| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jon E Grant, Roxanne Hook, Stephanie Valle, Eve Chesivoir, Samuel R Chamberlai. Tolcapone in obsessive-compulsive disorder: a randomized double-blind placebo-controlled crossover trial. International clinical psychopharmacology. vol 36. issue 5. 2021-10-04. PMID:34310432. |
tolcapone is a catechol-o-methyl-transferase (comt) enzyme inhibitor that augments cortical dopaminergic transmission. |
2021-10-04 |
2023-08-13 |
human |
| Gerly Tamm, Kairi Kreegipuu, Jaanus Harr. Platelet MAO activity and COMT Val158Met genotype interaction predicts visual working memory updating efficiency. Behavioural brain research. vol 407. 2021-09-02. PMID:33745984. |
platelet monoamine oxidase (mao) has been used as a marker for central serotonergic capacity, and catechol-o-methyltransferase (comt) as a marker for central dopaminergic capacity. |
2021-09-02 |
2023-08-13 |
human |
| Lilian R F Faro, Lorenzo A Justo, Miguel Alfonso, Rafael Durá. Possible synergies between isatin, an endogenous MAO inhibitor, and antiparkinsonian agents on the dopamine release from striatum of freely moving rats. Neuropharmacology. vol 171. 2021-06-25. PMID:32304702. |
for this, we co-administered isatin with the mao inhibitors selegiline and clorgyline, l-dopa, the catechol-o-methyl-transferase (comt) inhibitors tropolone and dinitrocatechol, with the dopaminergic agonist ropinirole, and with the psychostimulant caffeine, in order to evaluate possible synergies between these substances to increase the dopamine extracellular levels in freely moving rats. |
2021-06-25 |
2023-08-13 |
rat |
| William C Hochberger, Courtney L M Eskridge, Jeffrey R Bishop, James L Reilly, Leah H Rubin, Sarah Keedy, Elliot S Gershon, Carol A Tamminga, Godfrey D Pearlson, Michael Ragozzino, Matcheri S Keshavan, John A Sweeney, S Kristian Hil. Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives. Schizophrenia research. vol 223. 2021-06-17. PMID:32829984. |
dopaminergic activity in prefrontal cortex is modulated by the low (met) and high (val) activity of the rs4680 val158met single nucleotide polymorphism (snp) in the catechol-o-methyltransferase (comt) gene. |
2021-06-17 |
2023-08-13 |
Not clear |
| Yu L L Luo, Jie Chen, Yuqi Wang, Xinying Li, Huajian Ca. Dopaminergic and neurotrophic genetic polymorphisms modulate the implicit gender-science stereotype. PsyCh journal. vol 10. issue 3. 2021-06-03. PMID:33619907. |
we explored whether single nucleotide polymorphisms (snps) in dopaminergic and neurotrophic systems (i.e., comt, bdnf genotypes) explain variations in the implicit gender-science stereotype. |
2021-06-03 |
2023-08-13 |
Not clear |
| I Rincón-Pérez, V Echeverry-Alzate, A J Sánchez-Carmona, K M Bühler, J A Hinojosa, J A López-Moreno, J Alber. The influence of dopaminergic polymorphisms on selective stopping. Behavioural brain research. vol 381. 2021-05-26. PMID:31863847. |
this study aimed to investigate for the first time the influence of two relevant dopaminergic polymorphisms (in comt and drd2 genes) on stimulus-selective stopping in a sample of 529 adults. |
2021-05-26 |
2023-08-13 |
Not clear |
| Jiesi Wang, Hang Xu, Dongmei Wang, Gaoxia Wei, Huixia Zhou, Li Wang, Yongjie Zhou, Xiangyang Zhan. The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia. Journal of psychiatric research. vol 136. 2021-05-14. PMID:33127070. |
catechol-o-methyltransferase (comt) and interleukin-10 (il-10) play critical functions in dopaminergic and inflammatory systems respectively, and their genetic polymorphisms are both associated with cognitive function. |
2021-05-14 |
