| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mike Jager, Mi-Jeong Lee, Chendi Li, Stephen R Farmer, Susan K Fried, Matthew D Layn. Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue. PloS one. vol 13. issue 5. 2018-12-11. PMID:29799877. |
white adipose tissue expands through both adipocyte hypertrophy and hyperplasia and it is hypothesized that fibrosis or excess accumulation of extracellular matrix within adipose tissue may limit tissue expansion contributing to metabolic dysfunction. |
2018-12-11 |
2023-08-13 |
mouse |
| Halil İbrahim Saygı, Zeynep Banu Güngör, Fatma Kalay, İsmail Seçki. In glomerular cells of puromycin aminonucleoside nephrosis rats both phosphorylated and total STAT3 levels increased during proteinuria. Acta histochemica. vol 120. issue 6. 2018-11-08. PMID:30054017. |
ultrastructural examinations showed glomerular damages such as significant decrease in slit pore number, a significant gradual increase in glomerular basement membrane thickness and podocyte hypertrophy on 5th and 15th days; besides significant increase in mesangial matrix. |
2018-11-08 |
2023-08-13 |
rat |
| Andre L P Tavares, Jessie A Brown, Emily C Ulrich, Katerina Dvorak, Raymond B Runya. Runx2-I is an Early Regulator of Epithelial-Mesenchymal Cell Transition in the Chick Embryo. Developmental dynamics : an official publication of the American Association of Anatomists. vol 247. issue 3. 2018-11-07. PMID:28631378. |
emt can be separated into an activation stage involving hypertrophy and cell separation and an invasion stage where cells invade the extracellular matrix. |
2018-11-07 |
2023-08-13 |
mouse |
| Ding-Sheng Jiang, Hao-Long Zeng, Rui Li, Bo Huo, Yun-Shu Su, Jing Fang, Qing Yang, Li-Gang Liu, Min Hu, Cai Cheng, Xue-Hai Zhu, Xin Yi, Xiang We. Aberrant Epicardial Adipose Tissue Extracellular Matrix Remodeling in Patients with Severe Ischemic Cardiomyopathy: Insight from Comparative Quantitative Proteomics. Scientific reports. vol 7. 2018-11-06. PMID:28256566. |
the hypertrophic cardiomyopathy, adrenergic signaling in cardiomyocytes, extracellular matrix (ecm)-receptor interaction, phagosome, glycolysis/gluconeogenesis, and ppar signaling pathway were highlighted by the kegg pathway analysis. |
2018-11-06 |
2023-08-13 |
human |
| Alek G Erickson, Taylor D Laughlin, Sarah M Romereim, Catherine N Sargus-Patino, Angela K Pannier, Andrew T Dudle. A Tunable, Three-Dimensional In Vitro Culture Model of Growth Plate Cartilage Using Alginate Hydrogel Scaffolds. Tissue engineering. Part A. vol 24. issue 1-2. 2018-11-05. PMID:28525313. |
in bead cultures, encapsulated chondrocytes showed high viability, cartilage matrix deposition, low levels of chondrocyte hypertrophy, and a progressive increase in cell proliferation over 7 days in culture. |
2018-11-05 |
2023-08-13 |
mouse |
| Zhouyangfan Peng, Yapei Li, Pingyu Zeng, Xiaohui L. [Progress in the study on roles of cathepsin in hypertension]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 42. issue 12. 2018-10-24. PMID:29317587. |
cathepsins are widely expressed in human various tissue and cells and they are involved in the pathogenesis of hypertension through activation of renin - angiotensin system, degradation of cytoplasmic matrix, proliferation of smooth muscle cell and hypertrophy of myocyte. |
2018-10-24 |
2023-08-13 |
human |
| Patrícia M Ferrão, Líndice M Nisimura, Otacílio C Moreira, Marcelo G Land, Mirian C Pereira, Leila de Mendonça-Lima, Tania C Araujo-Jorge, Mariana C Waghabi, Luciana R Garzon. Inhibition of TGF-β pathway reverts extracellular matrix remodeling in T. cruzi-infected cardiac spheroids. Experimental cell research. vol 362. issue 2. 2018-10-05. PMID:29208458. |
