| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| N V Medvedev, N K Gorshunov. [Apoptosis and interstitial fibrosis in development of myocardial remodelling in elderly patients with arterial hypertension]. Advances in gerontology = Uspekhi gerontologii vol 26 issue 2 2019 28976159 |
structural reorganization of a myocardium from concentric to eccentric hypertrophy and concentric remodelling of left ventricle was characterized by strengthening of cellular apoptosis and interstitial myocardial fibrosis in extracellular matrix expressiveness, prevalence of collagen synthesis over collagen degradation, progressing of myocardium dysfunction. |
2019-11-20 |
2023-01-26 |
Not clear |
| Qian Tang, Gang Zheng, Zhenhua Feng, Minji Tong, Jianxiang Xu, Zhiyan Hu, Ping Shang, Yu Chen, Chenggui Wang, Yiting Lou, Deheng Chen, Di Zhang, Majid Nisar, Xiaolei Zhang, Huazi Xu, Haixiao Li. Wogonoside inhibits IL-1\\xce\\xb2 induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis. Oncotarget vol 8 issue 37 2019 28977876 |
the inflammatory environment is correlated with extracellular matrix (ecm) degradation and chondrocyte hypertrophy in the development of osteoarthritis (oa). |
2019-11-20 |
2023-01-26 |
mouse |
| Jihong Shi, Shan Shi, Bin Wu, Jian Zhang, Yan Li, Xue Wu, Julei Zhang, Kejia Wang, Bin Zhao, Weixia Cai, Xiaozhi Bai, Dahai Hu, Hao Gua. Autophagy protein LC3 regulates the fibrosis of hypertrophic scar by controlling Bcl-xL in dermal fibroblasts. Oncotarget vol 8 issue 55 2019 29212187 |
hypertrophic scar (hs) is a serious skin fibrotic disease characterized by excessive hypercellularity and extracellular matrix (ecm) component deposition. |
2019-11-20 |
2023-01-26 |
rabbit |
| Chunpeng Zou, Weixin Li, Yong Pan, Zia A Khan, Jieli Li, Xixi Wu, Yi Wang, Liancheng Deng, Guang Liang, Yunjie Zha. 11\\xce\\xb2-HSD1 inhibition ameliorates diabetes-induced cardiomyocyte hypertrophy and cardiac fibrosis through modulation of EGFR activity. Oncotarget vol 8 issue 56 2019 29221204 |
we also show that high levels of glucose caused cardiomyocyte hypertrophy and increased matrix protein deposition in culture. |
2019-11-20 |
2023-01-26 |
Not clear |
| De Luca F, Baro. Control of Bone Growth by Fibroblast Growth Factors. Trends in endocrinology and metabolism: TEM vol 10 issue 2 2019 10322396 |
in organ culture, fgf-2 inhibits growth by decreasing growth plate chondrocyte proliferation, hypertrophy and cartilage matrix synthesis. |
2019-11-20 |
2023-01-24 |
mouse |
| Xinhua Hu, Xing Ji, Mengting Yang, Shihao Fan, Jirong Wang, Meiping Lu, Wei Shi, Liu Mei, Chengyun Xu, Xueying Fan, Musaddique Hussain, Jingyu Du, Junsong Wu, Ximei W. Cdc42 Is Essential for Both Articular Cartilage Degeneration and Subchondral Bone Deterioration in Experimental Osteoarthritis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 33 issue 5 2019 29314205 |
specifically, genetic disruption of cdc42, knockdown of cdc42 expression, or inhibition of cdc42 activity robustly attenuates the dmm-induced destruction, hypertrophy, high expression of matrix metallopeptidase-13 and collagen x, and activation of stat3 in articular cartilages. |
2019-10-23 |
2023-01-26 |
mouse |
| Xinning Yu, Tengfei Zhao, Yiying Qi, Jianyang Luo, Jinghua Fang, Xianyan Yang, Xiaonan Liu, Tengjing Xu, Quanming Yang, Zhongru Gou, Xuesong Da. In vitro Chondrocyte Responses in Mg-doped Wollastonite/Hydrogel Composite Scaffolds for Osteochondral Interface Regeneration. Scientific reports vol 8 issue 1 2019 30559344 |
an increase in csi-mg10 content is desirable for promoting the hypertrophy and mineralization of chondrocytes, as well as cell proliferation and matrix deposition. |
