| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muriel D Mardones, Kevin D Rostam, Margaret C Nickerson, Kunal Gupt. Canonical Wnt activator Chir99021 prevents epileptogenesis in the intrahippocampal kainate mouse model of temporal lobe epilepsy. Experimental neurology. 2024-03-24. PMID:38522659. |
the wnt signaling pathway mediates the development of dentate granule cell neurons in the hippocampus. |
2024-03-24 |
2024-03-27 |
mouse |
| Yanyi Ding, Long Li, Sinuo Wang, Yajun Cao, Minguang Yang, Yaling Dai, Huawei Lin, Jianhong Li, Yulu Liu, Zhifu Wang, Weilin Liu, Jing Ta. Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model. Biological research. vol 56. issue 1. 2023-12-02. PMID:38041203. |
here, we investigated whether spatial memory discrimination impairment can be improved by promoting the hippocampal dg granule cell neogenesis-mediated pattern separation in the early stage of ad by electroacupuncture (ea). |
2023-12-02 |
2023-12-10 |
mouse |
| Kathleen E Murray, Whitney A Ratliff, Vedad Delic, Bruce A Citro. Gulf War toxicant-induced reductions in dendritic arbors and spine densities of dentate granule cells are improved by treatment with a Nrf2 activator. Brain research. vol 1823. 2023-11-24. PMID:37989436. |
these findings indicate that gulf war toxicant exposure results in chronic changes to dentate granule cell morphology and that modulation of neuroprotective transcription factors such as nrf2 may improve long-term neuronal health in the hippocampus. |
2023-11-24 |
2023-11-28 |
mouse |
| Elisa M York, Anne Miller, Sylwia A Stopka, Juan Ramón Martínez-François, Md Amin Hossain, Gerard Baquer, Michael S Regan, Nathalie Y R Agar, Gary Yelle. The dentate gyrus differentially metabolizes glucose and alternative fuels during rest and stimulation. Journal of neurochemistry. 2023-11-06. PMID:37929637. |
here, we use mass spectrometry imaging (maldi-msi) to focus on the fuel metabolism of the dentate granule cell (dgc) layer in murine hippocampal slices. |
2023-11-06 |
2023-11-08 |
Not clear |
| Anne Miller, Elisa M York, Sylwia A Stopka, Juan Ramón Martínez-François, Md Amin Hossain, Gerard Baquer, Michael S Regan, Nathalie Y R Agar, Gary Yelle. Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation. Nature metabolism. 2023-10-05. PMID:37798473. |
to investigate metabolic adaptations in the neuron-enriched dentate granule cell (dgc) layer within its native tissue environment, we employed murine acute hippocampal brain slices, coupled with fast metabolite preservation and followed by mass spectrometry (ms) imaging, to generate spatially resolved metabolomics and isotope-tracing data. |
2023-10-05 |
2023-10-07 |
Not clear |
| Anne Miller, Elisa York, Sylwia Stopka, Juan Martínez-François, Md Amin Hossain, Gerard Baquer, Michael Regan, Nathalie Agar, Gary Yelle. Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation. Research square. 2023-08-07. PMID:37546759. |
to investigate metabolic adaptations in the neuron-enriched dentate granule cell (dgc) layer within its native tissue environment, we employed murine acute hippocampal brain slices coupled with fast metabolite preservation, followed by mass spectrometry imaging (maldi-msi) to generate spatially resolved metabolomics and isotope tracing data. |
2023-08-07 |
2023-08-14 |
Not clear |
| Meredith E Gamble, Rhea Marfatia, Marvin R Dia. Prenatal methadone exposure leads to long-term memory impairments and disruptions of dentate granule cell function in a sex-dependent manner. Addiction biology. vol 27. issue 5. 2022-08-24. PMID:36001432. |
additionally, using whole-cell patch-clamp electrophysiology, hippocampal dentate granule cell function was examined in adult offspring. |
2022-08-24 |
2023-08-14 |
rat |
| Cathryn A Cutia, Leanna K Leverton, Xiyu Ge, Rana Youssef, Lori T Raetzman, Catherine A Christian-Hinma. Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice. Experimental neurology. 2022-05-21. PMID:35597270. |
one, two, and four months after ihka or saline injection, in vivo measurements of estrous cycles and weight were followed by ex vivo examination of hippocampal dentate granule cell dispersion, circulating ovarian hormone and corticosterone levels, ovarian morphology, and pituitary gene expression. |
2022-05-21 |
2023-08-13 |
mouse |
| James K Chambers, Shinya Iwasaki, Shigeki Imamoto, Yuya Nakamoto, Kazuyuki Uchid. A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation. The Journal of veterinary medical science. 2022-03-28. PMID:35342145. |
histopathologically, the dentate gyrus granule cell layer of the hippocampus was irregularly arranged. |
2022-03-28 |
2023-08-13 |
cat |
| Sachin Makani, Stefano Lutzu, Pablo J Lituma, David L Hunt, Pablo E Castill. Retrograde Suppression of Post-Tetanic Potentiation at the Mossy Fiber-CA3 Pyramidal Cell Synapse. eNeuro. vol 8. issue 2. 2021-06-18. PMID:33593734. |
in the hippocampus, the excitatory synapse between dentate granule cell (gc) axons, or mossy fibers (mfs), and ca3 pyramidal cells (mf-ca3) expresses robust forms of short-term plasticity, such as frequency facilitation and post-tetanic potentiation (ptp). |
