| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan C Bernhard, Elizabeth Hulphers, Bernhard Rieder, James Ferguson, Dominik R\\xc3\\xbcnzler, Thomas Nau, Heinz Redl, Gordana Vunjak-Novakovi. Perfusion Enhances Hypertrophic Chondrocyte Matrix Deposition, But Not the Bone Formation. Tissue engineering. Part A vol 24 issue 11-12 2019 29373945 |
perfusion enhances hypertrophic chondrocyte matrix deposition, but not the bone formation. |
2019-06-17 |
2023-01-26 |
rat |
| Jonathan C Bernhard, Elizabeth Hulphers, Bernhard Rieder, James Ferguson, Dominik R\\xc3\\xbcnzler, Thomas Nau, Heinz Redl, Gordana Vunjak-Novakovi. Perfusion Enhances Hypertrophic Chondrocyte Matrix Deposition, But Not the Bone Formation. Tissue engineering. Part A vol 24 issue 11-12 2019 29373945 |
we studied the effects of perfusion on hypertrophic chondrocyte differentiation, matrix production, and subsequent bone formation. |
2019-06-17 |
2023-01-26 |
rat |
| Yue Wang, Zong-Ji Zheng, Yi-Jie Jia, Yan-Lin Yang, Yao-Ming Xu. Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease. Journal of translational medicine vol 16 issue 1 2019 29848325 |
early renal hypertrophy is the main pathological feature, which gradually leads to the deposition of glomerular extracellular matrix and tubulointerstitial fibrosis, eventually developing irreversible structural damage to the kidneys. |
2019-06-14 |
2023-01-26 |
Not clear |
| Yi Zhang, Li Zhang, Qiyu Zhang, Weilong Hong, Xiaohua Li. [microRNA-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences vol 46 issue 6 2019 29658663 |
[microrna-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1]. |
2019-05-20 |
2023-01-26 |
Not clear |
| Shikha Chawla, Sourabh Ghos. Regulation of fibrotic changes by the synergistic effects of cytokines, dimensionality and matrix: Towards the development of an in vitro human dermal hypertrophic scar model. Acta biomaterialia vol 69 issue 2019 29330036 |
regulation of fibrotic changes by the synergistic effects of cytokines, dimensionality and matrix: towards the development of an in vitro human dermal hypertrophic scar model. |
2019-05-08 |
2023-01-26 |
human |
| Morag J Young, Gail K Adle. Aldosterone, the Mineralocorticoid Receptor and Mechanisms of Cardiovascular Disease. Vitamins and hormones vol 109 issue 2019 30678863 |
aldosterone and the mr also play a key role in regulating tissue volume expansion in many tissues, via the regulation of hypertrophy and/or hyperplasia of cardiac or vascular smooth muscle cells and through regulation of the extra cellular matrix (ecm) and tissue fibrosis. |
2019-04-22 |
2023-01-26 |
Not clear |
| Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Akt2 causes TGF\\xce\\xb2-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. PloS one vol 13 issue 11 2019 30444896 |
akt2 causes tgf\xce\xb2-induced deptor downregulation facilitating mtor to drive podocyte hypertrophy and matrix protein expression. |
2019-04-15 |
2023-01-26 |
rat |
| Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Akt2 causes TGF\\xce\\xb2-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. PloS one vol 13 issue 11 2019 30444896 |
tgf\xce\xb2 promotes podocyte hypertrophy and expression of matrix proteins in fibrotic kidney diseases such as diabetic nephropathy. |
2019-04-15 |
2023-01-26 |
rat |
| Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Akt2 causes TGF\\xce\\xb2-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. PloS one vol 13 issue 11 2019 30444896 |
importantly, inhibition of akt2 blocked tgf\xce\xb2 -induced podocyte hypertrophy and expression of the matrix protein fibronectin. |
