| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan R Reinwald, Natalia Gass, Anne S Mallien, Alexander Sartorius, Robert Becker, Markus Sack, Claudia Falfan-Melgoza, Christian Clemm von Hohenberg, Damiana Leo, Natascha Pfeiffer, Anthonieke Middelman, Andreas Meyer-Lindenberg, Judith R Homberg, Wolfgang Weber-Fahr, Peter Gas. Dopamine transporter silencing in the rat: systems-level alterations in striato-cerebellar and prefrontal-midbrain circuits. Molecular psychiatry. 2022-03-05. PMID:35246636. |
silencing of dopamine transporter (dat), a main controlling factor of dopaminergic signaling, results in biochemical and behavioral features characteristic for neuropsychiatric diseases with presumed hyperdopaminergia including schizophrenia, attention deficit hyperactivity disorder (adhd), bipolar disorder, and obsessive-compulsive disorder (ocd). |
2022-03-05 |
2023-08-13 |
rat |
| Amgad Droby, Moran Artzi, Hedva Lerman, R Matthew Hutchison, Dafna Ben Bashat, Nurit Omer, Tanya Gurevich, Avi Orr-Urtreger, Batsheva Cohen, Jesse M Cedarbaum, Einat Even Sapir, Nir Giladi, Anat Mirelman, Avner Thale. Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-04. PMID:35241697. |
dopamine transporter (dat)-spectral positron emission computed tomography is widely used for capturing functional nigrostriatal dopaminergic activity. |
2022-03-04 |
2023-08-13 |
human |
| Tõnis Tokko, Grete Miškinyte, Diva Eensoo, Jaanus Harr. Driving risks of young drivers with symptoms of attention deficit hyperactivity disorder: association with the dopamine transporter gene VNTR polymorphism. Nordic journal of psychiatry. 2022-02-07. PMID:35130472. |
dopaminergic dysfunction has been found to occur in adhd, with the dopamine transporter (dat) gene vntr polymorphism ( |
2022-02-07 |
2023-08-13 |
Not clear |
| Skye Hsin-Hsien Yeh, Chi-Jung Tsai, Tsung-Hsun Yu, Yung-Hsiao Chiang, Shinn-Zong Lin, Nan-Jing Peng, Wen-Sheng Huan. 99mTc-TRODAT-1 SPECT Revealed That Striatal Dopamine Transport Availability Significantly Decreases in Late Mid-Aged Healthy Taiwanese and Then Remains Stable. Clinical nuclear medicine. 2022-01-26. PMID:35081059. |
neuroimaging studies in the past 20 years have documented an age-related decline in striatal dopamine transporters (dats), which is a marker of dopaminergic neurodegeneration; however, concerns about ethnic variations in the decline in dat with age have not been addressed. |
2022-01-26 |
2023-08-13 |
Not clear |
| Concepció Marin, Mireya Fuentes, Isam Alobid, Valeria Tubita, María Jesús Rojas-Lechuga, Joaquim Mullo. Olfactory Bulb Excitotoxicity as a Gap-Filling Mechanism Underlying the Link Between Traumatic Brain Injury-Induced Secondary Neuronal Degeneration and Parkinson's Disease-Like Pathology. Neurochemical research. 2022-01-24. PMID:35067829. |
we examined the number of nigral dopaminergic neurons (th +), nigral α-synuclein expression, the striatal dopamine transporter (dat) expression, and motor performance after bilateral ob n-methyl-d-aspartate (nmda)-induced excitotoxic lesions in rodents. |
2022-01-24 |
2023-08-13 |
Not clear |
| Elisabeth Plhak, Edith Gößnitzer, Reingard M Aigner, Herbert Kvaterni. Radioiodination and Purification of [ Pharmaceuticals (Basel, Switzerland). vol 15. issue 1. 2022-01-21. PMID:35056152. |
radioiodination and purification of [ dopaminergic transporter (dat) imaging with single photon emission computed tomography (spect) is used to diagnose parkinson's disease and to differentiate it from other neurodegenerative disorders without presynaptic dopaminergic dysfunction. |
2022-01-21 |
2023-08-13 |
Not clear |
| Balestrino Roberta, Barone Paolo, Filippi Massimo, Erro Robert. Unexpected ( Journal of neurology. 2021-12-09. PMID:34537866. |
magnetic resonance imaging-mri, computerized tomography-ct) are used to exclude secondary syndromes, presynaptic dopaminergic imaging including imaging of dopamine transporter (dat)-can help the neurologist in the differential diagnosis between neurodegenerative parkinsonian syndromes and parkinsonism without dopamine deficiency. |
