| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeyaram Bharathi J, Nagarjuna Palathoti, Muralikrishnan Dhanasekaran, R Sivasamy, Sivasankaran Ponnusankar, S P Dhanabal, V Sankar, Antony Justi. Neurotrophin mimetics and tropomyosin kinase receptors: a futuristic pharmacological tool for Parkinson's. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology vol issue 2023 36870001 |
while the motor symptoms and its clinical manifestations are attributed to the nigral dopaminergic neuronal death and basal ganglia dysfunction, studies have subsequently proven that the non-dopaminergic neurons in various brain regions are also additionally involved with the disease progression. |
2023-03-04 |
2023-03-06 |
Not clear |
| Sanghoon Kim, Edward Pajarillo, Ivan Nyarko-Danquah, Michael Aschner, Eunsook Le. Role of Astrocytes in Parkinson's Disease Associated with Genetic Mutations and Neurotoxicants. Cells vol 12 issue 4 2023 36831289 |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the aggregation of lewy bodies in the basal ganglia, resulting in movement impairment referred to as parkinsonism. |
2023-02-25 |
2023-03-06 |
Not clear |
| Sanghoon Kim, Edward Pajarillo, Ivan Nyarko-Danquah, Michael Aschner, Eunsook Le. Role of Astrocytes in Parkinson's Disease Associated with Genetic Mutations and Neurotoxicants. Cells vol 12 issue 4 2023 36831289 |
in the pd brain, dopaminergic neurons degenerate mainly in the basal ganglia, but recently emerging evidence has shown that astrocytes also significantly contribute to dopaminergic neuronal death. |
2023-02-25 |
2023-03-06 |
Not clear |
| Maeri Yamamoto, Toshiya Inad. Positron emission tomography studies in adult patients with attention-deficit/hyperactivity disorder. Japanese journal of radiology vol issue 2022 36480104 |
several previous pet studies on the central dopaminergic transmission-related ligands in patients with adhd have shown altered binding of dopamine markers in the basal ganglia. |
2022-12-08 |
2023-01-30 |
Not clear |
| Manabu Kubota, Keisuke Takahata, Kiwamu Matsuoka, Yasunori Sano, Yasuharu Yamamoto, Kenji Tagai, Ryosuke Tarumi, Hisaomi Suzuki, Shin Kurose, Shinichiro Nakajima, Hiroki Shiwaku, Chie Seki, Kazunori Kawamura, Ming-Rong Zhang, Hidehiko Takahashi, Yuhei Takado, Makoto Higuch. Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia. Schizophrenia bulletin vol issue 2022 36458958 |
phosphodiesterase 10a (pde10a) is a highly expressed enzyme in the basal ganglia, where cortical glutamatergic and midbrain dopaminergic inputs are integrated. |
2022-12-02 |
2023-01-30 |
Not clear |
| Thomas R Barber, Kinan Muhammed, Daniel Drew, Kevin M Bradley, Daniel R McGowan, Johannes C Klein, Sanjay G Manohar, Michele T M Hu, Masud Husai. Reward insensitivity is associated with dopaminergic deficit in rapid eye movement sleep behaviour disorder. Brain : a journal of neurology vol issue 2022 36395092 |
here, we investigate whether a non-invasive, objective measure of reward sensitivity might be a marker of dopaminergic status in prodromal parkinson's, by comparing with spect/ct measurement of dopaminergic loss in the basal ganglia. |
2022-11-17 |
2023-01-30 |
Not clear |
| Silvia Rota, Daniele Urso, Daniel J van Wamelen, Valentina Leta, Iro Boura, Per Odin, Alberto J Espay, Peter Jenner, K Ray Chaudhur. Why do 'OFF' periods still occur during continuous drug delivery in Parkinson's disease? Translational neurodegeneration vol 11 issue 1 2022 36229860 |
we propose that changes in dopaminergic and non-dopaminergic mechanisms in the basal ganglia might render these persistent 'off' periods unresponsive to dopaminergic therapy delivered via cdd. |
2022-10-13 |
2023-01-30 |
Not clear |
| Irina Ivan, Laura Irincu, \\xc5\\x9etefania Diaconu, Cristian Falup-Pecurari. Parkinsonism associated with viral infection. International review of neurobiology vol 165 issue 2022 36208896 |
in some cases, lesions or inflammatory processes in the basal ganglia or substantia nigra have been found to cause reversible or permanent impairment of the dopaminergic pathway, leading to the occurrence of extrapyramidal symptoms. |
