All Relations between dopaminergic and comt

Publication Sentence Publish Date Extraction Date Species
Giulia Spoto, Gabriella Di Rosa, Antonio Gennaro Nicoter. The Impact of Genetics on Cognition: Insights into Cognitive Disorders and Single Nucleotide Polymorphisms. Journal of personalized medicine. vol 14. issue 2. 2024-02-23. PMID:38392589. focusing on neurotransmitter regulation within the prefrontal cortex's dopaminergic circuits, this study emphasizes the role of genes like comt, prodh, and drd in shaping executive functions and influencing conditions such as adhd and schizophrenia. 2024-02-23 2024-02-25 Not clear
Kagistia Hana Utami, Nur Amirah Binte Muhammed Yusof, Marta Garcia-Miralles, Niels Henning Skotte, Srikanth Nama, Prabha Sampath, Sarah R Langley, Mahmoud A Poulad. Dysregulated COMT Expression in Fragile X Syndrome. Neuromolecular medicine. 2023-09-08. PMID:37684514. we show that deficits in comt were associated with an altered response in an assay of dopaminergic activity in fmr1 null mice. 2023-09-08 2023-10-07 mouse
Jiangbo Ying, Qian Hui Chew, Roger S McIntyre, Kang Si. Treatment-Resistant Schizophrenia, Clozapine Resistance, Genetic Associations, and Implications for Precision Psychiatry: A Scoping Review. Genes. vol 14. issue 3. 2023-03-29. PMID:36980961. extant evidence comprised associations between trs and clozapine resistance with genetic factors related to mainly dopaminergic and serotoninergic neurotransmitter systems, specifically, trs and rs4680, rs4818 within comt, and rs1799978 within drd2; clozapine resistance and drd3 polymorphisms, cyp1a2 polymorphisms; weight gain with lep and snap-25 genes; and agranulocytosis risk with hla-related polymorphisms. 2023-03-29 2023-08-14 Not clear
Martin Regensburger, Chi Wang Ip, Zacharias Kohl, Christoph Schrader, Peter P Urban, Jan Kassubek, Wolfgang H Jos. Clinical benefit of MAO-B and COMT inhibition in Parkinson's disease: practical considerations. Journal of neural transmission (Vienna, Austria : 1996). 2023-03-25. PMID:36964457. inhibitors of monoamine oxidase b (mao-b) and catechol-o-methyltransferase (comt) are major strategies to reduce levodopa degradation and thus to increase and prolong its effect in striatal dopaminergic neurotransmission in parkinson's disease patients. 2023-03-25 2023-08-14 Not clear
Darya Bazovkina, Nina B Illarionova, Elizabeth A Kulikova, Ekaterina Yu Bazhenova, Nadezhda A Sinyakova, Nikita V Khotskin, Sergey Nikitin, Vasily S Lankin, Elena E Terenina, Oleg V Trapezov, Aleksandr V Kuliko. Studying the brain monoaminergic systems and neurotrophic factors in minipigs with high and low tolerance to the presence of human. Brain, behavior and evolution. 2023-03-13. PMID:36913918. however, the expression of genes regulating a dopaminergic system (comt, drd1 and drd2) in ht and lt animal groups varied depending on brain structure. 2023-03-13 2023-08-14 human
Mirko Lehmann, Thomas Plieger, Martin Reuter, UlrichEttinge. Insights into the molecular genetic basis of individual differences in metacognition. Physiology & behavior. 2023-03-04. PMID:36870383. here, an initial step toward resolving this issue was undertaken by investigating functional polymorphisms from three genes of the dopaminergic or serotonergic systems (drd4, comt, and 5-httlpr) in relation to behaviorally assessed metacognition in six paradigms across three cognitive domains. 2023-03-04 2023-08-14 Not clear
Ashley C Parr, Heidi C Riek, Brian C Coe, Giovanna Pari, Mario Masellis, Connie Marras, Douglas P Muno. Genetic Variation in the Dopamine System is Associated with Mixed-Strategy Decision-Making in Parkinson's Patients. The European journal of neuroscience. 2022-12-01. PMID:36453013. using a within-subject, multi-center design, patients were examined on and off dopaminergic therapy, and genetic variation was examined via a multilocus genetic profile score representing the additive effects of three single nucleotide polymorphisms (snps) that influence dopamine transmission: rs4680 (comt val 2022-12-01 2023-08-14 human
