| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mirko Lehmann, Thomas Plieger, Martin Reuter, UlrichEttinge. Insights into the molecular genetic basis of individual differences in metacognition. Physiology & behavior vol issue 2023 36870383 |
here, an initial step toward resolving this issue was undertaken by investigating functional polymorphisms from three genes of the dopaminergic or serotonergic systems (drd4, comt, and 5-httlpr) in relation to behaviorally assessed metacognition in six paradigms across three cognitive domains. |
2023-03-04 |
2023-03-06 |
Not clear |
| Ashley C Parr, Heidi C Riek, Brian C Coe, Giovanna Pari, Mario Masellis, Connie Marras, Douglas P Muno. Genetic Variation in the Dopamine System is Associated with Mixed-Strategy Decision-Making in Parkinson's Patients. The European journal of neuroscience vol issue 2022 36453013 |
using a within-subject, multi-center design, patients were examined on and off dopaminergic therapy, and genetic variation was examined via a multilocus genetic profile score representing the additive effects of three single nucleotide polymorphisms (snps) that influence dopamine transmission: rs4680 (comt val |
2022-12-01 |
2023-01-30 |
human |
| Mihai Gabriel N\\xc4\\x83stase, Ilinca Vlaicu, Simona Corina Trif. Genetic polymorphism and neuroanatomical changes in schizophrenia. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie vol 63 issue 2 2022 36374137 |
comt is located on chromosome 22 and together with interleukin-10 (il-10) have an anti-inflammatory and immunosuppressive function that influences the dopaminergic system. |
2022-11-14 |
2023-01-30 |
Not clear |
| Elisa Rodr\\xc3\\xadguez-Toscano, Kenia Mart\\xc3\\xadnez, David Fraguas, Joost Janssen, Laura Pina-Camacho, B\\xc3\\xa1rbara Arias, Eduard Vieta, Gisela Mezquida, Silvia Amoretti, Miguel Bernardo, Josefina Castro-Fornieles, Manuel Jes\\xc3\\xbas Cuesta-Zorita, Antonio Lobo, Ana Gonz\\xc3\\xa1lez-Pinto, Iluminada Corripio Collado, Anna Man\\xc3\\xa9, Celso Arango, Mara Parellad. Prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by COMT Val Revista de psiquiatria y salud mental vol 15 issue 2 2022 35840287 |
prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by comt val core dysfunctions proposed for psychotic disorders include prefrontal cortex (pfc) dopaminergic hypoactivity, executive function (ef) deficits and reduced gray matter in the pfc. |
2022-07-15 |
2023-01-30 |
Not clear |
| Joseph P Schacht, Yeongbin Im, Michaela Hoffman, Konstantin E Voronin, Sarah W Book, Raymond F Anto. Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol issue 2022 35523943 |
inhibition of catechol-o-methyltransferase (comt), the enzyme primarily responsible for cortical dopamine inactivation, may increase cortical dopamine, especially among individuals with genetically mediated lower dopaminergic tone, such as comt rs4680 (val158met) val-allele homozygotes. |
2022-05-06 |
2023-01-27 |
human |
| Marieke Ag Martens, Nina Dalton, Jessica Scaife, Catherine J Harmer, Paul J Harrison, Elizabeth M Tunbridg. Catechol-O-methyltransferase activity does not influence emotional processing in men. Journal of psychopharmacology (Oxford, England) vol issue 2022 35443830 |
catechol-o-methyltransferase (comt) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. |
2022-04-21 |
2023-01-27 |
Not clear |
| Ima Trempler, Ellen Binder, Martin Reuter, Thomas Plieger, Isabel Standke, Falko Mecklenbrauck, Susanne Meinert, Andreas J Forstner, Markus M N\\xc3\\xb6then, Marcella Rietschel, Sophie St\\xc3\\xbcrmer, Udo Dannlowski, Marc Tittgemeyer, Rebekka Lencer, Gereon R Fink, Ricarda I Schubot. Effects of DRD2/ANKK1 and COMT Val158Met polymorphisms on stabilization against and adaptation to unexpected events. Cerebral cortex (New York, N.Y. : 1991) vol issue 2022 35235645 |