2019-04-15 |
2023-01-26 |
rat |
| Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Akt2 causes TGF\\xce\\xb2-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. PloS one vol 13 issue 11 2019 30444896 |
furthermore, we provide the first evidence that deptor downstream of akt2 contributes to podocyte hypertrophy and matrix protein expression found in glomerulosclerosis in different renal diseases. |
2019-04-15 |
2023-01-26 |
rat |
| Ugo E Pazzaglia, Marcella Reguzzoni, Lavinia Casati, Andrea Minini, Andrea G Salvi, Valeria Sibili. Long bone human anlage longitudinal and circumferential growth in the fetal period and comparison with the growth plate cartilage of the postnatal age. Microscopy research and technique vol 82 issue 3 2019 30582248 |
measurement of multiple parameters (% lac area, % total matrix area, total lac density and mean single lac area), which characterize the cartilage anlage growth, suggested the following correlations with chondrocyte duplication rate: (a) slow duplication rate \xe2\x89\x88 coupled, intralacunar chondrocytes (in central epiphysis); (b) repeated/frequent cell duplications \xe2\x89\x88 clusters (in the basal epiphyseal layer); (c) clusters of chondrocytes before becoming hypertrophic were stacked up on the top of each other (both in the anlage transition zone or in the columns of metaphyseal growth plate); (d) enhanced osteoclastic resorption of the lacroix bone bark lower end, extended to the more external metaphyseal trabeculae counterbalancing the discrepancy between the epiphyseal and the diaphyseal circumferential growth. |
2019-04-03 |
2023-01-26 |
human |
| Keshvad Hedayatyanfard, Seyed Ali Ziai, Feizollah Niazi, Iman Habibi, Behnam Habibi, Hamideh Moravve. Losartan ointment relieves hypertrophic scars and keloid: A pilot study. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society vol 26 issue 4 2019 30099811 |
keloid and hypertrophic scars are two types of fibrosis caused by extracellular matrix overexpression, and angiotensin ii via at |
2019-04-01 |
2023-01-26 |
Not clear |
| Ugo E Pazzaglia, Marcella Reguzzoni, Francesca Pagani, Valeria Sibilia, Terenzio Congiu, Andrea G Salvi, Anna Benett. Study of Endochondral Ossification in Human Fetalcartilage Anlagen of Metacarpals: Comparative Morphology of Mineral Deposition in Cartilage and in the Periosteal Bone Matrix. Anatomical record (Hoboken, N.J. : 2007) vol 301 issue 4 2019 29266881 |
the progression of mineral phase deposition in hypertrophic cartilage and periosteal bone matrix was studied in human metacarpals primary ossification centers before vascular invasion began. |
2019-04-01 |
2023-01-26 |
human |
| Nathaly Espitia Pinz\\xc3\\xb3n, John J P Brev\\xc3\\xa9, John G J M Bol, Benjamin Drukarch, Wia Baron, Anne-Marie van Da. Tissue transglutaminase in astrocytes is enhanced by inflammatory mediators and is involved in the formation of fibronectin fibril-like structures. Journal of neuroinflammation vol 14 issue 1 2019 29282083 |
subsequently, hypertrophic astrocytes fill the lesion and produce extracellular matrix (ecm) proteins that together form the astroglial scar. |
2019-03-21 |
2023-01-26 |
Not clear |
| Shani Samuel, Raja Elina Ahmad, Thamil Selvee Ramasamy, Puvanan Karunanithi, Sangeetha Vasudevaraj Naveen, Tunku Kamaru. Platelet-rich concentrate in serum-free medium enhances cartilage-specific extracellular matrix synthesis and reduces chondrocyte hypertrophy of human mesenchymal stromal cells encapsulated in alginate. Platelets vol 30 issue 1 2019 29090639 |
