| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leonardo Schirone, Maurizio Forte, Silvia Palmerio, Derek Yee, Cristina Nocella, Francesco Angelini, Francesca Pagano, Sonia Schiavon, Antonella Bordin, Albino Carrizzo, Carmine Vecchione, Valentina Valenti, Isotta Chimenti, Elena De Falco, Sebastiano Sciarretta, Giacomo Frat. A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling. Oxidative medicine and cellular longevity vol 2017 issue 2018 28751931 |
among the complex signaling network that characterizes myocardial remodeling, the distinct processes are myocyte loss, cardiac hypertrophy, alteration of extracellular matrix homeostasis, fibrosis, defective autophagy, metabolic abnormalities, and mitochondrial dysfunction. |
2018-04-17 |
2023-01-26 |
Not clear |
| Li Zhang, Qianmei Zhang, Shuangxin Liu, Yuanhan Chen, Ruizhao Li, Ting Lin, Chunping Yu, Hong Zhang, Zhongshun Huang, Xinchen Zhao, Xiaofan Tan, Zhuo Li, Zhiming Ye, Jianchao Ma, Bin Zhang, Wenjian Wang, Wei Shi, Xinling Lian. DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury. Kidney international vol 92 issue 1 2018 28318634 |
this was accompanied by alleviation of glomerular hypertrophy, mesangial matrix expansion, and podocyte injury. |
2018-04-03 |
2023-01-26 |
Not clear |
| Peter O Kwan, Edward E Tredge. Biological Principles of Scar and Contracture. Hand clinics vol 33 issue 2 2018 28363295 |
these cells also both modify and interact with extracellular matrix of the wound, ultimately forming hypertrophic scar. |
2018-03-21 |
2023-01-26 |
Not clear |
| Bisher Abuyassin, Mohammad Badran, Najib T Ayas, Ismail Lahe. Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea. PloS one vol 13 issue 2 2018 29389945 |
measurements of glomerular hypertrophy and mesangial matrix expansion were made in periodic acid-schiff stained kidney sections, while glomerular transforming growth factor-\xce\xb21 (tgf-\xce\xb21), connective tissue growth factor (ctgf) and vascular endothelial growth factor-a (vegf-a) proteins were semi-quantified by immunohistochemistry. |
2018-03-13 |
2023-01-26 |
mouse |
| Bisher Abuyassin, Mohammad Badran, Najib T Ayas, Ismail Lahe. Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea. PloS one vol 13 issue 2 2018 29389945 |
we conclude that ih causes kidney injury that is accompanied by glomerular hypertrophy, mesangial matrix expansion, increased expression of glomerular growth factors and an increased cellular apoptosis. |
2018-03-13 |
2023-01-26 |
mouse |
| Shun Wang, Mian Cheng, Zhengqing Hu, Shan Hu, Qiang Zou, Xin Lai, Beilei Liu, Hong Jiang, Congxin Huang, Gang W. Angiotensin II Facilitates Matrix Metalloproteinase-9-Mediated Myosin Light Chain Kinase Degradation in Pressure Overload-Induced Cardiac Hypertrophy. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology vol 44 issue 6 2018 29262413 |
angiotensin ii facilitates matrix metalloproteinase-9-mediated myosin light chain kinase degradation in pressure overload-induced cardiac hypertrophy. |
2018-03-12 |
2023-01-26 |
Not clear |
| Umadevi Subramanian, Prerna Kumar, Indra Mani, David Chen, Isaac Kessler, Ramu Periyasamy, Giri Raghavaraju, Kailash N Pande. Retinoic acid and sodium butyrate suppress the cardiac expression of hypertrophic markers and proinflammatory mediators in Npr1 gene-disrupted haplotype mice. Physiological genomics vol 48 issue 7 2018 27199456 |
the objective of the present study was to examine the genetically determined differences in the natriuretic peptide receptor-a (npra) gene (npr1) copies affecting the expression of cardiac hypertrophic markers, proinflammatory mediators, and matrix metalloproteinases (mmps) in a gene-dose-dependent manner. |
2018-01-25 |
2023-01-25 |
mouse |
| Young Jun Oh, Vanessa C Pau, Jochen Steppan, Gautam Sikka, Valeriani R Bead, Daniel Nyhan, Benjamin D Levine, Dan E Berkowitz, Lakshmi Santhana. Role of tissue transglutaminase in age-associated ventricular stiffness. Amino acids vol 49 issue 3 2017 27438265 |
aging is associated with increased cardiomyocyte loss, left-ventricular hypertrophy, and the accumulation of extracellular matrix, which results in declining cardiac function. |
2017-12-29 |
2023-01-25 |
rat |
| Ana B Garc\\xc3\\xada-Redondo, Andrea Aguado, Ana M Briones, Mercedes Salaice. NADPH oxidases and vascular remodeling in cardiovascular diseases. Pharmacological research vol 114 issue 2017 27773825 |
a misbalance between the production and detoxification of ros increases oxidative stress that is involved in the vascular remodeling associated with cardiovascular diseases such as hypertension by affecting inflammation, hypertrophy, migration, growth/apoptosis and extracellular matrix protein turnover. |
2017-12-26 |
2023-01-26 |
Not clear |
| Sandeep C Chaudhary, Maria Kuzynski, Massimo Bottini, Elia Beniash, Terje Dokland, Callie G Mobley, Manisha C Yadav, Anne Poliard, Odile Kellermann, Jos\\xc3\\xa9 Luis Mill\\xc3\\xa1n, Dobrawa Napieral. Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro. Matrix biology : journal of the International Society for Matrix Biology vol 52-54 issue 2017 26883946 |
