| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yeruva Sai Lakshmi, D S N B K Prasanth, Karumuri Taraka Sunil Kumar, Sheikh F Ahmad, Seemaladinne Ramanjaneyulu, Nalluri Rahul, Praveen Kumar Pasal. Unravelling the Molecular Mechanisms of a Quercetin Nanocrystal for Treating Potential Parkinson's Disease in a Rotenone Model: Supporting Evidence of Network Pharmacology and In Silico Data Analysis. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893129. |
que regulates the key targets drd2 and drd4, which significantly affect dopaminergic synapses. |
2023-10-30 |
2023-11-08 |
Not clear |
| Bartosz Słomiński, Maria Skrzypkowska, Małgorzata Myśliwiec, Piotr Trzonkowsk. Variant in the dopamine-4-receptor gene (DRD4) in patients with type 1 diabetes. Neuroendocrinology. 2023-04-20. PMID:37080173. |
iintroduction because dopaminergic signaling pathways are one of the regulators of autoimmunity, we hypothesize that the -521c>t drd4 gene polymorphism may correlate with the risk of diabetes mellitus type 1 (dm1) and its comorbidities. |
2023-04-20 |
2023-08-14 |
Not clear |
| Michał Szulc, Radosław Kujawski, Amanda Pacholak, Marta Poprawska, Kamila Czora-Poczwardowska, Bogna Geppert, Przemysław Ł Mikołajcza. Cannabidiol as a Modulator of the Development of Alcohol Tolerance in Rats. Nutrients. vol 15. issue 7. 2023-04-13. PMID:37049542. |
in the prefrontal cortex, hippocampus, and striatum, the cannabinoid (cb1r and cb2r) and dopaminergic (drd1, drd2, drd4, drd5) receptors' mrna level changes were analyzed using the quantitative rt-pcr method. |
2023-04-13 |
2023-08-14 |
rat |
| Adriana M Medina, Megan Hastings Hagenauer, David M Krolewski, Evan Hughes, Liam Cannon Thew Forrester, David M Walsh, Maria Waselus, Evelyn Richardson, Cortney A Turner, P Adolfo Sequeira, Preston M Cartagena, Robert C Thompson, Marquis P Vawter, Blynn G Bunney, Richard M Myers, Jack D Barchas, Francis S Lee, Alan F Schatzberg, William E Bunney, Huda Akil, Stanley J Watso. Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia. Translational psychiatry. vol 13. issue 1. 2023-04-08. PMID:37031222. |
these results included a large diagnosis-related decrease in two important therapeutic targets with low levels of expression, htr2b and drd4, as well as other findings related to dopaminergic, gabaergic and astrocytic function. |
2023-04-08 |
2023-08-14 |
human |
| Mirko Lehmann, Thomas Plieger, Martin Reuter, UlrichEttinge. Insights into the molecular genetic basis of individual differences in metacognition. Physiology & behavior. 2023-03-04. PMID:36870383. |
here, an initial step toward resolving this issue was undertaken by investigating functional polymorphisms from three genes of the dopaminergic or serotonergic systems (drd4, comt, and 5-httlpr) in relation to behaviorally assessed metacognition in six paradigms across three cognitive domains. |
2023-03-04 |
2023-08-14 |
Not clear |
| S D McBride, K Roberts, A J Hemmings, S Ninomiya, M O Parke. The impulsive horse: comparing genetic, physiological and behavioral indicators to that of human addiction. Physiology & behavior. 2022-07-01. PMID:35777460. |
we examined aspects of this mechanism in the horse by assessing the effect of a dopamine receptor genotype (drd4) and central dopaminergic tone (measured via spontaneous blink rate [sbr] and behavioral initiation rate [bir]), on measures of impulsivity, compulsivity (3-choice serial reaction time task) and sympathetic/ parasympathetic system balance (heart rate variability [hrv]). |
2022-07-01 |
2023-08-14 |
human |
