| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Hu, Huaming Cao, Jie Sheng, Yizhuo Sun, Yuping Zhu, Qin Lin, Na Yi, Siyu He, Luying Peng, Li L. The functional role of circRNA CHRC through miR-431-5p/KLF15 signaling axis in the progression of heart failure. Journal of genetics and genomics = Yi chuan xue bao. 2024-04-04. PMID:38575112. |
in summary, circrna chrc attenuates cardiac hypertrophy via sponging mir-431-5p to maintain the normal level of klf15 expression. |
2024-04-04 |
2024-04-07 |
mouse |
| Calum Forteath, Ify Mordi, Raid Nisr, Erika J Gutierrez-Lara, Noor Alqurashi, Iain R Phair, Amy R Cameron, Craig Beall, Ibrahim Nisr, Mohapradeep Mohan, Aaron K F Wong, Adel Dihoum, Anwar Mohammad, Colin N A Palmer, Douglas Lamont, Kei Sakamoto, Benoit Viollet, Marc Foretz, Chim C Lang, Graham Ren. Amino acid homeostasis is a target of metformin therapy. Molecular metabolism. 2023-06-11. PMID:37302544. |
in humans, metformin attenuated increased risk of left ventricular hypertrophy due to the aa allele of klf15, which is an inducer of bcaa catabolism. |
2023-06-11 |
2023-08-14 |
Not clear |
| Aditya Kumar, Starry He, Prashant Mal. Systematic discovery of transcription factors that improve hPSC-derived cardiomyocyte maturation via temporal analysis of bioengineered cardiac tissues. APL bioengineering. vol 7. issue 2. 2023-05-30. PMID:37252678. |
individually overexpressing each of these tfs in immature hpsc-cms identified five tfs (klf15, zbtb20, esrra, hopx, and camta2) as regulators of calcium handling, metabolic function, and hypertrophy. |
2023-05-30 |
2023-08-14 |
human |
| Ning Li, Ying-Jia Xu, Hong-Yu Shi, Chen-Xi Yang, Yu-Han Guo, Ruo-Gu Li, Xing-Biao Qiu, Yi-Qing Yang, Min Zhan. KLF15 Loss-of-Function Mutation Underlying Atrial Fibrillation as well as Ventricular Arrhythmias and Cardiomyopathy. Genes. vol 12. issue 3. 2021-08-03. PMID:33809104. |
the findings indicate klf15 as a new causative gene responsible for af as well as ventricular arrhythmias and hypertrophic cardiomyopathy, and they provide novel insight into the molecular mechanisms underlying cardiac arrhythmias and hypertrophic cardiomyopathy. |
2021-08-03 |
2023-08-13 |
human |
| Shu-Fan Zou, Yang Yu, Yan Peng, Ying-Bin Xiao, Zhao Jian, Yun-Han Jiang, Sai Chen, Fu-Qin Tang, Lin Che. KLF15 is a protective regulatory factor of heart failure induced by pressure overload. Molecular medicine reports. vol 21. issue 3. 2020-10-06. PMID:31922214. |
wt and tg mice subjected to 2 weeks of overload displayed adaptive lv hypertrophy characterized by ventricular thickness, cardiomyocyte size, ejection fraction and fractional shortening of heart‑lung weight ratio and klf15, and increases in vascular endothelial growth factor (vegf) expression without other pathological changes. |
2020-10-06 |
2023-08-13 |
mouse |
| Shu-Fan Zou, Yang Yu, Yan Peng, Ying-Bin Xiao, Zhao Jian, Yun-Han Jiang, Sai Chen, Fu-Qin Tang, Lin Che. KLF15 is a protective regulatory factor of heart failure induced by pressure overload. Molecular medicine reports. vol 21. issue 3. 2020-10-06. PMID:31922214. |
klf15 was revealed to be a critical factor regulating the expression of ctgf, vegf, p‑p38 and p‑smad3, and could alleviate the progression from adaptive lv hypertrophy to decompensatory cardiac insufficiency. |
2020-10-06 |
2023-08-13 |
mouse |
| Yuguang Zhao, Wenjing Song, Lizhe Wang, Madhavi J Rane, Fujun Han, Lu Ca. Multiple roles of KLF15 in the heart: Underlying mechanisms and therapeutic implications. Journal of molecular and cellular cardiology. vol 129. 2020-06-22. PMID:30831134. |
recent studies have also revealed a vital role for klf15 as an inhibitor of pathological cardiac hypertrophy and fibrosis via its effects on factors such as myocyte enhancer factor 2 (mef2), gata-binding protein 4 (gata4), transforming growth factor-β (tgf-β), and myocardin. |
2020-06-22 |
2023-08-13 |
Not clear |
| Claudia Noack, Lavanya M Iyer, Norman Y Liaw, Eric Schoger, Sara Khadjeh, Eva Wagner, Monique Woelfer, Maria-Patapia Zafiriou, Hendrik Milting, Samuel Sossalla, Katrin Streckfuss-Boemeke, Gerd Hasenfuß, Wolfram-Hubertus Zimmermann, Laura C Zelarayá. KLF15-Wnt-Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart. Journal of the American College of Cardiology. vol 74. issue 14. 2020-05-20. PMID:31582141. |
previous studies suggest klf15 as a key regulator of cm hypertrophy. |
2020-05-20 |
2023-08-13 |
Not clear |
| Sheila K Patel, Elena Velkoska, Daniel Gayed, Jay Ramchand, Jessica Lesmana, Louise M Burrel. Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15. BMC nephrology. vol 19. issue 1. 2019-05-24. PMID:29970016. |
the transcription factor kruppel-like factor 15 (klf15) is expressed in the heart and regulates cardiac remodelling through inhibition of hypertrophy and fibrosis. |
