| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kumara Kaluarachchi, Lakshman Samaranayak. The first report of the presence of collagen X in mammalian dentinal matrix. Morphologie : bulletin de l'Association des anatomistes. vol 108. issue 362. 2024-04-05. PMID:38579391. |
collagen x is an extracellular matrix protein, usually found in the hypertrophic cartilage destined to be mineralized. |
2024-04-05 |
2024-04-10 |
Not clear |
| Laura Dönges, Atharva Damle, Andrea Mainardi, Thomas Bock, Monica Schönenberger, Ivan Martin, Andrea Barber. Engineered human osteoarthritic cartilage organoids. Biomaterials. vol 308. 2024-03-30. PMID:38554643. |
here, by imposing specific inflammatory challenges upon mesenchymal stromal cells at a defined stage of chondrogenesis, we engineered a human organotypic model which recapitulates main oa pathological traits such as chondrocyte hypertrophy, cartilage matrix mineralization, enhanced catabolism and mechanical stiffening. |
2024-03-30 |
2024-04-02 |
human |
| Shubha S Bellur, Stéphan Troyanov, Olga Vorobyeva, Rosanna Coppo, Ian Sd Robert. Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy. Kidney international. 2024-03-30. PMID:38554992. |
all biopsies were evaluated for glomeruli with segmental capillary occlusion by matrix ("not otherwise specified", nos lesion), simple capsular adhesion without capillary occlusion (adh), tip lesions, and podocyte hypertrophy (ph). |
2024-03-30 |
2024-04-02 |
Not clear |
| Wen-Hai Zhuo, Hwee Weng Dennis Hey, Wing Moon Raymond Lam, Xiaoyun Chloe Chan, Loo Hoey Lit, Yong Soon Chiong, Hee-Kit Won. Increased matrix metalloproteinase-2 in ligamentum flavum hypertrophy and the regulation of MMP-2/TIMPs by elastin-derived peptides. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024-03-28. PMID:38546147. |
increased matrix metalloproteinase-2 in ligamentum flavum hypertrophy and the regulation of mmp-2/timps by elastin-derived peptides. |
2024-03-28 |
2024-03-30 |
rat |
| Wen-Hai Zhuo, Hwee Weng Dennis Hey, Wing Moon Raymond Lam, Xiaoyun Chloe Chan, Loo Hoey Lit, Yong Soon Chiong, Hee-Kit Won. Increased matrix metalloproteinase-2 in ligamentum flavum hypertrophy and the regulation of MMP-2/TIMPs by elastin-derived peptides. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024-03-28. PMID:38546147. |
the study aimed to examine matrix metalloproteinase-2 (mmp-2) expression in a rat ligamentum flavum (lf) hypertrophy model in vivo, and the effect of elastin-derived peptides (edps) on mmp-2 and tissue inhibitors of metalloproteinases (timps) in rat lf cells in vitro. |
2024-03-28 |
2024-03-30 |
rat |
| Peng Pi, Liqing Zeng, Zhipeng Zeng, Keqiang Zong, Bing Han, Xizhe Bai, Yan Wan. The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review. Frontiers in endocrinology. vol 15. 2024-03-21. PMID:38510704. |
disorders of glucose metabolism can lead to chondrocyte hypertrophy and extracellular matrix degradation, and promote the occurrence and development of oa. |
2024-03-21 |
2024-03-23 |
Not clear |
| Samantha Donsante, Alice Pievani, Biagio Palmisano, Melissa Finamore, Grazia Fazio, Alessandro Corsi, Andrea Biondi, Shunji Tomatsu, Rocco Piazza, Marta Serafini, Mara Riminucc. Modeling skeletal dysplasia in Hurler syndrome using patient-derived bone marrow osteoprogenitor cells. JCI insight. vol 9. issue 5. 2024-03-08. PMID:38456506. |
we also noticed that mps ih hypertrophic cartilage was characterized by dysregulation of signaling pathways controlling cartilage hypertrophy and fate, extracellular matrix organization, and glycosaminoglycan metabolism. |
2024-03-08 |
2024-03-10 |
Not clear |
