| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin L Brown, Alexis Agelan, Diana S Woodruff-Pa. Unimpaired trace classical eyeblink conditioning in Purkinje cell degeneration (pcd) mutant mice. Neurobiology of learning and memory. vol 93. issue 3. 2010-06-23. PMID:19931625. |
young adult purkinje cell degeneration (pcd) mutant mice, with complete loss of cerebellar cortical purkinje cells, are impaired in delay eyeblink classical conditioning. |
2010-06-23 |
2023-08-12 |
mouse |
| D H Dolle. The Identity in Dog and Man of the Sequence of Changes produced by functional Activity in the Purkinje Cell of the Cerebellum. The Journal of medical research. vol 25. issue 2. 2010-06-22. PMID:19972033. |
the identity in dog and man of the sequence of changes produced by functional activity in the purkinje cell of the cerebellum. |
2010-06-22 |
2023-08-12 |
dog |
| Maria Christina Sergaki, Francois Guillemot, Rebecca Matsa. Impaired cerebellar development and deficits in motor coordination in mice lacking the neuronal protein BM88/Cend1. Molecular and cellular neurosciences. vol 44. issue 1. 2010-06-17. PMID:20153830. |
however, detailed analysis revealed alterations in cerebellar layering arising from increased proliferation of granule cell precursors, delayed radial granule cell migration and impaired purkinje cell differentiation. |
2010-06-17 |
2023-08-12 |
mouse |
| Daniel J DiLorenzo, Joseph Jankovic, Richard K Simpson, Hidehiro Takei, Suzanne Z Powel. Long-term deep brain stimulation for essential tremor: 12-year clinicopathologic follow-up. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 2. 2010-06-16. PMID:20063387. |
cerebellar axonal spheroids and purkinje cell loss were found. |
2010-06-16 |
2023-08-12 |
Not clear |
| Loren A Martin, Dan Goldowitz, Guy Mittlema. Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. The European journal of neuroscience. vol 31. issue 3. 2010-05-17. PMID:20105240. |
repetitive behavior and increased activity in mice with purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. |
2010-05-17 |
2023-08-12 |
mouse |
| Loren A Martin, Dan Goldowitz, Guy Mittlema. Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. The European journal of neuroscience. vol 31. issue 3. 2010-05-17. PMID:20105240. |
in this study, we examined the relationship between cerebellar pathology and these behaviors in a mouse model of purkinje cell loss. |
2010-05-17 |
2023-08-12 |
mouse |
| Loren A Martin, Dan Goldowitz, Guy Mittlema. Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. The European journal of neuroscience. vol 31. issue 3. 2010-05-17. PMID:20105240. |
although the performance of lc/+ mice is probably related to their motor deficits, the significant relationships between purkinje cell number and repetitive lever-pressing behavior as well as open-field activity measures provide support for a role of cerebellar pathology in generating repetitive behavior and increased activity in chimeric mice. |
2010-05-17 |
2023-08-12 |
mouse |
| Sven Jarius, Klaus P Wandinger, Sigrun Horn, Heike Heuer, Brigitte Wildeman. A new Purkinje cell antibody (anti-Ca) associated with subacute cerebellar ataxia: immunological characterization. Journal of neuroinflammation. vol 7. 2010-04-27. PMID:20226058. |
immunohistochemical studies on mouse, rat, and monkey brain sections revealed binding of a high-titer (up to 1:10,000) igg antibody to the cerebellar molecular layer, purkinje cell (pc) layer, and white matter. |
2010-04-27 |
2023-08-12 |
mouse |
| Emma M Perkins, Yvonne L Clarkson, Nancy Sabatier, David M Longhurst, Christopher P Millward, Jennifer Jack, Junko Toraiwa, Mitsunori Watanabe, Jeffrey D Rothstein, Alastair R Lyndon, David J A Wyllie, Mayank B Dutia, Mandy Jackso. Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 14. 2010-04-26. PMID:20371805. |
we developed a mouse lacking full-length beta-iii spectrin and found that homozygous mice reproduced features of sca5 including gait abnormalities, tremor, deteriorating motor coordination, purkinje cell loss, and cerebellar atrophy (molecular layer thinning). |
2010-04-26 |
2023-08-12 |
mouse |
| Emma M Perkins, Yvonne L Clarkson, Nancy Sabatier, David M Longhurst, Christopher P Millward, Jennifer Jack, Junko Toraiwa, Mitsunori Watanabe, Jeffrey D Rothstein, Alastair R Lyndon, David J A Wyllie, Mayank B Dutia, Mandy Jackso. Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 14. 2010-04-26. PMID:20371805. |
these findings implicate a loss of beta-iii spectrin function in sca5 pathogenesis and indicate that there are at least two physiological effects of beta-iii spectrin loss that underpin a progressive loss of inhibitory cerebellar output, namely an intrinsic purkinje cell membrane defect due to reduced sodium currents and alterations in glutamate signaling. |
2010-04-26 |
2023-08-12 |
mouse |