Mihai Gabriel Năstase, Ilinca Vlaicu, Simona Corina Trif. Genetic polymorphism and neuroanatomical changes in schizophrenia. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 63. issue 2. 2022-11-14. PMID:36374137. comt is located on chromosome 22 and together with interleukin-10 (il-10) have an anti-inflammatory and immunosuppressive function that influences the dopaminergic system. 2022-11-14 2023-08-14 Not clear
Elisa Rodríguez-Toscano, Kenia Martínez, David Fraguas, Joost Janssen, Laura Pina-Camacho, Bárbara Arias, Eduard Vieta, Gisela Mezquida, Silvia Amoretti, Miguel Bernardo, Josefina Castro-Fornieles, Manuel Jesús Cuesta-Zorita, Antonio Lobo, Ana González-Pinto, Iluminada Corripio Collado, Anna Mané, Celso Arango, Mara Parellad. Prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by COMT Val Revista de psiquiatria y salud mental. vol 15. issue 2. 2022-07-15. PMID:35840287. prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by comt val core dysfunctions proposed for psychotic disorders include prefrontal cortex (pfc) dopaminergic hypoactivity, executive function (ef) deficits and reduced gray matter in the pfc. 2022-07-15 2023-08-14 Not clear
Joseph P Schacht, Yeongbin Im, Michaela Hoffman, Konstantin E Voronin, Sarah W Book, Raymond F Anto. Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-05-06. PMID:35523943. inhibition of catechol-o-methyltransferase (comt), the enzyme primarily responsible for cortical dopamine inactivation, may increase cortical dopamine, especially among individuals with genetically mediated lower dopaminergic tone, such as comt rs4680 (val158met) val-allele homozygotes. 2022-05-06 2023-08-13 human
Marieke Ag Martens, Nina Dalton, Jessica Scaife, Catherine J Harmer, Paul J Harrison, Elizabeth M Tunbridg. Catechol-O-methyltransferase activity does not influence emotional processing in men. Journal of psychopharmacology (Oxford, England). 2022-04-21. PMID:35443830. catechol-o-methyltransferase (comt) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. 2022-04-21 2023-08-13 Not clear
Ima Trempler, Ellen Binder, Martin Reuter, Thomas Plieger, Isabel Standke, Falko Mecklenbrauck, Susanne Meinert, Andreas J Forstner, Markus M Nöthen, Marcella Rietschel, Sophie Stürmer, Udo Dannlowski, Marc Tittgemeyer, Rebekka Lencer, Gereon R Fink, Ricarda I Schubot. Effects of DRD2/ANKK1 and COMT Val158Met polymorphisms on stabilization against and adaptation to unexpected events. Cerebral cortex (New York, N.Y. : 1991). 2022-03-02. PMID:35235645. genetic variations affecting dopaminergic neuromodulation such as the drd2/ankk1 and the comt val158met polymorphisms contribute to goal-directed behavior that requires a balance between stabilization and updating of current states and behaviors. 2022-03-02 2023-08-13 Not clear
Lorena Cuenca-Bermejo, Pilar Almela, Pablo Gallo-Soljancic, José E Yuste, Vicente de Pablos, Víctor Bautista-Hernández, Emiliano Fernández-Villalba, María-Luisa Laorden, María-Trinidad Herrer. Cardiac tyrosine hydroxylase activation and MB-COMT in dyskinetic monkeys. Scientific reports. vol 11. issue 1. 2021-12-10. PMID:34615910. we analyzed the dopaminergic system in the nigrostriatal pathway of parkinsonian and dyskinetic monkeys and the expression of some key proteins in the metabolism and synthesis of catecholamines in the heart: total and phosphorylated (phospho) tyrosine hydroxylase (th), and membrane (mb) and soluble (s) isoforms of catechol-o-methyl transferase (comt). 2021-12-10 2023-08-13 monkey
