| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jae-Min Lee, Jongmin Park, Joo-Hee Lee, Hyo-Bum Kwak, Mi-Hyun No, Jun-Won Heo, Youn-Jung Ki. Low-intensity treadmill exercise protects cognitive impairment by enhancing cerebellar mitochondrial calcium retention capacity in a rat model of chronic cerebral hypoperfusion. Journal of exercise rehabilitation. vol 17. issue 5. 2021-11-23. PMID:34805021. |
the present study showed that lite hindered the deficit of spatial working memory and loss of purkinje cell in the cerebellum induced by cch. |
2021-11-23 |
2023-08-13 |
rat |
| Pamela McMillan, Jeanna Wheeler, Rachel E Gatlin, Laura Taylor, Tim Strovas, Misa Baum, Thomas D Bird, Caitlin Latimer, C Dirk Keene, Brian C Kraemer, Nicole F Liachk. Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice. Acta neuropathologica communications. vol 8. issue 1. 2021-11-09. PMID:33228809. |
these behavioral phenotypes occur in conjunction with progressive weight loss, neuroinflammation, and severe cerebellar degeneration with purkinje neuron loss. |
2021-11-09 |
2023-08-13 |
mouse |
| Adrian Handforth, Eric J Lan. Increased Purkinje Cell Complex Spike and Deep Cerebellar Nucleus Synchrony as a Potential Basis for Syndromic Essential Tremor. A Review and Synthesis of the Literature. Cerebellum (London, England). vol 20. issue 2. 2021-11-05. PMID:33048308. |
increased purkinje cell complex spike and deep cerebellar nucleus synchrony as a potential basis for syndromic essential tremor. |
2021-11-05 |
2023-08-13 |
rat |
| Melanie P Jensen, James B Rowe, Kieren S J Allinso. A case report of metastatic renal cell carcinoma causing corticobasal syndrome. Clinical neuropathology. vol 40. issue 3. 2021-11-02. PMID:33433315. |
there was also purkinje cell loss and mild lymphocytic inflammation in the cerebellum, but the significance of this was unclear. |
2021-11-02 |
2023-08-13 |
Not clear |
| Yuning Liu, Hong Xing, Bradley J Wilkes, Fumiaki Yokoi, Huanxin Chen, David E Vaillancourt, Yuqing L. The abnormal firing of Purkinje cells in the knockin mouse model of DYT1 dystonia. Brain research bulletin. vol 165. 2021-10-26. PMID:32976982. |
manipulating the purkinje cell firing and cerebellar output may show great promise for treating dyt1 dystonia. |
2021-10-26 |
2023-08-13 |
mouse |
| David D Bushart, Annie J Zalon, Hongjiu Zhang, Logan M Morrison, Yuanfang Guan, Henry L Paulson, Vikram G Shakkottai, Hayley S McLoughli. Antisense Oligonucleotide Therapy Targeted Against ATXN3 Improves Potassium Channel-Mediated Purkinje Neuron Dysfunction in Spinocerebellar Ataxia Type 3. Cerebellum (London, England). vol 20. issue 1. 2021-10-25. PMID:32789747. |
previous studies suggest that potassium channel dysfunction underlies early abnormalities in cerebellar cortical purkinje neuron firing in sca3. |
2021-10-25 |
2023-08-13 |
mouse |
| Meike E van der Heijden, Elizabeth P Lackey, Ross Perez, Fatma S Ișleyen, Amanda M Brown, Sarah G Donofrio, Tao Lin, Huda Y Zoghbi, Roy V Sillito. Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons. eLife. vol 10. 2021-10-19. PMID:34542409. |
these data argue that excitatory cerebellar neurons define the maturation time-window for postnatal purkinje cell functions and refine cerebellar-dependent behaviors. |
2021-10-19 |
2023-08-13 |
mouse |
| Thien Timothy Hua, Julie Bejoy, Liqing Song, Zhe Wang, Ziwei Zeng, Yi Zhou, Yan Li, Qing-Xiang Amy San. Cerebellar Differentiation from Human Stem Cells Through Retinoid, Wnt, and Sonic Hedgehog Pathways. Tissue engineering. Part A. vol 27. issue 13-14. 2021-10-15. PMID:32873223. |
different combinations of the morphogens (ra/chir, ra/pmr, chir/pmr, and ra/chir/pmr) were utilized, and the spheroids (day 35) were characterized for the markers of three cerebellum layers (the molecular layer, the purkinje cell layer, and the granule cell layer). |
2021-10-15 |
2023-08-13 |
human |
| Joshua J White, Laurens W J Bosman, Francois G C Blot, Catarina Osório, Bram W Kuppens, Wilhelmina H J J Krijnen, Charlotte Andriessen, Chris I De Zeeuw, Dick Jaarsma, Martijn Schonewill. Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1. Brain pathology (Zurich, Switzerland). vol 31. issue 5. 2021-10-13. PMID:33724582. |
our results show that, in a mouse model otherwise characterized by widespread purkinje cell degeneration, sparing of specific subpopulations is sufficient to maintain normal performance of specific behaviors within the context of the functional, modular map of the cerebellum. |
2021-10-13 |
2023-08-13 |
mouse |
| Niccolò E Mencacci, Marisa M Brockmann, Jinye Dai, Sander Pajusalu, Burcu Atasu, Joaquin Campos, Gabriela Pino, Paulina Gonzalez-Latapi, Christopher Patzke, Michael Schwake, Arianna Tucci, Alan Pittman, Javier Simon-Sanchez, Gemma L Carvill, Bettina Balint, Sarah Wiethoff, Thomas T Warner, Apostolos Papandreou, Audrey Soo, Reet Rein, Liis Kadastik-Eerme, Sanna Puusepp, Karit Reinson, Tiiu Tomberg, Hasmet Hanagasi, Thomas Gasser, Kailash P Bhatia, Manju A Kurian, Ebba Lohmann, Katrin Õunap, Christian Rosenmund, Thomas C Südhof, Nicholas W Wood, Dimitri Krainc, Claudio Acun. Biallelic variants in TSPOAP1, encoding the active-zone protein RIMBP1, cause autosomal recessive dystonia. The Journal of clinical investigation. vol 131. issue 7. 2021-09-28. PMID:33539324. |
