| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sherilyn Junelle Recinto, Shobina Premachandran, Sriparna Mukherjee, Alexis Allot, Adam MacDonald, Moein Yaqubi, Samantha Gruenheid, Louis-Eric Trudeau, Jo Anne Stratto. Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content. The European journal of neuroscience. 2024-03-15. PMID:38487941. |
characterizing enteric neurons in dopamine transporter (dat)-cre reporter mice reveals dopaminergic subtypes with dual-transmitter content. |
2024-03-15 |
2024-03-17 |
mouse |
| Avelina Petri, Abigail Sullivan, Kristen Allen, Benjamin D Sach. Genetic loss of the dopamine transporter significantly impacts behavioral and molecular responses to sub-chronic stress in mice. Frontiers in molecular neuroscience. vol 17. 2024-03-15. PMID:38486964. |
overall, these results provide further evidence of the importance of dopaminergic neurotransmission in regulating stress susceptibility and suggest that genetic loss of dat prevents stress-induced increases in anxiety-like behavior. |
2024-03-15 |
2024-03-17 |
mouse |
| József Attila Szász, Adriana Octaviana Dulamea, Viorelia Adelina Constantin, Dafin Fior Mureşanu, Lăcrămioara Perju Dumbravă, Cristina Tiu, Dragoş Cătălin Jianu, Mihaela Simu, Amalia Ene, Any Axelerad, Cristian Falup-Pecurariu, Mihaela Lungu, Adina Gabriela Danci, Monica Sabau, Ştefan Strilciuc, Bogdan Ovidiu Popesc. Levodopa-Carbidopa-Entacapone Intestinal Gel in Advanced Parkinson Disease: A Multicenter Real-Life Experience. American journal of therapeutics. 2024-03-09. PMID:38460175. |
for parkinson disease (pd) patients who have been diagnosed with advanced disease that can no longer be effectively controlled with optimized oral or transdermal medications, a range of device-aided therapies (dat) are available, comprising either deep brain stimulation or infusion therapies providing continuous dopaminergic stimulation. |
2024-03-09 |
2024-03-12 |
Not clear |
| Nobuyoshi Matsumoto, Miyuki Miyano, Takaya Abe, Tetsuhiko Kashima, Eriko Kato-Ishikura, Ken-Ichi Inoue, Jiayan Liu, Hiroshi Kiyonari, Haruki Takeuchi, Yuji Ikegay. Generation of Dopamine Transporter (DAT)-mCherry Knock-in Rats by CRISPR-Cas9 Genome Editing. Biological & pharmaceutical bulletin. vol 47. issue 2. 2024-02-07. PMID:38325828. |
since dopamine transporter (dat) gene is known as a marker for dopaminergic neurons, we inserted chr2-mcherry into the downstream of the dat gene locus of the rat genome by clustered regularly interspaced short palindromic repeats (crispr)-associated protein 9 (crispr-cas9) genome editing and created dat-chr2-mcherry knock-in rats. |
2024-02-07 |
2024-02-10 |
rat |
| Yatao Du, Qin Li, Guangdi Zhou, Zhenzhen Cai, Qiuhong Man, Weiye Charles Wan. Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish. The Science of the total environment. 2024-01-28. PMID:38281643. |
we demonstrated that exposure to pfoa disrupted the glycosylation process of dat, inhibited its uptake function, and induced endoplasmic reticulum (er) stress in dopaminergic cells. |
2024-01-28 |
2024-01-31 |
human |
| Tarique Bagalkot, Alexander Sorki. Amphetamine induces sex-dependent loss of the striatal dopamine transporter in sensitized mice. eNeuro. 2024-01-02. PMID:38164591. |
acute amph administration leads to transient dat endocytosis which among other amph effects on dopaminergic neurons elevates extracellular dopamine. |
2024-01-02 |
2024-01-05 |
mouse |
| Madhur Shetty, Danielle E Bolland, Joshua Morrell, Bryon D Grove, James D Foster, Roxanne A Vaugha. Dopamine transporter membrane mobility is bidirectionally regulated by phosphorylation and palmitoylation. Current research in physiology. vol 6. 2023-12-19. PMID:38107792. |
dat activity is regulated by post-translational modifications that establish clearance capacity through impacts on transport kinetics, and dysregulation of these events may underlie dopaminergic imbalances in mood and psychiatric disorders. |
2023-12-19 |
2023-12-21 |
Not clear |
| Madhur Shetty, Danielle E Bolland, Joshua Morrell, Bryon D Grove, James D Foster, Roxanne A Vaugha. Dopamine transporter membrane mobility is bidirectionally regulated by phosphorylation and palmitoylation. Current research in physiology. vol 6. 2023-12-19. PMID:38107792. |
these findings grow the list of dat properties controlled by these post-translational modifications and highlight their role in establishment of dopaminergic tone in physiological and pathophysiological states. |
2023-12-19 |
2023-12-21 |
Not clear |
| Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Lis. Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra. Communications biology. vol 6. issue 1. 2023-11-10. PMID:37950046. |
these results have important implications, as dat is crucial for dopamine signalling, and is commonly used as a marker for dopaminergic sn neurons. |
2023-11-10 |
2023-11-20 |
mouse |
| Li He, Huihui Zheng, Jilong Qiu, Hong Chen, Huan Li, Yuejiao Ma, Yingying Wang, Qianjin Wang, Yuzhu Hao, Yueheng Liu, Qian Yang, Xin Wang, Manyun Li, Huixue Xu, Pu Peng, Zejun Li, Yanan Zhou, Qiuxia Wu, Shubao Chen, Xiaojie Zhang, Tieqiao Li. Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model. Neurotoxicity research. 2023-09-27. PMID:37755670. |