2019-10-18 |
2023-01-26 |
human |
| Xinning Yu, Tengfei Zhao, Yiying Qi, Jianyang Luo, Jinghua Fang, Xianyan Yang, Xiaonan Liu, Tengjing Xu, Quanming Yang, Zhongru Gou, Xuesong Da. In vitro Chondrocyte Responses in Mg-doped Wollastonite/Hydrogel Composite Scaffolds for Osteochondral Interface Regeneration. Scientific reports vol 8 issue 1 2019 30559344 |
it is noteworthy that the hdzcs in the 6% csi-mg10 scaffolds maintained a higher expression of the calcified cartilage zone specific extracellular matrix marker and hypertrophic marker, collagen type x. immunohistochemical and alizarin red staining reconfirmed these findings. |
2019-10-18 |
2023-01-26 |
human |
| Hanneke N Monsuur, Lenie J van den Broek, Pieter Koolwijk, Frank B Niessen, Susan Gibb. Endothelial cells enhance adipose mesenchymal stromal cell-mediated matrix contraction via ALK receptors and reduced follistatin: Potential role of endothelial cells in skin fibrosis. Journal of cellular physiology vol 233 issue 10 2019 29345319 |
in conclusion, our study shows that ec may play a critical role in fibrotic events, as seen in hypertrophic scars, by stimulating asc-mediated matrix contraction via regulation of fibrosis-related proteins. |
2019-10-03 |
2023-01-26 |
Not clear |
| Aaron J Rogers, Ramaswamy Kannappan, Hadil Abukhalifeh, Mohammed Ghazal, Jessica M Miller, Ayman El-Baz, Vladimir G Fast, Palaniappan Seth. Hemodynamic Stimulation Using the Biomimetic Cardiac Tissue Model (BCTM) Enhances Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cells, tissues, organs vol 206 issue 1-2 2019 30840966 |
following 7 days of gradually increasing stimulation, we show that hemodynamic loading results in (a) enhanced alignment of the cells and extracellular matrix, (b) significant increases in genes associated with physiological hypertrophy, (c) noticeable changes in sarcomeric organization and potential changes to cellular metabolism, and (d) a significant increase in fractional shortening, suggestive of a positive force frequency response. |
2019-09-19 |
2023-01-26 |
human |
| Marcela M Blascke de Mello, Juliana M Parente, Richard Schulz, Michele M Castr. Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension. Vascular pharmacology vol 116 issue 2019 30339939 |
matrix metalloproteinase (mmp)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension. |
2019-09-03 |
2023-01-26 |
rat |
| Xiaolu Ye, Zhiying Pang, Ningwen Zh. Dihydromyricetin attenuates hypertrophic scar formation by targeting activin receptor-like kinase 5. European journal of pharmacology vol 852 issue 2019 30807748 |
hypertrophic scar (hps) is a manifestation of abnormal tissue repair, representing excessive extracellular matrix production and abnormal function of fibroblasts, for which no satisfactory treatment is available at present. |
2019-09-03 |
2023-01-26 |
Not clear |
| Ang Li, Yiyong Wei, Clark Hung, Gordana Vunjak-Novakovi. Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix. Biomaterials vol 173 issue 2019 29758546 |
cartilage ecm promoted msc proliferation, production of cartilaginous matrix, and maturity of chondrogenic differentiation, and inhibited the hypertrophic differentiation of msc-derived chondrocytes. |
2019-08-13 |
2023-01-26 |
human |
| John E Madia. Letter by Madias Regarding Article, \"Left Ventricular Hypertrophy Revisited: Cell and Matrix Expansion Have Disease-Specific Relationships\". Circulation vol 137 issue 24 2019 29891629 |
letter by madias regarding article, "left ventricular hypertrophy revisited: cell and matrix expansion have disease-specific relationships". |
2019-08-02 |