in mice, complete loss of rimbp1, known to reduce neurotransmission, led to motor abnormalities reminiscent of dystonia, decreased purkinje cell dendritic arborization, and reduced numbers of cerebellar synapses. |
2021-09-28 |
2023-08-13 |
mouse |
| Aaron Sathyanesan, Panagiotis Kratimenos, Vittorio Gall. Disruption of neonatal Purkinje cell function underlies injury-related learning deficits. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 11. 2021-09-23. PMID:33688045. |
using a novel integration of gcamp6f fiber photometry with automated measurement of cerebellar behavior using the erasmusladder, we causally link cerebellar injury to altered purkinje cell responses during maladaptive behavior. |
2021-09-23 |
2023-08-13 |
Not clear |
| Felipe Cunha, Cristian Gutiérrez-Ibáñez, Kelsey Racicot, Douglas R Wylie, Andrew N Iwaniu. A quantitative analysis of cerebellar anatomy in birds. Brain structure & function. vol 226. issue 8. 2021-09-20. PMID:34357439. |
our estimate of cerebellar folding, the midsagittal foliation index, was a poor predictor of surface area and number of purkinje cells, but surface area was the best predictor of purkinje cell numbers. |
2021-09-20 |
2023-08-13 |
Not clear |
| Foluso A Atiba, Amos A Fatokun, Innocent O Imosemi, Adefolarin O Malom. Kola nut from Cola nitida vent. Schott administered to pregnant rats induces histological alterations in pups' cerebellum. PloS one. vol 16. issue 3. 2021-09-13. PMID:33684143. |
paraffin sections of the cerebellum were stained with haematoxylin and eosin for cerebellar cytoarchitecture, cresyl violet stain for purkinje cell count, glial fibrillary acidic protein (gfap) immunohistochemistry (ihc) for estimation of gliosis, and b-cell lymphoma 2 (bcl-2) ihc for apoptosis induction. |
2021-09-13 |
2023-08-13 |
human |
| Madeline Garza, Amanda L Pique. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. Frontiers in neurology. vol 12. 2021-09-08. PMID:34489848. |
some of the first autoantibodies identified against antigen targets include anti-neuronal nuclear antibody type 1 (anna-1 or anti-hu) and purkinje cell cytoplasmic antibody (pca-1) also known as anti-yo have been identified in paraneoplastic cerebellar degeneration. |
2021-09-08 |
2023-08-13 |
Not clear |
| Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Ya. Effect of long-term exposure to acrylamide on endoplasmic reticulum stress and autophagy in rat cerebellum. Ecotoxicology and environmental safety. vol 224. 2021-09-07. PMID:34450424. |
the results of hematoxylin and eosin and nissl staining indicated that acr impaired the structures of all three layers of the cerebellum, especially the purkinje cell layer, showing abnormal morphology with nucleus condensation and pyknosis. |
2021-09-07 |
2023-08-13 |
human |
| Ravi Chopra, David D Bushart, John P Cooper, Dhananjay Yellajoshyula, Logan M Morrison, Haoran Huang, Hillary P Handler, Luke J Man, Warunee Dansithong, Daniel R Scoles, Stefan M Pulst, Harry T Orr, Vikram G Shakkotta. Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32964235. |
atxn1[82q] purkinje neurons from the anterior cerebellum were found to degenerate earlier than those from the nodular zone, and this early degeneration was associated with selective dysregulation of ion channel transcripts and altered purkinje neuron spiking. |
2021-08-30 |
2023-08-13 |
Not clear |
| Astrid Buchberger, Lena Schepergerdes, Maren Flaßhoff, Conrad Kunick, Reinhard W Köste. A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome-associated kinase Dyrk1A overexpression. The Journal of biological chemistry. vol 297. issue 1. 2021-08-26. PMID:34090874. |
this impaired purkinje cell organization was progressive, leading to an age-dependent dispersal of purkinje neurons throughout the cerebellar molecular layer with larval swim deficits resulting in miscoordination of swimming and reduced exploratory behavior in aged adults. |
2021-08-26 |
2023-08-13 |
human |
| Anastasia Rumyantseva, Elisa Motori, Aleksandra Trifunovi. DARS2 is indispensable for Purkinje cell survival and protects against cerebellar ataxia. Human molecular genetics. vol 29. issue 17. 2021-08-24. PMID:32766765. |
we used conditional purkinje cell (pcs)-specific dars2 deletion to elucidate further the cell-type-specific contribution of this class of neurons to the cerebellar impairment observed in lbsl. |
2021-08-24 |
2023-08-13 |
Not clear |
| Tara Barron, Jun Hee Ki. Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum. Brain sciences. vol 10. issue 12. 2021-08-21. PMID:33255158. |
utilizing the non-human primate baboon cerebellum, we investigated purkinje cell development during the last trimester of pregnancy and the effect of nicu experience following premature birth on developmental features of purkinje cells. |
2021-08-21 |
2023-08-13 |
human |
| Tara Barron, Jun Hee Ki. Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum. Brain sciences. vol 10. issue 12. 2021-08-21. PMID:33255158. |
in addition, these alterations impact purkinje cell output, reducing the spontaneous firing frequency in deep cerebellar nucleus (dcn) neurons. |
2021-08-21 |
2023-08-13 |
human |