| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jo Sourbron, Lieven Laga. Fenfluramine: a plethora of mechanisms? Frontiers in pharmacology. vol 14. 2023-05-30. PMID:37251322. |
dopaminergic activity underlies appetite reduction, a common side effect with fenfluramine treatment, but any involvement in seizure reduction remains speculative. |
2023-05-30 |
2023-08-14 |
Not clear |
| Christophe Tribouilloy, Yannick Jobi. [Drug-induced valve heart disease]. La Revue du praticien. vol 66. issue 8. 2019-05-16. PMID:30512542. |
numerous reports have shown an unquestionable association between fibrotic valve heart disease (vhd) and the following drugs: ergot alkaloids (methysergide and ergotamine), ergot-derived dopaminergic agonists (pergolide and cabergoline) and drugs metabolized into norfenfluramine (fenfluramine, dexfenfluramine and benfluorex). |
2019-05-16 |
2023-08-13 |
Not clear |
| Michel Andrejak, Christophe Tribouillo. Drug-induced valvular heart disease: an update. Archives of cardiovascular diseases. vol 106. issue 5. 2013-10-22. PMID:23769407. |
numerous reports have shown an unquestionable association between fibrotic valve disease and the following drugs: ergot alkaloids (such as methysergide and ergotamine), ergot-derived dopaminergic agonists (such as pergolide and cabergoline) and drugs metabolized into norfenfluramine (such as fenfluramine, dexfenfluramine and benfluorex). |
2013-10-22 |
2023-08-12 |
Not clear |
| Laura S Lubbers, Peter T Zafian, Claris Gautreaux, Marisa Gordon, Stephen E Alves, Lucia Correa, Daniel S Lorrain, Gerard J Hickey, Victoria Luin. Estrogen receptor (ER) subtype agonists alter monoamine levels in the female rat brain. The Journal of steroid biochemistry and molecular biology. vol 122. issue 5. 2010-11-23. PMID:20800684. |
however, e and the erβ agonist increased levels of the dopaminergic metabolite, hva following fenfluramine. |
2010-11-23 |
2023-08-12 |
rat |
| Ada Ledonne, Luca Sebastianelli, Mauro Federici, Giorgio Bernardi, Nicola Biagio Mercur. The anorexic agents, sibutramine and fenfluramine, depress GABA(B)-induced inhibitory postsynaptic potentials in rat mesencephalic dopaminergic cells. British journal of pharmacology. vol 156. issue 6. 2009-07-20. PMID:19298257. |
the anorexic agents, sibutramine and fenfluramine, depress gaba(b)-induced inhibitory postsynaptic potentials in rat mesencephalic dopaminergic cells. |
2009-07-20 |
2023-08-12 |
rat |
| K M Kampman, J Volpicell. Combination of the dopaminergic agent, phentermine, and the serotonergic agent, fenfluramine, in the treatment of cocaine dependence. Journal of substance abuse treatment. vol 14. issue 4. 1998-01-07. PMID:9368218. |
combination of the dopaminergic agent, phentermine, and the serotonergic agent, fenfluramine, in the treatment of cocaine dependence. |
1998-01-07 |
2023-08-12 |
Not clear |
| M E Tancer, R B Mailman, M B Stein, G A Mason, S W Carson, R N Golde. Neuroendocrine responsivity to monoaminergic system probes in generalized social phobia. Anxiety. vol 1. issue 5. 1997-06-18. PMID:9160577. |
a double-blind, placebo-controlled, neuropharmacological challenge study was performed using probes for the serotonergic (fenfluramine), dopaminergic (levodopa), and noradrenergic (clonidine) systems. |
1997-06-18 |
2023-08-12 |
human |
| Y Zheng, B Russell, D Schmierer, R Lavert. The effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice. The Journal of pharmacy and pharmacology. vol 49. issue 1. 1997-04-24. PMID:9120777. |
aminorex and its analogues, with exception of 4s, 5s-dimethylaminorex, did not cause the long-term neurotransmitter depletion in either the dopaminergic or 5-ht-ergic systems that was observed after mdma or fenfluramine in cba mice. |
1997-04-24 |
2023-08-12 |
mouse |
| A Margolin, S K Avants, T R Koste. Pemoline for the treatment of cocaine dependence in methadone-maintained patients. Journal of psychoactive drugs. vol 28. issue 3. 1997-02-18. PMID:8895115. |
in view of suggestions that dopaminergic agents in the treatment of addictions may be enhanced when combined with serotonergic agents, a single-case study of pemoline plus fenfluramine is also reported. |
1997-02-18 |
2023-08-12 |
Not clear |
| W Zajaczkowski, E Moryl, M Pap. Discriminative stimulus effects of the NMDA receptor antagonists MK-801 and CGP 37849 in rats. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870053. |
in generalization tests the role of dopaminergic and serotonergic systems in the discriminative stimulus effects produced by both nmda receptor antagonists was studied with amphetamine (0.5 mg/kg), cocaine (5.0 and 7.5 mg/kg), and fenfluramine (2.5 and 5.0 mg/kg). |
1997-01-23 |
2023-08-12 |
rat |
| N Maeda, N Matsuoka, I Yamaguch. Role of the dopaminergic, serotonergic and cholinergic link in the expression of penile erection in rats. Japanese journal of pharmacology. vol 66. issue 1. 1995-03-21. PMID:7861668. |