2022-10-08 |
2023-01-30 |
human |
| Alexander N Rodichkin, Melissa K Edler, Jennifer L McGlothan, Tom\\xc3\\xa1s R Guilart. Pathophysiological studies of aging Slc39a14 knockout mice to assess the progression of Manganese-Induced Dystonia-Parkinsonism. Neurotoxicology vol issue 2022 36152728 |
neurochemical, neuropathological, and functional assessment of the dopaminergic system of the basal ganglia revealed absence of neurodegenerative changes of dopamine (da) neurons in the substantia nigra pars compacta (snc), with no changes in da or metabolite concentrations in the striatum of slc39a14-ko mice relative to wildtype (wt). |
2022-09-24 |
2023-01-30 |
mouse |
| Joshua Fejeran, Frank Salazar, Cesia M Alvarez, Faisal R Jahangir. Deep Brain Stimulation and Microelectrode Recording for the Treatment of Parkinson's Disease. Cureus vol 14 issue 8 2022 36110462 |
parkinson's disease (pd) is a neurological disorder in which nigrostriatal pathways involving the basal ganglia experience a decrease in neural activity regarding dopaminergic neurons.\xc2\xa0pd symptoms, such as muscle stiffness and involuntary tremors, have an adverse impact on the daily lives of those affected.\xc2\xa0current medical treatments seek to decrease the severity of these symptoms.\xc2\xa0deep brain stimulation (dbs) has become the preferred safe, and reliable treatment approach.\xc2\xa0dbs involves implanting microelectrodes into subcortical areas that produce electrical impulses directly to high populations of dopaminergic neurons.\xc2\xa0the most common targets are the subthalamic nucleus (stn), and the basal ganglia's globus pallidus pars interna (gpi).\xc2\xa0research studies suggest that dbs of the stn may cause a significant reduction in the daily dose of l-dopa compared to dbs of the gpi.\xc2\xa0dbs of the stn has suggested that there may be sweet spots within the stn that provide hyper-direct cortical connectivity pathways to the primary motor cortex (m1), supplementary motor area (sma), and prefrontal cortex (pfc).\xc2\xa0in addition, the pedunculopontine nucleus (ppn) may be a new target for dbs that helps treat locomotion problems associated with gait and posture.\xc2\xa0both microelectrode recording (mer) and magnetic resonance imaging (mri) are used to ensure electrode placement accuracy.\xc2\xa0using mer, stimulation of the stn at high frequencies (140<) decreased oscillatory neuronal firing by 67%.\xc2\xa0this paper investigates methods of intraoperative neuromonitoring during dbs as a form of pd treatment. |
2022-09-16 |
2023-01-30 |
Not clear |
| Arianna Bellucci, Francesca Longhena, Maria Grazia Spillantin. The Role of Rab Proteins in Parkinson's Disease Synaptopathy. Biomedicines vol 10 issue 8 2022 36009486 |
in patients affected by parkinson's disease (pd), the most common neurodegenerative movement disorder, the brain is characterized by the loss of dopaminergic neurons in the nigrostriatal system, leading to dyshomeostasis of the basal ganglia network activity that is linked to motility dysfunction. |
2022-08-26 |
2023-01-30 |
Not clear |
| Elissavet Akrioti, Timokratis Karamitros, Panagiotis Gkaravelas, Georgia Kouroupi, Rebecca Matsas, Era Taoufi. Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease. Biomolecules vol 12 issue 7 2022 35883433 |
neurodegeneration of dopamine neurons leads to a prominent dopaminergic deficiency in the basal ganglia, responsible for motor disturbances. |
2022-07-27 |
2023-01-30 |
Not clear |
| Winston W Liu, Diego V Boh\\xc3\\xb3rque. The neural basis of sugar preference. Nature reviews. Neuroscience vol issue 2022 35879409 |
based on these and other data, we propose a model in which specific populations of vagal neurons relay these sensory cues to distinct sets of neurons in the brain, including neurons in the caudal nucleus of the solitary tract, dopaminergic reward circuits in the basal ganglia and homeostatic feeding circuits in the hypothalamus, that alter current and future sugar consumption. |
