| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippe Jawinski, Sophie Tegelkamp, Christian Sander, Madlen Häntzsch, Jue Huang, Nicole Mauche, Markus Scholz, Janek Spada, Christine Ulke, Ralph Burkhardt, Andreas Reif, Ulrich Hegerl, Tilman Hensc. Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep. Chronobiology international. vol 33. issue 7. 2018-01-31. PMID:27148829. |
however, there is no consensus on the impact of two established dopaminergic gene variants: the catechol-o-methyltransferase val158met (comt val158met; rs4680) and the dopamine d4 receptor exon iii variable-number-of-tandem-repeat polymorphism (drd4 vntr). |
2018-01-31 |
2023-08-13 |
human |
| Devon N Gangi, Daniel S Messinger, Eden R Martin, Michael L Cuccar. Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention. Autism research : official journal of the International Society for Autism Research. vol 9. issue 11. 2018-01-26. PMID:26990357. |
we examined whether these common dopaminergic variants, drd4 and drd2, explain variability in ija in high-risk (n = 55) and low-risk (n = 38) siblings. |
2018-01-26 |
2023-08-13 |
Not clear |
| Devon N Gangi, Daniel S Messinger, Eden R Martin, Michael L Cuccar. Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention. Autism research : official journal of the International Society for Autism Research. vol 9. issue 11. 2018-01-26. PMID:26990357. |
drd4 and drd2 genotypes were coded according to associated dopaminergic functioning to create a gene score, with higher scores indicating more genotypes associated with less efficient dopaminergic functioning. |
2018-01-26 |
2023-08-13 |
Not clear |
| M V Alfimova, V E Golimbet, G I Korovaitseva, T V Lezheiko, D V Tikhonov, T K Ganisheva, N B Berezin, A A Snegireva, T K Shemiakin. [A role of interactions between N-methyl-D-aspartate and dopamine receptors in facial emotion recognition impairment in schizophrenia]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 117. issue 6. 2017-11-17. PMID:28745671. |
based on the view implicating the interplay between dopaminergic and glutamatergic systems into the pathogenesis of schizophrenia, authors explored the interaction effects of the c366g polymorphism in the grin2b gene encoding nmda receptor subunit nr2b with ankk1/drd2 taq1a and 48-vntr drd4 polymorphisms on fer. |
2017-11-17 |
2023-08-13 |
Not clear |
| Sarah A Eisenstein, Ryan Bogdan, Ling Chen, Stephen M Moerlein, Kevin J Black, Joel S Perlmutter, Tamara Hershey, Deanna M Barc. Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia. Journal of psychiatric research. vol 86. 2017-09-12. PMID:27886638. |
a subset of participants (n = 124) were genotyped for da-related polymorphisms in genes for drd4, drd2/ankk1, dat1, and comt, which were used to construct biologically-informed multi-locus genetic profile (mgp) scores reflective of subcortical dopaminergic signaling. |
2017-09-12 |
2023-08-13 |
human |
| Adam Fine, Alissa Mahler, Cortney Simmons, Chuansheng Chen, Robert Moyzis, Elizabeth Cauffma. Relations between three dopaminergic system genes, school attachment, and adolescent delinquency. Developmental psychology. vol 52. issue 11. 2017-08-30. PMID:27786532. |
both environmental factors and genetic variation, particularly in genes responsible for the dopaminergic system such as drd4, drd2, and dat1 (slc6a3), affect adolescent delinquency. |
2017-08-30 |
2023-08-13 |
human |
| Anna Junkiert-Czarnecka, Olga Hau. Genetical background of intelligence. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-10. PMID:27333929. |
studies on genetic background of intelligence focus on dopaminergic (drd2, drd4, comt, slc6a3, dat1, cckar) and adrenergic system (adrb2, chrm2) genes as well as, neutrofins (bdnf) and oxidative stress genes (ltf, prnp). |
2017-07-10 |
2023-08-13 |
human |
| Elisa M Trucco, Brian M Hicks, Sandra Villafuerte, Joel T Nigg, Margit Burmeister, Robert A Zucke. Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use. Journal of abnormal psychology. vol 125. issue 4. 2017-03-09. PMID:26845260. |
