| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ching-Chi Chiu, Yi-Hsin Weng, Tu-Hsueh Yeh, Juu-Chin Lu, Wan-Shia Chen, Allen Han-Ren Li, Ying-Ling Chen, Kuo-Chen Wei, Hung-Li Wan. Deficiency of RAB39B Activates ER Stress-Induced Pro-apoptotic Pathway and Causes Mitochondrial Dysfunction and Oxidative Stress in Dopaminergic Neurons by Impairing Autophagy and Upregulating α-Synuclein. Molecular neurobiology. 2023-01-30. PMID:36715921. |
cellular model of deletion or mutation of rab39b gene-induced pd was prepared by knocking down endogenous rab39b in human sh-sy5y dopaminergic cells. |
2023-01-30 |
2023-08-14 |
human |
| Ching-Chi Chiu, Yi-Hsin Weng, Tu-Hsueh Yeh, Juu-Chin Lu, Wan-Shia Chen, Allen Han-Ren Li, Ying-Ling Chen, Kuo-Chen Wei, Hung-Li Wan. Deficiency of RAB39B Activates ER Stress-Induced Pro-apoptotic Pathway and Causes Mitochondrial Dysfunction and Oxidative Stress in Dopaminergic Neurons by Impairing Autophagy and Upregulating α-Synuclein. Molecular neurobiology. 2023-01-30. PMID:36715921. |
deficiency of rab39b activates er stress-induced pro-apoptotic pathway and causes mitochondrial dysfunction and oxidative stress in dopaminergic neurons by impairing autophagy and upregulating α-synuclein. |
2023-01-30 |
2023-08-14 |
human |
| Ching-Chi Chiu, Yi-Hsin Weng, Tu-Hsueh Yeh, Juu-Chin Lu, Wan-Shia Chen, Allen Han-Ren Li, Ying-Ling Chen, Kuo-Chen Wei, Hung-Li Wan. Deficiency of RAB39B Activates ER Stress-Induced Pro-apoptotic Pathway and Causes Mitochondrial Dysfunction and Oxidative Stress in Dopaminergic Neurons by Impairing Autophagy and Upregulating α-Synuclein. Molecular neurobiology. 2023-01-30. PMID:36715921. |
transfection of shrna-induced 90% reduction in rab39b level significantly decreased viability of sh-sy5y dopaminergic neurons. |
2023-01-30 |
2023-08-14 |
human |
| Ching-Chi Chiu, Yi-Hsin Weng, Tu-Hsueh Yeh, Juu-Chin Lu, Wan-Shia Chen, Allen Han-Ren Li, Ying-Ling Chen, Kuo-Chen Wei, Hung-Li Wan. Deficiency of RAB39B Activates ER Stress-Induced Pro-apoptotic Pathway and Causes Mitochondrial Dysfunction and Oxidative Stress in Dopaminergic Neurons by Impairing Autophagy and Upregulating α-Synuclein. Molecular neurobiology. 2023-01-30. PMID:36715921. |
we hypothesized that deletion and mutation of rab39b gene induce degeneration of dopaminergic neurons by decreasing protein level of functional rab39b and causing rab39b deficiency. |
2023-01-30 |
2023-08-14 |
human |
| Yujing Gao, Gabrielle R Wilson, Sarah E M Stephenson, Mustapha Oulad-Abdelghani, Nicolas Charlet-Berguerand, Kiymet Bozaoglu, Catriona A McLean, Paul Q Thomas, David I Finkelstein, Paul J Lockhar. Distribution of Parkinson's disease associated RAB39B in mouse brain tissue. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32228644. |
we found high levels of rab39b within map2 positive cortical and hippocampal neurons, and th positive dopaminergic neurons in the substantia nigra pars compacta.our studies support and extend current knowledge of the localization of rab39b. |
2021-02-03 |
2023-08-13 |
mouse |