All Relations between cerebellum purkinje cell and cerebellum

Publication Sentence Publish Date Extraction Date Species
Mireia Ortega, Ilario De Toma, Álvaro Fernández-Blanco, Anna Calderón, Lucía Barahona, Ramón Trullàs, Eduard Sabidó, Mara Diersse. Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene. Frontiers in molecular neuroscience. vol 15. 2023-01-02. PMID:36590914. dyrk1a has also been implicated in cerebellar abnormalities observed in association with ds, and normalization of dyrk1a dosage rescues granular and purkinje cell densities in a trisomic ds mouse model. 2023-01-02 2023-08-14 mouse
Jonathan Mapelli, Giulia Maria Boiani, Egidio D'Angelo, Albertino Bigiani, Daniela Gandolf. Long-Term Synaptic Plasticity Tunes the Gain of Information Channels through the Cerebellum Granular Layer. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551941. thus, akin with the expansion recoding process theoretically attributed to the cerebellum granular layer, ltp and ltd could implement selective filtering lines channeling information toward the molecular and purkinje cell layers for further processing. 2022-12-23 2023-08-14 Not clear
A Barri, M T Wiechert, M Jazayeri, D A DiGregori. Synaptic basis of a sub-second representation of time in a neural circuit model. Nature communications. vol 13. issue 1. 2022-12-22. PMID:36550115. a cerebellar circuit model equipped with dynamic synapses produced a diverse set of transient granule cell firing patterns that provided a temporal basis set for learning precisely timed pauses in purkinje cell activity during simulated delay eyelid conditioning and bayesian interval estimation. 2022-12-22 2023-08-14 Not clear
Asha Vijayan, Shyam Diwaka. A cerebellum inspired spiking neural network as a multi-model for pattern classification and robotic trajectory prediction. Frontiers in neuroscience. vol 16. 2022-12-15. PMID:36518530. in the current work, a cerebellum-inspired spiking neural network with dynamics of cerebellar neurons and learning mechanisms attributed to the granular layer, purkinje cell (pc) layer, and cerebellar nuclei interconnected by excitatory and inhibitory synapses was implemented. 2022-12-15 2023-08-14 Not clear
Stijn Voerman, Bastiaan H A Urbanus, Martijn Schonewille, Joshua J White, Chris I De Zeeu. Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity. Communications biology. vol 5. issue 1. 2022-12-03. PMID:36463347. cerebellar learning is expressed as upbound or downbound changes in simple spike activity of purkinje cell subpopulations, but the underlying mechanism remains enigmatic. 2022-12-03 2023-08-14 mouse
Ella Borgenheimer, Katherine Hamel, Carrie Sheeler, Francisco Labrada Moncada, Kaelin Sbrocco, Ying Zhang, Marija Cvetanovi. Single nuclei RNA sequencing investigation of the Purkinje cell and glial changes in the cerebellum of transgenic Spinocerebellar ataxia type 1 mice. Frontiers in cellular neuroscience. vol 16. 2022-12-02. PMID:36457352. single nuclei rna sequencing investigation of the purkinje cell and glial changes in the cerebellum of transgenic spinocerebellar ataxia type 1 mice. 2022-12-02 2023-08-14 mouse
Cheryl Brandenburg, Anthony J Griswold, Derek J Van Booven, Michaela B C Kilander, Jeannine A Frei, Michael W Nestor, Derek M Dykxhoorn, Margaret A Pericak-Vance, Gene J Blat. Transcriptomic analysis of isolated and pooled human postmortem cerebellar Purkinje cells in autism spectrum disorders. Frontiers in genetics. vol 13. 2022-11-28. PMID:36437953. however, studies from human postmortem asd brains have consistently revealed disruptions in cerebellar circuitry, specifically reductions in purkinje cell (pc) number and size. 2022-11-28 2023-08-14 human