the penile erection induced by fenfluramine (1 mg/kg) was dose-dependently antagonized by pindolol (0.1-3.2 mg/kg), a 5-ht1 antagonist, or scopolamine (0.032-1 mg/kg), a muscarinic antagonist, but not by sulpiride (1-32 mg/kg), a dopaminergic antagonist. |
1995-03-21 |
2023-08-12 |
rat |
| E Mignot, A Renaud, S Nishino, J Arrigoni, C Guilleminault, W C Demen. Canine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancers. Psychopharmacology. vol 113. issue 1. 1995-03-20. PMID:7862832. |
a total of 14 compounds acting on the adrenergic (desipramine, nisoxetine, nortriptyline, tomoxetine, viloxazine), serotoninergic (fenfluramine, fluoxetine, indalpine, paroxetine, zimelidine) and dopaminergic (amfonelic acid, amineptine, bupropion, gbr 12909) systems were tested. |
1995-03-20 |
2023-08-12 |
human |
| N Maeda, N Matsuoka, I Yamaguch. Possible involvement of the septo-hippocampal cholinergic and raphe-hippocampal serotonergic activations in the penile erection induced by fenfluramine in rats. Brain research. vol 652. issue 2. 1994-12-29. PMID:7953728. |
the septo-hippocampal cholinergic deafferentations by medial septum lesion or fimbria-fornix transection also attenuated the penile erection induced by fenfluramine, whereas dopaminergic blockade by sulpiride (3.2-100 mg/kg) had hardly any effect. |
1994-12-29 |
2023-08-12 |
rat |
| G Torres, C Rivie. Induction of c-fos in rat brain by acute cocaine and fenfluramine exposure: a comparison study. Brain research. vol 647. issue 1. 1994-09-26. PMID:8069690. |
although cocaine shares the ability of fenfluramine to inhibit the synaptic reuptake of serotonin, previous observations from our group suggest that the genomic effects of fenfluramine in the rat striatum are primarily mediated by dopaminergic rather than serotonergic mechanisms. |
1994-09-26 |
2023-08-12 |
rat |
| R W Folti. Differential development of tolerance to the effects of d-amphetamine and fenfluramine on food intake in baboons. The Journal of pharmacology and experimental therapeutics. vol 252. issue 3. 1990-05-03. PMID:2319478. |
the absence of cross-tolerance or increased sensitivity between amphetamine and fenfluramine suggests that although both serotonergic and dopaminergic systems are involved in feeding, they can influence food intake independently. |
1990-05-03 |
2023-08-11 |
Not clear |
| N Bruneau, C Barthélémy, S Roux, J Jouve, G Lelor. Auditory evoked potential modifications according to clinical and biochemical responsiveness to fenfluramine treatment in children with autistic behavior. Neuropsychobiology. vol 21. issue 1. 1989-12-01. PMID:2682347. |
electrophysiological data were affected according to the clinical and biochemical responsiveness to fenfluramine: the auditory evoked potential amplitude increased, and the single-trial potential variability decreased at each intensity level only in responders whose dopaminergic metabolism was significantly modified by fenfluramine treatment. |
1989-12-01 |
2023-08-11 |
Not clear |
| C Barthelemy, N Bruneau, J Jouve, J Martineau, J P Muh, G Lelor. Urinary dopamine metabolites as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior. Journal of autism and developmental disorders. vol 19. issue 2. 1989-08-21. PMID:2745390. |
these results suggest that the clinical response to fenfluramine could be related to the dopaminergic action of this drug and that urinary da metabolite levels could be considered as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior. |
1989-08-21 |
2023-08-11 |
human |
| R P Maickel, K Johnson, D R Kinne. Effects of anorectic agents in rats bearing the Walker-256 tumor. Research communications in chemical pathology and pharmacology. vol 58. issue 3. 1988-04-07. PMID:3438577. |
the results obtained by dosage of d-amphetamine, fenfluramine or mazindol, on days 5 and 8 after tumor implantation, failed to demonstrate conclusively any predominant modification of a dopaminergic, noradrenergic, or serotonergic system in the anorectic effects of these agents. |
1988-04-07 |
2023-08-11 |
rat |
| M F Sugru. Neuropharmacology of drugs affecting food intake. Pharmacology & therapeutics. vol 32. issue 2. 1987-07-24. PMID:2885862. |
the statements that amphetamine-induced anorexia is unlikely to be due to central serotoninergic systems and that central noradrenergic and dopaminergic systems are not implicated in the appetite suppressant effect of fenfluramine are in all probability correct. |
1987-07-24 |
2023-08-11 |
Not clear |
| C Foresta, G Scanelli, A Tramarin, C Scandellar. Serotonin but not dopamine is involved in the naloxone-induced luteinizing hormone release in man. Fertility and sterility. vol 43. issue 3. 1985-04-29. PMID:3979585. |
two experimental models were studied, and two sets of effects on lh secretion induced by intravenous naloxone infusion (20 mg over 2 hours) in 14 normal men 20 to 25 years of age were evaluated: the effect of oral sulpiride (150 mg), a potent dopaminergic antagonist, and the effect of oral fenfluramine (60 mg), a drug that stimulates the serotoninergic receptors by releasing serotonin and inhibiting its reuptake. |
1985-04-29 |
2023-08-11 |
Not clear |