| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita, Takefumi Sone, Moe Watanabe, Aya Maekawa, Takuya Matsumoto, Wado Akamatsu, Katsuhide Igarashi, Hideki Tamura, Hideyuki Takeshima, Vivianne L Tawfik, Toshikazu Ushijima, Nobutaka Hattori, Hideyuki Okano, Minoru Narit. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31135049. |
in dopamine transporter (dat)-cre mice, overexpression of comt, specifically in dopaminergic neurons of the substantia nigra, produced cataleptic behaviours associated with impaired motor coordination. |
2020-03-12 |
2023-08-13 |
mouse |
| Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita, Takefumi Sone, Moe Watanabe, Aya Maekawa, Takuya Matsumoto, Wado Akamatsu, Katsuhide Igarashi, Hideki Tamura, Hideyuki Takeshima, Vivianne L Tawfik, Toshikazu Ushijima, Nobutaka Hattori, Hideyuki Okano, Minoru Narit. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31135049. |
these findings suggest that upregulation of comt, likely resulting from dna hypomethylation, in dopaminergic neurons may contribute to the initial stage of neuronal dysfunction in parkinson's disease. |
2020-03-12 |
2023-08-13 |
mouse |
| Mohini Ranganathan, Joao P De Aquino, Jose A Cortes-Briones, Rajiv Radhakrishnan, Brian Pittman, Savita Bhakta, Deepak C D'Souz. Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Psychopharmacology. vol 236. issue 11. 2020-01-28. PMID:31187152. |
the catechol-o-methyl transferase (comt) enzyme has been implicated in determining dopaminergic tone and the effects of delta-9-tetrahydrocannabinol (thc) in the human brain. |
2020-01-28 |
2023-08-13 |
human |
| Ataru Nakamura, Toshiya Inada, Yoshie Kitao, Yoshirou Katayam. Association between catechol-O-methyltransferase (COMT) polymorphism and severe alcoholic withdrawal symptoms in male Japanese alcoholics. Addiction biology. vol 6. issue 3. 2019-11-20. PMID:11900601. |
catechol-o-methyltransferase (comt) plays a crucial role in central dopaminergic systems. |
2019-11-20 |
2023-08-12 |
human |
| Julie A Dumas, Jenna A Makarewicz, Janice Bunn, Joshua Nickerson, Elizabeth McGe. Dopamine-dependent cognitive processes after menopause: the relationship between COMT genotype, estradiol, and working memory. Neurobiology of aging. vol 72. 2019-09-16. PMID:30212711. |
the present study examined how a gene related to functioning of the dopaminergic system, catechol-o-methyltransferase (comt), and estradiol were related to brain functioning in healthy postmenopausal women. |
2019-09-16 |
2023-08-13 |
human |
| Julie A Dumas, Jenna A Makarewicz, Janice Bunn, Joshua Nickerson, Elizabeth McGe. Dopamine-dependent cognitive processes after menopause: the relationship between COMT genotype, estradiol, and working memory. Neurobiology of aging. vol 72. 2019-09-16. PMID:30212711. |
these data indicate that after menopause comt genotype and potentially the menopause-related changes to the dopaminergic system are not related to cognition. |
2019-09-16 |
2023-08-13 |
human |
| Nathálya G H M Nogueira, Lidiane A Fernandes, Bárbara P Ferreira, Marco T S Batista, Karen C R Alves, Juliana O Parm. Association Between the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Manual Performance Asymmetries. Perceptual and motor skills. vol 126. issue 3. 2019-09-02. PMID:30841785. |
one enzyme involved in cognitive functions related to the dopaminergic system and to the prefrontal cortex is the catechol-o-methyltransferase (comt), and it has a trimodal activity distribution in the human population due to its functional polymorphism known as val158met. |
2019-09-02 |
2023-08-13 |
human |