2021-12-09 |
2023-08-13 |
Not clear |
| Sara Simorgh, Rafieh Alizadeh, Ronk Shabani, Fariba Karimzadeh, Elham Seidkhani, Jamal Majidpoor, Fatemeh Moradi, Hamidreza Kasbiya. Olfactory mucosa stem cells delivery via nasal route: a simple way for the treatment of Parkinson disease. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33433781. |
the results of real-time pcr and immunohistochemistry (ihc) analysis showed the expression of dopaminergic neuron markers such as pitx3, pax2, pax5 (as dopaminergic neurons markers), tyrosine hydroxylase (th), and dopamine transporter (dat) 2 months after ina of 1 × 10 |
2021-11-29 |
2023-08-13 |
rat |
| Yang Hyun Lee, Sangwon Lee, Seok Jong Chung, Han Soo Yoo, Jin Ho Jung, Kyoungwon Baik, Byoung Seok Ye, Young H Sohn, Mijin Yun, Phil Hyu Le. The pattern of FP-CIT PET in pure white matter hyperintensities-related vascular parkinsonism. Parkinsonism & related disorders. vol 82. 2021-11-22. PMID:33220520. |
to determine whether vascular parkinsonism (vap) patients with visually normal dopamine transporter (dat) scans have presynaptic dopaminergic depletion. |
2021-11-22 |
2023-08-13 |
Not clear |
| Emma A Honkanen, Mikael Eklund, Simo Nuuttila, Tommi Noponen, Elina Jaakkola, Elina Mäkinen, Risto Hirvilammi, Marko Seppänen, Kari Lindholm, Filip Scheperjans, Riitta Parkkola, Juho Joutsa, Andrea Varrone, Valtteri Kaasine. Dopamine transporter binding in symptomatic controls and healthy volunteers: Considerations for neuroimaging trials. NeuroImage. Clinical. vol 32. 2021-11-17. PMID:34482280. |
to evaluate possible differences between brain dopamine transporter (dat) binding in a group of symptomatic parkinsonism patients without dopaminergic degeneration and healthy individuals. |
2021-11-17 |
2023-08-13 |
human |
| Eleanor Porter, Andreas-Antonios Roussakis, Nicholas P Lao-Kaim, Paola Piccin. Multimodal dopamine transporter (DAT) imaging and magnetic resonance imaging (MRI) to characterise early Parkinson's disease. Parkinsonism & related disorders. vol 79. 2021-11-15. PMID:32861103. |
currently, in early idiopathic pd, dopamine transporter (dat)-specific imaging assesses the extent of striatal dopaminergic deficits, and conventional magnetic resonance imaging (mri) of the brain excludes the presence of significant ischaemic load in the basal ganglia as well as signs indicative of other forms of parkinsonism. |
2021-11-15 |
2023-08-13 |
Not clear |
| Piniel Alphayo Kambey, Ma Chengcheng, Guo Xiaoxiao, Ayanlaja Abiola Abdulrahman, Kouminin Kanwore, Iqra Nadeem, Wu Jiao, Dianshuai Ga. The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson's disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33507465. |
we first demonstrated that amodiaquine treatment ameliorated behavioural deficits in 6-ohda parkinson's disease mouse model, and it promoted dopaminergic neurons protection signified by tyrosine hydroxylase (th) and dopamine transporter (dat) mrna; tyrosine hydroxylase (th) protein expression level and the immunoreactivity in the substantia nigra compacta. |
2021-11-12 |
2023-08-13 |
mouse |
| Serena Venezia, Walter A Kaufmann, Gregor K Wenning, Nadia Stefanov. Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease. Parkinsonism & related disorders. vol 91. 2021-11-11. PMID:34530328. |
the facilitated propagation of α-synuclein is associated with early loss of dopamine transporter (dat) signal in the striatum and loss of dopaminergic neurons in substantia nigra pars compacta of tlr4 deficient mice. |
2021-11-11 |
2023-08-13 |
mouse |
| Ümit Özgür Akdemir, Ayşe Bora Tokçaer, Lütfiye Özlem Ata. Dopamine transporter SPECT imaging in Parkinson’s disease and parkinsonian disorders Turkish journal of medical sciences. vol 51. issue 2. 2021-11-08. PMID:33237660. |
