All Relations between dopaminergic and dat

Publication Sentence Publish Date Extraction Date Species
Ilene Trinh, Angeni Muralidhar, Justin Yang, Nicolás Phielip. Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease. Movement disorders clinical practice. vol 10. issue 6. 2023-06-19. PMID:37332639. dopamine transporter single-photon emission computed tomography (dat-spect) can be used to assess dopaminergic denervation by detecting loss of striatal dopamine transporters (dat). 2023-06-19 2023-08-14 Not clear
Tarique Bagalkot, Alexander Sorki. Endocytic down-regulation of the striatal dopamine transporter by amphetamine in sensitized mice in sex-dependent manner. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37293021. acute amph is proposed to cause transient dat endocytosis which among other amph effects on dopaminergic neurons elevates extracellular dopamine. 2023-06-09 2023-08-14 mouse
Carmen Costas-Ferreira, Rafael Durán, Lilian Ferreira Far. Neurotoxic effects of exposure to glyphosate in rat striatum: Effects and mechanisms of action on dopaminergic neurotransmission. Pesticide biochemistry and physiology. vol 193. 2023-05-29. PMID:37248010. so, two possible hypotheses could explain this additive effect: both glyphosate and nomifensine act through different mechanisms at the dopaminergic terminals to increase dopamine levels; or both nomifensine and glyphosate act on dat, with glyphosate simultaneously inhibiting reuptake and stimulating dopamine release by reversing the dat function. 2023-05-29 2023-08-14 rat
Jana Lubec, Ahmed M Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Höger, Gert Lube. Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979402. although dopaminergic treatment approaches represent a major step forward, current dopamine transporter (dat) inhibitors are not sufficiently specific as they also target other transporters and receptors, thus showing unwanted side effects. 2023-03-29 2023-08-14 rat
Mobina Alemi, Ana Raquel Pereira, Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cru. Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979799. we evaluated the impact of the inflammatory pain in the vta synapses by performing immunohistochemical characterization of specific markers for gabaergic (gad65/67) and dopaminergic neurons (dopamine transporter (dat), dopamine d2 receptor (d2r) and tyrosine hydroxylase (th)). 2023-03-29 2023-08-14 rat
Michael Kalyn, Hyojin Lee, Jory Curry, Wenqing Tu, Marc Ekker, Jan A Mennige. Effects of PFOS, F53-B and F53-B on locomotor behaviour, the dopamine system and mitochondrial function in developing zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 2023-03-23. PMID:36958660. using developing transgenic tg (dat:egfp) zebrafish, we here evaluated the consequences of exposure to 0, 0.1 and 1 mg/l pfos, f53-b and obs on the dopaminergic system, locomotor behaviour and mitochondrial function. 2023-03-23 2023-08-14 human
Michael Freissmut. Regulated Rapid Round Trips: Endocytotic Cycling of the Dopamine Transporter Shapes Motor Learning. The Journal of biological chemistry. 2023-03-19. PMID:36935007. they showed that dat cycling in the presynaptic specialization of dopaminergic neurons is subject to control by a cell-autonomous loop comprising dopamine autoreceptors and metabotropic glutamate receptors. 2023-03-19 2023-08-14 mouse
Zhengjie Yang, Yijie Xie, Kaixin Dou, Liying Yang, Anmu Xi. Associations of striatal dopamine transporter binding with motor and non-motor symptoms in early Parkinson's disease. Clinical and translational science. 2023-03-14. PMID:36915231. dopamine transporter (dat) imaging is an in vivo tool to assess presynaptic dopaminergic function in the clinical practices of parkinson's disease (pd). 2023-03-14 2023-08-14 Not clear
Ryoji Goto, Masanori Kurihara, Masashi Kameyama, Hiroki Komatsu, Masashi Higashino, Keiko Hatano, Ryoko Ihara, Mana Higashihara, Yasushi Nishina, Tomoyasu Matsubara, Kazutomi Kanemaru, Yuko Saito, Shigeo Murayama, Atsushi Iwat. Correlations between cerebrospinal fluid homovanillic acid and dopamine transporter SPECT in degenerative parkinsonian syndromes. Journal of neural transmission (Vienna, Austria : 1996). 2023-03-04. PMID:36871130. both cerebrospinal fluid (csf) homovanillic acid (hva) and striatal dopamine transporter (dat) binding on single-photon emission computed tomography (spect) reflect nigrostriatal dopaminergic function, but studies on the relationship between the two have been limited. 2023-03-04 2023-08-14 human
Laura Hautrive Milanesi, Domenika Rubert Rossato, Jéssica Leandra Oliveira Rosa, Lívia Ferraz D'avila, Vinícia Garzella Metz, Camila Reck Rampelotto, Viviane Gonçalves Pereira, Scheila Rezende Schaffazick, Cristiane de Bona da Silva, Marilise E Burge. Ferulic acid-loaded nanostructure prevents morphine reinstatement: the involvement of dopamine system, NRF2, and ΔFosB in the striatum brain area of rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023-02-15. PMID:36790483. morphine exposure increased the dopaminergic markers (d1r, d3r, dat) and Δfosb immunoreactivity in the ventral striatum; however, fa-nc treatment decreased d1r, d3r, and Δfosb and increased d2r, dat, and nrf2. 2023-02-15 2023-08-14 rat
