| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R D'Hooge, D Hartmann, J Manil, F Colin, V Gieselmann, P P De Dey. Neuromotor alterations and cerebellar deficits in aged arylsulfatase A-deficient transgenic mice. Neuroscience letters. vol 273. issue 2. 1999-11-22. PMID:10505624. |
examination of cerebellar histology showed that 2-year-old asa(-/-) mice have lost most of the calbindin immunoreactivity from their purkinje cell dendrites and show simplified dendritic architecture. |
1999-11-22 |
2023-08-12 |
mouse |
| R D'Hooge, D Hartmann, J Manil, F Colin, V Gieselmann, P P De Dey. Neuromotor alterations and cerebellar deficits in aged arylsulfatase A-deficient transgenic mice. Neuroscience letters. vol 273. issue 2. 1999-11-22. PMID:10505624. |
recordings of unitary potentials and stimulation of climbing fibers on cerebellar slices from 2-year-old mice indicated that, although the main cerebellar synapses seem to be present and functioning physiologically, the climbing fibers of asa-deficient mice may have enhanced effects on purkinje cell activity. |
1999-11-22 |
2023-08-12 |
mouse |
| R D'Hooge, D Hartmann, J Manil, F Colin, V Gieselmann, P P De Dey. Neuromotor alterations and cerebellar deficits in aged arylsulfatase A-deficient transgenic mice. Neuroscience letters. vol 273. issue 2. 1999-11-22. PMID:10505624. |
it is concluded that ambulatory dysfunctions in asa(-/-) mice might be explained by an imbalance in the consequences of climbing fiber signals upon purkinje cell activity due to selective neurodegeneration within the cerebellum. |
1999-11-22 |
2023-08-12 |
mouse |
| R Vigot, C Batin. Purkinje cell inhibitory responses to 3-APPA (3-aminopropylphosphinic acid) in RAT cerebellar slices. Neuroscience research. vol 34. issue 3. 1999-11-10. PMID:10515256. |
purkinje cell inhibitory responses to 3-appa (3-aminopropylphosphinic acid) in rat cerebellar slices. |
1999-11-10 |
2023-08-12 |
rat |
| K J Millen, J H Millonig, R J Wingate, J Alder, M E Hatte. Neurogenetics of the cerebellar system. Journal of child neurology. vol 14. issue 9. 1999-11-01. PMID:10488902. |
concomitantly, programs of gene expression define the principal neuronal classes, the granule cell and purkinje cell, that will establish the cerebellar circuitry in the postnatal period. |
1999-11-01 |
2023-08-12 |
Not clear |
| M Tanaka, K Tanak. [A candidate peptide reacting with cytotoxic T cells in paraneoplastic cerebellar degeneration with anti-Yo antibody]. Rinsho shinkeigaku = Clinical neurology. vol 39. issue 6. 1999-10-26. PMID:10502981. |
anti-yo antibody is present in some patients with paraneoplastic cerebellar degeneration (pcd), but there is no evidence that it causes purkinje cell loss. |
1999-10-26 |
2023-08-12 |
Not clear |
| A K Pringle, C R Gardner, R J Walke. Dual action of the benzodiazepine receptor inverse agonist RU34347 on responses to exogenously applied GABA in the rat cerebellar slice. General pharmacology. vol 33. issue 2. 1999-10-22. PMID:10461857. |
ru34347 has both inverse agonist (attenuation of gaba-responses) and agonist-like (reduction of spontaneous purkinje cell firing rate) in the cerebellar slice preparation. |
1999-10-22 |
2023-08-12 |
rat |
| J S Hallem, J H Thompson, G Gundappa-Sulur, R Hawkes, J G Bjaalie, J M Bowe. Spatial correspondence between tactile projection patterns and the distribution of the antigenic Purkinje cell markers anti-zebrin I and anti-zebrin II in the cerebellar folium crus IIA of the rat. Neuroscience. vol 93. issue 3. 1999-10-21. PMID:10473273. |
spatial correspondence between tactile projection patterns and the distribution of the antigenic purkinje cell markers anti-zebrin i and anti-zebrin ii in the cerebellar folium crus iia of the rat. |
1999-10-21 |
2023-08-12 |
rat |
| H Hosokawa, H Ninomiya, T Sawamura, Y Sugimoto, A Ichikawa, K Fujiwara, T Masak. Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain. Brain research. vol 838. issue 1-2. 1999-10-07. PMID:10446328. |
cat3 protein was also detected both in the cerebral and cerebellar gray matter and strong immunostaining was obtained in the olfactory cortex, hippocampus and cerebellar granular and purkinje cell layers. |
1999-10-07 |
2023-08-12 |
rat |
| D J Linde. Input-specific induction of cerebellar long-term depression does not require presynaptic alteration. Learning & memory (Cold Spring Harbor, N.Y.). vol 1. issue 2. 1999-09-29. PMID:10467590. |
in cerebellar long-term depression (ltd), conjunctive stimulation of parallel fiber (pf) and climbing fiber (cf) inputs to a purkinje neuron result in a selective depression of pf-purkinje neuron synaptic strength. |
1999-09-29 |
2023-08-12 |
Not clear |