genetic variations affecting dopaminergic neuromodulation such as the drd2/ankk1 and the comt val158met polymorphisms contribute to goal-directed behavior that requires a balance between stabilization and updating of current states and behaviors. |
2022-03-02 |
2023-01-27 |
Not clear |
| Lorena Cuenca-Bermejo, Pilar Almela, Pablo Gallo-Soljancic, Jos\\xc3\\xa9 E Yuste, Vicente de Pablos, V\\xc3\\xadctor Bautista-Hern\\xc3\\xa1ndez, Emiliano Fern\\xc3\\xa1ndez-Villalba, Mar\\xc3\\xada-Luisa Laorden, Mar\\xc3\\xada-Trinidad Herrer. Cardiac tyrosine hydroxylase activation and MB-COMT in dyskinetic monkeys. Scientific reports vol 11 issue 1 2021 34615910 |
we analyzed the dopaminergic system in the nigrostriatal pathway of parkinsonian and dyskinetic monkeys and the expression of some key proteins in the metabolism and synthesis of catecholamines in the heart: total and phosphorylated (phospho) tyrosine hydroxylase (th), and membrane (mb) and soluble (s) isoforms of catechol-o-methyl transferase (comt). |
2021-12-10 |
2023-01-26 |
monkey |
| Jingsong Ma, Mingzhe Zhao, Wei Zhou, Mo Li, Cong Huai, Lu Shen, Ting Wang, Hao Wu, Na Zhang, Zhiruo Zhang, Lin He, Shengying Qi. Association Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis. Current neuropharmacology vol 19 issue 10 2021 33100205 |
the comt genotype could, therefore, exert a major influence on antipsychotic treatment response as many of these agents also target dopaminergic transmission. |
2021-11-25 |
2023-01-26 |
Not clear |
| Anne Chong, Serenella Tolomeo, Yue Xiong, Dario Angeles, Mike Cheung, Benjamin Becker, Poh San Lai, Zhen Lei, Fabio Malavasi, Qianzi Tang, Soo Hong Chew, Richard P Ebstei. Blending oxytocin and dopamine with everyday creativity. Scientific reports vol 11 issue 1 2021 34376746 |
neural mechanisms of ct and ot show a strong association with dopaminergic (da) pathways, yet the link between ct and cd38, cd157, dopamine receptor d2 (drd2) and catechol-o-methyltransferase (comt) peripheral gene expression remain inconclusive, thus limiting our understanding of the neurobiology of ct. to address this issue, two principal domains of ct, divergent thinking (aut), were assessed. |
2021-11-08 |
2023-01-26 |
Not clear |
| Daniella J Furman, Ioannis Pappas, Robert L White, Andrew S Kayser, Mark D'Esposit. Enhancing dopamine tone modulates global and local cortical perfusion as a function of COMT val158met genotype. NeuroImage vol 242 issue 2021 34390874 |
here we examined the extent to which changes in resting cortical perfusion following the administration of two mechanistically-distinct dopaminergic drugs vary by comt genotype, and thereby track predictions of the inverted-u model. |
2021-11-05 |
2023-01-26 |
human |
| Anni Richter, Lieke de Boer, Marc Guitart-Masip, Gusalija Behnisch, Constanze I Seidenbecher, Bj\\xc3\\xb6rn H Schot. Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function. Journal of neural transmission (Vienna, Austria : 1996) vol 128 issue 11 2021 34302222 |
interestingly, after combining all three cohorts, exploratory analyses regarding the comt val108/158met polymorphism suggest that homozygotes for the met allele, which has been linked to higher prefrontal dopaminergic tone, show a lower learning bias. |
2021-10-29 |
2023-01-26 |
Not clear |
| Antonio Gennaro Nicotera, Gabriella Di Rosa, Laura Turriziani, Maria Cristina Costanzo, Emanuela Stracuzzi, Girolamo Aurelio Vitello, Rosanna Galati Rando, Antonino Musumeci, Mirella Vinci, Sebastiano Antonino Musumeci, Francesco Cal\\xc3\\xa. Role of COMT V158M Polymorphism in the Development of Dystonia after Administration of Antipsychotic Drugs. Brain sciences vol 11 issue 10 2021 34679357 |
given the patient's genetic condition, we hypothesized that the dopaminergic dysfunction had been aggravated by comt involvement, thus causing dystonia. |