| Cassandra Hoffmann, Tamsyn E Van Rheenen, Serafino G Mancuso, Andrew Zalesky, Jason Bruggemann, Rhoshel K Lenroot, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Christos Pantelis, Vanessa Cropley, Chad A Bousma. Exploring the moderating effects of dopaminergic polymorphisms and childhood adversity on brain morphology in schizophrenia-spectrum disorders. Psychiatry research. Neuroimaging. vol 281. 2019-07-25. PMID:30253269. |
polymorphisms in drd2 and comt were genotyped and a dopaminergic risk allelic load (ral) was calculated. |
2019-07-25 |
2023-08-13 |
human |
| Andrea L Rosso, Nicolaas I Bohnen, Lenore J Launer, Howard J Aizenstein, Kristine Yaffe, Caterina Rosan. Vascular and dopaminergic contributors to mild parkinsonian signs in older adults. Neurology. vol 90. issue 3. 2019-07-22. PMID:29247072. |
mild parkinsonian signs (mps) are an underappreciated neurologic condition in older adults; we assessed associations of mps with measures of dopaminergic (catechol-o-methyltransferase [comt] genotype, an indicator of synaptic dopamine levels) and vascular (white matter hyperintensities [wmh], an indicator of cerebral small vessel disease) factors. |
2019-07-22 |
2023-08-13 |
Not clear |
| Cong Cao, Lili Cao, Jie Che. Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies. Journal of youth and adolescence. vol 48. issue 4. 2019-05-28. PMID:30830534. |
the present study aimed to conduct the first meta-analysis that tested whether and how an important dopaminergic gene-the catechol-o-methyltransferase (comt) gene contributed to differences in child and adolescent environmental sensitivity. |
2019-05-28 |
2023-08-13 |
human |
| Kyoung-Sae Na, Eunsoo Won, June Kang, Aram Kim, Sunyoung Choi, Woo-Suk Tae, Yong-Ku Kim, Min-Soo Lee, Sook-Haeng Joe, Byung-Joo Ha. Differential effect of COMT gene methylation on the prefrontal connectivity in subjects with depression versus healthy subjects. Neuropharmacology. vol 137. 2019-02-20. PMID:29723539. |
expression of the catechol-o-methyl transferase (comt) gene mainly determines prefrontal dopaminergic availability. |
2019-02-20 |
2023-08-13 |
human |
| Claudia Schilling, Lena Gappa, Michael Schredl, Fabian Streit, Jens Treutlein, Josef Frank, Michael Deuschle, Andreas Meyer-Lindenberg, Marcella Rietschel, Stephanie H Wit. Fast sleep spindle density is associated with rs4680 (Val108/158Met) genotype of catechol-O-methyltransferase (COMT). Sleep. vol 41. issue 3. 2019-01-09. PMID:29325115. |
dopaminergic neurotransmission modulates activity within this network and importantly depends on activity of catechol-o-methyltransferase (comt). |
2019-01-09 |
2023-08-13 |
human |
| Yiqing He, Nick Martin, Gu Zhu, Yangyang Li. Candidate genes for novelty-seeking: a meta-analysis of association studies of DRD4 exon III and COMT Val158Met. Psychiatric genetics. vol 28. issue 6. 2019-01-02. PMID:30260901. |
two widely studied genetic polymorphisms in the dopaminergic system [drd4 exon iii variable number of tandem repeat (vntr) and comt val158met] have been reported to be associated with novelty-seeking, but the results have been highly inconsistent. |
2019-01-02 |
2023-08-13 |
Not clear |
| Hartmut Heinrich, Juliane Grunitz, Valeska Stonawski, Stefan Frey, Simone Wahl, Björn Albrecht, Tamme W Goecke, Matthias W Beckmann, Johannes Kornhuber, Peter A Fasching, Gunther H Moll, Anna Eichle. Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age. Scientific reports. vol 7. issue 1. 2018-12-19. PMID:28630479. |
