| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruxandra Julia Vorovenci, Angelo Antonin. The efficacy of oral adenosine A(2A) antagonist istradefylline for the treatment of moderate to severe Parkinson's disease. Expert review of neurotherapeutics. vol 15. issue 12. 2018-03-26. PMID:26630457. |
associations of a(2a) receptor antagonists with dopaminergic agents, as well as enzyme blockers like catechol-o-methyltransferase (comt) and monoamine oxidase-b (mao-b) inhibitors, should provide even greater benefit in advanced pd patients, and, thus, a more individualized treatment approach would be at hand. |
2018-03-26 |
2023-08-13 |
Not clear |
| Rabia R Chhangur, Joyce Weeland, Geertjan Overbeek, Walter Matthys, Bram Orobio de Castro, Danielle van der Giessen, Jay Belsk. Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children. Child development. vol 88. issue 3. 2018-03-13. PMID:27629597. |
this study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (drd4, drd2, dat1, maoa, and comt) benefited the most from the incredible years (iy) parent program. |
2018-03-13 |
2023-08-13 |
Not clear |
| b' Vjekoslav Peitl, Mario \\xc5\\xa0tefanovi\\xc4\\x87, Dalibor Karlovi\\xc4\\x8. Depressive symptoms in schizophrenia and dopamine and serotonin gene polymorphisms. Progress in neuro-psychopharmacology & biological psychiatry. vol 77. 2018-03-05. PMID:28416295.' |
as impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (sert 5-httlpr, mao-a vntr, comt val158met and dat vntr) and schizophrenia. |
2018-03-05 |
2023-08-13 |
human |
| Jeffry Quan, Mei-Lyn Ong, Jean-Francois Bureau, Lit Wee Sim, Shamini Sanmugam, Adam B Abdul Malik, Eric Wong, Johnny Wong, Yap-Seng Chong, Seang Mei Saw, Kenneth Kwek, Anqi Qiu, Joanna D Holbrook, Anne Rifkin-Grabo. The influence of CHRNA4, COMT, and maternal sensitivity on orienting and executive attention in 6-month-old infants. Brain and cognition. vol 116. 2018-02-22. PMID:28582665. |
this study examines how candidate polymorphisms from the cholinergic (chrna4 rs1044396) and dopaminergic (comt rs4680) systems, respectively indicative of parietal and prefrontal/anterior cingulate involvement, are related to 6-month-olds' (n=217) performance during a visual expectation eye-tracking paradigm. |
2018-02-22 |
2023-08-13 |
Not clear |
| Philippe Jawinski, Sophie Tegelkamp, Christian Sander, Madlen Häntzsch, Jue Huang, Nicole Mauche, Markus Scholz, Janek Spada, Christine Ulke, Ralph Burkhardt, Andreas Reif, Ulrich Hegerl, Tilman Hensc. Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep. Chronobiology international. vol 33. issue 7. 2018-01-31. PMID:27148829. |
however, there is no consensus on the impact of two established dopaminergic gene variants: the catechol-o-methyltransferase val158met (comt val158met; rs4680) and the dopamine d4 receptor exon iii variable-number-of-tandem-repeat polymorphism (drd4 vntr). |
2018-01-31 |
2023-08-13 |
human |
| B Vai, M Riberto, S Poletti, I Bollettini, C Lorenzi, C Colombo, F Benedett. Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorder. European psychiatry : the journal of the Association of European Psychiatrists. vol 41. 2017-12-26. PMID:28049082. |
catechol-o-methyltransferase (comt) inactivates catecholamines, val/val genotype was associated to an increased amygdala (amy) response to negative stimuli and can influence the symptoms severity and the outcome of bipolar disorder, probably mediated by the comt polymorphism (rs4680) interaction between cortical and subcortical dopaminergic neurotransmission. |
2017-12-26 |
2023-08-13 |
Not clear |
| Gwyneth Zai, Trevor W Robbins, Barbara J Sahakian, James L Kenned. A review of molecular genetic studies of neurocognitive deficits in schizophrenia. Neuroscience and biobehavioral reviews. vol 72. 2017-10-25. PMID:27866942. |
limited evidence also suggests the dopaminergic system genes, with the most studied catechol-o-methytransferase (comt) gene showing inconsistent findings. |
2017-10-25 |
2023-08-13 |
human |
| Masato Asanuma, Ikuko Miyazak. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC neuroscience. vol 17. issue 1. 2017-09-20. PMID:27456338. |
we examined changes in the numbers of dopaminergic neurons after treatment with l-dopa and 3-omd or entacapone, a peripheral comt inhibitor, using primary cultured mesencephalic neurons and striatal astrocytes. |
2017-09-20 |
2023-08-13 |
Not clear |
| Sarah A Eisenstein, Ryan Bogdan, Ling Chen, Stephen M Moerlein, Kevin J Black, Joel S Perlmutter, Tamara Hershey, Deanna M Barc. Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia. Journal of psychiatric research. vol 86. 2017-09-12. PMID:27886638. |
a subset of participants (n = 124) were genotyped for da-related polymorphisms in genes for drd4, drd2/ankk1, dat1, and comt, which were used to construct biologically-informed multi-locus genetic profile (mgp) scores reflective of subcortical dopaminergic signaling. |
2017-09-12 |
2023-08-13 |
human |
| Irene Nkam, Nicolas Ramoz, Florence Breton, Jasmina Mallet, Philip Gorwood, Caroline Dubertre. Impact of DRD2/ANKK1 and COMT Polymorphisms on Attention and Cognitive Functions in Schizophrenia. PloS one. vol 12. issue 1. 2017-08-18. PMID:28085950. |
