| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelsie E Oatmen, Elizabeth Cull, Francis G Spinal. Heart failure as interstitial cancer: emergence of a malignant fibroblast phenotype. Nature reviews. Cardiology vol 17 issue 8 2020 31686012 |
in animal models, a major factor driving progression from pressure-overload hypertrophy (poh) to hfpef is the activation and proliferation of an abnormal fibroblast phenotype that is resistant to apoptosis, degrades normal stromal matrix and is replaced with a fibrotic matrix structure. |
2020-10-26 |
2023-01-26 |
Not clear |
| Fumiko Yano, Shinsuke Ohba, Yasutaka Murahashi, Sakae Tanaka, Taku Saito, Ung-Il Chun. Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation. Scientific reports vol 9 issue 1 2020 31113964 |
runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation. |
2020-10-14 |
2023-01-26 |
Not clear |
| Weike Feng, Yue Zhao, Xiaotong Song, Yuan Wang, Qian Chen, Haijun Zhao, Guangying Lu, Hongyan Yuan, Zhichun Wu, Huayun Y. Zi Shen Huo Luo Formula Prevents Aldosterone-Induced Cardiomyocyte Hypertrophy and Cardiac Fibroblast Proliferation by Regulating the Striatin-Mediated MR/EGFR/ERK Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM vol 2020 issue 2020 33014117 |
excessive aldosterone can lead to myocardial extracellular matrix collagen proliferation, fibrosis, and cardiomyocyte hypertrophy and aggravate maladaptive remodeling. |
2020-10-06 |
2023-01-26 |
rat |
| Mitsuo Kat. Noncoding RNAs as therapeutic targets in early stage diabetic kidney disease. Kidney research and clinical practice vol 37 issue 3 2020 30254844 |
major features of dkd include accumulation of extracellular matrix proteins and glomerular hypertrophy, especially in early stage. |
2020-10-01 |
2023-01-26 |
human |
| Benazir Siddeek, Claire Mauduit, Hassib Chehade, Guillaume Blin, Marjorie Liand, Mariapia Chindamo, Mohamed Benahmed, Umberto Simeon. Long-term impact of maternal high-fat diet on offspring cardiac health: role of micro-RNA biogenesis. Cell death discovery vol 5 issue 2020 30854230 |
in this model, offspring exposed to maternal high-fat diet developed cardiac hypertrophy and increased extracellular matrix depot compared to those exposed to chow diet. |
2020-10-01 |
2023-01-26 |
rat |
| Chengjie Lian, Xudong Wang, Xianjian Qiu, Zizhao Wu, Bo Gao, Lei Liu, Guoyan Liang, Hang Zhou, Xiaoming Yang, Yan Peng, Anjing Liang, Caixia Xu, Dongsheng Huang, Peiqiang S. Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin \\xce\\xb21-SMAD1 interaction. Bone research vol 7 issue 2020 30854241 |
collagen type ii (col2a1) was previously considered to be only a structural component of the cartilage matrix, but recently, it has been revealed to be an extracellular signaling molecule that can significantly suppress chondrocyte hypertrophy. |
2020-10-01 |
2023-01-26 |
Not clear |
| Neil A Turner, Nicola M Blyth. Cardiac Fibroblast p38 MAPK: A Critical Regulator of Myocardial Remodeling. Journal of cardiovascular development and disease vol 6 issue 3 2020 31394846 |
one important signaling node that has been identified involves p38 mapk; a family of kinases activated in response to stress and inflammatory stimuli that modulates multiple aspects of cardiac fibroblast function, including inflammatory responses, myofibroblast differentiation, extracellular matrix turnover and the paracrine induction of cardiomyocyte hypertrophy. |
2020-10-01 |
2023-01-26 |
Not clear |
| Yuanheng Yang, Yuwei Liu, Zixuan Lin, He Shen, Caitlin Lucas, Biao Kuang, Rocky S Tuan, Hang Li. Condensation-Driven Chondrogenesis of Human Mesenchymal Stem Cells within Their Own Extracellular Matrix: Formation of Cartilage with Low Hypertrophy and Physiologically Relevant Mechanical Properties. Advanced biosystems vol 3 issue 12 2020 32648682 |
condensation-driven chondrogenesis of human mesenchymal stem cells within their own extracellular matrix: formation of cartilage with low hypertrophy and physiologically relevant mechanical properties. |
2020-10-01 |
2023-01-26 |
human |
| Masayo Aoki, Noriko M Matsumoto, Teruyuki Dohi, Hiroaki Kuwahawa, Satoshi Akaishi, Yuri Okubo, Rei Ogawa, Hirofumi Yamamoto, Kazuaki Takab. Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars. Molecular therapy. Nucleic acids vol 22 issue 2020 32911344 |
hypertrophic scars (hss) and keloids are histologically characterized by excessive extracellular matrix (ecm) deposition. |
2020-10-01 |
2023-01-26 |
mouse |
| Danyang Zhao, Yu Wang, Chao Du, Shengzhou Shan, Yifan Zhang, Zijing Du, Dong Ha. Honokiol Alleviates Hypertrophic Scar by Targeting Transforming Growth Factor-\\xce\\xb2/Smad2/3 Signaling Pathway. Frontiers in pharmacology vol 8 issue 2020 28469575 |
hypertrophic scar (hps) presents as excessive extracellular matrix deposition and abnormal function of fibroblasts. |
2020-10-01 |
2023-01-26 |
Not clear |
| Melissa A Lyle, Jonathan P Davis, Frank V Brozovic. Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy. Frontiers in physiology vol 8 issue 2020 28878690 |