polymorphisms across serotonergic (slc6a4, 5-httlpr), dopaminergic (drd4, u-vntr), noradrenergic (slc6a2, rs36021), and gabaergic (gabra2, rs279858; gabra6, rs3811995) genes were examined given prior support for associations with temperament, externalizing behavior, and substance use problems. |
2017-03-09 |
2023-08-13 |
Not clear |
| Ilhong Yun, Julak Lee, Seung-Gon Ki. Dopaminergic Polymorphisms, Academic Achievement, and Violent Delinquency. International journal of offender therapy and comparative criminology. vol 59. issue 13. 2017-01-24. PMID:25326467. |
at the same time, a novel empirical study from molecular genetics drawing on the national longitudinal study of adolescent health (add health) data has revealed that polymorphisms in three dopaminergic genes (dopamine transporter [dat1], dopamine d2 receptor [drd2], and dopamine d4 receptor [drd4]) are also linked to adolescents' grade point averages (gpas). |
2017-01-24 |
2023-08-13 |
Not clear |
| Lindsay N Douglas, Austen B McGuire, Ann M Manzardo, Merlin G Butle. High-resolution chromosome ideogram representation of recognized genes for bipolar disorder. Gene. vol 586. issue 1. 2017-01-03. PMID:27063557. |
the identified genes impacted a broad range of biological pathways and processes including cellular signaling pathways particularly camp and calcium (e.g., cacna1c, camk2a, camk2d, adcy1, adcy2); glutamatergic (e.g., grik1, grm3, grm7), dopaminergic (e.g., drd2, drd4, comt, maoa) and serotonergic (e.g., htr1a, htr2a, htr3b) neurotransmission; molecular transporters (e.g., slc39a3, slc6a3, slc8a1); and neuronal growth (e.g., bdnf, igfbp1, nrg1, nrg3). |
2017-01-03 |
2023-08-13 |
human |
| Crisciele Fontana, Márcia R Vitolo, Paula D B Campagnolo, Vanessa S Mattevi, Júlia P Genro, Silvana Almeid. DRD4 and SLC6A3 gene polymorphisms are associated with food intake and nutritional status in children in early stages of development. The Journal of nutritional biochemistry. vol 26. issue 12. 2016-12-13. PMID:26350252. |
variants of dopamine system genes such as the drd4 and the slc6a3 genes may be involved in food intake regulation because the dopaminergic system influences food reward. |
2016-12-13 |
2023-08-13 |
Not clear |
| Milky Kohno, Erika L Nurmi, Christopher P Laughlin, Angelica M Morales, Emma H Gail, Gerhard S Hellemann, Edythe D Londo. Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 3. 2016-10-06. PMID:26119471. |
for each participant, dopamine function was assessed using a gene composite score combining known functional variation across five genes involved in dopaminergic signaling: drd2, drd3, drd4, dat1, and comt. |
2016-10-06 |
2023-08-13 |
human |
| Z Naumovska, A K Nestorovska, A Filipce, Z Sterjev, K Brezovska, A Dimovski, L J Suturkov. Pharmacogenetics and antipsychotic treatment response. Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki). vol 36. issue 1. 2016-07-15. PMID:26076775. |
it highlights the most important findings about the impact of functional polymorphisms in genes coding the cyp450 metabolizing enzymes, abcb1 transporter gene, dopaminergic and serotonergic drug targets (drd2, drd3, drd4, 5-ht1, 5ht-2a, 5ht-2c, 5ht6) as well as genes responsible for metabolism of neurotransmitters and g signalling pathways (5-httlpr, bdnf, comt, rgs4) and points their role as potential biomarkers in everyday clinical practice. |
2016-07-15 |
2023-08-13 |
Not clear |
| Eric L Thibodeau, Dante Cicchetti, Fred A Rogosc. Child maltreatment, impulsivity, and antisocial behavior in African American children: Moderation effects from a cumulative dopaminergic gene index. Development and psychopathology. vol 27. issue 4 Pt 2. 2016-06-17. PMID:26535948. |
five genotypes in four dopaminergic genes (dopamine receptors d4, d2, known as drd4, drd2; dopamine active transporter 1, known as dat1; and catechol-o-methyltransferase, known as comt) conferring heightened environmental sensitivity were combined into one polygenic index. |
