| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Débora Masini, Ole Kieh. Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism. Nature communications. vol 13. issue 1. 2022-01-27. PMID:35082287. |
these motor actions are deficient in parkinson's disease (pd), where dopaminergic neurodegeneration alters basal ganglia activity. |
2022-01-27 |
2023-08-13 |
mouse |
| Dorota Frydecka, Błażej Misiak, Patryk Piotrowski, Tomasz Bielawski, Edyta Pawlak, Ewa Kłosińska, Maja Krefft, Kamila Al Noaimy, Joanna Rymaszewska, Ahmed A Moustafa, Jarosław Drapał. The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders. Brain sciences. vol 12. issue 1. 2022-01-21. PMID:35053751. |
schizophrenia spectrum disorders (sz) are characterized by impairments in probabilistic reinforcement learning (rl), which is associated with dopaminergic circuitry encompassing the prefrontal cortex and basal ganglia. |
2022-01-21 |
2023-08-13 |
human |
| Sandeep Sathyanandan Nair, Vignayanandam Ravindernath Muddapu, V Srinivasa Chakravarth. A Multiscale, Systems-Level, Neuropharmacological Model of Cortico-Basal Ganglia System for Arm Reaching Under Normal, Parkinsonian, and Levodopa Medication Conditions. Frontiers in computational neuroscience. vol 15. 2022-01-20. PMID:35046787. |
the model demonstrates how differential dopaminergic axonal degeneration in basal ganglia results in various cardinal symptoms of pd. |
2022-01-20 |
2023-08-13 |
Not clear |
| Robert Lalonde, Catherine Straziell. Neurochemical anatomy of dorsal and tonic immobility responses. Pharmacology, biochemistry, and behavior. 2022-01-13. PMID:35026175. |
the neurochemical basis of the dir appears to pass through the basal ganglia via dopaminergic fibers, while the neurochemical basis of the tir appears to include a circuit comprising the amygdala, the periaqueductal gray (pag), the dorsal raphe, and the nucleus magnus raphe (nmr) via glutamatergic, serotonergic, cholinergic, gabaergic, and opioid fibers. |
2022-01-13 |
2023-08-13 |
Not clear |
| Aviv D Mizrahi-Kliger, Lucia K Feldmann, Andrea A Kuhn, Hagai Bergma. Etiologies of insomnia in Parkinson's disease - Lessons from human studies and animal models. Experimental neurology. 2022-01-13. PMID:35026228. |
we start by outlining the phenomenology of pd insomnia and continue to analyze the evidence supporting insomnia as emanating from four distinct subdivisions of etiologies - the symptoms and comorbidities of the disease, the medical therapy, the degeneration of non-dopaminergic cell groups and subsequent alterations in circadian rhythms, and the degeneration of dopaminergic neurons in the brainstem and its resulting effect on the basal ganglia. |
2022-01-13 |
2023-08-13 |
human |
| Patrick D Skelton, Valerie Tokars, Loukia Parisiado. LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights. Cells. vol 11. issue 1. 2022-01-11. PMID:35011731. |
the lessons learned from improving our understanding of the pathogenic effects of lrrk2 mutations in striatal neurons will be applicable to both dissecting the cell-type specificity of lrrk2 function in the transcriptionally diverse subtypes of dopaminergic neurons and also increasing our understanding of basal ganglia development and biology. |
2022-01-11 |
2023-08-13 |
Not clear |
| Lan-Hsin Nancy Lee, Chen-Syuan Huang, Hsiang-Hao Chuang, Hsing-Jung Lai, Cheng-Kai Yang, Ya-Chin Yang, Chung-Chin Ku. An electrophysiological perspective on Parkinson's disease: symptomatic pathogenesis and therapeutic approaches. Journal of biomedical science. vol 28. issue 1. 2021-12-10. PMID:34886870. |
parkinson's disease (pd), or paralysis agitans, is a common neurodegenerative disease characterized by dopaminergic deprivation in the basal ganglia because of neuronal loss in the substantia nigra pars compacta. |
2021-12-10 |
2023-08-13 |
Not clear |
| Sena Çarıkcı, Nezehat Özgül Ünlüer, Şükrü Toru. Effects of cadence-compatible melodic rhythmic auditory stimulation implementation on gait in patients with Parkinson's disease. Somatosensory & motor research. vol 38. issue 2. 2021-12-01. PMID:33371768. |
progressive loss of dopaminergic neurons in basal ganglia is blamed as the main source of gait disturbance in parkinson's disease (pd). |
2021-12-01 |
2023-08-13 |
Not clear |
| Jae-Hyuk Shim, Hyeon-Man Bae. Diffusion Measure Changes of Substantia Nigra Subregions and the Ventral Tegmental Area in Newly Diagnosed Parkinson's Disease. Experimental neurobiology. vol 30. issue 5. 2021-11-19. PMID:34737241. |
additionally, we include the ventral tegmental area, a structure connected to various basal ganglia structures affected by dopaminergic neuronal loss and have historically shown significant alterations in parkinson's disease, in our analysis. |
2021-11-19 |
2023-08-13 |
Not clear |
| Canan Beate Schüller, Ben Jonathan Wagner, Thomas Schüller, Juan Carlos Baldermann, Daniel Huys, Julia Kerner Auch Koerner, Eva Niessen, Alexander Münchau, Valerie Brandt, Jan Peters, Jens Kuh. Temporal discounting in adolescents and adults with Tourette syndrome. PloS one. vol 16. issue 6. 2021-11-16. PMID:34143854. |
dopaminergic hyperactivity in the basal ganglia has previously been linked to increased sensitivity to positive reinforcement and increases in choice impulsivity. |
