| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irina V Kologrivova, Natalia V Naryzhnaya, Olga A Koshelskaya, Tatiana E Suslova, Elena S Kravchenko, Olga A Kharitonova, Vladimir V Evtushenko, Alla A Boshchenk. Association of Epicardial Adipose Tissue Adipocytes Hypertrophy with Biomarkers of Low-Grade Inflammation and Extracellular Matrix Remodeling in Patients with Coronary Artery Disease. Biomedicines vol 11 issue 2 2023 36830779 |
association of epicardial adipose tissue adipocytes hypertrophy with biomarkers of low-grade inflammation and extracellular matrix remodeling in patients with coronary artery disease. |
2023-02-25 |
2023-03-06 |
Not clear |
| Lei Huang, Meng Jin, Ruiying Gu, Kunlin Xiao, Mengnan Lu, Xinyu Huo, Mengyao Sun, Zhi Yang, Zhiyuan Wang, Weijie Zhang, Liqiang Zhi, Ziang Meng, Jie Ma, Jianbing Ma, Rui Zhan. miR-199a-5p Reduces Chondrocyte Hypertrophy and Attenuates Osteoarthritis Progression via the Indian Hedgehog Signal Pathway. Journal of clinical medicine vol 12 issue 4 2023 36835852 |
further investigations demonstrated that mir-199a-5p could directly regulate ihh expression and reduce chondrocyte hypertrophy and matrix degradation via the ihh signal pathway in the primary human chondrocytes. |
2023-02-25 |
2023-03-06 |
rat |
| Chin-Chan Lee, Chia-Chun Chen, Cheng-Kai Hsu, Yih-Ting Chen, Chun-Yu Chen, Kai-Jie Yang, Ming-Jui Hung, I-Wen W. Urinary microRNA in Diabetic Kidney Disease: A Literature Review. Medicina (Kaunas, Lithuania) vol 59 issue 2 2023 36837555 |
previous literatures have reported its potential role in the pathophysiology of diabetic kidney disease, including regulation of transforming growth factor-\xce\xb21-mediated fibrosis, extracellular matrix and cell adhesion proteins, cellular hypertrophy, growth factor, cytokine production, and redox system activation. |
2023-02-25 |
2023-03-06 |
Not clear |
| Joshua S Godwin, Casey L Sexton, Nicholas J Kontos, Bradley A Ruple, Darryn S Willoughby, Kaelin C Young, C Brooks Mobley, Michael D Robert. Extracellular matrix content and remodeling markers do not differ in college-aged men classified as higher- and lower-responders to resistance training. Journal of applied physiology (Bethesda, Md. : 1985) vol issue 2023 36759158 |
we determined if skeletal muscle extracellular matrix (ecm) content and remodeling markers adapted with resistance training or were associated with hypertrophic outcomes. |
2023-02-09 |
2023-03-06 |
human |
| Charly Robert, Fr\\xc3\\xa9d\\xc3\\xa9ric Kerff, Fabrice Bouillenne, Maxime Gavage, Maryl\\xc3\\xa8ne Vandevenne, Patrice Fil\\xc3\\xa9e, Andr\\xc3\\xa9 Matagn. Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition. The Journal of biological chemistry vol issue 2023 36642181 |
additionally, several in vitro cell-based assays, including enzymatic measurements, rt-qpcr and matrix staining, demonstrated their biological activity during cell chondrogenic and hypertrophic differentiation. |
2023-01-15 |
2023-01-30 |
human |
| Guoqing Li, Su Liu, Huihui Xu, Yixiao Chen, Jiapeng Deng, Ao Xiong, Deli Wang, Jian Weng, Fei Yu, Liang Gao, Changhai Ding, Hui Zen. Potential effects of teriparatide (PTH (1-34)) on osteoarthritis: a systematic review. Arthritis research & therapy vol 25 issue 1 2023 36609338 |
in vitro studies (n\xe2\x80\x89=\xe2\x80\x8911) concluded that pth (1-34) was important for chondrocytes via increasing the proliferation and matrix synthesis but preventing apoptosis or hypertrophy. |
2023-01-07 |
2023-01-30 |
Not clear |
| James T Pearso. Set7 methyltransferase roles in myocardial protection from chronic stressors. Clinical science (London, England : 1979) vol 137 issue 1 2023 36601782 |
recent transcriptome and fourier transform infrared spectroscopy analyses and in vivo assessments of cardiac function by lunardon and colleagues now reveal a clear role of set7 in the regulation of the extracellular matrix composition and cardiac hypertrophy in response to chronic isoproterenol induced cardiac stress. |
2023-01-05 |
2023-01-30 |
Not clear |
| Helena M Viola, Caitlyn Richworth, Tanya Solomon, Ian L Chin, Henrietta Cserne Szappanos, Srinivasan Sundararaj, Dmitry Shishmarev, Marco G Casarotto, Yu Suk Choi, Livia C Hoo. A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology. Communications biology vol 6 issue 1 2023 36596888 |
a maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology. |
2023-01-03 |
2023-01-30 |
human |
| Helena M Viola, Caitlyn Richworth, Tanya Solomon, Ian L Chin, Henrietta Cserne Szappanos, Srinivasan Sundararaj, Dmitry Shishmarev, Marco G Casarotto, Yu Suk Choi, Livia C Hoo. A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology. Communications biology vol 6 issue 1 2023 36596888 |
we identify a mechanosensing feedback mechanism between the extracellular matrix and cytoskeletal network that regulates mitochondrial function under healthy conditions, but participates in the progression of hypertrophic cardiomyopathy pathophysiology resulting from sarcomeric gene mutations. |
2023-01-03 |
2023-01-30 |
human |
| Hubert Kol. Obese visceral fat tissue inflammation: from protective to detrimental? BMC medicine vol 20 issue 1 2022 36575472 |
