| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Akosman, N Gocmen-Mas, H S Karabeki. Estimation of Purkinje cell quantification and volumetry in the cerebellum using a stereological technique. Folia morphologica. vol 70. issue 4. 2012-07-11. PMID:22117240. |
estimation of purkinje cell quantification and volumetry in the cerebellum using a stereological technique. |
2012-07-11 |
2023-08-12 |
Not clear |
| Robert A Maue, Robert W Burgess, Bing Wang, Christine M Wooley, Kevin L Seburn, Marie T Vanier, Maximillian A Rogers, Catherine C Chang, Ta-Yuan Chang, Brent T Harris, David J Graber, Carlos A A Penatti, Donna M Porter, Benjamin S Szwergold, Leslie P Henderson, John W Totenhagen, Theodore P Trouard, Ivan A Borbon, Robert P Erickso. A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations. Human molecular genetics. vol 21. issue 4. 2012-07-09. PMID:22048958. |
furthermore, histological analyses of liver, spleen, hippocampus, cortex and cerebellum reveal abnormal cholesterol accumulation, glial activation and purkinje cell loss at a slower rate than in the npc1(nih) mouse model. |
2012-07-09 |
2023-08-12 |
mouse |
| Hisako Nakayama, Taisuke Miyazaki, Kazuo Kitamura, Kouichi Hashimoto, Yuchio Yanagawa, Kunihiko Obata, Kenji Sakimura, Masahiko Watanabe, Masanobu Kan. GABAergic inhibition regulates developmental synapse elimination in the cerebellum. Neuron. vol 74. issue 2. 2012-06-29. PMID:22542190. |
in the cerebellum, one-to-one connection from excitatory climbing fiber (cf) to purkinje cell (pc) is established by elimination of early-formed surplus cfs. |
2012-06-29 |
2023-08-12 |
mouse |
| Andrew E Benesh, Jonathan T Fleming, Chin Chiang, Bruce D Carter, Matthew J Tysk. Expression and localization of myosin-1d in the developing nervous system. Brain research. vol 1440. 2012-06-20. PMID:22284616. |
analysis of mouse cerebellum prior to myelination at day 3 reveals that myosin-1d is present in the purkinje cell layer, granule cell layer, and region of the cerebellar nuclei. |
2012-06-20 |
2023-08-12 |
mouse |
| Veronika M Stein, Alexandra Crooks, Wenge Ding, Maria Prociuk, Patricia O'Donnell, Caroline Bryan, Tracey Sikora, Jasper Dingemanse, Marie T Vanier, Steven U Walkley, Charles H Vit. Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C. Journal of neuropathology and experimental neurology. vol 71. issue 5. 2012-06-11. PMID:22487861. |
miglustat delayed the onset of neurological signs and increased the lifespan of treated cats and was associated with decreased gm2 ganglioside accumulation in the cerebellum and improved purkinje cell survival. |
2012-06-11 |
2023-08-12 |
human |
| Sebok Kumar Halder, Hiroshi Ued. Regional distribution and cell type-specific subcellular localization of Prothymosin alpha in brain. Cellular and molecular neurobiology. vol 32. issue 1. 2012-05-17. PMID:21750924. |
strong immunoreactivity was also found in habenula, ependymal cells lining the dorsal third and fourth ventricle, and in neurons in the purkinje cell layer of cerebellum. |
2012-05-17 |
2023-08-12 |
Not clear |
| Moritoshi Hirono, Fumihito Saitow, Moeko Kudo, Hidenori Suzuki, Yuchio Yanagawa, Masahisa Yamada, Soichi Nagao, Shiro Konishi, Kunihiko Obat. Cerebellar globular cells receive monoaminergic excitation and monosynaptic inhibition from Purkinje cells. PloS one. vol 7. issue 1. 2012-05-14. PMID:22235322. |
because globular cells project their axons long in the transversal direction, the neuronal circuit that includes interplay between purkinje cells and globular cells could regulate purkinje cell activity in different microzones under the influence of monoamines and mossy fiber inputs, suggesting that globular cells likely play a unique modulatory role in cerebellar motor control. |
2012-05-14 |
2023-08-12 |
mouse |
| Olivia S Gugger, Jana Hartmann, Lutz Birnbaumer, Josef P Kapfhamme. P/Q-type and T-type calcium channels, but not type 3 transient receptor potential cation channels, are involved in inhibition of dendritic growth after chronic metabotropic glutamate receptor type 1 and protein kinase C activation in cerebellar Purkinje cells. The European journal of neuroscience. vol 35. issue 1. 2012-05-07. PMID:22188405. |
we have previously shown that chronic activation of either type 1 metabotropic glutamate receptors (mglur1s) or protein kinase c (pkc) in organotypic cerebellar slice cultures of mice and rats severely inhibits the growth and development of the purkinje cell dendritic tree. |
2012-05-07 |
2023-08-12 |
mouse |
| Charmaine Nelson, Maike D Glitsc. Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22207762. |
in the cerebellum, purkinje cell trpc3 channels underlie the slow excitatory postsynaptic potential observed after parallel fiber stimulation. |
2012-04-25 |
2023-08-12 |
Not clear |
| Yakup Batlevi, Albert R La Spad. Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging. Neurobiology of disease. vol 43. issue 1. 2012-04-09. PMID:20887789. |
in the purkinje cell degeneration (pcd) mouse, altered mitophagy may contribute to the dramatic neuron cell death observed in the cerebellum, suggesting that over-active mitophagy or insufficient mitophagy can both be deleterious. |
