| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaosan Tang, Heng Li, Baozeng An, Haibo Ma, Nana Huang, Xiaohong L. Transplantation of human cord blood-derived multipotent stem cells (CB-SCs) enhances the recovery of Parkinson in rats. Transplant immunology. 2022-08-29. PMID:36038047. |
after being transplanted into the striatum and substantia nigra of pd rats, most of cb-scs (>90%) developed a fate commitment to dopaminergic differentiation, expressed as the expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2022-08-29 |
2023-08-14 |
human |
| Takehiro Tamura, Genichi Sugihara, Kyoji Okita, Yohei Mukai, Hiroshi Matsuda, Hiroki Shiwaku, Shunsuke Takagi, Hiromitsu Daisaki, Ukihide Tateishi, Hidehiko Takahash. Dopamine dysfunction in depression: application of texture analysis to dopamine transporter single-photon emission computed tomography imaging. Translational psychiatry. vol 12. issue 1. 2022-08-03. PMID:35922402. |
however, results of recent neuroimaging studies on dopamine transporter (dat), which reflect the function of the dopaminergic system, are inconclusive. |
2022-08-03 |
2023-08-14 |
Not clear |
| Dag Nyholm, Wolfgang H Jos. Levodopa-entacapone-carbidopa intestinal gel infusion in advanced Parkinson's disease: real-world experience and practical guidance. Therapeutic advances in neurological disorders. vol 15. 2022-07-05. PMID:35785401. |
at this point, patients may wish to consider a device-aided therapy (dat) that provides continuous dopaminergic stimulation to help overcome these issues. |
2022-07-05 |
2023-08-14 |
Not clear |
| Jing Deng, Ting Zhang, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Recovery of dopaminergic system after cocaine exposure and impact of a long-acting cocaine hydrolase. Addiction biology. vol 27. issue 4. 2022-06-27. PMID:35754103. |
dysregulation of dopamine transporters (dat) within the dopaminergic system is an important biomarker of cocaine exposure. |
2022-06-27 |
2023-08-14 |
rat |
| Jing Deng, Ting Zhang, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Recovery of dopaminergic system after cocaine exposure and impact of a long-acting cocaine hydrolase. Addiction biology. vol 27. issue 4. 2022-06-27. PMID:35754103. |
depending on cocaine amount in-taken, one-time exposure in rats could lead to most (>95% of total) of dat translocating to plasma membrane of the dopaminergic neurons compared to normal dat distribution (~5.7% on the plasma membrane). |
2022-06-27 |
2023-08-14 |
rat |
| Jing Deng, Ting Zhang, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Recovery of dopaminergic system after cocaine exposure and impact of a long-acting cocaine hydrolase. Addiction biology. vol 27. issue 4. 2022-06-27. PMID:35754103. |
without further cocaine exposure, the time course of striatal dat distribution, in terms of intracellular and plasma membrane fractions of dat, represents a recovery process of the dopaminergic system. |
2022-06-27 |
2023-08-14 |
rat |
| Jing Deng, Ting Zhang, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Recovery of dopaminergic system after cocaine exposure and impact of a long-acting cocaine hydrolase. Addiction biology. vol 27. issue 4. 2022-06-27. PMID:35754103. |
the cocaine hydrolase protected dopaminergic system and helped the cocaine-altered dat distribution to recover by preventing the dopaminergic system from further damage by cocaine. |
2022-06-27 |
2023-08-14 |
rat |
| Eric Gyimah, Xian Zhu, Ziqi Zhang, Mengyuan Guo, Hai Xu, John Kenneth Mensah, Xing Dong, Zhen Zhang, Godfred Nana Wireko Gyima. Oxidative Stress and Apoptosis in Bisphenol AF-induced Neurotoxicity in Zebrafish Embryos. Environmental toxicology and chemistry. 2022-06-20. PMID:35723417. |
moreover, qpcr results depicted that bpaf (0.3 μm and 1.0 μm) significantly altered the normal dopaminergic signalling where dat was upregulated, while drd2a and th1 were downregulated, in a concentration-dependent manner. |
2022-06-20 |
2023-08-14 |
cat |
| Qi-Si Chen, Xin-Yi Li, Ling Li, Jia-Ying Lu, Yi-Min Sun, Feng-Tao Liu, Chuan-Tao Zuo, Jian Wan. Dopamine transporter imaging in progressive supranuclear palsy: Severe but nonspecific to subtypes. Acta neurologica Scandinavica. 2022-05-25. PMID:35611608. |
previous studies with a limited sample size suggested more severe dopaminergic transporter (dat) lesions in the striatum of progressive supranuclear palsy (psp) than those in parkinson's disease (pd) and multiple system atrophy-parkinsonism (msa-p). |
2022-05-25 |
2023-08-13 |
Not clear |
| Fang Wan, Ting Yu, Junjie Hu, Sijia Yin, Yunna Li, Liang Kou, Xiaosa Chi, Jiawei Wu, Yadi Sun, Qiulu Zhou, Wenkai Zou, Zhentao Zhang, Tao Wan. The pyrethroids metabolite 3-phenoxybenzoic acid induces dopaminergic degeneration. The Science of the total environment. 2022-05-23. PMID:35605864. |
the intervention of dat inhibitors and activators respectively alleviated and enhanced the dopaminergic toxicity of 3-pba, indicating that 3-pba interacts with dat. |
2022-05-23 |
2023-08-13 |
mouse |
