| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kine Anden\\xc3\\xa6s, Ida G Lunde, Naiyereh Mohammadzadeh, Christen P Dahl, Jan Magnus Aronsen, Mari E Strand, Sheryl Palmero, Ivar Sjaastad, Geir Christensen, Kristin V T Engebretsen, Theis T\\xc3\\xb8nnesse. The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling. PloS one vol 13 issue 7 2019 30052659 |
cardiac remodeling comprises cardiomyocyte hypertrophic growth, extracellular matrix alterations including fibrosis, and inflammation. |
2019-01-14 |
2023-01-26 |
mouse |
| Yinjie Liu, Ying Xiao, Jiaming Liu, Li Feng, Y James Kan. Copper-induced reduction in myocardial fibrosis is associated with increased matrix metalloproteins in a rat model of cardiac hypertrophy. Metallomics : integrated biometal science vol 10 issue 1 2019 29302675 |
copper-induced reduction in myocardial fibrosis is associated with increased matrix metalloproteins in a rat model of cardiac hypertrophy. |
2019-01-14 |
2023-01-26 |
rat |
| Ruzanna Shkhyan, Ben Van Handel, Jacob Bogdanov, Siyoung Lee, Yifan Yu, Mila Scheinberg, Nicholas W Banks, Sean Limfat, Arthur Chernostrik, Carlos Eduardo Franciozi, Mohammad Parvez Alam, Varghese John, Ling Wu, Gabriel B Ferguson, Ali Nsair, Frank A Petrigliano, C Thomas Vangsness, Kanagasabai Vadivel, Paul Bajaj, Liming Wang, Nancy Q Liu, Denis Evseenk. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Annals of the rheumatic diseases vol 77 issue 5 2019 29436471 |
human adult articular cartilage (ac) has little capacity for repair, and joint surface injuries often result in osteoarthritis (oa), characterised by loss of matrix, hypertrophy and chondrocyte apoptosis. |
2019-01-14 |
2023-01-26 |
mouse |
| Maday Fern\\xc3\\xa1ndez-Mayola, L\\xc3\\xa1zaro Betancourt, Alicia Molina-Kautzman, Sucel Palomares, Yssel Mendoza-Mar\\xc3\\xad, Dayana Ugarte-Moreno, Ana Aguilera-Barreto, Yilian Berm\\xc3\\xbadez-\\xc3\\x81lvarez, Vladimir Besada, Luis J Gonz\\xc3\\xa1lez, Ariana Garc\\xc3\\xada-Ojalvo, Ana J Mir-Ben\\xc3\\xadtez, Aleida Urquiza-Rodr\\xc3\\xadguez, Jorge Berlanga-Acost. Growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study. International wound journal vol 15 issue 4 2019 29464859 |
hypertrophic scars (hts) and keloids are forms of aberrant cutaneous healing with excessive extracellular matrix (ecm) deposition. |
2019-01-14 |
2023-01-26 |
Not clear |
| Grace C Limandjaja, Lenie J van den Broek, Melanie Breetveld, Taco Waaijman, Stan Monstrey, Edith M de Boer, Rik J Scheper, Frank B Niessen, Susan Gibb. Characterization of In Vitro Reconstructed Human Normotrophic, Hypertrophic, and Keloid Scar Models. Tissue engineering. Part C, Methods vol 24 issue 4 2018 29490604 |
notably, the expression of extracellular matrix associated genes showed distinguishing profiles between all scar types and normal skin (hyaluronan synthase-1, matrix-metalloprotease-3), between keloid and normal skin (collagen type iv), between normal scar and keloid (laminin \xce\xb11), and between keloid and hypertrophic scar (matrix-metalloprotease-1, integrin \xce\xb15). |
2018-12-21 |
2023-01-26 |
human |
| Guo Wei, Qingqing Xu, Lin Liu, Huanhuan Zhang, Xi Tan, Chunhong Zhang, Changyu Han, Yanxia Guo, Ganwen Han, Chunmin Zhan. LY2109761 reduces TGF-\\xce\\xb21-induced collagen production and contraction in hypertrophic scar fibroblasts. Archives of dermatological research vol 310 issue 8 2018 30046895 |
hypertrophic scars (hs) are fibro-hyperproliferative dermal lesions with effusive continuous accumulation of extracellular matrix components, particularly collagen. |
2018-12-17 |
2023-01-26 |
Not clear |
| Yuan Luo, Yiwen Zhang, Yuanliang Huan. Icariin Reduces Cartilage Degeneration in a Mouse Model of Osteoarthritis and is Associated with the Changes in Expression of Indian Hedgehog and Parathyroid Hormone-Related Protein. Medical science monitor : international medical journal of experimental and clinical research vol 24 issue 2018 30244259 |