2023-08-13 |
Not clear |
| Halise Devrimci-Ozguven, Y Hosgoren Alıcı, M Demirbugen Oz, H S Suzen, H E Kale, B Baska. The role of COMT polymorphism in modulation of prefrontal activity during verbal fluency in bipolar disorder. Neuroscience letters. vol 738. 2021-04-30. PMID:32822765. |
the enzyme catechol-o- methyltransferase (comt) has a critical role in cognitive responses by modulating dopaminergic activity in the prefrontal cortex (pfc). |
2021-04-30 |
2023-08-13 |
Not clear |
| Bianca L B Marino, Lucilene R de Souza, Kessia P A Sousa, Jaderson V Ferreira, Elias C Padilha, Carlos H T P da Silva, Carlton A Taft, Lorane I S Hage-Meli. Parkinson's Disease: A Review from Pathophysiology to Treatment. Mini reviews in medicinal chemistry. vol 20. issue 9. 2021-01-15. PMID:31686637. |
there is no cure for pd, and the pharmacological treatment consists of a dopaminergic supplement with levodopa, comt inhibitors, anticholinergics agents, dopaminergic agonists, and inhibitors of mao-b, which basically aims to control the symptoms, enabling better functional mobility and increasing life expectancy of the treated pd patients. |
2021-01-15 |
2023-08-13 |
Not clear |
| Spencer Byers, Ingrid P Buchler, Michael DePasquale, Helen L Rowley, Rajiv S Kulkarni, Lucy Pinder, Anna Kolobova, Cailian Li, Vinh Au, Daniel Akuma, Gongliang Zhang, Huijun Wei, Sharon C Cheetham, James C Barrow, Gregory V Car. Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility. Psychopharmacology. vol 237. issue 9. 2020-12-30. PMID:32474681. |
catechol-o-methyltransferase (comt) inhibitors modulate cortical dopaminergic function and have been proposed as potential cognitive enhancers. |
2020-12-30 |
2023-08-13 |
Not clear |
| Matea Nikolac Perkovic, Marina Sagud, Maja Zivkovic, Suzana Uzun, Gordana Nedic Erjavec, Oliver Kozumplik, Dubravka Svob Strac, Ninoslav Mimica, Alma Mihaljevic Peles, Nela Piva. Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32572118. |
antipsychotic drugs target primarily dopaminergic system which makes catechol-o-methyltransferase (comt) an interesting target in studies searching for treatment response predictors in schizophrenia. |
2020-12-10 |
2023-08-13 |
Not clear |
| Ariane Wiegand, Vanessa Nieratschker, Christian Plewni. Genetic Modulation of Transcranial Direct Current Stimulation Effects on Cognition. Frontiers in human neuroscience. vol 10. 2020-10-01. PMID:28066217. |
however, recently, the functional val(108/158)met polymorphism in the comt gene, that is particularly involved in the regulation of executive functions by means of the dopaminergic tone in frontal brain areas, has been demonstrated to specifically predict the effect of tdcs on cognitive control. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cornelia Sindermann, Ruixue Luo, Yingying Zhang, Keith M Kendrick, Benjamin Becker, Christian Monta. The COMT Val158Met Polymorphism and Reaction to a Transgression: Findings of Genetic Associations in Both Chinese and German Samples. Frontiers in behavioral neuroscience. vol 12. 2020-09-30. PMID:30127727. |
one promising candidate gene polymorphism, which may influence individual differences in avoidance of a transgressor and vengefulness, is the comt val158met (rs4680) polymorphism known to affect dopaminergic signaling and among others brain activity in situations in which people punish others for their behavior. |
2020-09-30 |
2023-08-13 |
Not clear |
| M Van Heel, P Bijttebier, S Claes, H Colpin, L Goossens, B Hankin, W Van Den Noortgate, K Verschueren, J Young, K Van Leeuwe. Parenting, Effortful Control, and Adolescents' Externalizing Problem Behavior: Moderation by Dopaminergic Genes. Journal of youth and adolescence. vol 49. issue 1. 2020-09-14. PMID:31650442. |