| Gurcharan Kaur, Biming Wu, Sanjana Murali, Thomas Lanigan, Rhima M Colema. A synthetic, closed-looped gene circuit for the autonomous regulation of RUNX2 activity during chondrogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 4. 2024-02-26. PMID:38407380. |
finally, we show the efficacy of inhibiting runx2 in preventing matrix loss in human mesenchymal stem cell-derived (hmsc-derived) cartilage under conditions that induce chondrocyte hypertrophic differentiation, including inflammation. |
2024-02-26 |
2024-02-28 |
human |
| Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Peng Cao, Kuo Shen, Hao Gua. PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL. Archives of biochemistry and biophysics. 2024-02-07. PMID:38325773. |
hypertrophic scar (hs) is a dermatological condition characterized by an excessive accumulation of proteins in the extracellular matrix (ecm) and an elevated cell count. |
2024-02-07 |
2024-02-10 |
Not clear |
| Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Peng Cao, Kuo Shen, Hao Gua. PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL. Archives of biochemistry and biophysics. 2024-02-07. PMID:38325773. |
the findings of our study provide validation for the role of pten in inhibiting the development of hypertrophic scars (hs) by modulating the expression of extracellular matrix (ecm) proteins and promoting apoptosis in hypertrophic scar fibroblasts (hsfs) via bcl-xl. |
2024-02-07 |
2024-02-10 |
Not clear |
| Jacob J Robino, Alexander P Plekhanov, Qingzhang Zhu, Michael D Jensen, Philipp E Scherer, Charles T Roberts, Oleg Varlamo. Adipose Tissue Analysis Toolkit (ATAT) for Automated Analysis of Adipocyte Size and Extracellular Matrix in White Adipose Tissue. bioRxiv : the preprint server for biology. 2024-02-06. PMID:38318208. |
the pathological expansion of white adipose tissue (wat) in obesity involves adipocyte hypertrophy accompanied by expansion of collagen-rich pericellular extracellular matrix (ecm) and the development of crown-like structures (cls). |
2024-02-06 |
2024-02-09 |
Not clear |
| Jacob J Robino, Alexander P Plekhanov, Qingzhang Zhu, Michael D Jensen, Philipp E Scherer, Charles T Roberts, Oleg Varlamo. Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue. Obesity (Silver Spring, Md.). 2024-02-06. PMID:38321231. |
the pathological expansion of white adipose tissue (wat) in obesity involves adipocyte hypertrophy accompanied by expansion of the collagen-rich pericellular extracellular matrix (ecm) and development of crown-like structures (cls). |
2024-02-06 |
2024-02-09 |
Not clear |
| Mohammad Ali Mohammadkhani, Soraya Shahrzad, Mehrdad Haghighi, Reza Ghanbari, Ashraf Mohamadkhan. Insights into Organochlorine Pesticides Exposure in the Development of Cardiovascular Diseases: A Systematic Review. Archives of Iranian medicine. vol 26. issue 10. 2024-02-04. PMID:38310416. |
changes in the regulatory function of peroxisome proliferator-activated γ receptor (pparγ), reduction of paroxonase activity (pon1), epigenetic changes of histone through induction of reactive oxygen species, vascular endothelial inflammation with mir-expression 126 and mir-31, increased collagen synthesis enzymes in the extracellular matrix and left ventricular hypertrophy (lvh) and fibrosis are mechanisms by which pcbs increase the risk of cvd. |
2024-02-04 |
2024-02-06 |
human |
| Fabrizio E Mancini, Paul E A Humphreys, Steven Woods, Nicola Bates, Sara Cuvertino, Julieta O'Flaherty, Leela Biant, Marco A N Domingos, Susan J Kimbe. Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis. Scientific reports. vol 14. issue 1. 2024-02-01. PMID:38302538. |