results icariin treatment (mice in the aclt + ica group) significantly reduced degeneration of cartilage in oa with increased cartilage thickness, associated with increased expression of collagen type ii alpha 1 (col2a1), decreased chondrocyte hypertrophy, and decreased expression of collagen type x (colx) and matrix metalloproteinase 13 (mmp13). |
2018-12-12 |
2023-01-26 |
mouse |
| Mike Jager, Mi-Jeong Lee, Chendi Li, Stephen R Farmer, Susan K Fried, Matthew D Layn. Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue. PloS one vol 13 issue 5 2018 29799877 |
white adipose tissue expands through both adipocyte hypertrophy and hyperplasia and it is hypothesized that fibrosis or excess accumulation of extracellular matrix within adipose tissue may limit tissue expansion contributing to metabolic dysfunction. |
2018-12-11 |
2023-01-26 |
mouse |
| Jingcheng Deng, Yuan Shi, Zhen Gao, Wenjie Zhang, Xiaoli Wu, Weigang Cao, Wei Li. Inhibition of Pathological Phenotype of Hypertrophic Scar Fibroblasts Via Coculture with Adipose-Derived Stem Cells. Tissue engineering. Part A vol 24 issue 5-6 2018 28562226 |
hypertrophic scar (hs) is a dermal fibroproliferative disease characterized by fibroblast over-proliferation, overproduction, and deposition of the extracellular matrix. |
2018-12-11 |
2023-01-26 |
Not clear |
| Musaddique Hussain, Chengyun Xu, Meiping Lu, Xiling Wu, Lanfang Tang, Ximei W. Wnt/\\xce\\xb2-catenin signaling links embryonic lung development and asthmatic airway remodeling. Biochimica et biophysica acta. Molecular basis of disease vol 1863 issue 12 2018 28866134 |
wnt/\xce\xb2-catenin is a signaling protein that exhibits the pivotal role in lung development, injury and repair while aberrant expression of wnt/\xce\xb2-catenin signaling leads to asthmatic airway remodeling: characterized by hyperplasia and hypertrophy of airway smooth muscle cells, alveolar and vascular damage goblet cells metaplasia, and deposition of extracellular matrix; resulting in decreased lung compliance and increased airway resistance. |
2018-12-11 |
2023-01-26 |
Not clear |
| Soumya Maity, Amit Bera, Nandini Ghosh-Choudhury, Falguni Das, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. microRNA-181a downregulates deptor for TGF\\xce\\xb2-induced glomerular mesangial cell hypertrophy and matrix protein expression. Experimental cell research vol 364 issue 1 2018 29397070 |
microrna-181a downregulates deptor for tgf\xce\xb2-induced glomerular mesangial cell hypertrophy and matrix protein expression. |
2018-12-11 |
2023-01-26 |
Not clear |
| Soumya Maity, Amit Bera, Nandini Ghosh-Choudhury, Falguni Das, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. microRNA-181a downregulates deptor for TGF\\xce\\xb2-induced glomerular mesangial cell hypertrophy and matrix protein expression. Experimental cell research vol 364 issue 1 2018 29397070 |
tgf\xce\xb2 contributes to mesangial cell hypertrophy and matrix protein increase in various kidney diseases including diabetic nephropathy. |
2018-12-11 |
2023-01-26 |
Not clear |
| Halil \\xc4\\xb0brahim Sayg\\xc4\\xb1, Zeynep Banu G\\xc3\\xbcng\\xc3\\xb6r, Fatma Kalay, \\xc4\\xb0smail Se\\xc3\\xa7ki. In glomerular cells of puromycin aminonucleoside nephrosis rats both phosphorylated and total STAT3 levels increased during proteinuria. Acta histochemica vol 120 issue 6 2018 30054017 |
ultrastructural examinations showed glomerular damages such as significant decrease in slit pore number, a significant gradual increase in glomerular basement membrane thickness and podocyte hypertrophy on 5th and 15th days; besides significant increase in mesangial matrix. |
2018-11-08 |
2023-01-26 |
rat |
