| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Falguni Das, Soumya Maity, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. The Journal of biological chemistry vol 294 issue 24 2020 31028173 |
the role of this acetylation to regulate kidney glomerular cell hypertrophy and matrix expansion is not known. |
2020-02-25 |
2023-01-26 |
rat |
| Falguni Das, Soumya Maity, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. The Journal of biological chemistry vol 294 issue 24 2020 31028173 |
in aggregate, our data uncovered a previously unrecognized role of s6 kinase deacetylation in high glucose-induced mesangial cell hypertrophy and matrix protein expression. |
2020-02-25 |
2023-01-26 |
rat |
| Atlante S Mendes, Marcela M Blascke de Mello, Juliana M Parente, Ana Carolina M Omoto, Evandro M Neto-Neves, Rubens Fazan, Jose E Tanus-Santos, Michele M Castr. Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. Life sciences vol 244 issue 2020 31830479 |
verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. |
2020-02-19 |
2023-01-26 |
rat |
| Atlante S Mendes, Marcela M Blascke de Mello, Juliana M Parente, Ana Carolina M Omoto, Evandro M Neto-Neves, Rubens Fazan, Jose E Tanus-Santos, Michele M Castr. Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. Life sciences vol 244 issue 2020 31830479 |
increased activity of calpain-1 and matrix metalloproteinase (mmp)-2 was observed in different models of arterial hypertension and contribute to thicken the left ventricle (lv) walls and to hypertrophy cardiac myocytes. |
2020-02-19 |
2023-01-26 |
rat |
| Kentaro Endo, Naoki Fujita, Takayuki Nakagawa, Ryohei Nishimur. Comparison of the effect of growth factors on chondrogenesis of canine mesenchymal stem cells. The Journal of veterinary medical science vol 81 issue 8 2020 31167981 |
the expression of cartilage matrix or hypertrophic gene/protein was also evaluated by qpcr and immunohistochemistry. |
2020-02-11 |
2023-01-26 |
Not clear |
| Edoardo Gronda, Stefania Sacchi, Giuditta Benincasa, Emilio Vanoli, Claudio Napol. Unresolved issues in left ventricular postischemic remodeling and progression to heart failure. Journal of cardiovascular medicine (Hagerstown, Md.) vol 20 issue 10 2020 31343451 |
we focused our attention on multiple factors, which include myocyte loss, hypertrophy, hyperplasia, extracellular matrix changes linked to myocardial fibrosis and scar, metabolic imbalance, as well as immunologic response occurring in the acute myocardial aftermath. |
2020-02-03 |
2023-01-26 |
Not clear |
| Magdalena Rodica Tr\\xc4\\x83istaru, Diana Kamal, Daniela Teodora Maria, Marian Valentin Zoril\\xc4\\x83, Drago\\xc5\\x9f Ovidiu Alexandru, Otilia Constantina Rogoveanu, Mirela Radu, Kamal Constantin Kama. Complex evaluation in patients with knee osteoarthritis. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie vol 60 issue 1 2020 31263841 |
in the histological assessment of our patients, we observed that the cells of the superficial areas were round and hypertrophic, the cartilage tissue had few proteoaminoglycans and glycosaminoglycans, with an airy aspect of the matrix and degenerate cells, numerically reduced. |
2020-01-27 |
2023-01-26 |
Not clear |
| Xiaoyang Wang, Jia Guo, Qiujie Wu, Cong Niu, Genyang Cheng, Dong Liu, Zhangsuo Liu, Zhanzheng Zhao, Jing Xia. Chemerin/chemR23 association with endothelial-mesenchymal transition in diabetic nephropathy. International journal of clinical and experimental pathology vol 10 issue 7 2020 31966583 |
mild glomerular hypertrophy was observed at 4 weeks and mild glomerular basement membrane thickening and mesangial matrix proliferation at 12 weeks. |
2020-01-26 |
2023-01-26 |
rat |
| Xiao-Ping Li, Pei Liu, Yan-Feng Li, Gan-Lin Zhang, De-Shan Zeng, Da-Lie Li. LPS induces activation of the TLR4 pathway in fibroblasts and promotes skin scar formation through collagen I and TGF-\\xce\\xb2 in skin lesions. International journal of clinical and experimental pathology vol 12 issue 6 2020 31934034 |
hypertrophic scars are proliferative diseases of dermal fibroblasts that produce abundant amounts of collagen and extracellular matrix in the skin after severe burns, inflammation and trauma. |
2020-01-17 |
2023-01-26 |
Not clear |
| Hua Wang, Haiyan Zhang, Qiuyi Sun, Jian Yang, Chun Zeng, Changhai Ding, Daozhang Cai, Anling Liu, Xiaochun Ba. Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression. Journal of cellular physiology vol 234 issue 3 2020 30145794 |
mechanistically, mtorc1 controls the hdac4-dependent expression of mir-483-5p to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and subchondral bone angiogenesis, and it consequently initiates and accelerates the development of oa. |
2020-01-09 |
2023-01-26 |
mouse |
| Lingzhi Zhong, Haojie Hao, Deyun Chen, Qian Hou, Ziying Zhu, Wenjun He, Sujing Sun, Mengli Sun, Meirong Li, Xiaobing F. Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway. Journal of cellular physiology vol 234 issue 3 2020 30317545 |
tissue contraction and the extracellular matrix deposition are part of the pathogenesis of hypertrophic scars. |
2020-01-09 |
2023-01-26 |
Not clear |
