| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Heck, R Lieb, A Ellgas, H Pfister, S Lucae, D Roeske, B Pütz, B Müller-Myhsok, M Uhr, F Holsboer, M Isin. Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking. Genes, brain, and behavior. vol 8. issue 4. 2009-09-11. PMID:19566713. |
to overcome this limitation, we performed an extended genetic association study analyzing 17 serotonergic (slc6a4, htr1a, htr1b, htr2a, htr2c, htr3a, htr6, maoa, tph1, tph2) and dopaminergic genes (slc6a3, drd2, drd3, drd4, comt, maoa, th, dbh), which have been previously reported to be implicated with personality traits. |
2009-09-11 |
2023-08-12 |
Not clear |
| Josep Marco-Pallarés, David Cucurell, Toni Cunillera, Ulrike M Krämer, Estela Càmara, Wido Nager, Peter Bauer, Rebecca Schüle, Ludger Schöls, Thomas F Münte, Antoni Rodriguez-Fornell. Genetic variability in the dopamine system (dopamine receptor D4, catechol-O-methyltransferase) modulates neurophysiological responses to gains and losses. Biological psychiatry. vol 66. issue 2. 2009-09-02. PMID:19251248. |
here, we study whether brain responses (event-related potentials [erps], oscillatory activity) to monetary gains and losses in normal human subjects are modulated as a function of two dopaminergic polymorphisms (catechol-o-methyltransferase [comt] valine [val]158methionine [met], dopamine receptor d4 [drd4] single nucleotide polymorphism [snp] -521). |
2009-09-02 |
2023-08-12 |
human |
| Michael G Vaughn, Kevin M Beaver, Matt DeLisi, Matthew O Howard, Brian E Perro. Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype. Alcohol (Fayetteville, N.Y.). vol 43. issue 3. 2009-05-28. PMID:19393859. |
although binge drinking is a serious public health problem, relatively few studies have investigated the relationship between specific dopaminergic genes such as the dopamine d4 receptor (drd4) and binge drinking attitudinal phenotypes. |
2009-05-28 |
2023-08-12 |
Not clear |
| Laura L Klitten, Martin F Rath, Steven L Coon, Jong-So Kim, David C Klein, Morten Mølle. Localization and regulation of dopamine receptor D4 expression in the adult and developing rat retina. Experimental eye research. vol 87. issue 5. 2009-04-02. PMID:18778704. |
the high drd4 expression in the rat retinal photoreceptors during the night supports physiological and pharmacologic evidence that the drd4 receptor is involved in the dopaminergic inhibition of melatonin synthesis upon light stimulation. |
2009-04-02 |
2023-08-12 |
rat |
| M H van IJzendoorn, M J Bakermans-Kranenburg, J Mesma. Dopamine system genes associated with parenting in the context of daily hassles. Genes, brain, and behavior. vol 7. issue 4. 2008-06-25. PMID:17973921. |
the other combinations of comt and drd4 polymorphisms did not show significant associations between daily hassles and maternal sensitivity, suggesting differential susceptibility to hassles depending on parents' dopaminergic system genes. |
2008-06-25 |
2023-08-12 |
Not clear |
| Eliza Congdon, Klaus Peter Lesch, Turhan Canl. Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: implications for impulsivity. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 1. 2008-04-03. PMID:17525955. |
the present study was therefore undertaken in a sample of healthy adults to investigate the influence of two candidate dopaminergic gene polymorphisms (drd4 and dat) on the endophenotype of impulsivity, which we operationalized as behavioral inhibition during the stop-signal task. |
2008-04-03 |
2023-08-12 |
Not clear |
| Ulrike M Krämer, Toni Cunillera, Estela Càmara, Josep Marco-Pallarés, David Cucurell, Wido Nager, Peter Bauer, Rebecca Schüle, Ludger Schöls, Antoni Rodriguez-Fornells, Thomas F Münt. The impact of catechol-O-methyltransferase and dopamine D4 receptor genotypes on neurophysiological markers of performance monitoring. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094258. |