in mineralizing tissues, such as dentin, bone and hypertrophic cartilage, this process is initiated by a specific population of extracellular vesicles (ev), called matrix vesicles (mv). |
2017-12-20 |
2023-01-25 |
Not clear |
| Teruyo Nakatani, Tiffany Chen, Nicola C Partridg. MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton. Bone vol 90 issue 2017 27320207 |
previously, we reported that hdac4 is a repressor of matrix metalloproteinase-13 (mmp13) transcription, and the absence of hdac4 leads to increased expression of mmp-13 both in vitro (osteoblastic cells) and in vivo (hypertrophic chondrocytes and trabecular osteoblasts). |
2017-12-18 |
2023-01-25 |
mouse |
| Katie Bardsley, Agnieska Kwarciak, Christine Freeman, Ian Brook, Paul Hatton, Aileen Crawfor. Repair of bone defects in\\xc2\\xa0vivo using tissue engineered hypertrophic cartilage grafts produced from nasal chondrocytes. Biomaterials vol 112 issue 2017 27770634 |
on subcutaneous implantation of the hypertrophic engineered constructs, the grafts became vascularised, cartilage mineralisation occurred and loss of the proteoglycan in the matrix was observed. |
2017-12-12 |
2023-01-26 |
rat |
| Christopher L Mendias, Andrew J Schwartz, Jeremy A Grekin, Jonathan P Gumucio, Kristoffer B Sug. Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy. Journal of applied physiology (Bethesda, Md. : 1985) vol 122 issue 3 2017 27979985 |
changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy. |
2017-12-12 |
2023-01-26 |
rat |
| Christopher L Mendias, Andrew J Schwartz, Jeremy A Grekin, Jonathan P Gumucio, Kristoffer B Sug. Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy. Journal of applied physiology (Bethesda, Md. : 1985) vol 122 issue 3 2017 27979985 |
additionally, the extracellular matrix (ecm) stores and transmits forces from muscle fibers to tendons and bones, and determining how the ecm changes during hypertrophy is important in understanding the adaptation of muscle tissue to mechanical loading. |
2017-12-12 |
2023-01-26 |
rat |
| X Wang, Y Zhang, B H Jiang, Q Zhang, R P Zhou, L Zhang, Chen Wan. Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism. Experimental cell research vol 361 issue 2 2017 29056521 |
hypertrophic scar (hs) formation is associated with the fibrosis of fibrocytes caused by excessive extracellular matrix (ecm) synthesis and deposition, the initial event of hs formation. |
2017-11-29 |
2023-01-26 |
Not clear |
| Britta A Anderson, Audrey McAlinde. miR-483 targets SMAD4 to suppress chondrogenic differentiation of human mesenchymal stem cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol 35 issue 11 2017 28244607 |
while the in vivo expression patterns led us to hypothesize that mir-483 may enhance chondrogenesis or suppress hypertrophic marker expression, surprisingly, mir-483 overexpression reduced chondrocyte gene expression and cartilage matrix production. |
2017-11-20 |
2023-01-26 |
human |
| L C Lee, G S Kassab, J M Guccion. Mathematical modeling of cardiac growth and remodeling. Wiley interdisciplinary reviews. Systems biology and medicine vol 8 issue 3 2017 26952285 |
to facilitate the discussion, we have organized the g&r models in terms of (1) the physical focus (biochemical vs mechanical) and (2) the process that they describe (myocyte hypertrophy vs extracellular matrix remodeling). |
2017-11-13 |
2023-01-25 |
Not clear |
| Xiaoqian Ji, Changzheng Li, Yitao Ou, Ning Li, Kai Yuan, Guizhi Yang, Xiaoyan Chen, Zhicheng Yang, Bing Liu, Wai W Cheung, Lijing Wang, Ren Huang, Tian La. Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-\\xce\\xbaB pathway. Molecular and cellular endocrinology vol 437 issue 2017 27378149 |
diabetic nephropathy (dn) is characterized by proliferation of mesangial cells, mesangial hypertrophy and extracellular matrix (ecm) accumulation. |
2017-11-07 |
2023-01-25 |
mouse |
| Julia M\\xc3\\xbcnch, Maxim Avanesov, Peter Bannas, Dennis S\\xc3\\xa4ring, Elisabeth Kr\\xc3\\xa4mer, Giulia Mearini, Lucie Carrier, Anna Suling, Gunnar Lund, Monica Patte. Serum Matrix Metalloproteinases as Quantitative Biomarkers for Myocardial Fibrosis and Sudden Cardiac Death Risk Stratification in Patients With Hypertrophic Cardiomyopathy. Journal of cardiac failure vol 22 issue 10 2017 27018569 |
serum matrix metalloproteinases as quantitative biomarkers for myocardial fibrosis and sudden cardiac death risk stratification in patients with hypertrophic cardiomyopathy. |
2017-11-02 |
2023-01-25 |
Not clear |
| Ling Chen, Jingyun Li, Qian Li, Hui Yan, Bei Zhou, Yanli Gao, Jun L. Non-Coding RNAs: The New Insight on Hypertrophic Scar. Journal of cellular biochemistry vol 118 issue 8 2017 28067426 |
hypertrophic scarring (hs), a fibroproliferative disorder caused by abnormal wound healing after skin injury, is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. |
2017-11-02 |
2023-01-26 |
Not clear |