2023-01-26 |
Not clear |
| Rebecca Kozor, James C Moon, Thomas A Treibe. Response by Kozor et al to Letter Regarding Article, \"Left Ventricular Hypertrophy Revisited: Cell and Matrix Expansion Have Disease-Specific Relationships\". Circulation vol 137 issue 24 2019 29891630 |
response by kozor et al to letter regarding article, "left ventricular hypertrophy revisited: cell and matrix expansion have disease-specific relationships". |
2019-08-02 |
2023-01-26 |
Not clear |
| Thomas A Treibel, Paul Richard Scully, James C Moo. Myocardial Hypertrophy, Matrix Expansion, and Focal Scar: Progression and Regression in Aortic Stenosis. Circulation. Cardiovascular imaging vol 11 issue 6 2019 29914870 |
myocardial hypertrophy, matrix expansion, and focal scar: progression and regression in aortic stenosis. |
2019-07-31 |
2023-01-26 |
Not clear |
| Xia Lu, Sheng Luan, Ping Dai, Kun Luo, Baolong Chen, Baoxiang Cao, Li Sun, Yunjun Yan, Jie Kon. Insights into the molecular basis of immunosuppression and increasing pathogen infection severity of ammonia toxicity by transcriptome analysis in pacific white shrimp Litopenaeus vannamei. Fish & shellfish immunology vol 88 issue 2019 30885745 |
a total of 13 pathways were obtained mainly involving in this process, which mainly led to the following changes: (1) increasing the immunosuppression, anemia, endocrine dysfunction, neurotoxic effect and neuroinvasion, atherosclerosis and thrombogenesis, blood-brain barrier penetration, thyroid disorder, necrosis, inflammation, and circadian disturbance; (2) reducing the ability of vascular remodeling, angiogenesis, cell survival, migration, apoptosis, and lymph transferred to blood stream; (3) leading to cell hypertrophy, cellular shape changes, and mesangial matrix expansion. |
2019-07-25 |
2023-01-26 |
Not clear |
| Daniel Elieh Ali Komi, Leif Bjerme. Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights. Clinical reviews in allergy & immunology vol 56 issue 2 2019 30506113 |
the release of mc mediators and mc/airway cell interactions during remodeling phase of asthma results in persistent cellular and structural changes in the airway wall mainly epithelial cell shedding, goblet cell hyperplasia, hypertrophy of asm bundles, fibrosis in subepithelial region, abnormal deposition of extracellular matrix (ecm), increased tissue vascularity, and basement membrane thickening. |
2019-07-23 |
2023-01-26 |
human |
| Thomas A Treibel, Rebecca Kozor, Rebecca Schofield, Giulia Benedetti, Marianna Fontana, Anish N Bhuva, Amir Sheikh, Bego\\xc3\\xb1a L\\xc3\\xb3pez, Arantxa Gonz\\xc3\\xa1lez, Charlotte Manisty, Guy Lloyd, Peter Kellman, Javier D\\xc3\\xadez, James C Moo. Reverse Myocardial Remodeling Following\\xc2\\xa0Valve Replacement in Patients\\xc2\\xa0With Aortic Stenosis. Journal of the American College of Cardiology vol 71 issue 8 2019 29471937 |
left ventricular (lv) hypertrophy, a key process in human cardiac disease, results from cellular (hypertrophy) and extracellular matrix expansion (interstitial fibrosis). |
2019-07-18 |
2023-01-26 |
human |
| Kazunori Hayashi, Akinobu Suzuki, Sayed Abdullah Ahmadi, Hidetomi Terai, Kentaro Yamada, Masatoshi Hoshino, Hiromitsu Toyoda, Shinji Takahashi, Koji Tamai, Shoichiro Ohyama, Akgar Javid, Mohammad Suhrab Rahmani, Maruf Mohammad Hasib, Hiroaki Nakamur. Mechanical stress induces elastic fibre disruption and cartilage matrix increase in ligamentum flavum. Scientific reports vol 7 issue 1 2019 29026131 |
these findings indicate that mechanical stress plays a crucial role in lf hypertrophy through cartilage matrix increase. |
2019-06-28 |
2023-01-26 |
Not clear |