here, we studied the impact of two polymorphisms affecting dopaminergic functioning in the prefrontal cortex [catechol-o-methyltransferase (comt) val108/158met and dopamine d4 receptor (drd4) single-nucleotide polymorphism (snp)-521] on neurophysiological correlates of performance monitoring. |
2008-01-14 |
2023-08-12 |
human |
| Daniela Sabbatini da Silva Lobo, Homero P Vallada, Joanne Knight, Silvia S Martins, Hermano Tavares, Valentim Gentil, James L Kenned. Dopamine genes and pathological gambling in discordant sib-pairs. Journal of gambling studies. vol 23. issue 4. 2007-11-09. PMID:17394052. |
recent studies have suggested the involvement of the dopaminergic system in addictions and impulse control disorders and associations of dopamine receptor genes (drd1, drd2, and drd4) and pg have been reported. |
2007-11-09 |
2023-08-12 |
human |
| Cristian Patrick Zeni, Ana Paula Guimarães, Guilherme V Polanczyk, Julia P Genro, Tatiana Roman, Mara H Hutz, Luis Augusto Rohd. No significant association between response to methylphenidate and genes of the dopaminergic and serotonergic systems in a sample of Brazilian children with attention-deficit/hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 3. 2007-07-18. PMID:17171656. |
we assessed effects of polymorphisms in candidate dopaminergic (drd4, dat1) and serotonergic genes (htr1b, htr2a, and 5-htt) on the response to treatment in 111 patients for whom methylphenidate (mph) was prescribed. |
2007-07-18 |
2023-08-12 |
Not clear |
| C Mehler-Wex, P Riederer, M Gerlac. Dopaminergic dysbalance in distinct basal ganglia neurocircuits: implications for the pathophysiology of Parkinson's disease, schizophrenia and attention deficit hyperactivity disorder. Neurotoxicity research. vol 10. issue 3-4. 2007-03-20. PMID:17197367. |
genetic studies have shown an association between adhd and genes involved in dopaminergic neurotransmission (for example the dopamine receptor genes drd4 and drd5, and the dat gene dat1). |
2007-03-20 |
2023-08-12 |
mouse |
| Johannes Müller, Gesine Dreisbach, Burkhard Brocke, Klaus-Peter Lesch, Alexander Strobel, Thomas Goschk. Dopamine and cognitive control: the influence of spontaneous eyeblink rate, DRD4 exon III polymorphism and gender on flexibility in set-shifting. Brain research. vol 1131. issue 1. 2007-03-09. PMID:17156756. |
we investigated the influence of two correlates of dopaminergic activity, the spontaneous eyeblink rate and the drd4 exon iii polymorphism, and the potential impact of gender on flexibility in an attentional set-shifting paradigm. |
2007-03-09 |
2023-08-12 |
human |
| Benno Graf Schimmelmann, Susann Friedel, Hanna Christiansen, Astrid Dempfle, Anke Hinney, Johannes Hebebran. [Genetic findings in Attention-Deficit and Hyperactivity Disorder (ADHD)]. Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie. vol 34. issue 6. 2007-01-29. PMID:17094061. |
meta-analyses of a large number of candidate gene studies suggest association with gene variants of the dopaminergic receptors drd4 and drd5, the serotonergic receptor htr1b, and the synaptosomal receptor protein (snap-25). |
2007-01-29 |
2023-08-12 |
Not clear |
| Alessandro Serretti, Laura Mandelli, Cristina Lorenzi, Samuela Landoni, Raffaella Calati, Chiara Insacco, C Robert Cloninge. Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms. Neuropsychobiology. vol 53. issue 1. 2006-05-11. PMID:16319504. |
we focused on genes of the serotoninergic and dopaminergic systems (dopamine receptor d4 gene, drd4; serotonin transporter gene, promoter region sertpr; tryptophan hydroxylase gene, tph; monoamine oxidase a gene, mao-a). |
2006-05-11 |
2023-08-12 |
human |
| Alexander Strobel, Stefan Debener, Kristin Anacker, Johannes Müller, Klaus-Peter Lesch, Burkhard Brock. Dopamine D4 receptor exon III genotype influence on the auditory evoked novelty P3. Neuroreport. vol 15. issue 15. 2005-04-08. PMID:15640766. |