2021-11-16 |
2023-08-13 |
human |
| Eleanor Porter, Andreas-Antonios Roussakis, Nicholas P Lao-Kaim, Paola Piccin. Multimodal dopamine transporter (DAT) imaging and magnetic resonance imaging (MRI) to characterise early Parkinson's disease. Parkinsonism & related disorders. vol 79. 2021-11-15. PMID:32861103. |
currently, in early idiopathic pd, dopamine transporter (dat)-specific imaging assesses the extent of striatal dopaminergic deficits, and conventional magnetic resonance imaging (mri) of the brain excludes the presence of significant ischaemic load in the basal ganglia as well as signs indicative of other forms of parkinsonism. |
2021-11-15 |
2023-08-13 |
Not clear |
| B J Wilkes, J C DeSimone, Y Liu, W T Chu, S A Coombes, Y Li, D E Vaillancour. Cell-specific effects of Dyt1 knock-out on sensory processing, network-level connectivity, and motor deficits. Experimental neurology. vol 343. 2021-11-09. PMID:34119482. |
these findings suggest that (1) the added impact of torsina dysfunction in medium spiny and dopaminergic neurons of the basal ganglia generate more profound deficits than the dysfunction of cholinergic neurons alone, and (2) that sensory network impairments are linked to motor deficits in dyt1 dystonia. |
2021-11-09 |
2023-08-13 |
mouse |
| V M DeAngelo, J D Hilliard, G C McConnel. Dopaminergic but not cholinergic neurodegeneration is correlated with gait disturbances in PINK1 knockout rats. Behavioural brain research. vol 417. 2021-11-08. PMID:34534596. |
pd hallmarks include a decrease in stride length, run speed, and swing time; an increase in stride time, stance time, and base of support; dopaminergic degeneration in the basal ganglia; and cholinergic degeneration in the pedunculopontine nucleus (ppn). |
2021-11-08 |
2023-08-13 |
rat |
| b' Antonio Gennaro Nicotera, Gabriella Di Rosa, Laura Turriziani, Maria Cristina Costanzo, Emanuela Stracuzzi, Girolamo Aurelio Vitello, Rosanna Galati Rando, Antonino Musumeci, Mirella Vinci, Sebastiano Antonino Musumeci, Francesco Cal\\xc3\\xa. Role of COMT V158M Polymorphism in the Development of Dystonia after Administration of Antipsychotic Drugs. Brain sciences. vol 11. issue 10. 2021-10-26. PMID:34679357.' |
typically, dystonic movements are considered the result of impaired function and/or abnormalities of dopaminergic neurotransmission/signaling in the basal ganglia. |
2021-10-26 |
2023-08-13 |
Not clear |
| Alicia M P Warnecke, Moon S Kang, Michael W Jakowec, Daryl L Davie. The macrocyclic lactones ivermectin and moxidectin show differential effects on rotational behavior in the 6-hydroxydopamine mouse model of Parkinson's disease. Behavioural brain research. vol 393. 2021-10-25. PMID:32668263. |
p2 × 4rs are expressed throughout the central nervous system including the dopaminergic circuitry of the substantia nigra, basal ganglia, and related reward networks. |
2021-10-25 |
2023-08-13 |
mouse |
| Kathryn Biernacki, Mei-Heng Lin, Travis E Bake. Recovery of reward function in problematic substance users using a combination of robotics, electrophysiology, and TMS. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. vol 158. 2021-10-25. PMID:33068631. |
theoretical and empirical work suggest that addictive drugs potentiate dopaminergic reinforcement learning signals and disrupt the reward function of its neural targets, including the anterior midcingulate cortex (amcc) and the basal ganglia. |
2021-10-25 |
2023-08-13 |
Not clear |
| Reka Natarajan, Bryan K Yamamot. The Basal Ganglia as a Substrate for the Multiple Actions of Amphetamines. Basal ganglia. vol 1. issue 2. 2021-10-20. PMID:21804952. |
this review focuses on how alterations in dopaminergic neurotransmission within distinct basal ganglia pathways can modify their functional output to predict and explain the acute and long term behavioral consequences of amphetamine exposure. |
2021-10-20 |
2023-08-12 |
Not clear |
| Lars Freudenmacher, Maria Schauer, Wolfgang Walkowiak, Arndt von Twicke. Refinement of the dopaminergic system of anuran amphibians based on connectivity with habenula, basal ganglia, limbic system, pallium, and spinal cord. The Journal of comparative neurology. vol 528. issue 6. 2021-10-18. PMID:31617943. |
refinement of the dopaminergic system of anuran amphibians based on connectivity with habenula, basal ganglia, limbic system, pallium, and spinal cord. |
2021-10-18 |
2023-08-13 |
Not clear |
| Kim De Keyser, Miet De Letter, Patrick Santens, Durk Talsma, Dick Botteldooren, Annelies Bockstae. Neurophysiological investigation of auditory intensity dependence in patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 3. 2021-10-15. PMID:33515333. |
this interpretation is consistent with the involvement of the basal ganglia and the role of dopaminergic and serotonergic neurotransmission in auditory gating. |
2021-10-15 |
2023-08-13 |
human |
| Merve Kasap, Donard S Dwye. Na Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 6. 2021-10-15. PMID:33961117. |
na parkinson's disease (pd) is a debilitating movement disorder often accompanied by neuropsychiatric symptoms that stem from the loss of dopaminergic function in the basal ganglia and altered neurotransmission more generally. |
2021-10-15 |
2023-08-13 |
Not clear |