Jingsong Ma, Mingzhe Zhao, Wei Zhou, Mo Li, Cong Huai, Lu Shen, Ting Wang, Hao Wu, Na Zhang, Zhiruo Zhang, Lin He, Shengying Qi. Association Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis. Current neuropharmacology. vol 19. issue 10. 2021-11-25. PMID:33100205. the comt genotype could, therefore, exert a major influence on antipsychotic treatment response as many of these agents also target dopaminergic transmission. 2021-11-25 2023-08-13 Not clear
Anne Chong, Serenella Tolomeo, Yue Xiong, Dario Angeles, Mike Cheung, Benjamin Becker, Poh San Lai, Zhen Lei, Fabio Malavasi, Qianzi Tang, Soo Hong Chew, Richard P Ebstei. Blending oxytocin and dopamine with everyday creativity. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34376746. neural mechanisms of ct and ot show a strong association with dopaminergic (da) pathways, yet the link between ct and cd38, cd157, dopamine receptor d2 (drd2) and catechol-o-methyltransferase (comt) peripheral gene expression remain inconclusive, thus limiting our understanding of the neurobiology of ct. to address this issue, two principal domains of ct, divergent thinking (aut), were assessed. 2021-11-08 2023-08-13 Not clear
Daniella J Furman, Ioannis Pappas, Robert L White, Andrew S Kayser, Mark D'Esposit. Enhancing dopamine tone modulates global and local cortical perfusion as a function of COMT val158met genotype. NeuroImage. vol 242. 2021-11-05. PMID:34390874. here we examined the extent to which changes in resting cortical perfusion following the administration of two mechanistically-distinct dopaminergic drugs vary by comt genotype, and thereby track predictions of the inverted-u model. 2021-11-05 2023-08-13 human
Anni Richter, Lieke de Boer, Marc Guitart-Masip, Gusalija Behnisch, Constanze I Seidenbecher, Björn H Schot. Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 11. 2021-10-29. PMID:34302222. interestingly, after combining all three cohorts, exploratory analyses regarding the comt val108/158met polymorphism suggest that homozygotes for the met allele, which has been linked to higher prefrontal dopaminergic tone, show a lower learning bias. 2021-10-29 2023-08-13 Not clear
b' Antonio Gennaro Nicotera, Gabriella Di Rosa, Laura Turriziani, Maria Cristina Costanzo, Emanuela Stracuzzi, Girolamo Aurelio Vitello, Rosanna Galati Rando, Antonino Musumeci, Mirella Vinci, Sebastiano Antonino Musumeci, Francesco Cal\\xc3\\xa. Role of COMT V158M Polymorphism in the Development of Dystonia after Administration of Antipsychotic Drugs. Brain sciences. vol 11. issue 10. 2021-10-26. PMID:34679357.' given the patient's genetic condition, we hypothesized that the dopaminergic dysfunction had been aggravated by comt involvement, thus causing dystonia. 2021-10-26 2023-08-13 Not clear
Mag Martens, Fa Kennedy McConnell, N Filippini, C E Mackay, P J Harrison, E M Tunbridg. Dopaminergic modulation of regional cerebral blood flow: An arterial spin labelling study of genetic and pharmacological manipulation of COMT activity. NeuroImage. vol 234. 2021-10-13. PMID:33789133. dopaminergic modulation of regional cerebral blood flow: an arterial spin labelling study of genetic and pharmacological manipulation of comt activity. 2021-10-13 2023-08-13 Not clear
Giuseppe G Miranda, Karen M Rodrigue, Kristen M Kenned. Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan. Brain structure & function. vol 226. issue 1. 2021-10-05. PMID:33179159. here, we investigated in 176 participants aged 20-94 years whether: (1) drd2 c carriers differ from t carriers in cortical thickness or subcortical volume in areas of high concentrations of d2 receptors that receive projections from mesocortical or nigrostriatal dopaminergic pathways; (2) whether the drd2*comt relationship has any synergistic effects on cortical thickness; (3) whether the effect of drd2 on brain structure depends upon age; and (4) whether drd2-related regional thinning affects executive function performance. 2021-10-05 2023-08-13 human