chondroprogenitors obtained from rapid-e could generate cartilaginous pellets that expressed ac-related matrix proteins such as lubricin, aggrecan, and collagen ii, but additionally expressed collagen x, indicative of hypertrophy. |
2024-02-01 |
2024-02-04 |
human |
| Boya Yu, Yalei Cao, Shiyi Li, Ruiqi Bai, Guiwen Zhou, Qiang Fu, Liming Liang, Weijie Gu, Lixia Zhang, Minliang Che. Identification and validation of CRLF1 and NRG1 as immune-related signatures in hypertrophic scar. Genomics. 2024-01-23. PMID:38262564. |
hypertrophic scar (hts) is a prevalent chronic inflammatory skin disorder characterized by abnormal proliferation and extracellular matrix deposition and the precise mechanisms underlying hts remain elusive. |
2024-01-23 |
2024-01-26 |
Not clear |
| Saida Mebarek, Rene Buchet, Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, Leyre Brizuela, Giada Corti, Federica Collacchi, Genevieve Anghieri, Andrea Magrini, Pietro Ciancaglini, Jose Luis Millan, Owen Davies, Massimo Bottin. Do Media Extracellular Vesicles and Extracellular Vesicles Bound to the Extracellular Matrix Represent Distinct Types of Vesicles? Biomolecules. vol 14. issue 1. 2024-01-23. PMID:38254642. |
mineralization-competent cells, including hypertrophic chondrocytes, mature osteoblasts, and osteogenic-differentiated smooth muscle cells secrete media extracellular vesicles (media vesicles) and extracellular vesicles bound to the extracellular matrix (matrix vesicles). |
2024-01-23 |
2024-01-25 |
Not clear |
| Nilotpal Majumder, Subhadeep Roy, Aarushi Sharma, Shuchi Arora, Raju Vaishya, Amitabha Bandyopadhyay, Sourabh Ghos. Assessing the advantages of 3D bioprinting and 3D spheroids in deciphering the osteoarthritis healing mechanism using human chondrocytes and polarized macrophages. Biomedical materials (Bristol, England). 2024-01-10. PMID:38198731. |
additionally, the presence of anti-inflammatory m2 macrophages significantly upregulated the expression of chondrogenic biomarkers (col-ii, acan) with an attenuated expression of the chondrocyte hypertrophy (col-x), chondrocyte dedifferentiation (col-i) and matrix catabolism (mmp-1 and mmp-13) genes even in the absence of the interleukins. |
2024-01-10 |
2024-01-13 |
human |
| Ilaria Bernabei, Elodie Faure, Mario Romani, Julien Wegrzyn, Jürgen Brinckmann, Véronique Chobaz, Alexander So, Thomas Hugle, Nathalie Busso, Sonia Nas. Inhibiting Lysyl Oxidases prevents pathologic cartilage calcification. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 171. 2024-01-06. PMID:38183742. |
through unbiased transcriptomic analysis we confirmed a positive correlation between lox(l) genes and genes for calcification, hypertrophy and extracellular matrix catabolism. |
2024-01-06 |
2024-01-09 |
mouse |
| Zilu Qu, Yao Chen, Kun Du, JiaXi Qiao, Liuqing Chen, Jinbo Chen, Li We. ALA-PDT promotes the death and contractile capacity of hypertrophic scar fibroblasts through inhibiting the TGF-β1/Smad2/3/4 signaling pathway. Photodiagnosis and photodynamic therapy. vol 45. 2023-12-21. PMID:38128289. |
hypertrophic scars, an abnormal wound-healing response to burn injuries, are characterized by massive fibroblast proliferation and excessive deposition of extracellular matrix and collagen. |
2023-12-21 |
2023-12-24 |
Not clear |
| Xiaoming Zhang, Jared M McLendon, Bailey D Peck, Biyi Chen, Long-Sheng Song, Ryan L Boudrea. Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix. Molecular therapy. Nucleic acids. vol 34. 2023-12-19. PMID:38111915. |
the integration of rna sequencing and mirna-target interactomes reveals that mir-29 regulates genes involved in calcium handling, cell stress and hypertrophy, metabolism, ion transport, and extracellular matrix remodeling. |
2023-12-19 |
2023-12-21 |
mouse |