eventual lipid overload of hypertrophic adipocytes leads to endoplasmic reticulum stress and the secretion of a variety of signals causing increased sympathetic tone, lipolysis by adipocytes, lipid uptake by macrophages, matrix remodeling, angiogenesis, and immune cell activation. |
2022-12-27 |
2023-01-30 |
Not clear |
| Shikha Chawla, Andrea Mainardi, Nilotpal Majumder, Laura D\\xc3\\xb6nges, Bhupendra Kumar, Paola Occhetta, Ivan Martin, Christian Egloff, Sourabh Ghosh, Amitabha Bandyopadhyay, Andrea Barber. Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies. Cells vol 11 issue 24 2022 36552796 |
afterwards, we will present the strategies developed and proposed to impede chondrocyte hypertrophy and cartilage matrix mineralization/calcification. |
2022-12-23 |
2023-01-30 |
Not clear |
| Zhencheng Yu, Yun Li, Rao Fu, Yaxin Xue, Danyang Zhao, Dong Ha. Platycodin D inhibits the proliferation and migration of hypertrophic scar-derived fibroblasts and promotes apoptosis through a caspase-dependent pathway. Archives of dermatological research vol issue 2022 36526799 |
abnormal fibroblast proliferation and excessive extracellular matrix (ecm) deposition lead to the formation of hypertrophic scars (hss). |
2022-12-16 |
2023-01-30 |
human |
| Ashley A Thurstin, Allison N Egeli, Edie C Goldsmith, Francis G Spinale, Holly A LaVoi. Tissue Inhibitor of Metalloproteinase 4 (Timp4) Deletion in Mice Impacts Maternal Cardiac Function during Pregnancy and Postpartum. American journal of physiology. Heart and circulatory physiology vol issue 2022 36459450 |
reversible physiological cardiac hypertrophy of the maternal heart occurs during pregnancy and involves extracellular matrix (ecm) remodeling. |
2022-12-02 |
2023-01-30 |
mouse |
| Cassandra L Clift, Janet Saunders, Richard R Drake, Peggi M Ange. Perspectives on pediatric congenital aortic valve stenosis: Extracellular matrix proteins, post translational modifications, and proteomic strategies. Frontiers in cardiovascular medicine vol 9 issue 2022 36439995 |
this is especially true in cases of pediatric congenital aortic valve stenosis (pcavs), in which extracellular matrix (ecm) dysregulation is a hallmark of the disease, eventually leading to left ventricular hypertrophy and heart failure. |
2022-11-28 |
2023-01-30 |
Not clear |
| Yan Yang, Lutong Liu, Xiaojin Wu, Xue Wang, Qiang Lu, Zhen Zhan. CO Burns & trauma vol 10 issue 2022 36380852 |
co hypertrophic scars are skin fibrotic diseases, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix. |
2022-11-16 |
2023-01-30 |
Not clear |
| Farideh Amirrad, Gregory A Fishbein, Robert A Edwards, Surya M Naul. Hypertrophic and fibrotic human PKD hearts are associated with macrophage infiltration and abnormal TGF-\\xce\\xb2 Cell and tissue research vol issue 2022 36376769 |
our histopathology data of human pkd hearts showed an increased extracellular matrix associated with cardiac hypertrophy and fibrosis. |
2022-11-15 |
2023-01-30 |
human |
| Alice Ruth Lapthorn, Marcus Maximillian Ilg, Justine Victoria Sullivan, Peter Dziewulski, Selim Celle. Phenotypic screening identifies hydroxypyridone anti-fungals as novel medicines for the prevention of hypertrophic scars. European journal of pharmacology vol issue 2022 36343693 |
hypertrophic scars are a result of dysregulated wound healing, characterised by persistent myofibroblast transformation and the excessive accumulation of extracellular matrix (ecm). |
2022-11-07 |
2023-01-30 |
human |
| Hongxin Chen, Kai Xu, Chao Sun, Si Gui, Juanjuan Wu, Song Wan. Inhibition of ANGPT2 activates autophagy during hypertrophic scar formation via PI3K/AKT/mTOR pathway. Anais brasileiros de dermatologia vol issue 2022 36272879 |
hypertrophic scar (hs), a fibroproliferative disorder caused by aberrant wound healing following skin injuries such as burns, lacerations and surgery, is characterized by invasive proliferation of fibroblasts and excessive extracellular matrix (ecm) accumulation. |
2022-10-22 |
2023-01-30 |
Not clear |
| Lishan Lin, Yaling Yu, Kangping Liu, Yixin Jiang, Zhenlei Zho. Downregulation of miR-30b-5p Facilitates Chondrocyte Hypertrophy and Apoptosis via Targeting Runx2 in Steroid-Induced Osteonecrosis of the Femoral Head. International journal of molecular sciences vol 23 issue 19 2022 36232582 |
the nobly increased expression of matrix metallopeptidase 13 (mmp13) and type x collagen (col10a1) as runx2 downstream genes contributed to the hypertrophic differentiation of chondrocytes, and the efficiently upregulated level of matrix metallopeptidase 9 (mmp9) may trigger chondrocyte apoptosis with mps treatments. |
2022-10-14 |
2023-01-30 |
Not clear |
| Z H Chen, B Yu, Q F Ye, Y F Wan. [Research advances on interleukin-6 in hypertrophic scar formation]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns vol 38 issue 9 2022 36177594 |
hypertrophic scar is a pathological repair result of excessive accumulation of extracellular matrix after skin damage, which affects the appearance and function of patients with varying degrees. |
2022-09-30 |
2023-01-30 |
Not clear |