in the present study, we tested in a three-dimensional (3d) model of cardiac cells culture (named cardiac spheroids), capable of mimicking the aspects of fibrosis and hypertrophy observed in cc, the role of tgf-β pathway inhibition in restoring extracellular matrix (ecm) balance disrupted by t. cruzi infection. |
2018-10-05 |
2023-08-13 |
Not clear |
| Oscar Orihuela-Rodríguez, Héctor A. Carmona-Ruíz, Fernando Laredo-Sánchez, José Ramón Paniagua-Sierr. Left ventricular hypertrophy, fibrosis heart, and diastolic dysfunction in chronic kidney disease Revista medica del Instituto Mexicano del Seguro Social. vol 55. issue Suppl. 2. 2018-10-02. PMID:29697909. |
myocardial hypertrophy induces the activation of cellular apoptosis signals and activates metabolic pathways able to increase extracellular matrix production up to fibrosis. |
2018-10-02 |
2023-08-13 |
Not clear |
| Durgesh Kumar, Umesh Kumar Goand, Sanchita Gupta, Kripa Shankar, Salil Varshney, Sujith Rajan, Ankita Srivastava, Abhishek Gupta, Achchhe Lal Vishwakarma, Anurag Kumar Srivastava, Anil N Gaikwa. Saroglitazar reduces obesity and associated inflammatory consequences in murine adipose tissue. European journal of pharmacology. vol 822. 2018-08-20. PMID:29331565. |
in the ewat of saroglitazar treated mice, histological analysis showed reduced adipocyte hypertrophy and matrix deposition (picrosirius red staining). |
2018-08-20 |
2023-08-13 |
mouse |
| Durgesh Kumar, Umesh Kumar Goand, Sanchita Gupta, Kripa Shankar, Salil Varshney, Sujith Rajan, Ankita Srivastava, Abhishek Gupta, Achchhe Lal Vishwakarma, Anurag Kumar Srivastava, Anil N Gaikwa. Saroglitazar reduces obesity and associated inflammatory consequences in murine adipose tissue. European journal of pharmacology. vol 822. 2018-08-20. PMID:29331565. |
saroglitazar exerted its beneficial effects on adipose tissue by limiting, diet-induced adipose tissue dysfunction, adipocyte hypertrophy, adipocyte cell damage and extracellular matrix deposition in obesity. |
2018-08-20 |
2023-08-13 |
mouse |
| Tangni Gómez-Leduc, Magalie Hervieu, Florence Legendre, Mouloud Bouyoucef, Nicolas Gruchy, Laurent Poulain, Claire de Vienne, Michel Herlicoviez, Magali Demoor, Philippe Galér. Chondrogenic commitment of human umbilical cord blood-derived mesenchymal stem cells in collagen matrices for cartilage engineering. Scientific reports. vol 6. 2018-08-13. PMID:27604951. |
although growth factors increased the transcription of hypertrophic chondrocyte markers such as col10a1 and mmp13, the cells present in the neo-tissue maintained their phenotype and did not progress to terminal differentiation and mineralization of the extracellular matrix after subcutaneous implantation in nude mice. |
2018-08-13 |
2023-08-13 |
mouse |
| Kevin A Murach, Christopher S Fry, Tyler J Kirby, Janna R Jackson, Jonah D Lee, Sarah H White, Esther E Dupont-Versteegden, John J McCarthy, Charlotte A Peterso. Starring or Supporting Role? Satellite Cells and Skeletal Muscle Fiber Size Regulation. Physiology (Bethesda, Md.). vol 33. issue 1. 2018-07-25. PMID:29212890. |
emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy. |
2018-07-25 |
2023-08-13 |
mouse |
| Jayaraman Jayamani, R Ravikanth Reddy, Balaraman Madhan, Ganesh Shanmuga. Disintegration of collagen fibrils by Glucono-δ-lactone: An implied lead for disintegration of fibrosis. International journal of biological macromolecules. vol 107. issue Pt A. 2018-07-24. PMID:28866016. |
