| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masayo Aoki, Noriko M Matsumoto, Teruyuki Dohi, Hiroaki Kuwahawa, Satoshi Akaishi, Yuri Okubo, Rei Ogawa, Hirofumi Yamamoto, Kazuaki Takab. Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars. Molecular therapy. Nucleic acids. vol 22. 2020-10-01. PMID:32911344. |
hypertrophic scars (hss) and keloids are histologically characterized by excessive extracellular matrix (ecm) deposition. |
2020-10-01 |
2023-08-13 |
mouse |
| Sheng-Chieh Lin, Hsiu-Chu Chou, Bor-Luen Chiang, Chung-Ming Che. CTGF upregulation correlates with MMP-9 level in airway remodeling in a murine model of asthma. Archives of medical science : AMS. vol 13. issue 3. 2020-09-30. PMID:28507585. |
connective tissue growth factor (ctgf) mediates hypertrophy, proliferation, and extracellular matrix synthesis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bach Quang Le, Clemens Van Blitterswijk, Jan De Boe. An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair. Bioengineering (Basel, Switzerland). vol 4. issue 2. 2020-09-30. PMID:28952514. |
an approach to in vitro manufacturing of hypertrophic cartilage matrix for bone repair. |
2020-09-30 |
2023-08-13 |
human |
| Bach Quang Le, Clemens Van Blitterswijk, Jan De Boe. An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair. Bioengineering (Basel, Switzerland). vol 4. issue 2. 2020-09-30. PMID:28952514. |
devitalized hypertrophic cartilage matrix (dcm) is an attractive concept for an off-the-shelf bone graft substitute. |
2020-09-30 |
2023-08-13 |
human |
| Bach Quang Le, Clemens Van Blitterswijk, Jan De Boe. An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair. Bioengineering (Basel, Switzerland). vol 4. issue 2. 2020-09-30. PMID:28952514. |
upon implantation, dcm can trigger the natural endochondral ossification process, but only when the hypertrophic cartilage matrix has been reconstituted correctly. |
2020-09-30 |
2023-08-13 |
human |
| Taryn E Travis, Pejhman Ghassemi, Nicholas J Prindeze, Lauren T Moffatt, Bonnie C Carney, Abdulnaser Alkhalil, Jessica C Ramella-Roman, Jeffrey W Shup. Matrix Metalloproteinases Are Differentially Regulated and Responsive to Compression Therapy in a Red Duroc Model of Hypertrophic Scar. Eplasty. vol 18. 2020-09-30. PMID:29375731. |
matrix metalloproteinases are differentially regulated and responsive to compression therapy in a red duroc model of hypertrophic scar. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jun Qi, Yifei Liu, Kesu Hu, Yi Zhang, Yangyang Wu, Xia Zhan. MicroRNA-26a inhibits hyperplastic scar formation by targeting Smad2. Experimental and therapeutic medicine. vol 15. issue 5. 2020-09-30. PMID:29731824. |
hypertrophic scar (hs) is a fibrotic disease in which excessive extracellular matrix forms due to the response of fibroblasts to tissue damage. |
2020-09-30 |
2023-08-13 |
human |
| Kevin A Murach, Davis A Englund, Esther E Dupont-Versteegden, John J McCarthy, Charlotte A Peterso. Myonuclear Domain Flexibility Challenges Rigid Assumptions on Satellite Cell Contribution to Skeletal Muscle Fiber Hypertrophy. Frontiers in physiology. vol 9. 2020-09-30. PMID:29896117. |
satellite cells respond to muscle damage, and also play an important role in extracellular matrix remodeling during loading-induced hypertrophy. |
2020-09-30 |
2023-08-13 |
Not clear |
| M M Akhtar, P M Elliot. Anderson-Fabry disease in heart failure. Biophysical reviews. vol 10. issue 4. 2020-09-30. PMID:29909504. |
gb3 accumulation induces pathology via the release of pro-inflammatory cytokines, growth-promoting factors and by oxidative stress, resulting in myocardial extracellular matrix remodelling, left ventricular hypertrophy (lvh), vascular dysfunction and interstitial fibrosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hong-Wei Wang, Yi-He Chen, Yan-Yan Chen, Wei Huang, Xian-Dong Zhu, Fu-Biao Ni, Guo-Di Wu, Zi-Qiang Xu, Zhou-Qing Huang, Bi-Cheng Chen, Fang-Yi Xia. Islet transplantation attenuates cardiac fibrosis in diabetic rats through inhibition of TGF-β American journal of translational research. vol 10. issue 8. 2020-09-30. PMID:30210683. |
in addition, islet transplantation attenuated the increased levels of ctn-i and ck-mb, cleaved-caspase-3 in response to dm, and ameliorated diabetic-induced cardiac hypertrophy and interstitial fibrosis, along with improved extracellular matrix (ecm) deposition. |
2020-09-30 |
2023-08-13 |
rat |
| Aurore Van de Walle, Waïss Faissal, Claire Wilhelm, Nathalie Lucian. Role of growth factors and oxygen to limit hypertrophy and impact of high magnetic nanoparticles dose during stem cell chondrogenesis. Computational and structural biotechnology journal. vol 16. 2020-09-30. PMID:30524668. |
a major difficulty is to drive the chondrogenic differentiation of the cells such as they produce an extracellular matrix free of hypertrophic collagen. |
2020-09-30 |
2023-08-13 |
human |
| Aurore Van de Walle, Waïss Faissal, Claire Wilhelm, Nathalie Lucian. Role of growth factors and oxygen to limit hypertrophy and impact of high magnetic nanoparticles dose during stem cell chondrogenesis. Computational and structural biotechnology journal. vol 16. 2020-09-30. PMID:30524668. |