| Hairong Peng, Shui Yu, Yukai Zhang, Yanqing Yin, Jiawei Zho. Intestinal Dopamine Receptor D2 is Required for Neuroprotection Against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Dopaminergic Neurodegeneration. Neuroscience bulletin. 2022-04-11. PMID:35399136. |
selective ablation of drd2, but not drd4, in the intestinal epithelium, caused a more severe loss of dopaminergic neurons in the substantia nigra following mptp challenge, and this was accompanied by a reduced abundance of succinate-producing alleoprevotella in the gut microbiota. |
2022-04-11 |
2023-08-13 |
mouse |
| Osama Y Alshogran, Laith N Al-Eitan, Shoroq M Altawalbeh, Hatem A Ama. Association of DRD4 exon III and 5-HTTLPR VNTR genetic polymorphisms with psychiatric symptoms in hemodialysis patients. PloS one. vol 16. issue 3. 2021-10-13. PMID:33784353. |
given that the dopaminergic and serotonergic pathways are involved in the etiology of psychiatric disease, this study evaluated the genetic association of dopamine d4 receptor (drd4) and serotonin transporter (slc6a4) genes with psychiatric symptom susceptibility among hd patients. |
2021-10-13 |
2023-08-13 |
Not clear |
| Carla Leukel, Dirk Schümann, Raffael Kalisch, Tobias Sommer, Nico Bunzec. Dopamine Related Genes Differentially Affect Declarative Long-Term Memory in Healthy Humans. Frontiers in behavioral neuroscience. vol 14. 2020-12-18. PMID:33328916. |
to further investigate this issue, we focused on previously described polymorphisms of genes affecting dopaminergic neurotransmission: dat1 40 base pair (bp), dat1 30 bp, drd4 48 bp, and cannabinoid receptor type 1 (cnr1). |
2020-12-18 |
2023-08-13 |
human |
| Huihui Ji, Xuting Xu, Guili Liu, Huifen Liu, Qinwen Wang, Wenwen Shen, Longhui Li, Xiaohu Xie, Haochang Hu, Lei Xu, Wenhua Zhou, Shiwei Dua. Dopamine receptor D4 promoter hypermethylation increases the risk of drug addiction. Experimental and therapeutic medicine. vol 15. issue 2. 2020-10-01. PMID:29434815. |
dopamine receptor d4 (drd4), a key receptor in the dopaminergic system, may facilitate the development of drug addiction. |
2020-10-01 |
2023-08-13 |
Not clear |
| M Van Heel, P Bijttebier, S Claes, H Colpin, L Goossens, B Hankin, W Van Den Noortgate, K Verschueren, J Young, K Van Leeuwe. Parenting, Effortful Control, and Adolescents' Externalizing Problem Behavior: Moderation by Dopaminergic Genes. Journal of youth and adolescence. vol 49. issue 1. 2020-09-14. PMID:31650442. |
this article used a moderated mediation model to examine whether effortful control mediated the link between parenting and externalizing problem behavior, and whether dopaminergic genes (i.e., polygenic index score including dat1, drd2, drd4, comt) moderated this link. |
2020-09-14 |
2023-08-13 |
Not clear |
| Maciej Bieliński, Natalia Lesiewska, Roman Junik, Anna Kamińska, Andrzej Tretyn, Alina Borkowsk. Dopaminergic Genes Polymorphisms and Prefrontal Cortex Efficiency Among Obese People - Whether Gender is a Differentiating Factor? Current molecular medicine. vol 19. issue 6. 2020-08-13. PMID:31032750. |
in this study, we assessed the association between dopaminergic gene polymorphisms: dat1 (slc6a3), comtval158met, drd4 (48-bp variable number of tandem repeats - vntr) and wcst parameters to investigate the functions of the frontal lobes in obese individuals. |
2020-08-13 |
2023-08-13 |
Not clear |
| R N Mustafin, R F Enikeeva, S B Malykh, R G Valinurov, E K Khusnutdinov. [Genetics and epigenetics of attention deficit hyperactivity disorder]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 9. 2019-03-25. PMID:30335081. |