there are two primary components that produce pulmonary arterial hypertension (pah); aberrant structural changes (smooth muscle cell proliferation, smooth muscle cell hypertrophy, and the deposition of matrix proteins within the media of pulmonary arterial vessels), and excess vasoconstriction. |
2020-10-01 |
2023-01-26 |
Not clear |
| Yi Zhang, Xiaohua Lin, Li Zhang, Weilong Hong, Kang Zen. MicroRNA-222 regulates the viability of fibroblasts in hypertrophic scars via matrix metalloproteinase 1. Experimental and therapeutic medicine vol 15 issue 2 2020 29434768 |
microrna-222 regulates the viability of fibroblasts in hypertrophic scars via matrix metalloproteinase 1. |
2020-10-01 |
2023-01-26 |
Not clear |
| Kevin A Murach, Davis A Englund, Esther E Dupont-Versteegden, John J McCarthy, Charlotte A Peterso. Myonuclear Domain Flexibility Challenges Rigid Assumptions on Satellite Cell Contribution to Skeletal Muscle Fiber Hypertrophy. Frontiers in physiology vol 9 issue 2020 29896117 |
satellite cells respond to muscle damage, and also play an important role in extracellular matrix remodeling during loading-induced hypertrophy. |
2020-09-30 |
2023-01-26 |
Not clear |
| M M Akhtar, P M Elliot. Anderson-Fabry disease in heart failure. Biophysical reviews vol 10 issue 4 2020 29909504 |
gb3 accumulation induces pathology via the release of pro-inflammatory cytokines, growth-promoting factors and by oxidative stress, resulting in myocardial extracellular matrix remodelling, left ventricular hypertrophy (lvh), vascular dysfunction and interstitial fibrosis. |
2020-09-30 |
2023-01-26 |
Not clear |
| Hong-Wei Wang, Yi-He Chen, Yan-Yan Chen, Wei Huang, Xian-Dong Zhu, Fu-Biao Ni, Guo-Di Wu, Zi-Qiang Xu, Zhou-Qing Huang, Bi-Cheng Chen, Fang-Yi Xia. Islet transplantation attenuates cardiac fibrosis in diabetic rats through inhibition of TGF-\\xce\\xb2 American journal of translational research vol 10 issue 8 2020 30210683 |
in addition, islet transplantation attenuated the increased levels of ctn-i and ck-mb, cleaved-caspase-3 in response to dm, and ameliorated diabetic-induced cardiac hypertrophy and interstitial fibrosis, along with improved extracellular matrix (ecm) deposition. |
2020-09-30 |
2023-01-26 |
rat |
| Aurore Van de Walle, Wa\\xc3\\xafss Faissal, Claire Wilhelm, Nathalie Lucian. Role of growth factors and oxygen to limit hypertrophy and impact of high magnetic nanoparticles dose during stem cell chondrogenesis. Computational and structural biotechnology journal vol 16 issue 2020 30524668 |
a major difficulty is to drive the chondrogenic differentiation of the cells such as they produce an extracellular matrix free of hypertrophic collagen. |
2020-09-30 |
2023-01-26 |
human |
| Aurore Van de Walle, Wa\\xc3\\xafss Faissal, Claire Wilhelm, Nathalie Lucian. Role of growth factors and oxygen to limit hypertrophy and impact of high magnetic nanoparticles dose during stem cell chondrogenesis. Computational and structural biotechnology journal vol 16 issue 2020 30524668 |
we focus on the synthesis of two of the most important constituents present in the cartilaginous extracellular matrix (collagen ii and aggrecan) and on the expression of collagen x, the signature of hypertrophic cartilage, in order to provide a quantitative index of the type of cartilage produced (i.e. |
2020-09-30 |
2023-01-26 |
human |
| I A Marino-Mart\\xc3\\xadnez, A G Mart\\xc3\\xadnez-Castro, V M Pe\\xc3\\xb1a-Mart\\xc3\\xadnez, C A Acosta-Olivo, F V\\xc3\\xadlchez-Cavazos, A Guzm\\xc3\\xa1n-L\\xc3\\xb3pez, Edelmiro P\\xc3\\xa9rez Rodr\\xc3\\xadguez, V J Romero-D\\xc3\\xadaz, J A Ortega-Blanco, J Lara-Aria. Human amniotic membrane intra-articular injection prevents cartilage damage in an osteoarthritis model. Experimental and therapeutic medicine vol 17 issue 1 2020 30651759 |
at 6 weeks post-injection, the left knees exhibited hypertrophy, cracks, cell clusters, decreased matrix staining and structure loss. |
2020-09-30 |
2023-01-26 |
human |
| Yue Zhou, Mo Chen, Regis J O'Keefe, Jie Shen, Zhi Li, Jian Zhou, Xuedong Zhou, Jeremy J Ma. Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis. American journal of translational research vol 11 issue 3 2020 30972197 |
dnmt3b deficiency using conditional knockout mice led to the onset of osteoarthritis-like conditions including cartilage clefts, cartilage matrix loss and premature chondrocyte hypertrophy, which suggested that dnmt3b functioned as a osteoarthritis suppressor. |
2020-09-30 |
2023-01-26 |
mouse |
| Sheng-Chieh Lin, Hsiu-Chu Chou, Bor-Luen Chiang, Chung-Ming Che. CTGF upregulation correlates with MMP-9 level in airway remodeling in a\\xc2\\xa0murine model of asthma. Archives of medical science : AMS vol 13 issue 3 2020 28507585 |
connective tissue growth factor (ctgf) mediates hypertrophy, proliferation, and extracellular matrix synthesis. |
2020-09-30 |
2023-01-26 |
Not clear |