| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Selvaraj Vimalra. Alkaline phosphatase: Structure, expression and its function in bone mineralization. Gene vol 754 issue 2020 32522695 |
mineralization is the production, inside matrix vesicles, of hydroxyapatite crystals that bud from the outermembrane of hypertrophic osteoblasts and chondrocytes. |
2020-08-05 |
2023-01-26 |
Not clear |
| Hiroaki Ichikawa, Michiko Shimada, Masato Narita, Ikuyo Narita, Yoshihiro Kimura, Makoto Tanaka, Tomohiro Osanai, Ken Okumura, Hirofumi Tomit. Rivaroxaban, a Direct Factor Xa Inhibitor, Ameliorates Hypertensive Renal Damage Through Inhibition of the Inflammatory Response Mediated by Protease-Activated Receptor Pathway. Journal of the American Heart Association vol 8 issue 8 2020 30957622 |
moreover, rivaroxaban treatment attenuated histologic changes of glomerular hypertrophy, mesangial matrix expansion, effacement of the podocyte foot process, and thickened glomerular basement membrane in the ren-tg. |
2020-07-23 |
2023-01-26 |
mouse |
| Macarena Orejudo, Ana B Garc\\xc3\\xada-Redondo, Ra\\xc3\\xbal R Rodrigues-Diez, Raquel Rodrigues-D\\xc3\\xadez, Laura Santos-Sanchez, Antonio Tejera-Mu\\xc3\\xb1oz, Jes\\xc3\\xbas Egido, Rafael Selgas, Mercedes Salaices, Ana M Briones, Marta Ruiz-Orteg. Interleukin-17A induces vascular remodeling of small arteries and blood pressure elevation. Clinical science (London, England : 1979) vol 134 issue 5 2020 32104886 |
the mechanisms of il-17a seem to involve an induction of vascular smooth muscle cell (vsmc) hypertrophy and phenotype changes, in the absence of extracellular matrix (ecm) proteins accumulation. |
2020-07-20 |
2023-01-26 |
mouse |
| Laia Ca\\xc3\\xb1es, Ingrid Mart\\xc3\\xad-P\\xc3\\xa0mies, Carme Ballester-Servera, Adela Herraiz-Mart\\xc3\\xadnez, Judith Alonso, Mar\\xc3\\xada Gal\\xc3\\xa1n, J Francisco Nistal, Pedro Muniesa, Jes\\xc3\\xbas Osada, Leif Hove-Madsen, Cristina Rodr\\xc3\\xadguez, Jos\\xc3\\xa9 Mart\\xc3\\xadnez-Gonz\\xc3\\xa1le. Neuron-derived orphan receptor-1 modulates cardiac gene expression and exacerbates angiotensin II-induced cardiac hypertrophy. Clinical science (London, England : 1979) vol 134 issue 3 2020 31985010 |
nor-1 transgenesis up-regulated two key genes involved in cardiac hypertrophy (myh7, encoding for \xce\xb2-myosin heavy chain (\xce\xb2-mhc)) and fibrosis (loxl2, encoding for the extracellular matrix (ecm) modifying enzyme, loxl2). |
2020-07-15 |
2023-01-26 |
mouse |
| Gui-Fang Sun, Hong-Chang Li, Yue-Ping Zhan, Xiao-Fen Zhang, Li-Yun Pan, Ya-Feng Chen, Ke Xu, Dian-Xu Fen. SnoN residue (1-366) attenuates hypertrophic scars through resistance to transforming growth factor-\\xce\\xb21-induced degradation. Laboratory investigation; a journal of technical methods and pathology vol 99 issue 12 2020 31409891 |
hypertrophic scars (hss) are characterized by fibroblast hyperproliferation and excessive matrix deposition. |
2020-06-29 |
2023-01-26 |
human |
| Yujin Ma, Jingxia Shi, Feifei Wang, Shipeng Li, Jie Wang, Chaoxia Zhu, Liping Li, Haibo Lu, Chun Li, Junqiang Yan, Xin Zhang, Hongwei Jian. MiR-130b increases fibrosis of HMC cells by regulating the TGF-\\xce\\xb21 pathway in diabetic nephropathy. Journal of cellular biochemistry vol 120 issue 3 2020 30260005 |
basement membrane thickening, glomerular hypertrophy, and deposition of multiple extracellular matrix characterize the pathological basis of diabetic nephropathy (dn), a condition which ultimately leads to glomerular and renal interstitial fibrosis. |