platelet-rich concentrate in serum-free medium enhances cartilage-specific extracellular matrix synthesis and reduces chondrocyte hypertrophy of human mesenchymal stromal cells encapsulated in alginate. |
2019-03-15 |
2023-01-26 |
human |
| Shani Samuel, Raja Elina Ahmad, Thamil Selvee Ramasamy, Puvanan Karunanithi, Sangeetha Vasudevaraj Naveen, Tunku Kamaru. Platelet-rich concentrate in serum-free medium enhances cartilage-specific extracellular matrix synthesis and reduces chondrocyte hypertrophy of human mesenchymal stromal cells encapsulated in alginate. Platelets vol 30 issue 1 2019 29090639 |
results showed that the cells cultured in the presence of prc for 24\xc2\xa0days maintained a chondrocytic phenotype and demonstrated minimal upregulation of cartilaginous extracellular matrix (ecm) marker genes (sox9, tnc, col2, acan, comp) and reduced expression of chondrocyte hypertrophy genes (col x, runx2) compared to the standard chondrogenic medium (p\xc2\xa0<\xc2\xa00.05). |
2019-03-15 |
2023-01-26 |
human |
| Thomas A Treibel, Rebecca Kozor, Katia Menacho, Silvia Castelletti, Heerajnarain Bulluck, Stefania Rosmini, Sabrina Nordin, Viviana Maestrini, Marianna Fontana, James C Moo. Left Ventricular Hypertrophy Revisited: Cell and Matrix Expansion Have Disease-Specific Relationships. Circulation vol 136 issue 25 2019 29255128 |
left ventricular hypertrophy revisited: cell and matrix expansion have disease-specific relationships. |
2019-03-14 |
2023-01-26 |
Not clear |
| Zhi-Feng Xiao, Guo-Yi Su, Yu Hou, Shu-Dong Chen, Ding-Kun Li. Cartilage degradation in osteoarthritis: A process of osteochondral remodeling resembles the endochondral ossification in growth plate? Medical hypotheses vol 121 issue 2019 30396477 |
many factors such as mechanics, inflammation and immunological abnormality could drive the joint tissues metabolic and disturb the steady state of cartilage and bone, which further devoted to a serial pathological manifestations, consisting of hypertrophy and apoptosis of articular chondrocytes, degradation of cartilage matrix, angiogenesis and calcification of hyaline cartilage, replication of tidemark, formation of osteophytes, degeneration of ligaments and, in the knee, the menisci, hypertrophy of the joint capsule and remodeling of subchondral bone along with increased permeability of the osteochondral interface. |
2019-03-05 |
2023-01-26 |
Not clear |
| Safdar Hussain, Mengyao Sun, Yuanxu Guo, Nosheen Mushtaq, Yitong Zhao, Ying Yuan, Nazim Hussain, Ezra Osoro, Abubakar Suleiman, Muhammad Sadiq, Fujun Zhang, Yan Han, Jian Sun, Shemin L. SFMBT2 positively regulates SOX9 and chondrocyte proliferation. International journal of molecular medicine vol 42 issue 6 2019 30272322 |
sox9 deletion in chondrocytes at the late stages of cartilage development results in decreased chondrocyte proliferation; inhibited expression of cartilage matrix genes, including indian hedgehog and the downstream parathyroid hormone\xe2\x80\x91related protein; and premature conversion of proliferating chondrocytes into hypertrophic chondrocytes, which mineralize their matrix prematurely. |
2019-02-25 |
2023-01-26 |
human |
| Xabier Unamuno, Javier G\\xc3\\xb3mez-Ambrosi, Amaia Rodr\\xc3\\xadguez, Sara Becerril, Gema Fr\\xc3\\xbchbeck, Victoria Catal\\xc3\\xa1. Adipokine dysregulation and adipose tissue inflammation in human obesity. European journal of clinical investigation vol 48 issue 9 2019 29995306 |
the mechanisms underlying adipose tissue dysfunction include adipocyte hypertrophy and hyperplasia, increased inflammation, impaired extracellular matrix remodelling and fibrosis together with an altered secretion of adipokines. |
2019-01-28 |
2023-01-26 |
human |