| D J Linde. Input-specific induction of cerebellar long-term depression does not require presynaptic alteration. Learning & memory (Cold Spring Harbor, N.Y.). vol 1. issue 2. 1999-09-29. PMID:10467590. |
to allow for an unambiguous analysis of postsynaptic processes, an ltd induction protocol has been developed using cultured cerebellar cells in which pulses of quisqualate and direct purkinje neuron depolarization replace pf and cf stimulation, respectively. |
1999-09-29 |
2023-08-12 |
Not clear |
| K A Young, W D Hirst, E Solito, G P Wilki. De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum. Glia. vol 26. issue 4. 1999-09-09. PMID:10383052. |
in the normal cerebellum lipocortin-1 immunoreactivity was detected in purkinje cell bodies and molecular layer interneurons. |
1999-09-09 |
2023-08-12 |
rat |
| K K de Balogh, A P Dimande, J J van der Lugt, R J Molyneux, T W Naudé, W G Welma. A lysosomal storage disease induced by Ipomoea carnea in goats in Mozambique. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 11. issue 3. 1999-08-24. PMID:10353359. |
residual alterations in the brain in chronic cases revealed predominantly cerebellar lesions characterized by loss of purkinje neurons and gliosis of the purkinje cell layer. |
1999-08-24 |
2023-08-12 |
Not clear |
| R Zhao, A M Lawler, S J Le. Characterization of GDF-10 expression patterns and null mice. Developmental biology. vol 212. issue 1. 1999-08-24. PMID:10419686. |
in adult animals, gdf-10 is expressed at high levels in the brain, where gdf-10 is localized primarily to cells in the purkinje cell layer of the cerebellum, and in the uterus, where the expression levels of gdf-10 are regulated both during the menstrual cycle and during pregnancy. |
1999-08-24 |
2023-08-12 |
mouse |
| K Tsutsui, K Uken. Neurosteroids in the cerebellar Purkinje neuron and their actions (review). International journal of molecular medicine. vol 4. issue 1. 1999-08-20. PMID:10373637. |
recently, we demonstrated neurosteroidogenesis in the purkinje cell, a typical cerebellar neuron, in mammals and other vertebrates. |
1999-08-20 |
2023-08-12 |
Not clear |
| K Tsutsui, K Uken. Neurosteroids in the cerebellar Purkinje neuron and their actions (review). International journal of molecular medicine. vol 4. issue 1. 1999-08-20. PMID:10373637. |
pregnenolone sulfate, one of neurosteroids synthesized in the cerebellar purkinje cell, may contribute to some important events in the cerebellum by modulating neurotransmission. |
1999-08-20 |
2023-08-12 |
Not clear |
| K Ishikawa, M Watanabe, K Yoshizawa, T Fujita, H Iwamoto, T Yoshizawa, K Harada, K Nakamagoe, Y Komatsuzaki, A Satoh, M Doi, T Ogata, I Kanazawa, S Shoji, H Mizusaw. Clinical, neuropathological, and molecular study in two families with spinocerebellar ataxia type 6 (SCA6). Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369828. |
pathologically, three sca6 brains consistently showed purkinje cell dominant cortical cerebellar degeneration. |
1999-08-19 |
2023-08-12 |
Not clear |
| K Ishikawa, M Watanabe, K Yoshizawa, T Fujita, H Iwamoto, T Yoshizawa, K Harada, K Nakamagoe, Y Komatsuzaki, A Satoh, M Doi, T Ogata, I Kanazawa, S Shoji, H Mizusaw. Clinical, neuropathological, and molecular study in two families with spinocerebellar ataxia type 6 (SCA6). Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 1. 1999-08-19. PMID:10369828. |
the present study showed that sca6 is characterised by purkinje cell dominant cortical cerebellar degeneration, highly stable transmission of the cag repeat expansion, and lack of ubiquitin immunoreactive nuclear inclusions. |
1999-08-19 |
2023-08-12 |
Not clear |
| J J Waite, M L Wardlow, A E Powe. Deficit in selective and divided attention associated with cholinergic basal forebrain immunotoxic lesion produced by 192-saporin; motoric/sensory deficit associated with Purkinje cell immunotoxic lesion produced by OX7-saporin. Neurobiology of learning and memory. vol 71. issue 3. 1999-08-05. PMID:10196110. |
the cholinergic basal forebrain lesion may mask some of the effects of cerebellar damage up to a threshold after which effects of purkinje cell loss predominate when 192-saporin is administered intraventricularly. |
1999-08-05 |
2023-08-12 |
rat |
| U Grüsser-Cornehls, C Grüsser, J Bäurl. Vermectomy enhances parvalbumin expression and improves motor performance in weaver mutant mice: an animal model for cerebellar ataxia. Neuroscience. vol 91. issue 1. 1999-08-02. PMID:10336081. |
in purkinje cell degeneration mice (pcd/pcd) lacking nearly all purkinje cells and displaying milder motor deficiencies than wv, in comparison to wild-type mice, a strong increase in parvalbumin- and (co-localized with parvalbumin) glycine-immunopositive somata in the deep cerebellar and vestibular nuclei has recently been found. |
1999-08-02 |
2023-08-12 |
mouse |