colin Smith, Bryan J Traynor, John Hardy, Andrew B Singleton, Mark R Cookso. Age-associated changes in gene expression in human brain and isolated neurons. Neurobiology of aging. vol 34. issue 4. 2013-08-01. PMID:23177596. |
we were able to replicate 5 gene associations from either frontal cortex or cerebellum in the purkinje cell dataset, suggesting that there is a subset of genes which have robust changes with aging. |
2013-08-01 |
2023-08-12 |
human |
| Chris J Roome, Thomas Knöpfel, Ruth M Empso. Functional contributions of the plasma membrane calcium ATPase and the sodium-calcium exchanger at mouse parallel fibre to Purkinje neuron synapses. Pflugers Archiv : European journal of physiology. vol 465. issue 2. 2013-07-17. PMID:23138229. |
we investigated how two calcium clearance mechanisms, the sodium-calcium exchanger-ncx, and the plasma membrane calcium atpase-pmca2, function at the facilitating cerebellar parallel fibre to purkinje neuron (pf-pn) synapse. |
2013-07-17 |
2023-08-12 |
mouse |
| Michael Gregory Paine, Dongfang Che, Luchuan Li, Robert William Neuma. Cerebellar Purkinje cell neurodegeneration after cardiac arrest: effect of therapeutic hypothermia. Resuscitation. vol 83. issue 12. 2013-07-08. PMID:22683500. |
the cerebellum is among the brain regions most vulnerable to damage caused by cardiac arrest, and cerebellar purkinje cell loss may contribute to neurologic dysfunction, including post-hypoxic myoclonus. |
2013-07-08 |
2023-08-12 |
Not clear |
| E A Gilbert, Y H Lim, M K Vickaryous, C L Armstron. Heterochronic protein expression patterns in the developing embryonic chick cerebellum. Anatomical record (Hoboken, N.J. : 2007). vol 295. issue 10. 2013-07-08. PMID:22865685. |
comparing this data to that seen in mice, we found that the sequence of purkinje cell formation, protein expression, and development is similar in both species, but these events consistently begin ∼5-7 days earlier in the precocial chick cerebellum, suggesting an important role for heterochrony in neurodevelopment. |
2013-07-08 |
2023-08-12 |
mouse |
| Karen Ma, Rachel Babij, Etty Cortés, Jean-Paul G Vonsattel, Elan D Loui. Cerebellar pathology of a dual clinical diagnosis: patients with essential tremor and dystonia. Tremor and other hyperkinetic movements (New York, N.Y.). vol 2. 2013-07-04. PMID:23439731. |
while the basal ganglia have traditionally been implicated in dystonia, cerebellar involvement has been suggested as well, and a recent study showed purkinje cell (pc) loss. |
2013-07-04 |
2023-08-12 |
Not clear |
| Shuhong Qiao, Sun-Hong Kim, Detlef Heck, Daniel Goldowitz, Mark S LeDoux, Ramin Homayoun. Dab2IP GTPase activating protein regulates dendrite development and synapse number in cerebellum. PloS one. vol 8. issue 1. 2013-07-02. PMID:23326475. |
however, dab2ip deficiency produced a number of cerebellar abnormalities such as a delay in the development of purkinje cell (pc) dendrites, a decrease in the parallel fiber synaptic marker vglut1, and an increase in the climbing fiber synaptic marker vglut2. |
2013-07-02 |
2023-08-12 |
mouse |
| Dustin Anderson, Jordan D T Engbers, N Colin Heath, Theodore M Bartoletti, W Hamish Mehaffey, Gerald W Zamponi, Ray W Turne. The Cav3-Kv4 complex acts as a calcium sensor to maintain inhibitory charge transfer during extracellular calcium fluctuations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 18. 2013-07-01. PMID:23637173. |
in the cerebellar molecular layer, synaptic input reduces [ca](o) by up to 0.4 mm in the vicinity of stellate cell interneurons and purkinje cell dendrites. |
2013-07-01 |
2023-08-12 |
rat |
| Ka Kui Tong, Kin Ming Kwa. Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development. Molecular and cellular biology. vol 33. issue 10. 2013-06-17. PMID:23459943. |
here, we report that cerebellum-specific double conditional inactivation of smad1 and smad5 (smad1/5) results in cerebellar hypoplasia, reduced granule cell numbers, and disorganized purkinje neuron migration during embryonic development. |