the purpose of the current exploratory study was to examine the interaction of dopaminergic genes (coding for dopamine receptor d2, drd2, and for catecholamine-o-methyl-transferase, comt) with the diagnostic of schizophrenia in (i) the executive control of attention, (ii) selective attention, and (iii) executive functions. |
2017-08-18 |
2023-08-13 |
Not clear |
| Rajesh Narendran, Divya Tumuluru, Maureen A May, Kodavali V Chowdari, Michael L Himes, Kelli Fasenmyer, W Gordon Frankle, Vishwajit L Nimgaonka. Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype. PloS one. vol 11. issue 6. 2017-07-19. PMID:27322568. |
basic investigations link a val158met polymorphism (rs4680) in the catechol-o-methyltransferase (comt) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex. |
2017-07-19 |
2023-08-13 |
Not clear |
| Rajesh Narendran, Divya Tumuluru, Maureen A May, Kodavali V Chowdari, Michael L Himes, Kelli Fasenmyer, W Gordon Frankle, Vishwajit L Nimgaonka. Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype. PloS one. vol 11. issue 6. 2017-07-19. PMID:27322568. |
previous pet studies have documented the relationship between comt val158met polymorphism and d1 and d2/3 receptor binding potential (bp), and interpreted them in terms of dopaminergic tone. |
2017-07-19 |
2023-08-13 |
Not clear |
| Anna Junkiert-Czarnecka, Olga Hau. Genetical background of intelligence. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-10. PMID:27333929. |
studies on genetic background of intelligence focus on dopaminergic (drd2, drd4, comt, slc6a3, dat1, cckar) and adrenergic system (adrb2, chrm2) genes as well as, neutrofins (bdnf) and oxidative stress genes (ltf, prnp). |
2017-07-10 |
2023-08-13 |
human |
| J P Schach. COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review. The pharmacogenomics journal. vol 16. issue 5. 2017-06-05. PMID:27241058. |
comt val158met moderation of dopaminergic drug effects on cognitive function: a critical review. |
2017-06-05 |
2023-08-13 |
Not clear |
| J P Schach. COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review. The pharmacogenomics journal. vol 16. issue 5. 2017-06-05. PMID:27241058. |
overall, comt val158met genotype represents an enticing target for identifying individuals who are more likely to respond positively to dopaminergic drugs. |
2017-06-05 |
2023-08-13 |
Not clear |
| T Amorim-Barbosa, M P Serrão, I Brandão, M A Vieira-Coelh. Catechol-O-methyltransferase activity in erythrocytes from patients with eating disorders. Eating and weight disorders : EWD. vol 21. issue 2. 2017-04-06. PMID:26296436. |
abnormal feeding has been linked to disruptions in brain dopaminergic activity and recent studies have assessed the role of catechol-o-methyltransferase (comt) in eating disorders. |
2017-04-06 |
2023-08-13 |
Not clear |
| Camille Pham-Lake, Elizabeth B Aronoff, Chad R Camp, Aimee Vester, Sam J Peters, W Michael Caudl. Impairment in the mesohippocampal dopamine circuit following exposure to the brominated flame retardant, HBCDD. Environmental toxicology and pharmacology. vol 50. 2017-03-13. PMID:28214749. |
these exposures elicited significant reductions in presynaptic dopaminergic proteins, including th, comt, mao-b, dat, vmat2, and alpha-synuclein. |
2017-03-13 |
2023-08-13 |
mouse |
| Lindsay N Douglas, Austen B McGuire, Ann M Manzardo, Merlin G Butle. High-resolution chromosome ideogram representation of recognized genes for bipolar disorder. Gene. vol 586. issue 1. 2017-01-03. PMID:27063557. |
the identified genes impacted a broad range of biological pathways and processes including cellular signaling pathways particularly camp and calcium (e.g., cacna1c, camk2a, camk2d, adcy1, adcy2); glutamatergic (e.g., grik1, grm3, grm7), dopaminergic (e.g., drd2, drd4, comt, maoa) and serotonergic (e.g., htr1a, htr2a, htr3b) neurotransmission; molecular transporters (e.g., slc39a3, slc6a3, slc8a1); and neuronal growth (e.g., bdnf, igfbp1, nrg1, nrg3). |
2017-01-03 |
2023-08-13 |
human |
| Fatemeh Noohi, Nate B Boyden, Youngbin Kwak, Jennifer Humfleet, Martijn L T M Müller, Nicolaas I Bohnen, Rachael D Seidle. Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation. Neuropsychologia. vol 84. 2016-12-16. PMID:26926580. |
we selected three genetic polymorphisms: catechol-o-methyl transferase (comt val158met) and dopamine d2 receptor (drd2 g>t), which are involved with dopaminergic regulation, and brain derived neurotrophic factor (bdnf val66met) that modulates neuroplasticity and has been shown to interact with dopaminergic genes. |
2016-12-16 |
2023-08-13 |
Not clear |
| Milky Kohno, Erika L Nurmi, Christopher P Laughlin, Angelica M Morales, Emma H Gail, Gerhard S Hellemann, Edythe D Londo. Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 3. 2016-10-06. PMID:26119471. |
for each participant, dopamine function was assessed using a gene composite score combining known functional variation across five genes involved in dopaminergic signaling: drd2, drd3, drd4, dat1, and comt. |
2016-10-06 |
2023-08-13 |
human |