| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Javier Apam-Castillejos, Hiram Tendilla-Beltrán, Rubén Antonio Vázquez-Roque, Andrea Judith Vázquez-Hernández, Estefania Fuentes-Medel, Fernando García-Dolores, Alfonso Díaz, Gonzalo Flore. Second-generation antipsychotic olanzapine attenuates behavioral and prefrontal cortex synaptic plasticity deficits in a neurodevelopmental schizophrenia-related rat model. Journal of chemical neuroanatomy. 2022-09-26. PMID:36156295. |
in the prefrontal cortex (pfc), olz restored the pyramidal cell structural plasticity in the nvhl rats, enhancing the dendritic arbor length, the spinogenesis and the proportion of mature spines. |
2022-09-26 |
2023-08-14 |
rat |
| Adejoke Elizabeth Memudu, Rukky Precious Adanik. Alpha lipoic acid reverses scopolamine-induced spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of Wistar rats. IBRO neuroscience reports. vol 13. 2022-06-06. PMID:35664083. |
alpha lipoic acid reverses scopolamine-induced spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of wistar rats. |
2022-06-06 |
2023-08-14 |
rat |
| Moushumi Nath, Sanjeev K Bhardwaj, Lalit K Srivastava, Tak Pan Won. Altered excitatory and decreased inhibitory transmission in the prefrontal cortex of male mice with early developmental disruption to the ventral hippocampus. Cerebral cortex (New York, N.Y. : 1991). 2022-03-17. PMID:35297476. |
using whole-cell recordings to assess pfc cellular activity in transgenic male mouse lines, we show early developmental disconnection of vhpc inputs, by excitotoxic lesion or cell-specific ablations, impairs pyramidal cell firing output and produces a persistent increase in excitatory and decrease in inhibitory synaptic inputs onto pyramidal cells. |
2022-03-17 |
2023-08-13 |
mouse |
| Chelsea S Sullivan, Vishwa Mohan, Paul B Manis, Sheryl S Moy, Young Truong, Bryce W Duncan, Patricia F Manes. Developmental Regulation of Basket Interneuron Synapses and Behavior through NCAM in Mouse Prefrontal Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 8. 2021-11-29. PMID:32249896. |
parvalbumin (pv)-expressing basket interneurons in the prefrontal cortex (pfc) regulate pyramidal cell firing, synchrony, and network oscillations. |
2021-11-29 |
2023-08-13 |
mouse |
| Dibyadeep Datta, John F Enwright, Dominique Arion, Constantinos D Paspalas, Yury M Morozov, David A Lewis, Amy F T Arnste. Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits. Frontiers in neuroanatomy. vol 14. 2021-10-12. PMID:33328902. |
mapping phosphodiesterase 4d (pde4d) in macaque dorsolateral prefrontal cortex: postsynaptic compartmentalization in layer iii pyramidal cell circuits. |
2021-10-12 |
2023-08-13 |
human |
| Amy F T Arnsten, Lu E Jin, Nao J Gamo, Brian Ramos, Constantinos D Paspalas, Yury M Morozov, Anna Kata, Nigel S Bamford, Mark F Yeckel, Leonard K Kaczmarek, Lynda El-Hassa. Role of KCNQ potassium channels in stress-induced deficit of working memory. Neurobiology of stress. vol 11. 2020-10-01. PMID:31832507. |
the current study examined whether stress and increased camp-pka signaling in rat medial pfc (mpfc) reduce pyramidal cell firing and impair working memory by activating kcnq potassium channels. |
2020-10-01 |
2023-08-13 |
rat |
| Dibyadeep Datta, Amy F T Arnste. Unique Molecular Regulation of Higher-Order Prefrontal Cortical Circuits: Insights into the Neurobiology of Schizophrenia. ACS chemical neuroscience. vol 9. issue 9. 2019-12-11. PMID:29470055. |
in particular, neuropathological studies of schizophrenia have found selective atrophy of the pyramidal cell microcircuits in deep layer iii of the dorsolateral pfc (dlpfc) and compensatory weakening of related gabaergic interneurons. |
2019-12-11 |
2023-08-13 |
monkey |
| Kazuhiko Yamamuro, Hiroki Yoshino, Yoichi Ogawa, Manabu Makinodan, Michihiro Toritsuka, Masayuki Yamashita, Gabriel Corfas, Toshifumi Kishimot. Social Isolation During the Critical Period Reduces Synaptic and Intrinsic Excitability of a Subtype of Pyramidal Cell in Mouse Prefrontal Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 3. 2019-05-07. PMID:28158488. |
social isolation during the critical period reduces synaptic and intrinsic excitability of a subtype of pyramidal cell in mouse prefrontal cortex. |
2019-05-07 |
2023-08-13 |
mouse |
| Fani Koukouli, Marie Rooy, Dimitrios Tziotis, Kurt A Sailor, Heidi C O'Neill, Josien Levenga, Mirko Witte, Michael Nilges, Jean-Pierre Changeux, Charles A Hoeffer, Jerry A Stitzel, Boris S Gutkin, David A DiGregorio, Uwe Masko. Nicotine reverses hypofrontality in animal models of addiction and schizophrenia. Nature medicine. vol 23. issue 3. 2017-08-07. PMID:28112735. |
two-photon calcium imaging in awake mouse models showed that nicotine can differentially influence pfc pyramidal cell activity by nachr modulation of layer ii/iii hierarchical inhibitory circuits. |
2017-08-07 |
2023-08-13 |
mouse |