in a sample of 46 healthy volunteers, we observed an interactive effect of drd4 exon iii genotype and the eye-blink rate, a measure of central dopaminergic activity, on the novelty p3. |
2005-04-08 |
2023-08-12 |
human |
| Alexander Strobel, Stefan Debener, Kristin Anacker, Johannes Müller, Klaus-Peter Lesch, Burkhard Brock. Dopamine D4 receptor exon III genotype influence on the auditory evoked novelty P3. Neuroreport. vol 15. issue 15. 2005-04-08. PMID:15640766. |
these findings suggest that the drd4 exon iii polymorphism influences the processing of novelty and that this influence depends on tonic dopaminergic activity. |
2005-04-08 |
2023-08-12 |
human |
| Alda M Ambrósio, James L Kennedy, Fabio Macciardi, Cathy Barr, Maria J Soares, Catarina R Oliveira, Carlos N Pat. No evidence of association or linkage disequilibrium between polymorphisms in the 5' upstream and coding regions of the dopamine D4 receptor gene and schizophrenia in a Portuguese population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 125B. issue 1. 2005-03-21. PMID:14755438. |
alterations in dopaminergic system have been implicated in the pathophysiology of this disease for many years, and this study was performed to assess the possible involvement of the dopamine d4 receptor (drd4) gene polymorphisms either in the 5' upstream or in the coding regions, in the etiology of schizophrenia. |
2005-03-21 |
2023-08-12 |
Not clear |
| Lindsey Ken. Recent advances in the genetics of attention deficit hyperactivity disorder. Current psychiatry reports. vol 6. issue 2. 2004-07-20. PMID:15038917. |
association findings for several candidate genes within the dopaminergic system, the drd4 and drd5 receptor genes and the dopamine transporter gene, dat1, have been well replicated, and the first of several ongoing genome linkage scan study results have been published. |
2004-07-20 |
2023-08-12 |
Not clear |
| Naomi Lowe, Aiveen Kirley, Ziarih Hawi, Pak Sham, Harvey Wickham, Christopher J Kratochvil, Shelley D Smith, Saretta Y Lee, Florence Levy, Lindsey Kent, Fiona Middle, Luis A Rohde, Tatiana Roman, Eda Tahir, Yanke Yazgan, Philip Asherson, Jonathan Mill, Anita Thapar, Antony Payton, Richard D Todd, Timothy Stephens, Richard P Ebstein, Iris Manor, Cathy L Barr, Karen G Wigg, Richard J Sinke, Jan K Buitelaar, Susan L Smalley, Stan F Nelson, Joseph Biederman, Stephen V Faraone, Michael Gil. Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. American journal of human genetics. vol 74. issue 2. 2004-04-06. PMID:14732906. |
the disorder has a significant genetic component, and theories of etiology include abnormalities in the dopaminergic system, with drd4, dat1, snap25, and drd5 being implicated as major susceptibility genes. |
2004-04-06 |
2023-08-12 |
Not clear |
| Yoshiji Yamada, Fujiko Ando, Naoakira Niino, Hiroshi Shimokat. Association of a polymorphism of the dopamine receptor D4 gene with bone mineral density in Japanese men. Journal of human genetics. vol 48. issue 12. 2004-02-26. PMID:14605948. |
given that the dopaminergic system might also play an important role in bone metabolism, the relation of the -521c-->t polymorphism of drd4 to bone mineral density (bmd) was examined in 2,228 japanese subjects (1,123 men; 1,105 women) who were randomly recruited to a population-based, prospective cohort study. |
2004-02-26 |
2023-08-12 |
human |
| A Strobel, S Debener, D Schmidt, R Hünnerkopf, K-P Lesch, B Brock. Allelic variation in serotonin transporter function associated with the intensity dependence of the auditory evoked potential. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 118B. issue 1. 2003-07-14. PMID:12627465. |
because dopaminergic influences on the intensity dependence have also been reported, we furthermore explored the role of a functional polymorphism in the dopamine d4 receptor gene (drd4 exon iii) in the modulation of the aep intensity dependence. |
2003-07-14 |
2023-08-12 |
Not clear |