for cpg sites at genes of the dopaminergic (comt, ankk1) and the neurotrophic (bdnf, ngfr) system, associations with the nogo-p3 as well as adhd symptom severity were found suggesting that these systems are involved in response control deficits in adhd. |
2018-12-19 |
2023-08-13 |
human |
| Kathleen E Hupfeld, David E Vaillancourt, Rachael D Seidle. Genetic markers of dopaminergic transmission predict performance for older males but not females. Neurobiology of aging. vol 66. 2018-10-05. PMID:29525179. |
we examined 4 single-nucleotide polymorphisms involved in dopaminergic metabolism: bdnf (val66met), drd3 (ser9gly), dbh (c>t), and comt (val158met) for their relationship to motor and cognitive function in healthy older adults (n = 4605 and n = 7331) who participated in the u.s. health and retirement study. |
2018-10-05 |
2023-08-13 |
human |
| b' Ivana Glavina Jela\\xc5\\xa1, Ivan Devi\\xc4\\x87, Dalibor Karlovi\\xc4\\x8. Cloninger\'s temperament and character dimensions and dopaminergic genes: DAT1 VNTR and COMT Val158Met polymorphisms. Psychiatria Danubina. vol 30. issue 1. 2018-09-06. PMID:29546858.' |
cloninger's temperament and character dimensions and dopaminergic genes: dat1 vntr and comt val158met polymorphisms. |
2018-09-06 |
2023-08-13 |
Not clear |
| D Bäckström, M Eriksson Domellöf, G Granåsen, J Linder, S Mayans, E Elgh, H Zetterberg, K Blennow, L Forsgre. Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease. Acta neurologica Scandinavica. vol 137. issue 1. 2018-06-20. PMID:28869277. |
this study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine d2-receptor availability (catechol-o-methyltransferase [comt] val |
2018-06-20 |
2023-08-13 |
Not clear |
| R Slopień, A Rózycka, A Slopień, M Pawlak, A Warenik-Szymankiewicz, S Sajdak, P Jagodzińsk. The genetic background of climacteric symptoms in women during menopause. Clinical and experimental obstetrics & gynecology. vol 43. issue 4. 2018-06-20. PMID:29734534. |
among the candidate genes in the aetiology of depression the following were selected for the research: the serotonergic system receptor genes: 5htr2a, 5htr1b, 5htr2c, tph 1, tph2, and mao-a; the genes of noradrenergic and dopaminergic systems (comt, net), the genes of the gabaergic (gabrbl) system, a gene of the estrogen receptor (esr1), and the genes of the enzymes crucial in the methyl cycle (mthrf, mtr, and mthfd1). |
2018-06-20 |
2023-08-13 |
human |
| Aya Matsusue, Takaki Ishikawa, Tomomi Michiue, Brian Waters, Kenji Hara, Masayuki Kashiwagi, Mio Takayama, Natsuki Ikematsu, Shin-Ichi Kub. Association between cerebrospinal fluid dopamine concentrations and catechol-O-methyltransferase gene polymorphisms in forensic autopsy cases of methamphetamine abusers. Forensic science international. vol 270. 2018-06-15. PMID:27987399. |
since catechol-o-methyltransferase (comt) metabolizes catecholamines and mediates adrenergic, noradrenergic, and dopaminergic signaling responses, we investigated the effects of the comt polymorphisms rs4633 and rs4680 on cerebrospinal fluid (csf) catecholamine concentrations in autopsies of subjects who died of drug intoxication. |
2018-06-15 |
2023-08-13 |
human |
| Xiaoxue Gao, Jinting Liu, Pingyuan Gong, Junhui Wang, Wan Fang, Hongming Yan, Lusha Zhu, Xiaolin Zho. Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making. Social cognitive and affective neuroscience. vol 12. issue 9. 2018-05-24. PMID:28431168. |
this effect has been found to be modulated by the serotonin transporter gene (slc6a4) and the catechol-o-methyltransferase gene (comt) polymorphisms, which are on the dopaminergic and serotonergic pathways and which are associated with affective processing. |
2018-05-24 |
2023-08-13 |
human |