| Zizhen Zhang, Vinicius M Gadotti, Lina Chen, Ivana A Souza, Patrick L Stemkowski, Gerald W Zampon. Role of Prelimbic GABAergic Circuits in Sensory and Emotional Aspects of Neuropathic Pain. Cell reports. vol 12. issue 5. 2016-05-09. PMID:26212331. |
we found that peripheral nerve injury inhibits pyramidal cell firing in the prelimbic area of the prefrontal cortex as a result of feed-forward inhibition mediated by parvalbumin-expressing gabaergic interneurons. |
2016-05-09 |
2023-08-13 |
mouse |
| Matthew S Lazarus, Keerthi Krishnan, Z Josh Huan. GAD67 deficiency in parvalbumin interneurons produces deficits in inhibitory transmission and network disinhibition in mouse prefrontal cortex. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 5. 2016-01-19. PMID:24275833. |
we found substantial deficits in transmission from pv to pyramidal neurons in prefrontal cortex, along with increases of pyramidal cell excitability and excitation/inhibition balance in pv cells. |
2016-01-19 |
2023-08-12 |
mouse |
| Vincent Foster, Arthur E Oakley, Janet Y Slade, Roslyn Hall, Tuomo M Polvikoski, Matthew Burke, Alan J Thomas, Ahmad Khundakar, Louise M Allan, Raj N Kalari. Pyramidal neurons of the prefrontal cortex in post-stroke, vascular and other ageing-related dementias. Brain : a journal of neurology. vol 137. issue Pt 9. 2014-11-06. PMID:24974383. |
we found pyramidal cell volumes in layers iii and v in the dorsolateral prefrontal cortex of post-stroke and vascular dementia and, of mixed and alzheimer's disease subjects to be reduced by 30-40% compared to post-stroke patients with no dementia and controls. |
2014-11-06 |
2023-08-13 |
human |
| Tsung-Ung W Wo. Neurobiology of schizophrenia onset. Current topics in behavioral neurosciences. vol 16. 2014-07-31. PMID:23975845. |
specifically, converging lines of evidence suggest that oxidative stress, extracellular matrix (ecm) deficit and impaired glutamatergic innervation may contribute to the functional impairment of pv neurons, which may then lead to aberrant developmental synaptic pruning of pyramidal cell circuits during adolescence in the pfc. |
2014-07-31 |
2023-08-12 |
Not clear |
| Tomofumi Oga, Hirosato Aoi, Tetsuya Sasaki, Ichiro Fujita, Noritaka Ichinoh. Postnatal development of layer III pyramidal cells in the primary visual, inferior temporal, and prefrontal cortices of the marmoset. Frontiers in neural circuits. vol 7. 2014-05-19. PMID:23483808. |
the estimates of the total numbers of spines in the basal dendrites of a single pyramidal cell were larger in te and pfc than in v1 throughout development and peaked around 3 months after birth in all three areas. |
2014-05-19 |
2023-08-12 |
marmoset |
| Constantinos D Paspalas, Min Wang, Amy F T Arnste. Constellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: potential substrate for working memory deficits in schizophrenia. Cerebral cortex (New York, N.Y. : 1991). vol 23. issue 7. 2014-01-07. PMID:22693343. |
the data suggest that a camp signalplex is selectively positioned in the spines to gate pfc pyramidal cell microcircuits. |
2014-01-07 |
2023-08-12 |
monkey |
| Naydu Marmolejo, Jesse Paez, Jonathan B Levitt, Liesl B Jone. Early postnatal lesion of the medial dorsal nucleus leads to loss of dendrites and spines in adult prefrontal cortex. Developmental neuroscience. vol 34. issue 6. 2013-09-19. PMID:23406908. |
research suggests that the medial dorsal nucleus (md) of the thalamus influences pyramidal cell development in the prefrontal cortex (pfc) in an activity-dependent manner. |
2013-09-19 |
2023-08-12 |
rat |
| Yun Wang, Thomas H Zhou, Zhina Zhi, Amey Barakat, Lynn Hlatky, Henry Querfurt. Multiple effects of β-amyloid on single excitatory synaptic connections in the PFC. Frontiers in cellular neuroscience. vol 7. 2013-09-12. PMID:24027495. |
pyramidal cell (pc) connections are typically facilitating (f) or depressing (d) in pfc. |
2013-09-12 |
2023-08-12 |
rat |
| Amy F T Arnsten, Min J Wang, Constantinos D Paspala. Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses. Neuron. vol 76. issue 1. 2012-12-10. PMID:23040817. |
working memory arises from recurrent excitation within layer iii pfc pyramidal cell nmda circuits, which are afflicted in aging and schizophrenia. |
2012-12-10 |
2023-08-12 |
Not clear |
| Laia Lladó-Pelfort, Noemí Santana, Valentina Ghisi, Francesc Artigas, Pau Celad. 5-HT1A receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons. Cerebral cortex (New York, N.Y. : 1991). vol 22. issue 7. 2012-11-13. PMID:21893679. |
5-ht1a receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on gaba interneurons. |
2012-11-13 |
2023-08-12 |
rat |
| Kyriaki Sidiropoulou, Panayiota Poiraz. Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons. PLoS computational biology. vol 8. issue 4. 2012-08-01. PMID:22570601. |
moreover, the presence of pyramidal cell subtypes with different firing patterns, such as regular spiking and intrinsic bursting, raises the question as to what their distinct role might be in persistent firing in the pfc. |
2012-08-01 |
2023-08-12 |
Not clear |