we focus on the synthesis of two of the most important constituents present in the cartilaginous extracellular matrix (collagen ii and aggrecan) and on the expression of collagen x, the signature of hypertrophic cartilage, in order to provide a quantitative index of the type of cartilage produced (i.e. |
2020-09-30 |
2023-08-13 |
human |
| I A Marino-Martínez, A G Martínez-Castro, V M Peña-Martínez, C A Acosta-Olivo, F Vílchez-Cavazos, A Guzmán-López, Edelmiro Pérez Rodríguez, V J Romero-Díaz, J A Ortega-Blanco, J Lara-Aria. Human amniotic membrane intra-articular injection prevents cartilage damage in an osteoarthritis model. Experimental and therapeutic medicine. vol 17. issue 1. 2020-09-30. PMID:30651759. |
at 6 weeks post-injection, the left knees exhibited hypertrophy, cracks, cell clusters, decreased matrix staining and structure loss. |
2020-09-30 |
2023-08-13 |
human |
| Yue Zhou, Mo Chen, Regis J O'Keefe, Jie Shen, Zhi Li, Jian Zhou, Xuedong Zhou, Jeremy J Ma. Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis. American journal of translational research. vol 11. issue 3. 2020-09-30. PMID:30972197. |
dnmt3b deficiency using conditional knockout mice led to the onset of osteoarthritis-like conditions including cartilage clefts, cartilage matrix loss and premature chondrocyte hypertrophy, which suggested that dnmt3b functioned as a osteoarthritis suppressor. |
2020-09-30 |
2023-08-13 |
mouse |
| Eduardo T Santana, Regiane Dos Santos Feliciano, Andrey J Serra, Eduardo Brigidio, Ednei L Antonio, Paulo J F Tucci, Lubov Nathanson, Mariana Morris, José A Silv. Comparative mRNA and MicroRNA Profiling during Acute Myocardial Infarction Induced by Coronary Occlusion and Ablation Radio-Frequency Currents. Frontiers in physiology. vol 7. 2020-09-29. PMID:27932994. |
we analyzed 48 mrnas expressions of nine different signal transduction pathways (cell survival and metabolism signs, matrix extracellular, cell cycle, oxidative stress, apoptosis, calcium signaling, hypertrophy markers, angiogenesis, and inflammation) in rat left ventricle 1 week after mi generated by both coronary occlusion and ab-rf. |
2020-09-29 |
2023-08-13 |
rat |
| O P Molodykh, I V Sorokina, E V Vinogradova, V I Kapustina, A A Khodako. Ultrastructure of the Liver in Response to Cyclophosphamide and Triterpenoids. Bulletin of experimental biology and medicine. vol 168. issue 3. 2020-09-28. PMID:31938907. |
the cytotoxic effect of betulonic acid manifests in modification of the fine structure of hepatocyte mitochondria, sequestration of glycogen, intensification of autophagic processes, emergence of necrobiotic changes in hepatocytes and endotheliocytes; betulonic acid amide actively modifies the mitochondrial fine structure (hypertrophic organelles, matrix rarefaction, uneven dilatation of cristae). |
2020-09-28 |
2023-08-13 |
Not clear |
| Wenqiang Yan, Xingquan Xu, Qian Xu, Ziying Sun, Qing Jiang, Dongquan Sh. Platelet-rich plasma combined with injectable hyaluronic acid hydrogel for porcine cartilage regeneration: a 6-month follow-up. Regenerative biomaterials. vol 7. issue 1. 2020-09-28. PMID:32153994. |
the ha hydrogel combined with prp-treated group showed more hyaline-like cartilage exhibited by macroscopic appearance and histological staining in terms of extracellular matrix and type ii collagen without formation of hypertrophic cartilage, indicating its capacity to improve cartilage healing in the minipig model evaluated at 6 months, with full-thickness cartilage defect of 8.5 mm diameter and osteochondral defect of 6.5 mm diameter, 5 mm depth exhibiting apparent regeneration. |
2020-09-28 |
2023-08-13 |
rabbit |
| Eri Shirakami, Sho Yamakawa, Kenji Hayashid. Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence. Burns & trauma. vol 8. 2020-09-28. PMID:32341924. |
hypertrophic scar formation is considered a result of the imbalance between extracellular matrix synthesis and degradation during wound healing. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jingjie Luan, Haitao Tao, Yue S. Taladegib controls early chondrocyte hypertrophy via inhibiting smoothened/Gli1 pathway. American journal of translational research. vol 12. issue 5. 2020-09-28. PMID:32509193. |
abs treatment accelerated the process of chondrocyte hypertrophy and upregulated the expression of type x collagen, matrix metalloproteinase-13 (mmp-13), runx-2 but decreased type ii collagen, sox-9, and aggrecan both in protein and mrna levels, which abolished by the present of taladegib with the activation of smo and gli1. |
2020-09-28 |
2023-08-13 |
human |
| Asish K Ghos. p300 in Cardiac Development and Accelerated Cardiac Aging. Aging and disease. vol 11. issue 4. 2020-09-28. PMID:32765954. |
stress-induced vascular injury activates pathways involved in pathogenesis of accelerated cardiac aging that includes cellular dysfunction, pathological cardiac hypertrophy, diabetic cardiomyopathy, cardiac matrix remodeling, cardiac dysfunction and heart failure. |
2020-09-28 |
2023-08-13 |
Not clear |