dopamine transporter spect imaging in parkinson’s disease and parkinsonian disorders the dopamine transporter (dat) imaging provides an objective tool for the assessment of dopaminergic function of presynaptic terminals which is valuable for the differential diagnosis of parkinsonian disorders related to a striatal dopaminergic deficiency from movement disorders not related a striatal dopaminergic deficiency. |
2021-11-08 |
2023-08-13 |
human |
| Rocío Guerrero-Bautista, Aurelio Franco-García, Juana M Hidalgo, Francisco Fernández-Gómez, M Victoria Milanés, Cristina Núñe. Blockade of D3 receptor prevents changes in DAT and D3R expression in the mesolimbic dopaminergic circuit produced by social stress- and cocaine prime-induced reinstatement of cocaine-CPP. Journal of psychopharmacology (Oxford, England). vol 34. issue 11. 2021-11-04. PMID:32648812. |
blockade of d3 receptor prevents changes in dat and d3r expression in the mesolimbic dopaminergic circuit produced by social stress- and cocaine prime-induced reinstatement of cocaine-cpp. |
2021-11-04 |
2023-08-13 |
Not clear |
| Ryota Bando, Hideki Otsuka, Tamaki Otani, Noritake Matsuda, Shota Azane, Yamato Kunikane, Yoichi Otomi, Wataru Sako, Yuishin Izumi, Masafumi Harad. A new quantitative index in the diagnosis of Parkinson syndrome by dopamine transporter single-photon emission computed tomography. Annals of nuclear medicine. vol 35. issue 4. 2021-10-25. PMID:33630226. |
using the standardized uptake value (suv) of dat spect, we propose "functional dopamine transporter volume (f-dtv)" as a new quantitative index to evaluate the three-dimensional volume of functional dopamine transporters and assess its diagnostic ability in differentiating dopaminergic neurodegenerative diseases (dndd) from non-dndd. |
2021-10-25 |
2023-08-13 |
Not clear |
| S De Bruyne, T L Boos, L Wyffels, J L Goeman, K C Rice, F De Vo. Synthesis, radiosynthesis and in vivo evaluation of [I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine as a selective tracer for imaging the dopamine transporter. Journal of labelled compounds & radiopharmaceuticals. vol 52. issue 8. 2021-10-20. PMID:19746191. |
dopamine transporter (dat) neuroimaging is a useful tool in parkinson's disease diagnosis, staging and follow-up providing information on the integrity of the dopaminergic neurotransmitter system in vivo. |
2021-10-20 |
2023-08-12 |
mouse |
| Beatriz Franco, Diego Silva Mota, Paulo Daubian-Nosé, Natália de Almeida Rodrigues, Laís Angélica de Paula Simino, Thaís de Fante, Rosangela Maria Neves Bezerra, Fúlvia de Barros Manchado Gobatto, Mauro Manconi, Adriana Souza Torsoni, Andrea Maculano Esteve. Iron deficiency in pregnancy: Influence on sleep, behavior, and molecular markers of adult male offspring. Journal of neuroscience research. 2021-10-15. PMID:34651324. |
sleep, behavior, and analysis of key genes of dopaminergic system (d2, dat) were performed after 8 weeks. |
2021-10-15 |
2023-08-13 |
rat |
| Sanne K Meles, Wolfgang H Oertel, Klaus L Leender. Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-09-23. PMID:34530732. |
studies have focused on radiotracer imaging of the dopaminergic nigrostriatal system, which can be assessed with dopamine transporter (dat) single photon emission computed tomography (spect). |
2021-09-23 |
2023-08-13 |
human |
| Sven R Suwijn, Hamdia Samim, Carsten Eggers, Alberto J Espay, Susan Fox, Anthony E Lang, Mike Samuel, Monty Silverdale, Constant V M Verschuur, Joke M Dijk, Hein J Verberne, Jan Booij, Rob M A de Bi. Value of Clinical Signs in Identifying Patients with Scans without Evidence of Dopaminergic Deficit (SWEDD). Journal of Parkinson's disease. vol 10. issue 4. 2021-09-17. PMID:32597819. |
in clinical trials that recruited patients with early parkinson's disease (pd), 4-15% of the participants with a clinical diagnosis of pd had normal dopamine transporter single photon emission computed tomography (dat spect) scans, also called "scans without evidence of dopaminergic deficit" (swedd). |
2021-09-17 |
2023-08-13 |
human |