| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Jeon, J M Kim, J M Jeong, K M Kim, Y S Chang, D S Lee, M C Le. Dopamine transporter imaging with [123I]-beta-CIT demonstrates presynaptic nigrostriatal dopaminergic damage in Wilson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 65. issue 1. 1998-07-23. PMID:9667562. |
(1r)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane (beta-cit) is a specific ligand that binds to the dopamine transporter (dat), and can examine the integrity of dopaminergic nerve terminals. |
1998-07-23 |
2023-08-12 |
Not clear |
| F Fumagalli, R R Gainetdinov, K J Valenzano, M G Caro. Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 13. 1998-07-02. PMID:9634552. |
these observations demonstrate that dat is required for, and da is an essential mediator of, meth-induced striatal dopaminergic neurotoxicity, whereas serotonergic deficits are only partially dependent on dat. |
1998-07-02 |
2023-08-12 |
mouse |
| B S Jeon, J M Jeong, S S Park, J M Kim, Y S Chang, H C Song, K M Kim, K Y Yoon, M C Lee, S B Le. Dopamine transporter density measured by [123I]beta-CIT single-photon emission computed tomography is normal in dopa-responsive dystonia. Annals of neurology. vol 43. issue 6. 1998-06-25. PMID:9629849. |
the dopamine transporter (dat) is a protein in the dopaminergic nerve terminals. |
1998-06-25 |
2023-08-12 |
human |
| M J Kuha. Recent biochemical studies of the dopamine transporter--a CNS drug target. Life sciences. vol 62. issue 17-18. 1998-05-26. PMID:9585138. |
the dat is an important component of the dopaminergic synapse. |
1998-05-26 |
2023-08-12 |
Not clear |
| M J Kuha. Recent biochemical studies of the dopamine transporter--a CNS drug target. Life sciences. vol 62. issue 17-18. 1998-05-26. PMID:9585138. |
also, different levels of dat are found in different dopaminergic nuclei. |
1998-05-26 |
2023-08-12 |
Not clear |
| M G Murer, G Dziewczapolski, L B Menalled, M C García, Y Agid, O Gershanik, R Raisman-Vozar. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Annals of neurology. vol 43. issue 5. 1998-05-21. PMID:9585350. |
it was unexpected that quantification of immunoautoradiograms showed a partial recovery of all three dopaminergic markers (th, dat, and vmat2) in the denervated territories of the striatum of moderately lesioned rats receiving levodopa. |
1998-05-21 |
2023-08-12 |
rat |
| R R Gainetdinov, F Fumagalli, Y M Wang, S R Jones, A I Levey, G W Miller, M G Caro. Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice. Journal of neurochemistry. vol 70. issue 5. 1998-05-18. PMID:9572281. |
dopaminergic nerve terminal integrity, as assessed by dat protein expression, also revealed more drastic reductions in the vmat2 +/- mice: 59 versus 35% loss at 7.5 mg/kg and 95 versus 58% loss at 15 mg/kg for vmat2 +/- and vmat2 +/+ mice, respectively. |
1998-05-18 |
2023-08-12 |
mouse |
| Y Itzhak, C Gandia, P L Huang, S F Al. Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495865. |
methamphetamine (meth) is a powerful psychostimulant that produces dopaminergic neurotoxicity manifested by a decrease in the levels of dopamine, tyrosine hydroxylase activity and dopamine transporter (dat) binding sites in the nigrostriatal system. |
1998-04-09 |
2023-08-12 |
mouse |
| Y Itzhak, C Gandia, P L Huang, S F Al. Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495865. |
although a moderate reduction in the levels of dopamine (35%) and dat binding sites (32%) occurred in striatum of heterozygote nnos(+/-) mice, a more profound depletion of the dopaminergic markers (up to 68%) was observed in the wild-type animals. |
1998-04-09 |
2023-08-12 |
mouse |
| A P Kouzmenko, A M Pereira, B S Sing. Intronic sequences are involved in neural targeting of human dopamine transporter gene expression. Biochemical and biophysical research communications. vol 240. issue 3. 1998-01-13. PMID:9398650. |
dopamine transporter (dat) plays a key role in terminating synaptic dopaminergic transmission. |
1998-01-13 |
2023-08-12 |
human |
| A P Kouzmenko, A M Pereira, B S Sing. Intronic sequences are involved in neural targeting of human dopamine transporter gene expression. Biochemical and biophysical research communications. vol 240. issue 3. 1998-01-13. PMID:9398650. |
dat acts exclusively on the plasma membrane of presynaptic dopaminergic neurons and dat gene is an appropriate model for the study of dopaminergic neuron-specific regulation of gene activity. |
1998-01-13 |
2023-08-12 |
human |
| M J Nirenberg, J Chan, A Pohorille, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 18. 1997-10-03. PMID:9278525. |
thus, it is not known whether there are differences in the amount, subcellular localization, or plasmalemmal targeting of dat within individual dopaminergic axons in the two regions. |
1997-10-03 |
2023-08-12 |
Not clear |
| M J Nirenberg, J Chan, A Pohorille, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 18. 1997-10-03. PMID:9278525. |
dopaminergic axons in the shell contain lower mean densities of both total dat gold particles (per square micron) and plasmalemmal dat gold particles (per micron) than those in the core. |
1997-10-03 |
2023-08-12 |
Not clear |
| M J Nirenberg, J Chan, A Pohorille, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 18. 1997-10-03. PMID:9278525. |
as a result, they identify intrinsic, cell-specific differences in the expression of dat within dopaminergic axons in these functionally distinct striatal compartments. |
1997-10-03 |
2023-08-12 |
Not clear |
| R Bossé, F Fumagalli, M Jaber, B Giros, R R Gainetdinov, W C Wetsel, C Missale, M G Caro. Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron. vol 19. issue 1. 1997-10-02. PMID:9247269. |
deletion of the dopamine transporter (dat) results in increased dopaminergic tone, anterior pituitary hypoplasia, dwarfism, and an inability to lactate. |
1997-10-02 |
2023-08-12 |
mouse |
| R Betarbet, R Turner, V Chockkan, M R DeLong, K A Allers, J Walters, A I Levey, J T Greenamyr. Dopaminergic neurons intrinsic to the primate striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 17. 1997-09-23. PMID:9254687. |
to establish the dopaminergic nature of the th-i cells, sections were double-labeled with antibodies to dopamine transporter (dat). |
1997-09-23 |
2023-08-12 |
monkey |
| R Betarbet, R Turner, V Chockkan, M R DeLong, K A Allers, J Walters, A I Levey, J T Greenamyr. Dopaminergic neurons intrinsic to the primate striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 17. 1997-09-23. PMID:9254687. |
immunofluorescence studies demonstrated that nearly all th-i cells were double-labeled with dat, suggesting that they contain the machinery to be functional dopaminergic neurons. |
1997-09-23 |
2023-08-12 |
monkey |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
the dopamine transporter (dat) plays an important role in the plasmalemmal reuptake of dopamine and, thus, in the termination of normal dopaminergic neurotransmission. |
1997-07-21 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
dat is also a major binding site for cocaine and other stimulants, the psychoactive effects of which are associated primarily with the inhibition of dopamine reuptake within mesocorticolimbic dopaminergic neurons. |
1997-07-21 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
we used electron microscopy with an anti-peptide antiserum directed against the n-terminal domain of dat to determine the subcellular localization of this transporter in the rat ventral tegmental area (vta), the region that contains the cell bodies and dendrites of these dopaminergic neurons. |
1997-07-21 |
2023-08-12 |
rat |