Ri Wang, Chao Liu, Wenyan Guo, Lixuan Wang, Siruan Chen, Jiaojiao Zhao, Xia Qin, Wanjun Bai, Zuxiao Yang, Dezhi Kong, Zhanfeng Jia, Shufeng Liu, Wei Zhan. Movement disorder caused by FRRS1L deficiency may be associated with morphological and functional disorders in Purkinje cells. Brain research bulletin. vol 191. 2022-11-04. PMID:36330921. deletion also impairs purkinje cell dendritic spine formation and ampar expression in the cerebellum and damages the electrophysiological discharge rhythm of purkinje cells. 2022-11-04 2023-08-14 mouse
Deniz Yilmazer-Hanke, Najwa Ouali Alami, Lubin Fang, Sigried Klotz, Gabor G Kovacs, Helmut Pankratz, Joachim Weis, Istvan Katona, Angelika Scheuerle, Wolfgang J Streit, Kelly Del Tredic. Differential Glial Chitotriosidase 1 (CHIT1) and Chitinase 3-like protein 1 (CHI3L1) Expression in the Human Primary Visual Cortex and Cerebellum after Global Hypoxia-Ischemia. Neuroscience. 2022-11-04. PMID:36332693. initial striatal cortical and cerebellar purkinje cell damage, detectable already 1/2 d after hibi, led to delayed neuronal death, whereas loss of cerebellar nfh-positive stellate and calr-positive granule cells was variable. 2022-11-04 2023-08-14 human
Sylvie Picker-Minh, Ilaria Luperi, Ethiraj Ravindran, Nadine Kraemer, Sami Zaqout, Gisela Stoltenburg-Didinger, Olaf Ninnemann, Luis R Hernandez-Miranda, Shyamala Mani, Angela M Kaind. PTRH2 is Necessary for Purkinje Cell Differentiation and Survival and its Loss Recapitulates Progressive Cerebellar Atrophy and Ataxia Seen in IMNEPD Patients. Cerebellum (London, England). 2022-10-11. PMID:36219306. ptrh2 is necessary for purkinje cell differentiation and survival and its loss recapitulates progressive cerebellar atrophy and ataxia seen in imnepd patients. 2022-10-11 2023-08-14 Not clear
Deniz A Madencioglu, Karina A Kruth, Thomas H Wassink, Vincent A Magnotta, John A Wemmie, Aislinn J William. Modeling Human Cerebellar Development In Vitro in 2D Structure. Journal of visualized experiments : JoVE. issue 187. 2022-10-03. PMID:36190246. at 35 days of differentiation, ipsc-derived cerebellar cell cultures express cerebellar markers including atoh1, ptf1α, pax6, and kirrel2, suggesting that this protocol generates glutamatergic and gabaergic cerebellar neuronal precursors, as well as purkinje cell progenitors. 2022-10-03 2023-08-14 human
Elizabeth J Apsley, Esther B E Becke. Purkinje Cell Patterning-Insights from Single-Cell Sequencing. Cells. vol 11. issue 18. 2022-09-23. PMID:36139493. traditional methods have characterized cerebellar development and cell types, including purkinje cell subtypes, based on knowledge of selected markers. 2022-09-23 2023-08-14 mouse
Singla Rubal, Mishra Abhishek, Joshi Rupa, Sarma Phulen, Rajput Kumar, Gurjeet Kaur, Sarma AmitRaj, Ashish Jain, Ajay Prakash, Bhatia Alka, Medhi Bikas. Homotaurine ameriolates the core ASD symptomatology in VPA rats through GABAergic signalling: Role of GAD67. Brain research bulletin. 2022-09-16. PMID:36113682. the offspring of the vpa exposed group exhibited significant (p<0.05) developmental delays, behavioral deficits [decreased sociability and social novelty (three-chamber sociability test), spatial memory (morris water maze), increased stereotypy (self-grooming)], increased oxidative stress (decreased gsh, sod, catalase, and increased mda), increased pro-inflammatory (il-1β, 6, tnf-α) and decreased anti-inflammatory (il-10) cytokines, purkinje cell loss in the cerebellum and pyknosis in pfc (h/e, nissil staining) and decreased gad67 expression in the cerebellum (rt-pcr & immunohistochemistry). 2022-09-16 2023-08-14 rat
Singla Rubal, Mishra Abhishek, Joshi Rupa, Sarma Phulen, Rajput Kumar, Gurjeet Kaur, Sarma AmitRaj, Ashish Jain, Ajay Prakash, Bhatia Alka, Medhi Bikas. Homotaurine ameriolates the core ASD symptomatology in VPA rats through GABAergic signalling: Role of GAD67. Brain research bulletin. 2022-09-16. PMID:36113682. compared to the dc, ht treatment (50mg/kg) was able to ameliorate the aberrant core behavioral deficits, decreased oxidative stress, decreased pro-inflammatory and increased anti-inflammatory cytokine profile with preservation of the purkinje cell density in the cerebellum, decreased pyknosis in the prefrontal cortex and normalised the expression of gad67. 2022-09-16 2023-08-14 rat