excess accumulation of collagen (fibrosis) undergoes self-aggregation, which leads to fibrillar collagen, on the extracellular matrix is the hallmark of a number of diseases such as keloids, hypertrophic scars, and systemic scleroderma. |
2018-07-24 |
2023-08-13 |
Not clear |
| Paiyz E Mikael, Hyun S Kim, Syam P Nukavarap. Hybrid extracellular matrix design for cartilage-mediated bone regeneration. Journal of biomedical materials research. Part B, Applied biomaterials. vol 106. issue 1. 2018-07-17. PMID:28140522. |
thus, 70:30 ha-fb matrix demonstrated a healthy formation of chondrogenic and hypertrophic stages with rich stage-specific ecm components. |
2018-07-17 |
2023-08-13 |
human |
| Christoph Hoffmann, Cora Weiger. Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations. Cold Spring Harbor perspectives in medicine. vol 7. issue 11. 2018-06-25. PMID:28389517. |
myokines control adaptive processes in skeletal muscle by acting as paracrine regulators of fuel oxidation, hypertrophy, angiogenesis, inflammatory processes, and regulation of the extracellular matrix. |
2018-06-25 |
2023-08-13 |
Not clear |
| Zhong Li, Wei Zhan. Protective effect of berberine on renal fibrosis caused by diabetic nephropathy. Molecular medicine reports. vol 16. issue 2. 2018-06-11. PMID:29067464. |
pas and masson staining revealed that there was notable glomerular hypertrophy and mesangial matrix expansion in dn rats. |
2018-06-11 |
2023-08-13 |
rat |
| Jibin Sha, Bo Sui, Xiaoqing Su, Qingfang Meng, Chenggang Zhan. Alteration of oxidative stress and inflammatory cytokines induces apoptosis in diabetic nephropathy. Molecular medicine reports. vol 16. issue 5. 2018-06-06. PMID:28944839. |
the kidney was severely damaged in the diabetes model group, with inflammatory cell invasion, increasing amount of interstitial matrix and hypertrophy with vacuolar degeneration of renal tubular cells. |
2018-06-06 |
2023-08-13 |
Not clear |
| Meiling Zhu, Qian Feng, Yuxin Sun, Gang Li, Liming Bia. Effect of cartilaginous matrix components on the chondrogenesis and hypertrophy of mesenchymal stem cells in hyaluronic acid hydrogels. Journal of biomedical materials research. Part B, Applied biomaterials. vol 105. issue 8. 2018-05-24. PMID:27478104. |
effect of cartilaginous matrix components on the chondrogenesis and hypertrophy of mesenchymal stem cells in hyaluronic acid hydrogels. |
2018-05-24 |
2023-08-13 |
Not clear |
| Massimo Bottini, Saida Mebarek, Karen L Anderson, Agnieszka Strzelecka-Kiliszek, Lukasz Bozycki, Ana Maria Sper Simão, Maytê Bolean, Pietro Ciancaglini, Joanna Bandorowicz Pikula, Slawomir Pikula, David Magne, Niels Volkmann, Dorit Hanein, José Luis Millán, Rene Buche. Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models. Biochimica et biophysica acta. General subjects. vol 1862. issue 3. 2018-05-22. PMID:29108957. |
matrix vesicles (mvs) are released from hypertrophic chondrocytes and from mature osteoblasts, the cells responsible for endochondral and membranous ossification. |
2018-05-22 |
2023-08-13 |
Not clear |
| Hongrui Liu, Dongfang Li, Shanshan Liu, Zhaopeng Liu, Minqi L. Histochemical evidence of IGF2 mRNA-binding protein 2-mediated regulation of osteoclast function and adhesive ability. Histochemistry and cell biology. vol 149. issue 4. 2018-05-16. PMID:29322325. |
in our present study, imp2-deficient mice exhibited more immature bone structures, characterized by abundant residual cartilage cores; growth plates containing more rich cartilage matrix, which was arranged irregularly; and a significantly thicker hypertrophic chondrocyte layer in the femoral metaphysis, compared with wild-type mice. |
2018-05-16 |
2023-08-13 |
mouse |