2022-07-25 |
2023-01-30 |
Not clear |
| Rosa Mastrogiacomo, Gabriella Trigilio, C\\xc3\\xa9line Devroye, Daniel Dautan, Valentina Ferretti, Gabriele Losi, Lucia Caffino, Genny Orso, Roberto Marotta, Federica Maltese, Enrica Vitali, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Annamaria Lia, Debora A Rothmond, John L Waddington, Filippo Drago, Fabio Fumagalli, Maria Antonietta De Luca, Gian Marco Leggio, Giorgio Carmignoto, Cynthia S Weickert, Francesca Manag\\xc3\\xb2, Francesco Papale. Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia. Molecular psychiatry vol issue 2022 35821415 |
in agreement, dys1a disruption only in astrocytes resulted in decreased motivation and sensorimotor gating deficits, increased astrocytic dopamine d2 receptors and decreased dopaminergic tone within basal ganglia. |
2022-07-13 |
2023-01-27 |
mouse |
| Rosa Mastrogiacomo, Gabriella Trigilio, C\\xc3\\xa9line Devroye, Daniel Dautan, Valentina Ferretti, Gabriele Losi, Lucia Caffino, Genny Orso, Roberto Marotta, Federica Maltese, Enrica Vitali, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Annamaria Lia, Debora A Rothmond, John L Waddington, Filippo Drago, Fabio Fumagalli, Maria Antonietta De Luca, Gian Marco Leggio, Giorgio Carmignoto, Cynthia S Weickert, Francesca Manag\\xc3\\xb2, Francesco Papale. Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia. Molecular psychiatry vol issue 2022 35821415 |
therefore, we started to show a hitherto unknown role for the dys1a isoform in astrocytic-related modulation of basal ganglia behavioral and dopaminergic phenotypes, with relevance to schizophrenia. |
2022-07-13 |
2023-01-27 |
mouse |
| Arjun Patel, Catherine A Olang, Gregory Lewis, Kesava Mandalaneni, Nikhilesh Anand, Vasavi Rakesh Gorantl. An Overview of Parkinson's Disease: Curcumin as a Possible Alternative Treatment. Cureus vol 14 issue 5 2022 35719816 |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by dopamine deficiency in the brain. |
2022-06-20 |
2023-01-27 |
Not clear |
| Naohisa Ueda, Yuichi Higashiyama, Asami Saito, Katsuo Kimura, Yoshiharu Nakae, Masanao Endo, Hideto Joki, Chiharu Kugimoto, Hitaru Kishida, Hiroshi Doi, Hideyuki Takeuchi, Shigeru Koyano, Fumiaki Tanak. Relationship between motor learning and gambling propensity in Parkinson's disease. Journal of clinical and experimental neuropsychology vol issue 2022 35658796 |
the basal ganglia and related dopaminergic cortical areas are important neural systems underlying motor learning and are also implicated in impulse control disorders (icds). |
2022-06-06 |
2023-01-27 |
Not clear |
| Miriam Schirru, Florence V\\xc3\\xa9ronneau-Veilleux, Fahima Nekka, Mauro Ursin. Phasic Dopamine Changes and Hebbian Mechanisms during Probabilistic Reversal Learning in Striatal Circuits: A Computational Study. International journal of molecular sciences vol 23 issue 7 2022 35408811 |
the basal ganglia (bg) dopaminergic system, under a top-down control of the pre-frontal cortex, is known to be involved in flexible action selection through reinforcement learning. |
2022-04-12 |
2023-01-27 |
Not clear |
| Xiaodong Wang, Yinhao Wang, Jian Chen, Juan Li, Yang Liu, Wei Che. Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson's disease. Experimental brain research vol issue 2022 35384454 |
in parkinson's disease (pd) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (da) and glutamate (glu) levels change, resulting in dysfunction of basal ganglia motor regulation. |
2022-04-06 |
2023-01-27 |
mouse |
| Mehmet Nuri Kocak, Orhan Ates, Ahmet Hac\\xc4\\xb1muftuoglu, Irem Ates, Erdal Tekin, Onur Ceylan, Ufuk Okka. Does Intravitreal Dopamine Agonist and Antagonist Administration Have Effects on the Brain? An Experimental Study in Rats. The Eurasian journal of medicine vol 54 issue 1 2022 35307630 |
in this context, the study was aimed to investigate the possible interaction between the retina and basal ganglia through the dopaminergic system. |
2022-03-21 |
2023-01-27 |
rat |