2021-10-26 |
2023-01-26 |
Not clear |
| Mag Martens, Fa Kennedy McConnell, N Filippini, C E Mackay, P J Harrison, E M Tunbridg. Dopaminergic modulation of regional cerebral blood flow: An arterial spin labelling study of genetic and pharmacological manipulation of COMT activity. NeuroImage vol 234 issue 2021 33789133 |
dopaminergic modulation of regional cerebral blood flow: an arterial spin labelling study of genetic and pharmacological manipulation of comt activity. |
2021-10-13 |
2023-01-26 |
Not clear |
| Giuseppe G Miranda, Karen M Rodrigue, Kristen M Kenned. Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan. Brain structure & function vol 226 issue 1 2021 33179159 |
here, we investigated in 176 participants aged 20-94\xc2\xa0years whether: (1) drd2 c carriers differ from t carriers in cortical thickness or subcortical volume in areas of high concentrations of d2 receptors that receive projections from mesocortical or nigrostriatal dopaminergic pathways; (2) whether the drd2*comt relationship has any synergistic effects on cortical thickness; (3) whether the effect of drd2 on brain structure depends upon age; and (4) whether drd2-related regional thinning affects executive function performance. |
2021-10-05 |
2023-01-26 |
human |
| Jon E Grant, Roxanne Hook, Stephanie Valle, Eve Chesivoir, Samuel R Chamberlai. Tolcapone in obsessive-compulsive disorder: a randomized double-blind placebo-controlled crossover trial. International clinical psychopharmacology vol 36 issue 5 2021 34310432 |
tolcapone is a catechol-o-methyl-transferase (comt) enzyme inhibitor that augments cortical dopaminergic transmission. |
2021-10-04 |
2023-01-26 |
human |
| Gerly Tamm, Kairi Kreegipuu, Jaanus Harr. Platelet MAO activity and COMT Val158Met genotype interaction predicts visual working memory updating efficiency. Behavioural brain research vol 407 issue 2021 33745984 |
platelet monoamine oxidase (mao) has been used as a marker for central serotonergic capacity, and catechol-o-methyltransferase (comt) as a marker for central dopaminergic capacity. |
2021-09-02 |
2023-01-26 |
human |
| Lilian R F Faro, Lorenzo A Justo, Miguel Alfonso, Rafael Dur\\xc3\\xa1. Possible synergies between isatin, an endogenous MAO inhibitor, and antiparkinsonian agents on the dopamine release from striatum of freely moving rats. Neuropharmacology vol 171 issue 2021 32304702 |
for this, we co-administered isatin with the mao inhibitors selegiline and clorgyline, l-dopa, the catechol-o-methyl-transferase (comt) inhibitors tropolone and dinitrocatechol, with the dopaminergic agonist ropinirole, and with the psychostimulant caffeine, in order to evaluate possible synergies between these substances to increase the dopamine extracellular levels in freely moving rats. |
2021-06-25 |
2023-01-26 |
rat |
| William C Hochberger, Courtney L M Eskridge, Jeffrey R Bishop, James L Reilly, Leah H Rubin, Sarah Keedy, Elliot S Gershon, Carol A Tamminga, Godfrey D Pearlson, Michael Ragozzino, Matcheri S Keshavan, John A Sweeney, S Kristian Hil. Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives. Schizophrenia research vol 223 issue 2021 32829984 |
dopaminergic activity in prefrontal cortex is modulated by the low (met) and high (val) activity of the rs4680 val158met single nucleotide polymorphism (snp) in the catechol-o-methyltransferase (comt) gene. |
2021-06-17 |
2023-01-26 |
Not clear |
| Yu L L Luo, Jie Chen, Yuqi Wang, Xinying Li, Huajian Ca. Dopaminergic and neurotrophic genetic polymorphisms modulate the implicit gender-science stereotype. PsyCh journal vol 10 issue 3 2021 33619907 |
we explored whether single nucleotide polymorphisms (snps) in dopaminergic and neurotrophic systems (i.e., comt, bdnf genotypes) explain variations in the implicit gender-science stereotype. |
2021-06-03 |
2023-01-26 |
Not clear |