2021-06-18 |
2023-08-13 |
mouse |
| Ahmad Alhourani, Kenneth N Fish, Thomas A Wozny, Vivek Sudhakar, Ronald L Hamilton, R Mark Richardso. GABA bouton subpopulations in the human dentate gyrus are differentially altered in mesial temporal lobe epilepsy. Journal of neurophysiology. vol 123. issue 1. 2021-05-10. PMID:31800363. |
specifically, we found increased density of pvbc boutons, while pvchc boutons decreased significantly in the dentate granule cell layer of subjects with hippocampal sclerosis compared with matched controls. |
2021-05-10 |
2023-08-13 |
human |
| Gona Choi, Hyeri Kang, Wenkei Chu, Sunggu Yang, Sungchil Yan. Dynamics of longitudinal dentate gyrus axons associated with seizure. The Journal of physiology. vol 599. issue 8. 2021-04-20. PMID:33675053. |
axon collaterals of dg granule neurons project towards neighbouring dg granule cell layer longitudinal axons in the dg-dg circuit possess denser synapses than transverse axons in the dg-ca3 circuit the size of varicosities of the longitudinal axons, but not transverse ones, is regulated by seizures as measured behaviourally varicosity size of dg-dg axons can be a symptomatic marker of dg-related brain diseases abstract: the hippocampus network has captured the attention of neuroscientists as a model for understanding cognition and behaviour. |
2021-04-20 |
2023-08-13 |
Not clear |
| Dongseok Park, Seungjoon Kim, Hyeonho Kim, Jungsu Shin, Hyeji Jung, Ji Won U. Seizure progression triggered by IQSEC3 loss is mitigated by reducing activated microglia in mice. Glia. vol 68. issue 12. 2021-04-06. PMID:32645240. |
in the current study, we show that mice with hippocampal dentate gyrus (dg)-specific iqsec3 knockdown (kd) exhibit microglial activation and death of dg granule cell. |
2021-04-06 |
2023-08-13 |
mouse |
| Christine L Remmers, Charlotte C M Castillon, John N Armstrong, Anis Contracto. Recruitment of parvalbumin and somatostatin interneuron inputs to adult born dentate granule neurons. Scientific reports. vol 10. issue 1. 2021-03-10. PMID:33067500. |
gaba is a key regulator of adult-born dentate granule cell (abdgc) maturation so mapping the functional connectivity between abdgcs and local interneurons is required to understand their development and integration into the hippocampal circuit. |
2021-03-10 |
2023-08-13 |
mouse |
| Ahmed Gilani, Bette K Kleinschmidt-DeMaster. How frequent is double pathology in Rasmussen encephalitis? Clinical neuropathology. vol 39. issue 2. 2020-11-23. PMID:31854297. |
three additional cases showed dysmorphic neurons in the hippocampus (n = 2) and dentate granule cell layer dispersion/bilamination (n = 1). |
2020-11-23 |
2023-08-13 |
Not clear |
| Lukas Muri, Simone Oberhänsli, Michelle Buri, Ngoc Dung Le, Denis Grandgirard, Rémy Bruggmann, René M Müri, Stephen L Lei. Repetitive transcranial magnetic stimulation activates glial cells and inhibits neurogenesis after pneumococcal meningitis. PloS one. vol 15. issue 9. 2020-10-27. PMID:32915781. |
hippocampal injury-which compromises neurofunctional outcome-occurs as apoptosis of progenitor cells and immature neurons of the hippocampal dentate granule cell layer thereby impairing the regenerative capacity of the hippocampal stem cell niche. |
2020-10-27 |
2023-08-13 |
rat |
| Christin M Godale, Steve C Danze. Signaling Pathways and Cellular Mechanisms Regulating Mossy Fiber Sprouting in the Development of Epilepsy. Frontiers in neurology. vol 9. 2020-10-01. PMID:29774009. |
the sprouting of hippocampal dentate granule cell axons, termed mossy fibers, into the dentate inner molecular layer is one of the most consistent findings in tissue from patients with mesial temporal lobe epilepsy. |
2020-10-01 |
2023-08-13 |
Not clear |
| William D Hendricks, Gary L Westbrook, Eric Schnel. Early detonation by sprouted mossy fibers enables aberrant dentate network activity. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 22. 2020-04-06. PMID:31085654. |
in temporal lobe epilepsy, sprouting of hippocampal mossy fiber axons onto dentate granule cell dendrites creates a recurrent excitatory network. |
2020-04-06 |
2023-08-13 |
Not clear |
| Chad Smith, Tal Frolinger, Justin Brathwaite, Steven Sims, Giulio M Pasinett. Dietary polyphenols enhance optogenetic recall of fear memory in hippocampal dentate gyrus granule neuron subpopulations. Communications biology. vol 1. 2020-01-11. PMID:30271926. |
dietary polyphenols enhance optogenetic recall of fear memory in hippocampal dentate gyrus granule neuron subpopulations. |
2020-01-11 |
2023-08-13 |
Not clear |
| I Mahar, B Labonte, S Yogendran, E Isingrini, L Perret, M A Davoli, A Rachalski, B Giros, G Turecki, N Mechawa. Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide. Translational psychiatry. vol 7. issue 9. 2019-11-20. PMID:28949336. |
disrupted hippocampal neuregulin-1/erbb3 signaling and dentate gyrus granule cell alterations in suicide. |
2019-11-20 |
2023-08-13 |
Not clear |