the edns were assessed by measuring the expression of two dopaminergic neuronal markers, dopamine transporter (dat) and tyrosine hydroxylase (th), at the transcriptional and protein levels. |
2023-09-27 |
2023-10-07 |
rat |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
selective dopaminergic vulnerability in parkinson's disease: new insights into the role of dat. |
2023-09-11 |
2023-10-07 |
Not clear |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
several mechanisms, previously considered in isolation, have been proposed to contribute to the pathophysiology of dopaminergic degeneration: dopamine oxidation-mediated neurotoxicity, high dopamine transporter (dat) expression density per neuron, and autophagy-lysosome pathway (alp) dysfunction. |
2023-09-11 |
2023-10-07 |
Not clear |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
in pd, alp dysfunction could increase dat density per neuron, and enhance dopamine reuptake, oxidation, and neurotoxicity, potentially contributing to the progressive loss of dopaminergic neurons. |
2023-09-11 |
2023-10-07 |
Not clear |
| Tao Ke, Ganesh Ambigapathy, Thanh Ton, Archana Dhasarathy, Lucia Carvell. Long-Lasting Epigenetic Changes in the Dopamine Transporter in Adult Animals Exposed to Amphetamine during Embryogenesis: Investigating Behavioral Effects. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37685899. |
the dopamine transporter (dat) is an integral member of the dopaminergic system and is responsible for the release and reuptake of dopamine from the synaptic space into the dopaminergic neurons. |
2023-09-09 |
2023-10-07 |
Not clear |
| Jan Booij, Sem P Tellier, John Seibyl, Chris Vrien. Dopamine Transporter Availability in Early Parkinson's Disease is Dependent on Sunlight Exposure. Movement disorders : official journal of the Movement Disorder Society. 2023-09-06. PMID:37670567. |
preliminary studies suggested seasonality of dopaminergic functioning, but it is unknown whether dopamine transporter (dat) expression in humans is also dependent on the seasons. |
2023-09-06 |
2023-10-07 |
Not clear |
| Natalia F Sardi, Ana C Pescador, Evellyn M Azevedo, José A Pochapski, Caroline Kukolj, Katherinne M Spercoski, Anderson J M Andrade, Claudio da Cunha, Luana Fische. Sleep and pain: a role for the anterior cingulate cortex, nucleus accumbens and dopamine in the increased pain sensitivity following sleep restriction. The journal of pain. 2023-09-06. PMID:37673193. |
data on indirect dopaminergic parameters, dat glycosylation and darpp-32 phosphorylation, as well as dopamine, serotonin and norepinephrine levels, suggest that dopaminergic function decreases in the nucleus accumbens and anterior cingulate cortex after sleep restriction. |
2023-09-06 |
2023-10-07 |
rat |
| Luiz Henrique Dias de Oliveira, Jorddy Neves Cruz, Cleydson Breno Rodrigues Dos Santos, Eduardo Borges de Mel. Multivariate QSAR, similarity search and ADMET studies based in a set of methylamine derivatives described as dopamine transporter inhibitors. Molecular diversity. 2023-09-05. PMID:37670118. |
the dopamine transporter (dat), responsible for the regulation of dopaminergic neurotransmission, is implicated in the etiology of several neuropsychiatric disorders which, in turn, have contributed to high rates of disability and numerous deaths in recent years, significantly impacting the global health system. |
2023-09-05 |
2023-10-07 |
Not clear |
| Deepika Suri, Giulia Zanni, Darshini Mahadevia, Nao Chuhma, Rinki Saha, Stephen Spivack, Nicolò Pini, Gregory S Stevens, Annette Ziolkowski-Blake, Eleanor H Simpson, Peter Balsam, Stephen Rayport, Mark S Ansorg. Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression. Molecular psychiatry. 2023-08-02. PMID:37532798. |
lastly, using optogenetics to drive dopamine neurons, we find that increased vta but not snc dopaminergic activity mimics the increase in impulsive behavior in the go/nogo task observed after adolescent dat blockade. |
2023-08-02 |
2023-08-14 |
mouse |
| Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhan. Current coffee consumption is associated with decreased striatal dopamine transporter availability in Parkinson's disease patients and healthy controls. BMC medicine. vol 21. issue 1. 2023-07-25. PMID:37491235. |
we therefore aim to investigate the role of coffee consumption in nigrostriatal dopaminergic neurodegeneration using dopamine transporter (dat) imaging in pd and healthy controls (hc). |
2023-07-25 |
2023-08-14 |
Not clear |
| Manon Auffret, Daniel Weiss, Fabrizio Stocchi, Marc Vérin, Wolfgang H Jos. Access to device-aided therapies in advanced Parkinson's disease: navigating clinician biases, patient preference, and prognostic uncertainty. Journal of neural transmission (Vienna, Austria : 1996). 2023-07-12. PMID:37436446. |
device-aided therapies (dat), which include deep brain stimulation and pump-based continuous dopaminergic stimulation with either levodopa or apomorphine, are among the major advances in the clinical management of parkinson's disease (pd). |
2023-07-12 |
2023-08-14 |
Not clear |