2020-06-22 |
2023-01-26 |
human |
| Jiaji Yue, Shanzi Jin, Shizhong Gu, Rui Sun, Qingwei Lian. High concentration magnesium inhibits extracellular matrix calcification and protects articular cartilage via Erk/autophagy pathway. Journal of cellular physiology vol 234 issue 12 2020 31161622 |
the significant cytopathological changes of osteoarthritis are chondrocyte hypertrophy, proteoglycan loss, extracellular matrix (ecm) calcification, and terminally, the replacement of cartilage by bone. |
2020-06-12 |
2023-01-26 |
Not clear |
| Xu Chen, Jie Su, Jianyu Feng, Liang Cheng, Qing Li, Chen Qiu, Qijun Zhen. TRIM72 contributes to cardiac fibrosis via regulating STAT3/Notch-1 signaling. Journal of cellular physiology vol 234 issue 10 2020 30820965 |
we developed a cardiac hypertrophy model using transverse aortic constriction (tac) to uncover mechanisms relevant to excessive deposition of extracellular matrix in mouse myocardial cells. |
2020-05-19 |
2023-01-26 |
mouse |
| Jianmei Li, Fei Kang, Xiaoshan Gong, Yun Bai, Jingjin Dai, Chunrong Zhao, Ce Dou, Zhen Cao, Mengmeng Liang, Rui Dong, Hong Jiang, Xiaochao Yang, Shiwu Don. Ceria nanoparticles enhance endochondral ossification-based critical-sized bone defect regeneration by promoting the hypertrophic differentiation of BMSCs FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 33 issue 5 2020 30776318 |
however, inadequate chondrocyte hypertrophy can hinder vascular invasion and matrix mineralization during endochondral ossification. |
2020-05-12 |
2023-01-26 |
Not clear |
| Manuel F Landecho, Carlota Tuero, V\\xc3\\xadctor Valent\\xc3\\xad, Idoia Bilbao, Magdalena de la Higuera, Gema Fr\\xc3\\xbchbec. Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk. Nutrients vol 11 issue 11 2020 31694146 |
the mechanisms underlying adipose tissue dysfunction include adipocyte hypertrophy and hyperplasia, increased inflammation, impaired extracellular matrix remodeling, and fibrosis together with an altered secretion of adipokines. |
2020-04-28 |
2023-01-26 |
Not clear |
| Anda Mariana Bra\\xc5\\x9foveanu, Lauren\\xc5\\xa3iu Mogoant\\xc4\\x83, Gheorghe Dan M\\xc4\\x83l\\xc4\\x83escu, Octavian Ion Predescu, Bogdan Virgil Cotoi, Feng Ifrim Che. Hypertensive cardiomyopathy - histopathological and immunohistochemical aspects. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie vol 60 issue 2 2020 31658322 |
in hypertensive patients, it progresses into the left ventricle hypertrophy, as a result of some major changes of the cardiomyocytes, but also of the extracellular conjunctive matrix (ecm). |
2020-04-21 |
2023-01-26 |
Not clear |
| Gil Soon Park, Min Kyun An, Ji Ha Yoon, Seok Soon Park, Sung Hoon Koh, Theodora M Mauro, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Ki. Botulinum toxin type A suppresses pro-fibrotic effects via the JNK signaling pathway in hypertrophic scar fibroblasts. Archives of dermatological research vol 311 issue 10 2020 31501922 |
hypertrophic scar is a dermal fibroproliferative disease characterized by the overproduction and deposition of extracellular matrix, and the hyperproliferation and enhanced angiogenesis of fibroblasts, along with their enhanced differentiation to myofibroblasts. |
2020-04-20 |
2023-01-26 |
human |
| Girish Pattappa, Ruth Schewior, Isabelle Hofmeister, Jennifer Seja, Johannes Zellner, Brian Johnstone, Denitsa Docheva, Peter Angel. Physioxia Has a Beneficial Effect on Cartilage Matrix Production in Interleukin-1 Beta-Inhibited Mesenchymal Stem Cell Chondrogenesis. Cells vol 8 issue 8 2020 31434236 |