2013-06-17 |
2023-08-12 |
Not clear |
| Maria Traka, Kathleen J Millen, Devon Collins, Benayahu Elbaz, Grahame J Kidd, Christopher M Gomez, Brian Popk. WDR81 is necessary for purkinje and photoreceptor cell survival. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 16. 2013-06-17. PMID:23595742. |
moreover, immunoelectron microscopy and analysis of mitochondrial-enriched cerebellum fractions indicate that wdr81 is localized in mitochondria of purkinje cell neurons. |
2013-06-17 |
2023-08-12 |
mouse |
| Selene Lomoio, Irene López-González, Ester Aso, Margarita Carmona, Benjamín Torrejón-Escribano, Elda Scherini, Isidro Ferre. Cerebellar amyloid-β plaques: disturbed cortical circuitry in AβPP/PS1 transgenic mice as a model of familial Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 31. issue 2. 2013-06-04. PMID:22561329. |
cerebellar amyloid-β (aβ) deposition in the form of neuritic plaques and purkinje cell loss are common in certain pedigrees of familial alzheimer's disease (fad) mainly linked to ps1 mutations. |
2013-06-04 |
2023-08-12 |
mouse |
| N V Gounko, J D Swinny, D Kalicharan, S Jafari, N Corteen, M Seifi, R Bakels, J J L van der Wan. Corticotropin-releasing factor and urocortin regulate spine and synapse formation: structural basis for stress-induced neuronal remodeling and pathology. Molecular psychiatry. vol 18. issue 1. 2013-05-30. PMID:22547117. |
we used organotypic slice cultures of the cerebellum and restraint stress in behaving animals to determine whether crf in vitro and stress in vivo affects purkinje cell (pc) spine density. |
2013-05-30 |
2023-08-12 |
Not clear |
| Blake A Ebner, Melissa A Ingram, Justin A Barnes, Lisa A Duvick, Jill L Frisch, H Brent Clark, Huda Y Zoghbi, Timothy J Ebner, Harry T Or. Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 13. 2013-05-23. PMID:23536093. |
purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum. |
2013-05-23 |
2023-08-12 |
mouse |
| Jonathan L Brigman, Elizabeth M Powell, Guy Mittleman, Jared W Youn. Examining the genetic and neural components of cognitive flexibility using mice. Physiology & behavior. vol 107. issue 5. 2013-05-17. PMID:22234243. |
research presented includes examining: 1) corticostriatal networks underlying reversal learning using glun2b knockout mice, cfos expression, and in vivo electrophysiological recording; 2) cerebellar contribution to reversal learning using mutants with purkinje cell loss and in vivo electrochemical recording; 3) parvalbumin contribution to reversal learning and set-shifting using plaur mutants and in vitro recording to examine fast-spiking interneurones; and 4) alpha 7 nachr contribution to reversal learning, set-shifting, motivation, and the 'eureka moment' of rule acquisition. |
2013-05-17 |
2023-08-12 |
mouse |
| Katherine E Hekman, Guo-Yun Yu, Christopher D Brown, Haipeng Zhu, Xiaofei Du, Kristina Gervin, Dag Erik Undlien, April Peterson, Giovanni Stevanin, H Brent Clark, Stefan M Pulst, Thomas D Bird, Kevin P White, Christopher M Gome. A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult. Human molecular genetics. vol 21. issue 26. 2013-05-15. PMID:23001565. |
the autosomal dominant spinocerebellar ataxias (scas) are a genetically heterogeneous group of disorders exhibiting cerebellar atrophy and purkinje cell degeneration whose subtypes arise from 31 distinct genetic loci. |
2013-05-15 |
2023-08-12 |
Not clear |
| Masayuki Yoshida, Hiroki Kond. Fear conditioning-related changes in cerebellar Purkinje cell activities in goldfish. Behavioral and brain functions : BBF. vol 8. 2013-04-23. PMID:23114007. |
in the present study, we tracked purkinje cell activities throughout a fear conditioning procedure and aimed to elucidate further how cerebellar circuits function during the acquisition and expression of conditioned fear. |
2013-04-23 |
2023-08-12 |
Not clear |