| Fang Wan, Ting Yu, Junjie Hu, Sijia Yin, Yunna Li, Liang Kou, Xiaosa Chi, Jiawei Wu, Yadi Sun, Qiulu Zhou, Wenkai Zou, Zhentao Zhang, Tao Wan. The pyrethroids metabolite 3-phenoxybenzoic acid induces dopaminergic degeneration. The Science of the total environment. 2022-05-23. PMID:35605864. |
in particular, low concentrations of 3-pba increase the dat, which in turn induces 3-pba to enter the dopaminergic neurons to exert toxic effects. |
2022-05-23 |
2023-08-13 |
mouse |
| Christina Besada, Stacia I Lewandowski, Ole V Mortense. MKP3 Overexpression and ERK1/2 Phosphorylation in Dopaminergic Neurons Regulate DAT Trafficking and Function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552965. |
mkp3 overexpression and erk1/2 phosphorylation in dopaminergic neurons regulate dat trafficking and function. |
2022-05-13 |
2023-08-13 |
rat |
| Yibin Xu, Stacia Lewandowski, Christina Besad. Allosteric Dopamine transporter modulator inhibits cocaine-induced behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555950. |
we targeted the nac as it is a part of the brain that plays a crucial role in the mesolimbic dopaminergic pathway and has been recognized by its high density of dat. |
2022-05-13 |
2023-08-13 |
rat |
| Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukl. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease. ACS chemical neuroscience. 2022-05-09. PMID:35533351. |
further, the dize-mediated activation of ace2 led to increased tyrosine hydroxylase (th) and dopamine transporters (dat) expression in the rat brain, indicating the protection of dopaminergic (daergic) neurons from 6-ohda induced neurotoxicity. |
2022-05-09 |
2023-08-13 |
rat |
| Xian-Guo Zou, Meng-Ting Xu, Xiao-Li Dong, You-Min Ying, Rong-Fa Guan, Wei-Cheng Wu, Kai Yang, Pei-Long Su. Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells. Journal of food biochemistry. 2022-04-25. PMID:35467031. |
the results showed that scmac extracts alleviated cell toxicity induced by 6-ohda and the loss of dopaminergic neurons, which was confirmed by the increase of cell viabilities, inhibition of cell apoptosis, the upregulation of tyrosine hydroxylase (th) and dopamine transporter (dat) levels and the downregulation of α-synuclein level. |
2022-04-25 |
2023-08-13 |
Not clear |
| Lingfei Li, Philip Wing-Lok Ho, Huifang Liu, Shirley Yin-Yu Pang, Eunice Eun-Seo Chang, Zoe Yuen-Kiu Choi, Yasine Malki, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong H. Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 ( International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409005. |
syngr3 interacts with the dopamine transporter (dat) to facilitate dopamine (da) uptake and synaptic da turnover in dopaminergic transmission. |
2022-04-12 |
2023-08-13 |
human |
| Victor Blokhin, Alina V Lavrova, Sergey A Surkov, Eduard R Mingazov, Natalia M Gretskaya, Vladimir V Bezuglov, Michael V Ugrumo. A New Method for the Visualization of Living Dopaminergic Neurons and Prospects for Using It to Develop Targeted Drug Delivery to These Cells. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409040. |
this method is based on the authors' hypothesis about the possibility of specifically internalizing into dopaminergic neurons substances with a high affinity for the dopamine transporter (dat). |
2022-04-12 |
2023-08-13 |
mouse |
| Victor Blokhin, Alina V Lavrova, Sergey A Surkov, Eduard R Mingazov, Natalia M Gretskaya, Vladimir V Bezuglov, Michael V Ugrumo. A New Method for the Visualization of Living Dopaminergic Neurons and Prospects for Using It to Develop Targeted Drug Delivery to These Cells. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409040. |
using a culture of mouse embryonic mesencephalic and luhmes cells (human embryonic mesencephalic cells), as well as slices of the substantia nigra of adult mice, we have obtained evidence that gbr-bp is internalized specifically into dopaminergic neurons in association with dat via a clathrin-dependent mechanism. |
2022-04-12 |
2023-08-13 |
mouse |
| Artem Savchenko, Carina Müller, Jana Lubec, Damiana Leo, Volker Korz, Leila Afjehi-Sadat, Jovana Malikovic, Fernando J Sialana, Gert Lubec, Ilya Sukhano. The Lack of Dopamine Transporter Is Associated With Conditional Associative Learning Impairments and Striatal Proteomic Changes. Frontiers in psychiatry. vol 13. 2022-04-04. PMID:35370807. |
while there is strong evidence for a role of striatal dopaminergic activity in learning and memory processes, little is known about the contribution of dat deficiency to conditional learning impairments and underlying molecular processes. |
2022-04-04 |
2023-08-13 |
human |
| Taewoo Kim, Hyo In Kim, Haejun Oh, Yoonsu Jeon, Hyeyoung Shin, Hyun Su Kim, Juhee Lim, Changjin Lim, Jakyung Yoo, Young-Ger Suh, Woo Sung Son, Hyun Jin Choi, Seok-Ho Ki. Discovery of new ERRγ agonists regulating dopaminergic neuronal phenotype in SH-SY5Y cells. Bioorganic chemistry. vol 122. 2022-03-18. PMID:35303621. |
importantly, 5d not only enhanced the expression of dopaminergic neuronal-specific molecules, th and dat but also activated the relevant signaling events, such as the creb-mediated signaling pathway. |
2022-03-18 |
2023-08-13 |
Not clear |