in vivo, articular chondrocytes reside under a low oxygen environment between 2-5% oxygen (physioxia) and have been shown to enhance in vitro msc chondrogenic matrix content with reduced hypertrophic marker expression under these conditions. |
2020-04-06 |
2023-01-26 |
Not clear |
| Tingxia Wang, Yun Li, Juan Chen, Lijian Xie, Tingting Xia. TGF-\\xce\\xb21/Smad3 signaling promotes collagen synthesis in pulmonary artery smooth muscle by down-regulating miR-29b. International journal of clinical and experimental pathology vol 11 issue 12 2020 31949646 |
deposition of fibronectin and collagen in the extracellular matrix (ecm) and the proliferation, migration, and hypertrophy of vascular smooth muscle cells (vsmcs) result in pulmonary arterial (pa) hypertrophy and muscularization, leading to increased pulmonary vascular resistance in pulmonary arterial hypertension (pah). |
2020-03-25 |
2023-01-26 |
rat |
| Lifan Liao, Shanxing Zhang, Guang-Qian Zhou, Ling Ye, Jian Huang, Lan Zhao, Di Che. Deletion of Runx2 in condylar chondrocytes disrupts TMJ tissue homeostasis. Journal of cellular physiology vol 234 issue 4 2020 30387127 |
the histologic and immunohistochemical data showed that runx2 deficiency caused condylar tissue disorganization, including loss of hc and reduced hypertrophic zone, reduced proliferative chondrocytes, and decreased cartilage matrix production. |
2020-03-16 |
2023-01-26 |
mouse |
| Lian Xu, Mengxia Fu, Dongrui Chen, Weiqing Han, Michael C Ostrowski, Paul Grossfeld, Pingjin Gao, Maoqing Y. Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition. BMB reports vol 52 issue 10 2020 30670148 |
the reduced cardiac fibrosis was accompanied by decreased expression of fibrotic matrix genes, reduced endmt with decreased snail, slug, twist, and zeb1 expression, as well as reduced cardiac hypertrophy and expression of hypertrophyassociated genes was observed. |
2020-03-12 |
2023-01-26 |
mouse |
| Van K Ninh, Elia C El Hajj, Alan J Mouton, Milad C El Hajj, Nicholas W Gilpin, Jason D Gardne. Chronic Ethanol Administration Prevents Compensatory Cardiac Hypertrophy in Pressure Overload. Alcoholism, clinical and experimental research vol issue 2020 29846943 |
alcoholic cardiomyopathy is characterized by a dilated cardiac phenotype with extensive hypertrophy and extracellular matrix (ecm) remodeling. |
2020-03-06 |
2023-01-26 |
Not clear |
| Zhenzhen Lu, Yifei Zhong, Wangyi Liu, Ling Xiang, Yueyi Den. The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease. Journal of diabetes research vol 2019 issue 2020 31534972 |
the pathological features of dkd are the hypertrophy of mesangial cells, apoptosis of podocytes, glomerular basement membrane (gbm) thickening, accumulation of extracellular matrix (ecm), glomerular sclerosis, and tubulointerstitial fibrosis. |
2020-02-27 |
2023-01-26 |
Not clear |
| Falguni Das, Soumya Maity, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. The Journal of biological chemistry vol 294 issue 24 2020 31028173 |
deacetylation of s6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. |
2020-02-25 |
2023-01-26 |
rat |
| Falguni Das, Soumya Maity, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. The Journal of biological chemistry vol 294 issue 24 2020 31028173 |
s6 kinase acts as a driver for renal hypertrophy and matrix accumulation, two key pathologic signatures of diabetic nephropathy. |
2020-02-25 |
2023-01-26 |
rat |