| Andre L P Tavares, Jessie A Brown, Emily C Ulrich, Katerina Dvorak, Raymond B Runya. Runx2-I is an Early Regulator of Epithelial-Mesenchymal Cell Transition in the Chick Embryo. Developmental dynamics : an official publication of the American Association of Anatomists vol 247 issue 3 2018 28631378 |
emt can be separated into an activation stage involving hypertrophy and cell separation and an invasion stage where cells invade the extracellular matrix. |
2018-11-07 |
2023-01-26 |
mouse |
| Ding-Sheng Jiang, Hao-Long Zeng, Rui Li, Bo Huo, Yun-Shu Su, Jing Fang, Qing Yang, Li-Gang Liu, Min Hu, Cai Cheng, Xue-Hai Zhu, Xin Yi, Xiang We. Aberrant Epicardial Adipose Tissue Extracellular Matrix Remodeling in Patients with Severe Ischemic Cardiomyopathy: Insight from Comparative Quantitative Proteomics. Scientific reports vol 7 issue 2018 28256566 |
the hypertrophic cardiomyopathy, adrenergic signaling in cardiomyocytes, extracellular matrix (ecm)-receptor interaction, phagosome, glycolysis/gluconeogenesis, and ppar signaling pathway were highlighted by the kegg pathway analysis. |
2018-11-06 |
2023-01-26 |
human |
| Alek G Erickson, Taylor D Laughlin, Sarah M Romereim, Catherine N Sargus-Patino, Angela K Pannier, Andrew T Dudle. A Tunable, Three-Dimensional In Vitro Culture Model of Growth Plate Cartilage Using Alginate Hydrogel Scaffolds. Tissue engineering. Part A vol 24 issue 1-2 2018 28525313 |
in bead cultures, encapsulated chondrocytes showed high viability, cartilage matrix deposition, low levels of chondrocyte hypertrophy, and a progressive increase in cell proliferation over 7 days in culture. |
2018-11-05 |
2023-01-26 |
mouse |
| Zhouyangfan Peng, Yapei Li, Pingyu Zeng, Xiaohui L. [Progress in the study on roles of cathepsin in hypertension]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences vol 42 issue 12 2018 29317587 |
cathepsins are widely expressed in human various tissue and cells and they are involved in the pathogenesis of hypertension through activation of renin - angiotensin system, degradation of cytoplasmic matrix, proliferation of smooth muscle cell and hypertrophy of myocyte. |
2018-10-24 |
2023-01-26 |
human |
| Patr\\xc3\\xadcia M Ferr\\xc3\\xa3o, L\\xc3\\xadndice M Nisimura, Otac\\xc3\\xadlio C Moreira, Marcelo G Land, Mirian C Pereira, Leila de Mendon\\xc3\\xa7a-Lima, Tania C Araujo-Jorge, Mariana C Waghabi, Luciana R Garzon. Inhibition of TGF-\\xce\\xb2 pathway reverts extracellular matrix remodeling in T. cruzi-infected cardiac spheroids. Experimental cell research vol 362 issue 2 2018 29208458 |
in the present study, we tested in a three-dimensional (3d) model of cardiac cells culture (named cardiac spheroids), capable of mimicking the aspects of fibrosis and hypertrophy observed in cc, the role of tgf-\xce\xb2 pathway inhibition in restoring extracellular matrix (ecm) balance disrupted by t. cruzi infection. |
2018-10-05 |
2023-01-26 |
Not clear |
| Oscar Orihuela-Rodr\\xc3\\xadguez, H\\xc3\\xa9ctor A. Carmona-Ru\\xc3\\xadz, Fernando Laredo-S\\xc3\\xa1nchez, Jos\\xc3\\xa9 Ram\\xc3\\xb3n Paniagua-Sierr. Left ventricular hypertrophy, fibrosis heart, and diastolic dysfunction in chronic kidney disease Revista medica del Instituto Mexicano del Seguro Social vol 55 issue Suppl. 2 2018 29697909 |
myocardial hypertrophy induces the activation of cellular apoptosis signals and activates metabolic pathways able to increase extracellular matrix production up to fibrosis. |
2018-10-02 |
2023-01-26 |
Not clear |
| Durgesh Kumar, Umesh Kumar Goand, Sanchita Gupta, Kripa Shankar, Salil Varshney, Sujith Rajan, Ankita Srivastava, Abhishek Gupta, Achchhe Lal Vishwakarma, Anurag Kumar Srivastava, Anil N Gaikwa. Saroglitazar reduces obesity and associated inflammatory consequences in murine adipose tissue. European journal of pharmacology vol 822 issue 2018 29331565 |
in the ewat of saroglitazar treated mice, histological analysis showed reduced adipocyte hypertrophy and matrix deposition (picrosirius red staining). |
2018-08-20 |
2023-01-26 |
mouse |