Takehiro Takahashi, Milan Stoiljkovic, Eric Song, Xiao-Bing Gao, Yuki Yasumoto, Eriko Kudo, Fernando Carvalho, Yong Kong, Annsea Park, Marya Shanabrough, Klara Szigeti-Buck, Zhong-Wu Liu, Ashley Kristant, Yalan Zhang, Parker Sulkowski, Peter M Glazer, Leonard K Kaczmarek, Tamas L Horvath, Akiko Iwasak. LINE-1 activation in the cerebellum drives ataxia. Neuron. 2022-09-07. PMID:36070749. we demonstrated that l1 activation in the cerebellum led to purkinje cell dysfunctions and degeneration and was sufficient to cause ataxia. 2022-09-07 2023-08-14 mouse
Ilknur Özen, Hongcheng Mai, Alessandro De Maio, Karsten Ruscher, Georgios Michalettos, Fredrik Clausen, Michael Gottschalk, Saema Ansar, Sertan Arkan, Ali Erturk, Niklas Marklun. Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits. Acta neuropathologica communications. vol 10. issue 1. 2022-09-05. PMID:36064443. despite a lack of direct input from the injury site to the cerebellum, these findings argue for novel long-range mechanisms causing purkinje cell injury that likely contribute to cerebellar dysfunction after tbi. 2022-09-05 2023-08-14 mouse
Justine H Liang, Jonathan Alevy, Viktor Akhanov, Ryan Seo, Cory A Massey, Danye Jiang, Joy Zhou, Roy V Sillitoe, Jeffrey L Noebels, Melanie A Samue. Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects. Disease models & mechanisms. 2022-08-16. PMID:35972048. we also show that kctd7 is required for purkinje cell survival in the cerebellum and that selective degeneration of these neurons is accompanied by defects in cerebellar brain microvascular organization and patterning. 2022-08-16 2023-08-14 mouse
Deiweson Souza-Monteiro, Maria Karolina Martins Ferreira, Leonardo Oliveira Bittencourt, Walessa Alana Bragança Aragão, Igor Gonçalves de Oliveira, Cristiane Socorro Ferraz Maia, Marco Aurelio M Freire, Fatemeh Vida Zohoori, Marília Afonso Rabelo Buzalaf, Rafael Rodrigues Lim. Intrauterine and Postnatal Exposure to High Levels of Fluoride Is Associated with Motor Impairments, Oxidative Stress, and Morphological Damage in the Cerebellum of Offspring Rats. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955690. the results pointed out that 50 mg f/l exposure during the intrauterine and lactational period of rats is capable of promoting oxidative stress in the cerebellum with a decrease in purkinje cell density and myelin basic protein compromise, which could be associated with functional motor impairments. 2022-08-12 2023-08-14 human
Timothy Hua, Chang Liu, Sonia Kiran, Kelly Gray, Sunghoon Jung, David G Meckes, Yan Li, Qing-Xiang Amy San. Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids. Scientific reports. vol 12. issue 1. 2022-07-27. PMID:35896708. however, the expression of cerebellar genes for the molecular layer (bhle22), the granule cell layer (gabrb2, pax6, tmem266, kcnip4), the bergmann glial cells (qk1, dao), and the purkinje cell layer (arhgef33, kit, mx1, myh10, ppp1r17, scgn) was significantly higher in the rcp condition than the control. 2022-07-27 2023-08-14 human
John E Greenlee, H Robert Brashea. The Discovery of Anti-Yo (Anti-PCA1) Antibody in Patients with Paraneoplastic Cerebellar Degeneration: Opening a Window into Autoimmune Neurological Disease. Cerebellum (London, England). 2022-07-26. PMID:35881322. although the role of anti-yo antibody in cerebellar injury has not been established in living animals, in vitro studies have demonstrated that anti-yo antibody causes purkinje cell death in the absence of t lymphocytes. 2022-07-26 2023-08-14 human