2019-05-24 |
2023-08-13 |
Not clear |
| Zhao Hui Zhuang, Yong Zhong, Yuec Han Chen, Zhi Wei Zhan. [Research progress on the roles of Krüppel-like factors in muscle tissues]. Yi chuan = Hereditas. vol 40. issue 9. 2019-03-28. PMID:30369477. |
in cardiac muscle, klf4, klf10, klf11 and klf15 are involved in the negative regulation of cardiac hypertrophy. |
2019-03-28 |
2023-08-13 |
human |
| Neil Hoa, Lisheng Ge, Kenneth S Korach, Ellis R Levi. Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents. Molecular and cellular endocrinology. vol 470. 2019-03-22. PMID:29127073. |
knockdown of klf15 in the myocytes induced myocyte hypertrophy and limited the anti-hypertrophic actions of e2 and β-lgnd2. |
2019-03-22 |
2023-08-13 |
rat |
| Neil Hoa, Lisheng Ge, Kenneth S Korach, Ellis R Levi. Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents. Molecular and cellular endocrinology. vol 470. 2019-03-22. PMID:29127073. |
estrogen receptor beta maintains expression of klf15 to prevent cardiac myocyte hypertrophy in female rodents. |
2019-03-22 |
2023-08-13 |
rat |
| Dan Shao, Outi Villet, Zhen Zhang, Sung Won Choi, Jie Yan, Julia Ritterhoff, Haiwei Gu, Danijel Djukovic, Danos Christodoulou, Stephen C Kolwicz, Daniel Raftery, Rong Tia. Glucose promotes cell growth by suppressing branched-chain amino acid degradation. Nature communications. vol 9. issue 1. 2018-12-17. PMID:30050148. |
restoration of klf15 prevents cardiac hypertrophy in response to pressure overload in wildtype mice but not in mutant mice deficient of bcaa degradation gene. |
2018-12-17 |
2023-08-13 |
mouse |
| Sheila K Patel, Jay Ramchand, Vincenzo Crocitti, Louise M Burrel. Kruppel-Like Factor 15 Is Critical for the Development of Left Ventricular Hypertrophy. International journal of molecular sciences. vol 19. issue 5. 2018-10-01. PMID:29702551. |
there is now compelling evidence that the transcription factor kruppel-like factor 15 (klf15) is an important negative regulator of cardiac hypertrophy in both experimental models and in man. |
2018-10-01 |
2023-08-13 |
human |
| Sheila K Patel, Jay Ramchand, Vincenzo Crocitti, Louise M Burrel. Kruppel-Like Factor 15 Is Critical for the Development of Left Ventricular Hypertrophy. International journal of molecular sciences. vol 19. issue 5. 2018-10-01. PMID:29702551. |
this review provides a summary of the experimental and human studies that have investigated the role of klf15 in the development of cardiac hypertrophy. |
2018-10-01 |
2023-08-13 |
human |
| Claudia Noack, Luis Peter Haupt, Wolfram-Hubertus Zimmermann, Katrin Streckfuss-Bömeke, Laura Cecilia Zelarayá. Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation. Stem cell research. vol 23. 2018-05-14. PMID:28925362. |
in the adult heart klf15 is important to maintain homeostasis and to repress hypertrophic remodeling. |
2018-05-14 |
2023-08-13 |
human |
| Sheila K Patel, Bryan Wai, Chim C Lang, Daniel Levin, Colin N A Palmer, Helen M Parry, Elena Velkoska, Stephen B Harrap, Piyush M Srivastava, Louise M Burrel. Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts. EBioMedicine. vol 18. 2018-01-17. PMID:28400202. |
the transcriptional factor kruppel like factor 15 (klf15) is expressed in the heart and acts as a repressor of cardiac hypertrophy in experimental models. |
2018-01-17 |
2023-08-13 |
Not clear |
| Sarah K Sasse, Vineela Kadiyala, Thomas Danhorn, Reynold A Panettieri, Tzu L Phang, Anthony N Gerbe. Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy. American journal of respiratory cell and molecular biology. vol 57. issue 2. 2017-08-18. PMID:28375666. |
we integrated transcriptome data from klf15 overexpression with genome-wide analysis of rna polymerase (rnap) ii and glucocorticoid receptor (gr) occupancy to identify phospholipase c delta 1 as both a klf15-regulated gene and a novel repressor of asm hypertrophy. |
2017-08-18 |
2023-08-13 |
human |
| Sarah K Sasse, Vineela Kadiyala, Thomas Danhorn, Reynold A Panettieri, Tzu L Phang, Anthony N Gerbe. Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy. American journal of respiratory cell and molecular biology. vol 57. issue 2. 2017-08-18. PMID:28375666. |
glucocorticoid receptor chip-seq identifies plcd1 as a klf15 target that represses airway smooth muscle hypertrophy. |
2017-08-18 |
2023-08-13 |
human |
| Sarah K Sasse, Vineela Kadiyala, Thomas Danhorn, Reynold A Panettieri, Tzu L Phang, Anthony N Gerbe. Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy. American journal of respiratory cell and molecular biology. vol 57. issue 2. 2017-08-18. PMID:28375666. |
here, we show that the transcription factor, krüppel-like factor 15 (klf15), is directly induced by glucocorticoids in primary human asm, and that klf15 represses asm hypertrophy. |
2017-08-18 |
2023-08-13 |
human |