this article used a moderated mediation model to examine whether effortful control mediated the link between parenting and externalizing problem behavior, and whether dopaminergic genes (i.e., polygenic index score including dat1, drd2, drd4, comt) moderated this link. |
2020-09-14 |
2023-08-13 |
Not clear |
| I Csoti, H Herbst, P Urban, D Woitalla, U Wüllne. Polypharmacy in Parkinson's disease: risks and benefits with little evidence. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 7. 2020-07-20. PMID:31222606. |
medical treatment targeting the dopaminergic system alone may include up to five different compounds: l-dopa (in combination with a dopa decarboxylase inhibitor), a catechol-o-methyltransferase (comt) and a monoamine oxidase (mao-b) inhibitor and a dopamine agonist. |
2020-07-20 |
2023-08-13 |
Not clear |
| Xavier Caldú, Jonatan Ottino-González, Consuelo Sánchez-Garre, Imma Hernan, Encarnació Tor, María-José Sender-Palacios, Jean-Claude Dreher, Maite Garolera, María Ángeles Jurad. Effect of the catechol-O-methyltransferase Val European eating disorders review : the journal of the Eating Disorders Association. vol 27. issue 4. 2020-04-29. PMID:30761671. |
theory of mind is highly dependent on prefrontal dopaminergic neurotransmission, which is regulated by catechol-o-methyltransferase (comt) activity. |
2020-04-29 |
2023-08-13 |
Not clear |
| Eszter Kotyuk, Janet Duchek, Denise Head, Anna Szekely, Alison M Goate, David A Balot. A Genetic Variant (COMT) Coding Dopaminergic Activity Predicts Personality Traits in Healthy Elderly. Personality and individual differences. vol 82. 2020-03-26. PMID:25960587. |
a genetic variant (comt) coding dopaminergic activity predicts personality traits in healthy elderly. |
2020-03-26 |
2023-08-13 |
human |
| Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita, Takefumi Sone, Moe Watanabe, Aya Maekawa, Takuya Matsumoto, Wado Akamatsu, Katsuhide Igarashi, Hideki Tamura, Hideyuki Takeshima, Vivianne L Tawfik, Toshikazu Ushijima, Nobutaka Hattori, Hideyuki Okano, Minoru Narit. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31135049. |
cell-specific overexpression of comt in dopaminergic neurons of parkinson's disease. |
2020-03-12 |
2023-08-13 |
mouse |
| Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita, Takefumi Sone, Moe Watanabe, Aya Maekawa, Takuya Matsumoto, Wado Akamatsu, Katsuhide Igarashi, Hideki Tamura, Hideyuki Takeshima, Vivianne L Tawfik, Toshikazu Ushijima, Nobutaka Hattori, Hideyuki Okano, Minoru Narit. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31135049. |
in this study, we found a dramatic increase in the expression of catechol-o-methyltransferase (comt), along with a lower level of dna methylation, in induced pluripotent stem cell-derived dopaminergic neurons from patients with parkin (park2) gene mutations compared to those from healthy controls. |
2020-03-12 |
2023-08-13 |
mouse |
| Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita, Takefumi Sone, Moe Watanabe, Aya Maekawa, Takuya Matsumoto, Wado Akamatsu, Katsuhide Igarashi, Hideki Tamura, Hideyuki Takeshima, Vivianne L Tawfik, Toshikazu Ushijima, Nobutaka Hattori, Hideyuki Okano, Minoru Narit. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31135049. |
in addition, a significant increase in the expression of comt was found in dopaminergic neurons of isogenic park2 induced pluripotent stem cell lines that mimicked loss of function of park2 by crispr cas9 technology. |
2020-03-12 |
2023-08-13 |
mouse |