| Ekrem Maloku, Ignacio R Covelo, Ingeborg Hanbauer, Alessandro Guidotti, Bashkim Kadriu, Qiaoyan Hu, John M Davis, Erminio Cost. Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 9. 2010-04-16. PMID:20150511. |
reelin is an extracellular matrix protein synthesized in cerebellar granule cells that plays an important role in purkinje cell positioning during cerebellar development and in modulating adult synaptic function. |
2010-04-16 |
2023-08-12 |
mouse |
| Ekrem Maloku, Ignacio R Covelo, Ingeborg Hanbauer, Alessandro Guidotti, Bashkim Kadriu, Qiaoyan Hu, John M Davis, Erminio Cost. Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 9. 2010-04-16. PMID:20150511. |
this finding suggests that lack of reelin impairs gabaergic purkinje neuron expression and/or positioning during cerebellar development. |
2010-04-16 |
2023-08-12 |
mouse |
| Daniela Di Bella, Federico Lazzaro, Alfredo Brusco, Massimo Plumari, Giorgio Battaglia, Annalisa Pastore, Adele Finardi, Claudia Cagnoli, Filippo Tempia, Marina Frontali, Liana Veneziano, Tiziana Sacco, Enrica Boda, Alessandro Brussino, Florian Bonn, Barbara Castellotti, Silvia Baratta, Caterina Mariotti, Cinzia Gellera, Valentina Fracasso, Stefania Magri, Thomas Langer, Paolo Plevani, Stefano Di Donato, Marco Muzi-Falconi, Franco Taron. Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Nature genetics. vol 42. issue 4. 2010-04-16. PMID:20208537. |
autosomal dominant spinocerebellar ataxias (scas) are genetically heterogeneous neurological disorders characterized by cerebellar dysfunction mostly due to purkinje cell degeneration. |
2010-04-16 |
2023-08-12 |
human |
| Stian Ludvigsen, Lars P Folko. Differences in in vitro cerebellar neuronal responses to hypoxia in eider ducks, chicken and rats. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 195. issue 11. 2010-04-06. PMID:19779726. |
to test this, we compared extracellular recordings of spontaneous activity in the purkinje cell layer of 400 mum thick isolated cerebellar slices from eider ducks, chickens and rats, before, during and after 60 min hypoxia (95%n(2)-5%co(2)) or chemical anoxia (hypoxia + 2 mm nacn). |
2010-04-06 |
2023-08-12 |
rat |
| Osamu Tao, Takuya Shimazaki, Yohei Okada, Hayato Naka, Kazuhisa Kohda, Michisuke Yuzaki, Hidehiro Mizusawa, Hideyuki Okan. Efficient generation of mature cerebellar Purkinje cells from mouse embryonic stem cells. Journal of neuroscience research. vol 88. issue 2. 2010-03-30. PMID:19705453. |
here we successfully established a coculture system that induced the maturation of pcs in esc-derived purkinje cell (edpc) precursors in sfeb, using as a feeder layer a cerebellum dissociation culture prepared from mice at postnatal day (p) 6-8. |
2010-03-30 |
2023-08-12 |
mouse |
| Anjali G Shah, Meyer J Friedman, Shanshan Huang, Meredith Roberts, Xiao-Jiang Li, Shihua L. Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17. Human molecular genetics. vol 18. issue 21. 2010-02-22. PMID:19643914. |
down-regulation of trka also occurs in the cerebellum of sca17 transgenic mice prior to purkinje cell degeneration. |
2010-02-22 |
2023-08-12 |
mouse |
| S-H Chung, R V Sillitoe, L Croci, A Badaloni, G Consalez, R Hawke. Purkinje cell phenotype restricts the distribution of unipolar brush cells. Neuroscience. vol 164. issue 4. 2010-02-19. PMID:19800947. |
finally, similar associations with specific purkinje cell clusters are seen during normal cerebellar development. |
2010-02-19 |
2023-08-12 |
mouse |
| G Mandolesi, V Vanni, R Cesa, G Grasselli, F Puglisi, P Cesare, P Strat. Distribution of the SNAP25 and SNAP23 synaptosomal-associated protein isoforms in rat cerebellar cortex. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19735702. |
in the cerebellum, climbing fiber (cf) and parallel fiber (pf) inputs, which impinge onto the same purkinje cell (pc), have very different functional properties. |
2010-02-08 |
2023-08-12 |
rat |
| Elan D Louis, Phyllis L Faust, Jean-Paul G Vonsattel, Lawrence S Honig, Alex Rajput, Ali Rajput, Rajesh Pahwa, Kelly E Lyons, Webster G Ross, Rodger J Elble, Cordelia Erickson-Davis, Carol B Moskowitz, Arlene Lawto. Torpedoes in Parkinson's disease, Alzheimer's disease, essential tremor, and control brains. Movement disorders : official journal of the Movement Disorder Society. vol 24. issue 11. 2010-01-15. PMID:19526585. |
purkinje cell axonal swellings ("torpedoes"), described in several cerebellar disorders as well as essential tremor (et), have not been quantified in common neurodegenerative conditions. |
2010-01-15 |
2023-08-12 |
Not clear |
| Asami Tanimura, Shinya Kawata, Kouichi Hashimoto, Masanobu Kan. Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents. Neuropharmacology. vol 57. issue 2. 2010-01-06. PMID:19447120. |
not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to purkinje cell synaptic transmission in young adult rodents. |
2010-01-06 |
2023-08-12 |
mouse |