| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J D Laughton, Y Charnay, B Belloir, L Pellerin, P J Magistretti, C Boura. Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain. Neuroscience. vol 96. issue 3. 2000-04-27. PMID:10717443. |
in addition, the granular and purkinje cell layers of the cerebellum showed a strong labeling. |
2000-04-27 |
2023-08-12 |
rat |
| Z H Lee, H Kim, K Y Ahn, K H Seo, J K Kim, C S Bae, K K Ki. Identification of a brain specific protein that associates with a refsum disease gene product, phytanoyl-CoA alpha-hydroxylase. Brain research. Molecular brain research. vol 75. issue 2. 2000-04-21. PMID:10686344. |
in situ hybridization analyses of the brain showed specific localization of pahx-ap #1 to the supragranular layer in the cerebral cortex, dentate gyrus, hippocampus, purkinje cell layer, deep cerebellar nucleus, trigeminal nucleus, abducent nucleus, facial nucleus, cochlear and vestibular nucleus, ganglion cell and nuclear layer of the retina. |
2000-04-21 |
2023-08-12 |
mouse |
| A Mouatt-Prigent, J O Karlsson, J Yelnik, Y Agid, E C Hirsc. Calpastatin immunoreactivity in the monkey and human brain of control subjects and patients with Parkinson's disease. The Journal of comparative neurology. vol 419. issue 2. 2000-04-12. PMID:10722997. |
the cerebellum was stained intensely, particularly in the granular and purkinje cell layers. |
2000-04-12 |
2023-08-12 |
human |
| A Buffo, M Zagrebelsky, A B Huber, A Skerra, M E Schwab, P Strata, F Ross. Application of neutralizing antibodies against NI-35/250 myelin-associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured purkinje cell axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 6. 2000-04-03. PMID:10704503. |
application of neutralizing antibodies against ni-35/250 myelin-associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured purkinje cell axons. |
2000-04-03 |
2023-08-12 |
rat |
| M Sabaratna. Pathological and neuropathological findings in two males with fragile-X syndrome. Journal of intellectual disability research : JIDR. vol 44 ( Pt 1). 2000-03-29. PMID:10711653. |
the cerebellum showed focal purkinje cell loss and corresponding bergmann gliosis. |
2000-03-29 |
2023-08-12 |
human |
| N Schweighofer, M A Arbi. A model of cerebellar metaplasticity. Learning & memory (Cold Spring Harbor, N.Y.). vol 4. issue 5. 2000-03-16. PMID:10701881. |
we propose here that the cerebellar cortex may use metaplasticity, and we demonstrate this by introducing the cerebellar adaptive rate learning (carl) algorithm that concentrates learning on those purkinje cell synapses whose adaptation is most relevant to learning an overall pattern. |
2000-03-16 |
2023-08-12 |
Not clear |
| A C Kreitzer, W G Regeh. Modulation of transmission during trains at a cerebellar synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 4. 2000-02-25. PMID:10662825. |
field recordings of presynaptic volleys, optical measurements of presynaptic calcium, and voltage-clamp recordings of postsynaptic currents were used to examine parallel fiber to purkinje cell synapses in cerebellar brain slices at 34 degrees c. in control conditions, regular stimulus trains (1-50 hz) evoked up to a 250% peak synaptic enhancement, whereas during irregular stimulation, a threefold variability in epsc amplitude was observed. |
2000-02-25 |
2023-08-12 |
Not clear |
| D H Shin, H Y Lee, K H Lee, H J Kim, W J Lee, D H Hwang, S H Baik, S S Ch. Localization of bcl-2 mRNA in the rabbit central nervous system. Neuroscience letters. vol 278. issue 1-2. 2000-02-22. PMID:10643804. |
although the bcl-2 expressions of the rabbit were generally similar to those of the other animals, some differences were also found; the cells in molecular and purkinje cell layers of the cerebellum, which were bcl-2 negative in the others, showed intense bcl-2 positive signals, while the ependymal cells, arachnoid villi and granular layer, which were positive in the other animals, were not well stained with bcl-2 riboprobes in the rabbit brain. |
2000-02-22 |
2023-08-12 |
rabbit |
| H C Leung, M Suh, R E Kettne. Cerebellar flocculus and paraflocculus Purkinje cell activity during circular pursuit in monkey. Journal of neurophysiology. vol 83. issue 1. 2000-02-16. PMID:10634849. |
cerebellar flocculus and paraflocculus purkinje cell activity during circular pursuit in monkey. |
2000-02-16 |
2023-08-12 |
monkey |
| T C Burazin, A L Gundlac. Localization of GDNF/neurturin receptor (c-ret, GFRalpha-1 and alpha-2) mRNAs in postnatal rat brain: differential regional and temporal expression in hippocampus, cortex and cerebellum. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581409. |
c-ret mrna was abundant in areas such as the lateral habenula, reticular thalamic nucleus, substantia nigra pars compacta, cranial motor nuclei, and the purkinje cell layer of the cerebellum. |