2016-06-17 |
2023-08-13 |
Not clear |
| Ansley Stanfill, Donna Hathaway, Ann Cashion, Ramin Homayouni, Patricia Cowan, Carol Thompson, Behrouz Madahian, Yvette Conle. A Pilot Study of Demographic and Dopaminergic Genetic Contributions to Weight Change in Kidney Transplant Recipients. PloS one. vol 10. issue 9. 2016-05-27. PMID:26406335. |
the purpose of this pilot study is to first examine the feasibility and methodology, and then to examine the associations of age, race, sex, and genotype for 13 snps and 3 vntrs in 9 dopaminergic pathway genes (ankk1, drd2, drd3, drd4, slc6a3/dat1, maoa, maob, comt, cpe) for associations with percent weight change at 12 months post-transplantation. |
2016-05-27 |
2023-08-13 |
Not clear |
| A E Gareeva, K O Kinyasheva, D Yu Galaktionova, E T Sabirov, R G Valinourov, A V Chudinov, A S Zasedatelev, T V Nasedkina, E K Khusnutdinov. [Brain neurotransmitter systems gene Polymorphism: the Search for pharmacogenetic markers of efficacy of haloperidol in Russians and Tatars]. Molekuliarnaia biologiia. vol 49. issue 6. 2016-02-23. PMID:26710776. |
in this paper, we analyzed the association of nine polymorphic variants of five genes of dopaminergic and serotonergic systems drd4, htr2a, tph1, slc18a1, comt in russian and tatars patients living in the republic of bashkortostan (rb) with the efficiency of a typical antipsychotic haloperidol on the scale of positive and negative systems of panss. |
2016-02-23 |
2023-08-13 |
Not clear |
| A E Gareeva, K O Kinyasheva, D Yu Galaktionova, E T Sabirov, R G Valinourov, A V Chudinov, A S Zasedatelev, T V Nasedkina, E K Khusnutdinov. [Brain neurotransmitter systems gene Polymorphism: the Search for pharmacogenetic markers of efficacy of haloperidol in Russians and Tatars]. Molekuliarnaia biologiia. vol 49. issue 6. 2016-02-23. PMID:26710776. |
the results of this study confirm the importance of changes in the nucleotide sequences of the studied genes of the serotoninergic and dopaminergic systems (htr2a, tph1, slc18a1 comt, drd4) in the formation of individual sensitivity to haloperidol. |
2016-02-23 |
2023-08-13 |
Not clear |
| Weidong Ji, Ning Li, Kang Ju, Hong Zheng, Chuang Yang, Ping Xu, Silu Chen, Aiai Cao, Xue Chen, Lanting Gu. Association of Catechol-O-methyltransferase val/met polymorphism with cognitive function in Gilles de la Tourette syndrome patients. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 36. issue 4. 2015-12-09. PMID:25367405. |
the mechanism of cognitive functions was associated with dopaminergic system, thus we access the associations between polymorphism of some dopaminergic system-related genes including catechol-o-methyltransferase (comt) met/val, dopamine receptor d4 (drd4) exon iii 48 bp vntr (variable number of tandem repeats), interleukin 1 (il-1) ra 86 bp and il-1β exon 5, and cognitive functions in gts patients. |
2015-12-09 |
2023-08-13 |
Not clear |
| Dylan B Jackson, Kevin M Beave. Sibling differences in low birth weight, dopaminergic polymorphisms, and ADHD symptomatology: evidence of GxE. Psychiatry research. vol 226. issue 2-3. 2015-09-28. PMID:25704081. |
moreover, possessing greater genetic risk on three dopaminergic genes (dat1, drd2, and drd4) relative to a sibling appears to exacerbate the link between sibling differences in birth weight and sibling differences in adhd symptomatology. |
2015-09-28 |
2023-08-13 |
Not clear |
| P Grant, F Gabriel, Y Kuepper, C Wielpuetz, J Henni. Psychosis-proneness correlates with expression levels of dopaminergic genes. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 5. 2015-02-20. PMID:24630741. |
we found significant negative correlations regarding the expression of the genes comt, maob, drd4, drd5 and fos, indicating that increased schizotypy coincides with higher levels of dopaminergic dysregulation on the mrna-level. |
2015-02-20 |
2023-08-12 |
human |