2012-04-09 |
2023-08-12 |
mouse |
| R Michelle Reith, Sharon Way, James McKenna, Katherine Haines, Michael J Gambell. Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration. Neurobiology of disease. vol 43. issue 1. 2012-04-09. PMID:21419848. |
to assess whether the murine purkinje cell loss has a correlate to the human tsc, we analyzed postmortem cerebellum samples from tsc patients and detected purkinje cell loss in half of the samples. |
2012-04-09 |
2023-08-12 |
mouse |
| Ronak S Patel, Mahesh Rachamalla, Namoju R Chary, Firdos Y Shera, Kulbhushan Tikoo, Gopabandhu Jen. Cytarabine induced cerebellar neuronal damage in juvenile rat: correlating neurobehavioral performance with cellular and genetic alterations. Toxicology. vol 293. issue 1-3. 2012-04-09. PMID:22212197. |
further, cellular abnormalities in the cerebellum such as purkinje cell misalignment and granule cell cytotoxicity were observed. |
2012-04-09 |
2023-08-12 |
rat |
| Ronak S Patel, Mahesh Rachamalla, Namoju R Chary, Firdos Y Shera, Kulbhushan Tikoo, Gopabandhu Jen. Cytarabine induced cerebellar neuronal damage in juvenile rat: correlating neurobehavioral performance with cellular and genetic alterations. Toxicology. vol 293. issue 1-3. 2012-04-09. PMID:22212197. |
positive correlation was observed between ara-c induced disturbance in the motor performance and the purkinje cell loss in rat cerebellum. |
2012-04-09 |
2023-08-12 |
rat |
| Martine Girard, Roxanne Larivière, David A Parfitt, Emily C Deane, Rebecca Gaudet, Nadya Nossova, Francois Blondeau, George Prenosil, Esmeralda G M Vermeulen, Michael R Duchen, Andrea Richter, Eric A Shoubridge, Kalle Gehring, R Anne McKinney, Bernard Brais, J Paul Chapple, Peter S McPherso. Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 5. 2012-03-30. PMID:22307627. |
disruption of mitochondrial transport into dendrites has been shown to lead to abnormal dendritic morphology, and we observe striking alterations in the organization of dendritic fields in the cerebellum of knockout mice that precedes purkinje cell death. |
2012-03-30 |
2023-08-12 |
mouse |
| Xiaohong Wang, Tetsuya Imura, Michael V Sofroniew, Shinji Fushik. Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell nonautonomous neurodegeneration of cerebellar Purkinje neurons. Glia. vol 59. issue 6. 2012-03-26. PMID:21381115. |
using conditional knockout (cko) mice in which the apc gene is inactivated in glial fibrillary acidic protein (gfap)-expressing cells, we show a selective and critical role for apc in maintaining the morphology and function of cerebellar bergmann glia, which are specialized astroglia that extend polarized radial processes from the purkinje cell layer to the pial surface. |
2012-03-26 |
2023-08-12 |
mouse |
| Stacey L Reeber, Roy V Sillito. Patterned expression of a cocaine- and amphetamine-regulated transcript peptide reveals complex circuit topography in the rodent cerebellar cortex. The Journal of comparative neurology. vol 519. issue 9. 2012-03-26. PMID:21452228. |
the cerebellum (cb) of mammals and birds consists of an evolutionarily conserved map defined by purkinje cell (pc) protein expression. |
2012-03-26 |
2023-08-12 |
mouse |
| Angela L Hewitt, Laurentiu S Popa, Siavash Pasalar, Claudia M Hendrix, Timothy J Ebne. Representation of limb kinematics in Purkinje cell simple spike discharge is conserved across multiple tasks. Journal of neurophysiology. vol 106. issue 5. 2012-03-26. PMID:21795616. |
encoding of movement kinematics in purkinje cell simple spike discharge has important implications for hypotheses of cerebellar cortical function. |
2012-03-26 |
2023-08-12 |
monkey |
| Zhengshan Zhao, Jing Wang, Chunying Zhao, Weina Bi, Zhenyu Yue, Zhongmin Alex M. Genetic ablation of PLA2G6 in mice leads to cerebellar atrophy characterized by Purkinje cell loss and glial cell activation. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046428. |
genetic ablation of pla2g6 in mice leads to cerebellar atrophy characterized by purkinje cell loss and glial cell activation. |
2012-03-26 |
2023-08-12 |
mouse |
| Zhengshan Zhao, Jing Wang, Chunying Zhao, Weina Bi, Zhenyu Yue, Zhongmin Alex M. Genetic ablation of PLA2G6 in mice leads to cerebellar atrophy characterized by Purkinje cell loss and glial cell activation. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046428. |
our findings indicate that the absence of pla2g6 causes neuroinflammation and purkinje cell loss and ultimately leads to cerebellar atrophy. |
2012-03-26 |
2023-08-12 |
mouse |
| Suleyman Gulsuner, Ayse Begum Tekinay, Katja Doerschner, Huseyin Boyaci, Kaya Bilguvar, Hilal Unal, Aslihan Ors, O Emre Onat, Ergin Atalar, A Nazli Basak, Haluk Topaloglu, Tulay Kansu, Meliha Tan, Uner Tan, Murat Gunel, Tayfun Ozceli. Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred. Genome research. vol 21. issue 12. 2012-03-25. PMID:21885617. |
it is highly expressed in the cerebellum and corpus callosum, in particular in the purkinje cell layer of the cerebellum. |
2012-03-25 |
2023-08-12 |
Not clear |