2000-02-14 |
2023-08-12 |
rat |
| Z Hu, V Lelievre, A Chao, X Zhou, J A Wasche. Characterization and messenger ribonucleic acid distribution of a cloned pituitary adenylate cyclase-activating polypeptide type I receptor in the frog Xenopus laevis brain. Endocrinology. vol 141. issue 2. 2000-02-10. PMID:10650947. |
in situ hybridization showed that the pac1 receptor gene was expressed highly in the pallium, preoptic nucleus, and nucleus of cerebellum, and moderately in the purkinje cell layer of the cerebellum. |
2000-02-10 |
2023-08-12 |
human |
| Y Yamakawa, T Hiran. Contribution of mGluR1 to the basal activity of a mouse cerebellar Purkinje neuron. Neuroscience letters. vol 277. issue 2. 2000-02-08. PMID:10624820. |
the physiological role of mglur1-induced inward current in a purkinje neuron was studied in a cerebellar slice preparation. |
2000-02-08 |
2023-08-12 |
mouse |
| K Tsutsui, K Ukena, M Takase, C Kohchi, R W Le. Neurosteroid biosynthesis in vertebrate brains. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. vol 124. issue 2. 2000-01-20. PMID:10622427. |
we recently demonstrated neuronal neurosteroidogenesis in the brain and indicated that the purkinje cell, a typical cerebellar neuron, actively synthesizes several neurosteroids de novo from cholesterol in both mammals and non-mammals. |
2000-01-20 |
2023-08-12 |
Not clear |
| B Melegh, L Seress, T Bedekovics, G Kispál, B Sümegi, K Trombitás, K Méhe. Muscle carnitine acetyltransferase and carnitine deficiency in a case of mitochondrial encephalomyopathy. Journal of inherited metabolic disease. vol 22. issue 7. 1999-12-21. PMID:10518284. |
histological examination of the autopsy specimens revealed a selective purkinje cell degeneration in the cerebellum: the cells had abnormal position, were shrunken and decreased in number, and displayed abnormal dendritic trees and fragmented, disorganized axons. |
1999-12-21 |
2023-08-12 |
Not clear |
| W Darmanto, M Inouye, S Hayasaka, Y Takagishi, M Ogawa, K Mikoshiba, Y Murat. Disturbed Purkinje cell migration due to reduced expression of Reelin by X-irradiation in developing rat cerebellum. Uchu Seibutsu Kagaku. vol 12. issue 3. 1999-12-12. PMID:11542484. |
disturbed purkinje cell migration due to reduced expression of reelin by x-irradiation in developing rat cerebellum. |
1999-12-12 |
2023-08-12 |
rat |
| D R Pierce, D K Williams, K E Ligh. Purkinje cell vulnerability to developmental ethanol exposure in the rat cerebellum. Alcoholism, clinical and experimental research. vol 23. issue 10. 1999-11-30. PMID:10549998. |
purkinje cell vulnerability to developmental ethanol exposure in the rat cerebellum. |
1999-11-30 |
2023-08-12 |
rat |
| R E McAlhany, R C Miranda, R H Finnell, J R Wes. Ethanol decreases Glial-Derived Neurotrophic Factor (GDNF) protein release but not mRNA expression and increases GDNF-stimulated Shc phosphorylation in the developing cerebellum. Alcoholism, clinical and experimental research. vol 23. issue 10. 1999-11-30. PMID:10550003. |
although differentiating purkinje cells of the cerebellum are particularly vulnerable to ethanol exposure, the mechanisms underlying ethanol-induced purkinje cell loss have not been well defined. |
1999-11-30 |
2023-08-12 |
Not clear |
| R E McAlhany, R C Miranda, R H Finnell, J R Wes. Ethanol decreases Glial-Derived Neurotrophic Factor (GDNF) protein release but not mRNA expression and increases GDNF-stimulated Shc phosphorylation in the developing cerebellum. Alcoholism, clinical and experimental research. vol 23. issue 10. 1999-11-30. PMID:10550003. |
our previous research indicated that exogenous glial-derived neurotrophic factor (gdnf) attenuated ethanol-induced purkinje cell loss in cerebellar explant cultures, which suggests that ethanol, in turn, may decrease endogenous trophic factor-mediated survival mechanisms. |
1999-11-30 |
2023-08-12 |
Not clear |
| M Hornig, H Weissenböck, N Horscroft, W I Lipki. An infection-based model of neurodevelopmental damage. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 21. 1999-11-24. PMID:10518583. |
architecture is markedly disrupted in hippocampus and cerebellum, with reduction in granule and purkinje cell numbers. |
1999-11-24 |
2023-08-12 |
human |
| M Tanaka, K Tanaka, S Tokiguchi, K Shinozawa, S Tsuj. Cytotoxic T cells against a peptide of Yo protein in patients with paraneoplastic cerebellar degeneration and anti-Yo antibody. Journal of the neurological sciences. vol 168. issue 1. 1999-11-23. PMID:10500270. |
anti-yo antibodies are present in the sera and cerebrospinal fluid of some patients with paraneoplastic cerebellar degeneration (pcd), but there is no evidence that the presence of anti-yo antibodies causes the purkinje cell loss seen in pcd patients. |
1999-11-23 |
2023-08-12 |
human |