| Renuga D Rajaram, Romain Dissard, Vincent Jaquet, Sophie de Seigneu. Potential benefits and harms of NADPH oxidase type 4 in the kidneys and cardiovascular system. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association vol 34 issue 4 2020 29931336 |
diabetes elevates nox4 expression in podocytes and mesangial cells, which was shown to damage glomeruli leading to podocyte loss, mesangial cell hypertrophy and matrix accumulation. |
2020-01-06 |
2023-01-26 |
mouse |
| Daisuke Maeda, Tateki Kubo, Koichiro Kiya, Kenichiro Kawai, Shinsuke Matsuzaki, Daichi Kobayashi, Toshihiro Fujiwara, Taiichi Katayama, Ko Hosokaw. Periostin is induced by IL-4/IL-13 in dermal fibroblasts and promotes RhoA/ROCK pathway-mediated TGF-\\xce\\xb21 secretion in abnormal scar formation. Journal of plastic surgery and hand surgery vol 53 issue 5 2019 31066603 |
excess scar formation can occur after skin injur\xe3\x81\xb5y and lead to abnormal scar formation, such as keloids and hypertrophic scars, which are characterised by substantial deposition of extracellular matrix in the dermis. |
2019-12-31 |
2023-01-26 |
human |
| Huan Zhou, Bin Wang, Ying-Xi Yang, Qiu-Jin Jia, Ao Zhang, Zhong-Wen Qi, Jun-Ping Zhan. Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature. BioMed research international vol 2019 issue 2019 31355277 |
in addition, neat1, ak139328, apf, caif, ak088388, carl, malat1, hotair, xist, and nrf are involved in postischemia myocardial remodeling, while mhrt, chast, chrf, ror, h19, plscr4, and miat are involved in myocardial hypertrophy, and malat1, wisper, meg3, and h19 are involved in extracellular matrix (ecm) reconstitution. |
2019-12-30 |
2023-01-26 |
Not clear |
| Gabor A Fulop, Francisco I Ramirez-Perez, Tamas Kiss, Stefano Tarantini, Marta Noa Valcarcel Ares, Peter Toth, Andriy Yabluchanskiy, Shannon M Conley, Praveen Ballabh, Luis A Martinez-Lemus, Zoltan Ungvari, Anna Csisza. IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging. The journals of gerontology. Series A, Biological sciences and medical sciences vol 74 issue 4 2019 29931048 |
mcas of control mice exhibited structural adaptation to hypertension, manifested as a significant increase in wall thickness, vascular smooth muscle cell (vsmc) hypertrophy, decreased internal diameter and up-regulation of extracellular matrix (ecm)-related genes. |
2019-12-26 |
2023-01-26 |
mouse |
| Marijn Rutgers, Frances Bach, Luci\\xc3\\xabnne Vonk, Mattie van Rijen, Vanessa Akrum, Antonette van Boxtel, Wouter Dhert, Laura Creemer. PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation. PloS one vol 14 issue 4 2019 30947269 |
extracellular matrix production, (pre)hypertrophy and pth signaling were assessed by rt-qpcr and/or immunohistochemistry for collagen type i, ii, x, runx2, mmp13, pthr1 and ihh and by determining glycosaminoglycan production and dna content. |
2019-12-19 |
2023-01-26 |
human |
| Marijn Rutgers, Frances Bach, Luci\\xc3\\xabnne Vonk, Mattie van Rijen, Vanessa Akrum, Antonette van Boxtel, Wouter Dhert, Laura Creemer. PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation. PloS one vol 14 issue 4 2019 30947269 |
in conclusion, pth supplementation to healthy human articular chondrocytes did not affect hypertrophic differentiation, but negatively influenced cartilage quality, the tissues' extracellular matrix and cell content. |
2019-12-19 |
2023-01-26 |
human |
| Rodolphe Rakic, Bastien Bourdon, Magali Demoor, St\\xc3\\xa9phane Maddens, Nathalie Saulnier, Philippe Gal\\xc3\\xa9r. Differences in the intrinsic chondrogenic potential of equine umbilical cord matrix and cord blood mesenchymal stromal/stem cells for cartilage regeneration. Scientific reports vol 8 issue 1 2019 30217993 |
we carried out an exhaustive characterization of the extracellular matrix generated by both these two types of mscs after the induction of chondrogenesis through evaluation of hyaline cartilage, hypertrophic and osteogenic markers (mrna, protein and histology levels). |
2019-12-06 |
2023-01-26 |
Not clear |
| Cintia do Carmo E Silva, J\\xc3\\xb4nathas Fernandes Queiroz de Almeida, Larissa Matuda Macedo, Marcos Barrouin Melo, Gustavo Rodrigues Pedrino, Fernanda Cristina Alcantara Dos Santos, Manoel Francisco Biancardi, Robson Augusto Souza Dos Santos, Adryano Augustto Vallad\\xc3\\xa3o de Carvalho, Elizabeth Pereira Mendes, Diego Basile Colugnati, Renata Mazaro-Costa, Carlos Henrique de Castr. Mas receptor contributes to pregnancy-induced cardiac remodelling. Clinical science (London, England : 1979) vol 130 issue 24 2019 27624141 |
in conclusion, these data show that although mas receptor blockade or deletion decreases physiological hypertrophy of pregnancy, it is associated with more extracellular matrix deposition. |
2019-11-20 |
2023-01-25 |
rat |
| Mitsuo Kato, Mei Wang, Zhuo Chen, Kirti Bhatt, Hyung Jung Oh, Linda Lanting, Supriya Deshpande, Ye Jia, Jennifer Y C Lai, Christopher L O'Connor, YiFan Wu, Jeffrey B Hodgin, Robert G Nelson, Markus Bitzer, Rama Nataraja. An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy. Nature communications vol 7 issue 2019 27686049 |
targeting early features of dn, including renal extracellular matrix accumulation (ecm) and glomerular hypertrophy, can prevent disease progression. |
2019-11-20 |
2023-01-25 |
Not clear |