Daniel Kalinowski, Krystyna Bogus-Nowakowska, Anna Kozłowska, Maciej Równia. Dopaminergic and cholinergic modulation of the amygdala is altered in female mice with oestrogen receptor β deprivation. Scientific reports. vol 13. issue 1. 2023-01-17. PMID:36650256. the results show that among dopaminergic markers, the expression of tyrosine hydroxylase (th), dopamine transporter (dat) and dopamine d 2023-01-17 2023-08-14 mouse
Patrick J Kearney, Nicholas C Bolden, Elizabeth Kahuno, Tucker L Conklin, Gilles E Martin, Gert Lubec, Haley E Melikia. Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function. The Journal of biological chemistry. 2023-01-14. PMID:36640864. despite its necessity for da neurotransmission, dat regulation in situ is poorly understood, and it is unknown whether regulated dat trafficking impacts dopaminergic signaling and/or behaviors. 2023-01-14 2023-08-14 Not clear
Patrick J Kearney, Nicholas C Bolden, Elizabeth Kahuno, Tucker L Conklin, Gilles E Martin, Gert Lubec, Haley E Melikia. Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function. The Journal of biological chemistry. 2023-01-14. PMID:36640864. further, dopaminergic mglu5 silencing elevated dat surface expression and abolished motor learning, which was rescued by inhibiting dat with a subthreshold ce-158 dose. 2023-01-14 2023-08-14 Not clear
Riccardo Camedda, Chiara Giuseppina Bonomi, Martina Gaia Di Donna, Agostino Chiaravallot. Functional Correlates of Striatal Dopamine Transporter Cerebrospinal Fluid Levels in Alzheimer's Disease: A Preliminary International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614193. results indicate that patients with higher csf dat levels have a better metabolic pattern in two key zones, suggesting less advanced disease status in patients with more conserved dopaminergic systems. 2023-01-08 2023-08-14 Not clear
Tahereh Ghaedian, Ali Razmkon, Leila Kalhor, Vahid Reza Ostovan, Omid Yousefi, Raziyeh Rezaei, Mohammad Reza Hossein-Tehrani, Abbas Rakhsh. Correlation of response to subthalamic deep brain stimulation in Parkinson's disease patients with striatal dopamine transporter density on 99mtc-TRODAT-1 SPECT. Neurological research. 2022-12-27. PMID:36573915. since the loss of dopaminergic neurons in the substantia nigra is the main pathophysiology of pd, we aimed to evaluate the association of response to dbs with preoperative dopamine transporter density (dat) and its postoperative changes in pd patients who underwent the bilateral implantation of the electrodes in the subthalamic nucleus (stn). 2022-12-27 2023-08-14 Not clear
Ciara Frances Pugh, Brian Thomas DeVree, Solveig Gaarde Schmidt, Claus Juul Lolan. Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Cells. vol 11. issue 23. 2022-12-11. PMID:36497070. pharmacological characterization of purified full-length dopamine transporter from the dopamine transporter (dat) is a member of the neurotransmitter:sodium symporter (nss) family, mediating the sodium-driven reuptake of dopamine from the extracellular space thereby terminating dopaminergic neurotransmission. 2022-12-11 2023-08-14 Not clear
Jing Deng, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Gender differences in cocaine-induced hyperactivity and dopamine transporter trafficking to the plasma membrane. Addiction biology. vol 27. issue 6. 2022-10-27. PMID:36301205. as well known, cocaine induces stimulant effects and dopamine transporter (dat) trafficking to the plasma membrane of dopaminergic neurons. 2022-10-27 2023-08-14 rat
Jing Deng, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Gender differences in cocaine-induced hyperactivity and dopamine transporter trafficking to the plasma membrane. Addiction biology. vol 27. issue 6. 2022-10-27. PMID:36301205. in the present study, we examined cocaine-induced hyperactivity along with cocaine-induced dat trafficking and the recovery rate of the dopaminergic system in female rats in comparison with male rats, demonstrating interesting gender differences. 2022-10-27 2023-08-14 rat
Matthew D Lycas, Aske L Ejdrup, Andreas T Sørensen, Nicolai O Haahr, Søren H Jørgensen, Daryl A Guthrie, Jonatan F Støier, Christian Werner, Amy Hauck Newman, Markus Sauer, Freja Herborg, Ulrik Gethe. Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity. Cell reports. vol 40. issue 13. 2022-09-28. PMID:36170827. here we show, by application of several super-resolution microscopy techniques to cultured neurons and mouse striatal slices, that the da transporter (dat), a key protein in varicosities of dopaminergic neurons, exists in the membrane in dynamic equilibrium between an inward-facing nanodomain-localized and outward-facing unclustered configuration. 2022-09-28 2023-08-14 mouse
Milca Abda Morais, Beatriz Silva Franco, Alessandro Spencer Souza Holanda, Laís Angélica de Paula Simino, Alana Carolina Costa Veras, Marcio Alberto Torsoni, Mauro Manconi, Adriana Souza Torsoni, Andrea Maculano Esteve. Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome. Journal of sleep research. 2022-09-02. PMID:36053904. to evaluate the tyrosine hydroxylase enzyme, dopamine transporter (dat) and type 2 dopaminergic receptor, qpcr and western blotting techniques were used. 2022-09-02 2023-08-14 rat