association studies have shown the relationship between adhd and genes of dopaminergic (drd4, drd5, slc6a3), serotoninergic (htr1b, 5-httlpr), glutamatergic (mglur, ndrg2) systems, metabolic pathways (slc2a3, slc6a4, cdh13, cfod1, gfod1), membrane proteins (kchip1, itga1, snap-25) as well as tumour-suppressor (ndrg2, nf1) and cytokine genes. |
2019-03-25 |
2023-08-13 |
Not clear |
| Jun Ho Hong, In Wook Hwang, Myung Ho Lim, Ho Jang Kwon, Han Jun Ji. Genetic associations between ADHD and dopaminergic genes (DAT1 and DRD4) VNTRs in Korean children. Genes & genomics. vol 40. issue 12. 2019-02-22. PMID:30099719. |
genetic associations between adhd and dopaminergic genes (dat1 and drd4) vntrs in korean children. |
2019-02-22 |
2023-08-13 |
Not clear |
| Yiqing He, Nick Martin, Gu Zhu, Yangyang Li. Candidate genes for novelty-seeking: a meta-analysis of association studies of DRD4 exon III and COMT Val158Met. Psychiatric genetics. vol 28. issue 6. 2019-01-02. PMID:30260901. |
two widely studied genetic polymorphisms in the dopaminergic system [drd4 exon iii variable number of tandem repeat (vntr) and comt val158met] have been reported to be associated with novelty-seeking, but the results have been highly inconsistent. |
2019-01-02 |
2023-08-13 |
Not clear |
| Yeimy González-Giraldo, Martha L Trujillo, Diego A Forer. Two dopaminergic genes, DRD4 and SLC6A3, are associated with body mass index in a Colombian sample of young adults. Archives of physiology and biochemistry. vol 124. issue 4. 2018-10-15. PMID:29145734. |
two dopaminergic genes, drd4 and slc6a3, are associated with body mass index in a colombian sample of young adults. |
2018-10-15 |
2023-08-13 |
human |
| Gonzalo H Oporto, Thomas Bornhardt, Verónica Iturriaga, Luis A Salaza. Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism. Clinical oral investigations. vol 22. issue 1. 2018-09-04. PMID:28451935. |
this research aimed to evaluate the frequency of single nucleotide polymorphisms (snps) in dopaminergic pathway genes (drd1, drd2, drd3, drd4, drd5, and maob) in patients undergoing bruxism treatment and controls. |
2018-09-04 |
2023-08-13 |
Not clear |
| Irene Tung, Julia E Morgan, Amanda N Noroña, Steve S Le. Prenatal programming of postnatal plasticity for externalizing behavior: Testing an integrated developmental model of genetic and temperamental sensitivity to the environment. Developmental psychobiology. vol 59. issue 8. 2018-07-02. PMID:28833035. |
birth weight, a global measure of the prenatal environment, moderated predictions of child negative emotionality from a composite of dopaminergic polymorphisms (i.e., drd4 and dat1), such that birth weight inversely predicted negative emotionality only for children with genetic plasticity. |
2018-07-02 |
2023-08-13 |
Not clear |
| Devon N Gangi, Lauren V Usher, Daniel S Messinge. An exploration of common dopaminergic variants and behavior problems in siblings at high risk for autism spectrum disorder. Infant behavior & development. vol 49. 2018-06-11. PMID:29054034. |
we investigated common dopaminergic variants (drd4 and drd2) in relation to behavior problems at 36 months. |
2018-06-11 |
2023-08-13 |
Not clear |
| Rabia R Chhangur, Joyce Weeland, Geertjan Overbeek, Walter Matthys, Bram Orobio de Castro, Danielle van der Giessen, Jay Belsk. Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children. Child development. vol 88. issue 3. 2018-03-13. PMID:27629597. |
this study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (drd4, drd2, dat1, maoa, and comt) benefited the most from the incredible years (iy) parent program. |
2018-03-13 |
2023-08-13 |
Not clear |